EP1027042A4 - Inhibitoren von farnesyl protein transferase - Google Patents
Inhibitoren von farnesyl protein transferaseInfo
- Publication number
- EP1027042A4 EP1027042A4 EP98948279A EP98948279A EP1027042A4 EP 1027042 A4 EP1027042 A4 EP 1027042A4 EP 98948279 A EP98948279 A EP 98948279A EP 98948279 A EP98948279 A EP 98948279A EP 1027042 A4 EP1027042 A4 EP 1027042A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitors
- protein transferase
- farnesyl protein
- farnesyl
- transferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6082397P | 1997-09-29 | 1997-09-29 | |
| US60823P | 1997-09-29 | ||
| PCT/US1998/019315 WO1999018951A1 (en) | 1997-09-29 | 1998-09-16 | Inhibitors of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1027042A1 EP1027042A1 (de) | 2000-08-16 |
| EP1027042A4 true EP1027042A4 (de) | 2004-08-18 |
Family
ID=22031967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP98948279A Withdrawn EP1027042A4 (de) | 1997-09-29 | 1998-09-16 | Inhibitoren von farnesyl protein transferase |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1027042A4 (de) |
| JP (1) | JP2001519387A (de) |
| AU (1) | AU735366B2 (de) |
| CA (1) | CA2304473A1 (de) |
| WO (1) | WO1999018951A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458783B1 (en) * | 1997-09-29 | 2002-10-01 | Bristol-Myers Squibb Company | Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase |
| NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| WO2000038618A2 (en) | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| US20020115696A1 (en) | 1999-06-18 | 2002-08-22 | Yoel Kloog | Treatment of post-angioplasty restenosis and atherosclerosis with ras antagonists |
| US6462086B1 (en) * | 1999-06-18 | 2002-10-08 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Non-malignant disease treatment with Ras antagonists |
| FR2796943A1 (fr) * | 1999-07-30 | 2001-02-02 | Aventis Pharma Sa | Derives de benzoxazinnes, leur procede de preparation et leur utilisation en therapeutique |
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| EP1222176A1 (de) | 1999-10-08 | 2002-07-17 | Bristol-Myers Squibb Pharma Company | Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein |
| CA2395862A1 (en) | 2000-02-17 | 2001-08-23 | Hong Liu | Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production |
| CN1436175A (zh) | 2000-04-03 | 2003-08-13 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Aβ－蛋白生产抑制剂的环状内酰胺 |
| EP1268434A1 (de) | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Zyklische lactame als a-beta proteinproduktionsinhibitoren |
| WO2001077086A1 (en) | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| CN1386118A (zh) | 2000-06-01 | 2002-12-18 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物 |
| WO2003041658A2 (en) * | 2001-11-13 | 2003-05-22 | Bristol-Myers Squibb Company | Process for the preparation of 3,7-disubstituted-2,3,4,5- tetrahydro-1h-1,4-benzodiazepine compounds |
| CA2559285A1 (en) * | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| CA2606226A1 (en) * | 2005-04-27 | 2006-11-02 | University Of Florida Research Foundation, Inc. | Materials and methods for enhanced degradation of mutant proteins associated with human disease |
| JP2010526825A (ja) | 2007-05-10 | 2010-08-05 | エーエムアール テクノロジー インコーポレイテッド | アリール置換およびヘテロアリール置換テトラヒドロベンゾ−１，４−ジアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用 |
| ES2813415T3 (es) * | 2011-08-10 | 2021-03-23 | Lankenau Inst Medical Res | Métodos y composiciones para el tratamiento de enfermedades autoinmunes e inflamatorias |
| CN110627770A (zh) | 2013-11-18 | 2019-12-31 | 福马疗法公司 | 作为bet溴域抑制剂的四氢喹啉组成物 |
| RU2720237C2 (ru) | 2013-11-18 | 2020-04-28 | Форма Терапеутикс, Инк. | Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет |
| PL3445744T3 (pl) * | 2016-04-18 | 2022-02-07 | Vivoryon Therapeutics Ag | Nowe inhibitory mepryny alfa i beta |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
-
1998
- 1998-09-16 AU AU94886/98A patent/AU735366B2/en not_active Ceased
- 1998-09-16 WO PCT/US1998/019315 patent/WO1999018951A1/en not_active Ceased
- 1998-09-16 JP JP2000515586A patent/JP2001519387A/ja active Pending
- 1998-09-16 CA CA002304473A patent/CA2304473A1/en not_active Abandoned
- 1998-09-16 EP EP98948279A patent/EP1027042A4/de not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001519387A (ja) | 2001-10-23 |
| AU735366B2 (en) | 2001-07-05 |
| AU9488698A (en) | 1999-05-03 |
| CA2304473A1 (en) | 1999-04-22 |
| WO1999018951A1 (en) | 1999-04-22 |
| EP1027042A1 (de) | 2000-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0004148A3 (en) | Inhibitors of farnesyl protein transferase | |
| HUP9902016A3 (en) | Inhibitors of farnesyl protein transferase | |
| IL126833A0 (en) | Inhibitors of protein farnesyl transferase | |
| EP0918771A4 (de) | Thiadioxobenzodiazepin-inhibitoren der farnesyl-protein-transferase | |
| EP0696593A3 (de) | Inhibitoren der farnesyl protein Transferase | |
| AU5772698A (en) | Inhibitors of farnesyl protein transferase | |
| EP1027042A4 (de) | Inhibitoren von farnesyl protein transferase | |
| HU9500934D0 (en) | Imidazole-containing inhibitors of farnesyl protein transferase | |
| PH11998001072B1 (en) | Inhibitors of protein isoprenyl transferases | |
| IL143409A0 (en) | Farnesyl protein transferase inhibitors | |
| AU5164898A (en) | Thioproline-containing inhibitors of farnesyl protein transferase | |
| ZA985203B (en) | Compounds useful for inhibition of farnesyl protein transferase | |
| HUP0202152A2 (en) | Tricyclyc farnesyl protein transferase inhibitors | |
| AU4329397A (en) | Semipeptoid farnesyl protein transferase inhibitors and analogs thereof | |
| ZA985210B (en) | Compounds for the inhibition of farnesyl protein transferase | |
| HUP9903221A3 (en) | Inhibitors of protein farnesyl transferase | |
| ZA971621B (en) | Inhibitors of farnesyl protein transferase | |
| HK1027561A (en) | Inhibitors of farnesyl protein transferase | |
| ZA985214B (en) | Compounds useful for inhibition of farnesyl protein transferase | |
| HUP0002186A3 (en) | Compounds useful for inhibition of farnesyl protein transferase | |
| IL149870A0 (en) | Inhibitors of farnesyl protein transferase | |
| ZA952696B (en) | Imidazole-containing inhibitors of farnesyl protein transferase | |
| SG28242A1 (en) | Imidazole-containing inhibitors of farnesyl protein transferase | |
| IL141626A0 (en) | Farnesyl transferase inhibitors | |
| GB9609981D0 (en) | Inhibitors of farnesyl-protien transferase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20000427 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20040706 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61P 35/00 B Ipc: 7C 07D 403/06 B Ipc: 7C 07D 403/12 B Ipc: 7C 07D 401/12 B Ipc: 7C 07D 409/06 B Ipc: 7C 07D 401/06 B Ipc: 7C 07D 243/14 B Ipc: 7C 07D 243/12 B Ipc: 7C 07D 241/36 B Ipc: 7C 07D 239/70 B Ipc: 7C 07D 237/26 B Ipc: 7A 61K 31/55 B Ipc: 7A 61K 31/54 B Ipc: 7A 61K 31/535 B Ipc: 7A 61K 31/53 B Ipc: 7A 61K 31/50 B Ipc: 7A 61K 31/495 B Ipc: 7A 61K 31/33 A |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20060331 |