EP1012334A4 - Zusammensetzungen und verfahren zur bestimmung von anti-viraler wirkstoff suszeptibilität und resistenz sowie anti-virales wirkstoff-screening - Google Patents

Zusammensetzungen und verfahren zur bestimmung von anti-viraler wirkstoff suszeptibilität und resistenz sowie anti-virales wirkstoff-screening

Info

Publication number
EP1012334A4
EP1012334A4 EP98940779A EP98940779A EP1012334A4 EP 1012334 A4 EP1012334 A4 EP 1012334A4 EP 98940779 A EP98940779 A EP 98940779A EP 98940779 A EP98940779 A EP 98940779A EP 1012334 A4 EP1012334 A4 EP 1012334A4
Authority
EP
European Patent Office
Prior art keywords
active substance
viral active
compositions
resistance
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98940779A
Other languages
English (en)
French (fr)
Other versions
EP1012334A1 (de
Inventor
Daniel J Capon
Jeannette M Whitcomb
Neil T Parkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Virologic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virologic Inc filed Critical Virologic Inc
Publication of EP1012334A1 publication Critical patent/EP1012334A1/de
Publication of EP1012334A4 publication Critical patent/EP1012334A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP98940779A 1997-07-30 1998-07-30 Zusammensetzungen und verfahren zur bestimmung von anti-viraler wirkstoff suszeptibilität und resistenz sowie anti-virales wirkstoff-screening Withdrawn EP1012334A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90350797A 1997-07-30 1997-07-30
US903507 1997-07-30
PCT/US1998/015967 WO1999006597A1 (en) 1997-07-30 1998-07-30 Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening

Publications (2)

Publication Number Publication Date
EP1012334A1 EP1012334A1 (de) 2000-06-28
EP1012334A4 true EP1012334A4 (de) 2004-12-29

Family

ID=25417619

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98940779A Withdrawn EP1012334A4 (de) 1997-07-30 1998-07-30 Zusammensetzungen und verfahren zur bestimmung von anti-viraler wirkstoff suszeptibilität und resistenz sowie anti-virales wirkstoff-screening

Country Status (6)

Country Link
EP (1) EP1012334A4 (de)
JP (1) JP2001512036A (de)
KR (1) KR20010022420A (de)
AU (1) AU8897698A (de)
CA (1) CA2298102A1 (de)
WO (1) WO1999006597A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242187B1 (en) 1996-01-29 2001-06-05 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
EP0852626B1 (de) * 1996-01-29 2002-04-03 Virologic, Inc. Verfahren und zusammensetzungen zur bestimmung der empfindlichkeit und resistenz gegen antivirale wirkstoffe und screening für antivirale wirkstoffe
US20030028011A1 (en) * 1997-07-30 2003-02-06 Parkin Neil T. Compositions and methods for determining susceptibility of hepatitis C virus to anti-viral drugs
AU7268000A (en) * 1999-07-21 2001-02-13 Martin Heinkelein Method for quantization of the antiviral effect of antiviral active principles
EP1352356B1 (de) * 2000-06-08 2009-10-14 Virco Bvba Verfahren um die resistenz gegen ein therapeutisches agenz vorherzusagen unter verwendung neuronaler netze
ES2346717T3 (es) * 2002-03-11 2010-10-19 Lab 21 Limited Metodo y composiciones para identificar y caracterizar la hepatitis c.
EP1454988A1 (de) * 2003-03-03 2004-09-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Infektiöse Flavivirus Pseudo-Partikel, welche funktionelle prM-E Hüllproteine enthalten
EP2527474A1 (de) 2006-10-20 2012-11-28 Innogenetics N.V. Verfahren zur Analyse von Sequenzvariationen innerhalb des HCV-NS3/4A-Genombereichs
EP2463390A1 (de) 2006-10-20 2012-06-13 Innogenetics N.V. Methodik zur Analyse von Sequenzvariationen innerhalb des HCV-NS5B-Genombereichs
WO2013082617A1 (en) * 2011-12-02 2013-06-06 Laboratory Corporation Of America Holdings Methods for the phenotypic detection of hcv inhibitor resistant subpopulations
CN113299340B (zh) * 2021-06-09 2023-06-30 四川大学华西医院 靶标试验药物的筛选方法、靶标试验药物筛选器

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291893A1 (de) * 1987-05-19 1988-11-23 The Du Pont Merck Pharmaceutical Company Stabile menschliche Zellinien, die ein Indikatorgenprodukt unter virusspezifischen genetischen Kontrollen exprimieren
WO1994008002A2 (en) * 1992-09-28 1994-04-14 Chiron Corporation Methods and compositions for controlling translation of hcv proteins
WO1995022622A1 (en) * 1994-02-18 1995-08-24 University Of Washington Methods and compositions for screening for anti-aids drugs
WO1997027480A1 (en) * 1996-01-26 1997-07-31 Virco N.V. Method of managing the chemotherapy of patients who are hiv positive based on the phenotypic drug sensitivity of human hiv strains
WO1997027319A1 (en) * 1996-01-29 1997-07-31 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291893A1 (de) * 1987-05-19 1988-11-23 The Du Pont Merck Pharmaceutical Company Stabile menschliche Zellinien, die ein Indikatorgenprodukt unter virusspezifischen genetischen Kontrollen exprimieren
WO1994008002A2 (en) * 1992-09-28 1994-04-14 Chiron Corporation Methods and compositions for controlling translation of hcv proteins
WO1995022622A1 (en) * 1994-02-18 1995-08-24 University Of Washington Methods and compositions for screening for anti-aids drugs
WO1997027480A1 (en) * 1996-01-26 1997-07-31 Virco N.V. Method of managing the chemotherapy of patients who are hiv positive based on the phenotypic drug sensitivity of human hiv strains
WO1997027319A1 (en) * 1996-01-29 1997-07-31 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ENOMOTO N ET AL: "Hepatitis C virus quasispecies populations during chronic hepatitis C infection", TRENDS IN MICROBIOLOGY 1995 UNITED KINGDOM, vol. 3, no. 11, 1995, pages 445 - 447, XP002284841, ISSN: 0966-842X *
HAHM BUMSUK ET AL: "Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity", VIROLOGY, vol. 226, no. 2, 1996, pages 318 - 326, XP002284878, ISSN: 0042-6822 *
See also references of WO9906597A1 *
STRAIR R K ET AL: "RECOMBINANT RETROVIRAL SYSTEMS FOR THE ANALYSIS OF DRUG RESISTANT HIV", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 21, no. 20, 1993, pages 4836 - 4842, XP002924448, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
JP2001512036A (ja) 2001-08-21
KR20010022420A (ko) 2001-03-15
WO1999006597A1 (en) 1999-02-11
EP1012334A1 (de) 2000-06-28
AU8897698A (en) 1999-02-22
CA2298102A1 (en) 1999-02-11

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