EP1023316A4 - Procedes et compositions pour la lipidation de molecules hydrophile - Google Patents

Procedes et compositions pour la lipidation de molecules hydrophile

Info

Publication number
EP1023316A4
EP1023316A4 EP97944483A EP97944483A EP1023316A4 EP 1023316 A4 EP1023316 A4 EP 1023316A4 EP 97944483 A EP97944483 A EP 97944483A EP 97944483 A EP97944483 A EP 97944483A EP 1023316 A4 EP1023316 A4 EP 1023316A4
Authority
EP
European Patent Office
Prior art keywords
lipidation
compositions
methods
hydrophilic molecules
hydrophilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP97944483A
Other languages
German (de)
English (en)
Other versions
EP1023316A2 (fr
Inventor
Wei-Chiang Shen
Jinghua Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Southern California USC filed Critical University of Southern California USC
Publication of EP1023316A2 publication Critical patent/EP1023316A2/fr
Publication of EP1023316A4 publication Critical patent/EP1023316A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP97944483A 1996-09-26 1997-09-26 Procedes et compositions pour la lipidation de molecules hydrophile Ceased EP1023316A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72130696A 1996-09-26 1996-09-26
US77177P 1996-09-26
US4949997P 1997-06-13 1997-06-13
US49499P 1997-06-13
PCT/US1997/017282 WO1998013007A2 (fr) 1996-09-26 1997-09-26 Procedes et compositions pour la lipidation de molecules hydrophile

Publications (2)

Publication Number Publication Date
EP1023316A2 EP1023316A2 (fr) 2000-08-02
EP1023316A4 true EP1023316A4 (fr) 2004-06-09

Family

ID=26727231

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97944483A Ceased EP1023316A4 (fr) 1996-09-26 1997-09-26 Procedes et compositions pour la lipidation de molecules hydrophile

Country Status (10)

Country Link
EP (1) EP1023316A4 (fr)
JP (1) JP2002515883A (fr)
KR (1) KR100691315B1 (fr)
CN (1) CN1127477C (fr)
AU (1) AU737865B2 (fr)
BR (1) BR9712128A (fr)
CA (1) CA2267179A1 (fr)
IL (1) IL129177A0 (fr)
NO (1) NO991465L (fr)
WO (1) WO1998013007A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169078B1 (en) 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
TWI242000B (en) * 1998-12-10 2005-10-21 Univ Southern California Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
GB0103877D0 (en) * 2001-02-16 2001-04-04 King S College London Novel Drug Delivery system
US20050054612A1 (en) * 2003-09-08 2005-03-10 Monahan Sean D. Delivery by labile hydrophobic modification of drugs
WO2005065239A2 (fr) * 2003-12-31 2005-07-21 Centocor, Inc. Nouvelles proteines recombinees avec thiol libre n-terminal
WO2008057298A2 (fr) * 2006-10-27 2008-05-15 Wei-Chiang Shen Interféron lipidisé et ses utilisations
EP2134352A4 (fr) * 2007-03-05 2011-05-25 Univ Leland Stanford Junior Compositions de wnt et procédés pour leur utilisation
CN101952306B (zh) * 2008-02-21 2014-09-10 皮护神经科学协会 Mntf肽的化妆和皮肤病制剂
ES2859923T3 (es) * 2013-02-28 2021-10-04 Univ Tufts Compuestos de disulfuro para el suministro de agentes farmacéuticos
US20160082126A1 (en) 2013-05-13 2016-03-24 Tufts University Nanocomplexes for delivery of saporin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022773A1 (fr) * 1995-01-25 1996-08-01 University Of Southern California Procedes et compositions de lipidisation de molecules hydrophiles
WO1997049425A1 (fr) * 1996-06-25 1997-12-31 Stichting Instituut Voor Dierhouderij En Diergezondheid Vaccins comprenant des antigenes fixes sur leurs supports par des liaisons labiles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022773A1 (fr) * 1995-01-25 1996-08-01 University Of Southern California Procedes et compositions de lipidisation de molecules hydrophiles
WO1997049425A1 (fr) * 1996-06-25 1997-12-31 Stichting Instituut Voor Dierhouderij En Diergezondheid Vaccins comprenant des antigenes fixes sur leurs supports par des liaisons labiles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIWADA H ET AL: "Application of synthetic liposomes based on acyl amino acids or acyl peptides as drug carriers. I. Their preparation and transport of glutathione into the liver.", CHEMICAL & PHARMACEUTICAL BULLETIN. JUL 1987, vol. 35, no. 7, July 1987 (1987-07-01), pages 2935 - 2942, XP002276804, ISSN: 0009-2363 *

Also Published As

Publication number Publication date
CN1127477C (zh) 2003-11-12
JP2002515883A (ja) 2002-05-28
WO1998013007A2 (fr) 1998-04-02
CN1235594A (zh) 1999-11-17
IL129177A0 (en) 2000-02-17
CA2267179A1 (fr) 1998-04-02
KR20000048608A (ko) 2000-07-25
NO991465L (no) 1999-05-10
AU4596797A (en) 1998-04-17
BR9712128A (pt) 2000-12-12
WO1998013007A8 (fr) 1999-05-20
EP1023316A2 (fr) 2000-08-02
KR100691315B1 (ko) 2007-03-12
NO991465D0 (no) 1999-03-25
AU737865B2 (en) 2001-09-06

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19990422

AK Designated contracting states

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R17D Deferred search report published (corrected)

Effective date: 19980402

A4 Supplementary search report drawn up and despatched

Effective date: 20040426

17Q First examination report despatched

Effective date: 20050517

17Q First examination report despatched

Effective date: 20050517

STAA Information on the status of an ep patent application or granted ep patent

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18R Application refused

Effective date: 20071129