Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
  • B65D25/02—Internal fittings
  • B65D25/04—Partitions
  • B65D25/08—Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents
• • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
  • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
  • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
  • Y10S215/00—Bottles and jars
  • Y10S215/08—Mixing

Definitions

• the present invention relates to a multi-chamber dispensing container, for the storage of at least two substances which must be stored separately, the extemporaneous mixture thereof, and the distribution of the mixture of these substances.
• the present invention will be more particularly described with respect to a dropper bottle, with two chambers, containing in a sterile manner during storage, for example, a lyophilized powder in a first chamber, and a liquid in a second chamber, these two substances then being mixed extemporaneously in the container, and the mixture then being dispensed.
• a multi-chamber dispenser container of the type mentioned above is already known, described by the international patent application published under the number WO-A-91/00094.
• This application generally describes the use of a multi-chamber dispensing container for storing and, in an extemporaneous manner, distributing a mixture of two liquids, in this case a solution of papaverine sulfate, and a basic solution such as bicarbonate of welded.
• the separation of the two solutions is necessary in order to prevent the precipitation of papaverine H * during its storage.
• the two solutions are stored in a container body in the form of a rubber tube, having an opening end and a bottom end, in two chambers separated by a plastic disc.
• This disc is arranged perpendicular to the container body, and is larger in diameter than the internal diameter of the container body. Thus the disc is held in place by the elastic grip of the container body on the edge peripheral of it.
• Dispensing means are also provided in the vicinity of the opening end of the container body, sealingly closing said opening, and take the form of an injection needle. Before activation, that is to say during storage, the two liquids are therefore separated in a sealed manner by the disc.
• the dispensing container is activated by a movement of the disc driven by the pressure of the hand and the thumb in an alternating movement on the body of the container. The disc is thus caused to fall into the bottom of the tube, and the two solutions can mix. The mixture is then distributed by injection into the body through the needle.
• the pressure necessary to move the disc in order to be able to mix the two substances is important because the diameter of the latter is greater than the internal diameter of the container body, the disc being moreover positively retained in the body by the through an annular groove provided on the inner wall of said container body;
• the disc can move freely in the tubular body, and during the distribution of the mixture by injection, the body is inverted, which causes the disc to at least partially block the outlet of the mixture by the needle.
• the present invention proposes to solve this problem by providing a multi-chamber dispenser container for the sealed storage, before activation, and the distribution in the mixed state, after activation, of at least two substances, in particular a liquid and a lyophilized powder, said container comprising a substantially tubular container body, of an elastically deformable material, having a bottom end, and an opening end, and at least one occlusion means having a continuous peripheral edge, disposed inside the body container, between the bottom end and the opening end, closing said body in a sealed manner along its said peripheral edge, and separating said body into at least two chambers, for the two substances respectively, the container further comprising means for distributing the substances in the mixed state, arranged in the vicinity of the opening end, and closing this lt tightly.
• the dispensing container according to the present invention is more particularly characterized in that before activation of the container, the occlusion means is disposed obliquely in the substantially tubular body, and comprises at least a first peripheral zone partially tearable under the effect of 'a transverse pressure of activation of the fingers, and at least a second peripheral zone, different from the first zone, tear-resistant under the effect of said activation pressure, keeping the occlusion means in place in the tubular body after activation .
• This solution has the advantage that the pressure to be exerted by the user is reduced to a minimum, because it is possible to activate the occlusion means, and therefore mix the substances contained in the different chambers, by a simple light finger pressure on the container body.
• the tear-proof zones allow the occlusion means to allow the substances to pass from one chamber to the other, while preventing the occlusion means from blocking the exit of the mixture during its distribution by the distribution means.
• the occlusion means can be made of the same material as that of the substantially tubular body.
• the first peripheral zone of the occlusion means can be in the form of a part of the peripheral edge, of reduced thickness compared to the central thickness of said occlusion means.
• the second peripheral zone of the occlusion means may comprise two bridges of material, constituting between them an axis of rotation for said occlusion means, during the activation of the container, said axis of rotation being arranged perpendicular to the direction. of the transverse activation pressure of the fingers.
• the occlusion means can be substantially in the form of a disc.
• the substantially tubular body has, on its outer surface, a gripping recess for a finger above the occlusion means, and a gripping recess for a finger below said occlusion means.
• the container may advantageously include a removable sleeve for blocking activation of the body of the substantially tubular container, made of an elastically non-deformable material, which surrounds said body at least at the level of the occlusion means.
• the distribution means are integrated into or mounted on the container body, and are constituted by a nose of substantially frustoconical shape provided with a dropper.
• the container may comprise a removable protection means protection cap, comprising at least one elastic engagement element with the container body and / or with the distribution means, and a plug element of said dispensing means, disposed inside the cap.
• FIG. 1 shows a partially cutaway perspective view of a dispensing container according to a preferred embodiment of the present invention
• FIG. 2 shows a sectional view of the container of Figure 1 during storage of a lyophilized powder and a sterile liquid
• - Figure 3 shows a sectional view of the container of Figure 1 during activation and release of the occlusion means
• FIG. 4 shows a sectional view of the container of Figure 1 after activation and release of the occlusion means, and mixing of the substances;
• FIG. 5 shows a sectional view along line V-V of Figure 4, showing the position of the occlusion means after activation and mixing of the substances.
• a multi-chamber dispenser container 1 comprises a substantially tubular container body 4 made of an elastically deformable material, therefore relatively flexible, for example made of low density polyethylene or polypropylene .
• the body 4 has a bottom end 5, closed for example by a plug 5a, and an opening end 6, as well as an occlusion means 7, which separates the body 4 into two chambers 9, 10 in a sealed manner.
• the body 4 may have, on its external surface, a recess 16 for gripping a finger above the occlusion means.
• the chamber 9 contains a liquid 2, and the chamber 10 a powder 3, for example lyophilized, but it is understood that the two substances can also be combinations, for example of two or more liquids, or of two powders, or that the chamber 10 contains a liquid 2 and the chamber 9 contains a powder 3.
• the container 1 comprises further means 11 for distributing substances 2,3 in the mixed state, arranged in the vicinity of the opening end 6, and closing the latter in leaktight manner, and which will be described in more detail below.
• the occlusion means 7 has a continuous peripheral edge 8, disposed inside the container body 4, between the bottom end 5 and the opening end 6, closing the body 4 in a sealed manner along its peripheral edge 8.
• the occlusion means 7 is disposed obliquely in the body 4, and comprises a first peripheral zone 12 partially tearable under the effect of a transverse pressure of activation of the fingers, and a second peripheral zone 13, different from the first zone 12, tear-resistant under the effect of the pressure d activation, keeping the occlusion means 7 in place in the tubular body 4 after activation.
• the occlusion means 7 is made of the same material as that of the substantially tubular body, therefore for example of low density polyethylene or polypropylene.
• the occlusion means is substantially in the form of a disc, for example circular or elliptical, but this shape can of course vary depending on the circumferential shape of the body 4 container, and may for example be of polygonal shape.
• the first peripheral zone 12 of the disc 7 is in the form of a part of the peripheral edge 8, of reduced thickness compared to the central thickness of the disc 7, and the second peripheral zone 13 comprises two bridges of material, for example thicker than the thickness of the disc 7, constituting between them an axis of rotation 15 for the latter, when the container 1 is activated.
• FIG. 5 which is a sectional view along the line VV of Figure 4, the axis of rotation 15 is arranged perpendicular to the direction of the transverse pressure of activation of the fingers, so as to force the rotation of the disc to take place in the direction of the activation force.
• the container comprises dispensing means 11, in particular integrated into or mounted on the body 4, for example - by irreversible and waterproof snap-in or by welding or molding in one piece.
• the distribution means consist of a nose 19 of substantially frustoconical shape provided with a dropper 20, provided at its proximal end, that is to say at the opening end 6 of the body 4, of an annular flange 24 fixed for example by welding to the body 4 along the perimeter of the latter.
• the distribution means 11 can also be covered by a cap 21, comprising inside a plug 23, adapted to receive and close the dropper 20 of the nose 19, and elastic gripping elements 22 with the body 4 of container 1 and / or with the distribution means 11.
• These elastic gripping elements may be constituted, for example, by elastic teeth which snap in reversibly on and around the annular flange 24 of the distribution means 11.
• the container may also comprise a removable sleeve 18 for activating the body 4, made of an elastically non-deformable material, which surrounds said body 4 at least at the level of the means of occlusion 7.
• the sleeve 18 is preferably made of a more rigid material than that constituting the body 4, for example made of high density polyethylene or polypropylene, so as to resist any pressure of the fingers or of the hand exerted on the container. As illustrated in FIG. 1, this sleeve 18 covers, starting from the bottom end 5, the gripping recesses 16, 17 and the body 4 up to the level of the disc 7, effectively preventing any inadvertent activation by the user.
• the sleeve 18 Before activation, the sleeve 18 is in place, as well as the cap 21 (see Figure 2). The sleeve 18 is then removed from below, exposing the body 4 of the container, and the gripping recesses 16,17. A slight activation pressure is exerted on the recesses by the fingers of the user, which causes the peripheral zone 12 to tear at this pressure, the disc 7 held by the bridges 13 entering in rotation so as to create an opening on either side of the axis 15, allowing the substances to be mixed (cf. Figures 3 and 4), either by shaking the container, or by pressing again and again with your fingers repeatedly on the container body.
• the cap is removed, and the mixture can be dispensed by the dispensing means 11 constituted by the nose 19 and the dropper 20. After dispensing the mixture, the cap can be put back by snap-fastening on the dispensing means 11, up to 'for future use.

Landscapes

• Engineering & Computer Science (AREA)
• Mechanical Engineering (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)
• Package Specialized In Special Use (AREA)
• Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
• Details Of Rigid Or Semi-Rigid Containers (AREA)
• Closures For Containers (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)
• External Artificial Organs (AREA)

Applications Claiming Priority (3)

Publications (2)

Family

ID=9503627

Family Applications (1)

Country Status (12)

Cited By (1)

Families Citing this family (36)

Family Cites Families (14)

• 1997
  • 1997-02-07 FR FR9701633A patent/FR2759348B1/fr not_active Expired - Fee Related
• 1998
  • 1998-01-30 EP EP98905468A patent/EP1015335B1/de not_active Expired - Lifetime
  • 1998-01-30 DE DE69809572T patent/DE69809572T2/de not_active Expired - Fee Related
  • 1998-01-30 WO PCT/FR1998/000177 patent/WO1998034842A1/fr not_active Ceased
  • 1998-01-30 BR BR9807555-1A patent/BR9807555A/pt active Search and Examination
  • 1998-01-30 US US09/355,520 patent/US6189688B1/en not_active Expired - Fee Related
  • 1998-01-30 CA CA002278668A patent/CA2278668A1/fr not_active Abandoned
  • 1998-01-30 AU AU61042/98A patent/AU724953B2/en not_active Ceased
  • 1998-01-30 RU RU99119322/13A patent/RU2184058C2/ru not_active IP Right Cessation
  • 1998-01-30 CN CN98802988A patent/CN1080685C/zh not_active Expired - Fee Related
  • 1998-01-30 JP JP53386398A patent/JP3294858B2/ja not_active Expired - Fee Related
  • 1998-01-30 AT AT98905468T patent/ATE228087T1/de not_active IP Right Cessation

Non-Patent Citations (1)

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