EP1012150A4 - Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases - Google Patents

Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases

Info

Publication number
EP1012150A4
EP1012150A4 EP98924794A EP98924794A EP1012150A4 EP 1012150 A4 EP1012150 A4 EP 1012150A4 EP 98924794 A EP98924794 A EP 98924794A EP 98924794 A EP98924794 A EP 98924794A EP 1012150 A4 EP1012150 A4 EP 1012150A4
Authority
EP
European Patent Office
Prior art keywords
tyrosine kinase
related disorders
protein tyrosine
active against
against protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98924794A
Other languages
German (de)
English (en)
Other versions
EP1012150A1 (fr
Inventor
Gerald Mcmahon
Peng Cho Tang
Laura Kay Shawver
Klaus Peter Hirth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sugen LLC
Original Assignee
Sugen LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen LLC filed Critical Sugen LLC
Publication of EP1012150A1 publication Critical patent/EP1012150A1/fr
Publication of EP1012150A4 publication Critical patent/EP1012150A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP98924794A 1997-05-19 1998-05-18 Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases Withdrawn EP1012150A4 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4694597P 1997-05-19 1997-05-19
US4708497P 1997-05-19 1997-05-19
US46945P 1997-05-19
US47084P 1997-05-19
US5662397P 1997-08-20 1997-08-20
US56623P 1997-08-20
US6159097P 1997-10-10 1997-10-10
US61590P 1997-10-10
PCT/US1998/010174 WO1998052944A1 (fr) 1997-05-19 1998-05-18 Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases

Publications (2)

Publication Number Publication Date
EP1012150A1 EP1012150A1 (fr) 2000-06-28
EP1012150A4 true EP1012150A4 (fr) 2002-05-29

Family

ID=27489113

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98924794A Withdrawn EP1012150A4 (fr) 1997-05-19 1998-05-18 Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases

Country Status (5)

Country Link
EP (1) EP1012150A4 (fr)
AR (1) AR015685A1 (fr)
AU (1) AU7687998A (fr)
CA (1) CA2302438A1 (fr)
WO (1) WO1998052944A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2362883A1 (fr) * 1999-02-12 2000-08-17 Quanam Medical Corporation Agents d'alkylation destines au traitement de proliferation cellulaire
GB9904103D0 (en) 1999-02-24 1999-04-14 Zeneca Ltd Quinoline derivatives
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
CA2366932C (fr) 1999-04-15 2009-08-25 Bristol-Myers Squibb Company Inhibiteurs cycliques de proteine tyrosine kinase
US6689883B1 (en) 1999-09-28 2004-02-10 Bayer Pharmaceuticals Corporation Substituted pyridines and pyridazines with angiogenesis inhibiting activity
US7977333B2 (en) 2000-04-20 2011-07-12 Bayer Healthcare Llc Substituted pyridines and pyridazines with angiogenesis inhibiting activity
US6903101B1 (en) 2000-08-10 2005-06-07 Bayer Pharmaceuticals Corporation Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
GB0322012D0 (en) 2003-09-19 2003-10-22 Syngenta Participations Ag Chemical compounds
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
EP1990048A3 (fr) * 2007-05-08 2009-05-06 Ulrike Wiebelitz Thérapie pour l'hyperplasie bénigne de la prostate
CA2716448A1 (fr) 2008-03-17 2009-09-24 Patrick Brossard Regime de dosage pour un agoniste selectif du recepteur s1p<sb>1</sb>
US20140179712A1 (en) 2012-12-21 2014-06-26 Astrazeneca Ab Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide
CN108929271B (zh) * 2018-06-29 2021-08-31 中国药科大学 酪氨酸酶抑制剂及其制备方法与用途

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0073973A1 (fr) * 1981-08-24 1983-03-16 BASF Aktiengesellschaft Anilides d'acides thiazolyl- et isothiazolyl carboxyliques, procédé pour les préparer et leur utilisation comme fongicides
EP0418667A2 (fr) * 1989-09-22 1991-03-27 BASF Aktiengesellschaft Amides d'acides carboxyliques
WO1991017748A1 (fr) * 1990-05-18 1991-11-28 Hoechst Aktiengesellschaft Amides d'acide carboxylique-4 d'isoxazol et cyanamides acetiques d'hydroxyalkylidene, medicaments contenant ces composes et leur application
WO1994001408A1 (fr) * 1992-07-10 1994-01-20 Laboratoires Glaxo S.A. Derives d'anilide
US5342851A (en) * 1992-10-07 1994-08-30 Mcneil-Ppc, Inc. Substituted thiazole derivatives useful as platelet aggregation inhibitors
WO1995019169A2 (fr) * 1994-01-07 1995-07-20 Sugen, Inc. Traitement de troubles lies au facteur mitogenique plaquettaire tels que les cancers a l'aide d'inhibiteurs du recepteur de facteur mitogenique plaquettaire
JPH07196637A (ja) * 1993-11-24 1995-08-01 Mitsui Toatsu Chem Inc イソチアゾールカルボン酸アミド誘導体の製造法
US5476866A (en) * 1993-10-01 1995-12-19 Roussel Uclaf Isoxazoles
WO1996033179A1 (fr) * 1995-04-21 1996-10-24 Sugen, Inc. Derives des thioamides et leur utilisation comme inhibiteurs de croissance cellulaire hyper-proliferative
WO1997011690A2 (fr) * 1995-09-29 1997-04-03 Microcide Pharmaceuticals, Inc. Inhibiteurs des voies de regulation
EP0769296A1 (fr) * 1995-10-25 1997-04-23 Hoechst Aktiengesellschaft Utilisation de derivés d'isoxazole et de crotonamide pour la fabrication d'un médicament pour le traitement de cancers
WO1997040019A1 (fr) * 1996-04-24 1997-10-30 Celltech Therapeutics Limited 5-aminopyrazoles utiles comme inhibiteurs selectifs de la proteine tyrosine kinase p56ick
WO1998028269A1 (fr) * 1996-12-23 1998-07-02 Du Pont Pharmaceuticals Company COMPOSES HETEROAROMATIQUES CONTENANT DE L'AZOTE, UTILISES EN TANT QU'INHIBITEURS DU FACTEUR Xa
WO1998057937A2 (fr) * 1997-06-19 1998-12-23 The Du Pont Merck Pharmaceutical Company INHIBITEURS DU FACTEUR Xa COMPRENANT UN GROUPE A SPECIFICITE P1 NEUTRE
WO1999024404A1 (fr) * 1997-11-07 1999-05-20 Amgen Inc. Composes pyridine substitues presentant une action anti-inflammatoire
WO1999043657A1 (fr) * 1998-02-27 1999-09-02 F. Hoffmann-La Roche Ag Derives de 2-arylethyl-(piperidin-4-ylmethyl)amines
EP0990645A1 (fr) * 1997-05-30 2000-04-05 Nippon Kayaku Kabushiki Kaisha Nouveaux derives sulfonamides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024190A2 (fr) * 1994-03-07 1995-09-14 Sugen, Inc. Inhibiteurs de tyrosine-kinase receptrice destines a inhiber les troubles lies a la proliferation cellulaire et compositions les contenant

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0073973A1 (fr) * 1981-08-24 1983-03-16 BASF Aktiengesellschaft Anilides d'acides thiazolyl- et isothiazolyl carboxyliques, procédé pour les préparer et leur utilisation comme fongicides
EP0418667A2 (fr) * 1989-09-22 1991-03-27 BASF Aktiengesellschaft Amides d'acides carboxyliques
WO1991017748A1 (fr) * 1990-05-18 1991-11-28 Hoechst Aktiengesellschaft Amides d'acide carboxylique-4 d'isoxazol et cyanamides acetiques d'hydroxyalkylidene, medicaments contenant ces composes et leur application
WO1994001408A1 (fr) * 1992-07-10 1994-01-20 Laboratoires Glaxo S.A. Derives d'anilide
US5342851A (en) * 1992-10-07 1994-08-30 Mcneil-Ppc, Inc. Substituted thiazole derivatives useful as platelet aggregation inhibitors
US5476866A (en) * 1993-10-01 1995-12-19 Roussel Uclaf Isoxazoles
JPH07196637A (ja) * 1993-11-24 1995-08-01 Mitsui Toatsu Chem Inc イソチアゾールカルボン酸アミド誘導体の製造法
WO1995019169A2 (fr) * 1994-01-07 1995-07-20 Sugen, Inc. Traitement de troubles lies au facteur mitogenique plaquettaire tels que les cancers a l'aide d'inhibiteurs du recepteur de facteur mitogenique plaquettaire
WO1996033179A1 (fr) * 1995-04-21 1996-10-24 Sugen, Inc. Derives des thioamides et leur utilisation comme inhibiteurs de croissance cellulaire hyper-proliferative
WO1997011690A2 (fr) * 1995-09-29 1997-04-03 Microcide Pharmaceuticals, Inc. Inhibiteurs des voies de regulation
EP0769296A1 (fr) * 1995-10-25 1997-04-23 Hoechst Aktiengesellschaft Utilisation de derivés d'isoxazole et de crotonamide pour la fabrication d'un médicament pour le traitement de cancers
WO1997040019A1 (fr) * 1996-04-24 1997-10-30 Celltech Therapeutics Limited 5-aminopyrazoles utiles comme inhibiteurs selectifs de la proteine tyrosine kinase p56ick
WO1998028269A1 (fr) * 1996-12-23 1998-07-02 Du Pont Pharmaceuticals Company COMPOSES HETEROAROMATIQUES CONTENANT DE L'AZOTE, UTILISES EN TANT QU'INHIBITEURS DU FACTEUR Xa
EP0990645A1 (fr) * 1997-05-30 2000-04-05 Nippon Kayaku Kabushiki Kaisha Nouveaux derives sulfonamides
WO1998057937A2 (fr) * 1997-06-19 1998-12-23 The Du Pont Merck Pharmaceutical Company INHIBITEURS DU FACTEUR Xa COMPRENANT UN GROUPE A SPECIFICITE P1 NEUTRE
WO1999024404A1 (fr) * 1997-11-07 1999-05-20 Amgen Inc. Composes pyridine substitues presentant une action anti-inflammatoire
WO1999043657A1 (fr) * 1998-02-27 1999-09-02 F. Hoffmann-La Roche Ag Derives de 2-arylethyl-(piperidin-4-ylmethyl)amines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002192888, Database accession no. 1576091 (BRN) *
DATABASE WPI Week 9539, Derwent World Patents Index; AN 1995-299548, XP002192889 *
J. CHEM. SOC. C (1968), (5), 611-14 *
See also references of WO9852944A1 *

Also Published As

Publication number Publication date
AU7687998A (en) 1998-12-11
EP1012150A1 (fr) 2000-06-28
CA2302438A1 (fr) 1998-11-26
WO1998052944A1 (fr) 1998-11-26
AR015685A1 (es) 2001-05-16

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