EP1027333A4 - Inhibiteurs de thrombine - Google Patents

Inhibiteurs de thrombine

Info

Publication number
EP1027333A4
EP1027333A4 EP98949536A EP98949536A EP1027333A4 EP 1027333 A4 EP1027333 A4 EP 1027333A4 EP 98949536 A EP98949536 A EP 98949536A EP 98949536 A EP98949536 A EP 98949536A EP 1027333 A4 EP1027333 A4 EP 1027333A4
Authority
EP
European Patent Office
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98949536A
Other languages
German (de)
English (en)
Other versions
EP1027333A1 (fr
Inventor
Craig Coburn
Adel M Naylor-Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806034.6A external-priority patent/GB9806034D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1027333A1 publication Critical patent/EP1027333A1/fr
Publication of EP1027333A4 publication Critical patent/EP1027333A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
EP98949536A 1997-09-30 1998-09-25 Inhibiteurs de thrombine Withdrawn EP1027333A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6053697P 1997-09-30 1997-09-30
US60536P 1997-09-30
GBGB9806034.6A GB9806034D0 (en) 1998-03-20 1998-03-20 Thrombin inhibitors
GB9806034 1998-03-20
PCT/US1998/020174 WO1999016750A1 (fr) 1997-09-30 1998-09-25 Inhibiteurs de thrombine

Publications (2)

Publication Number Publication Date
EP1027333A1 EP1027333A1 (fr) 2000-08-16
EP1027333A4 true EP1027333A4 (fr) 2000-11-08

Family

ID=26313327

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98949536A Withdrawn EP1027333A4 (fr) 1997-09-30 1998-09-25 Inhibiteurs de thrombine

Country Status (5)

Country Link
EP (1) EP1027333A4 (fr)
JP (1) JP2001518466A (fr)
AU (1) AU740170B2 (fr)
CA (1) CA2303832A1 (fr)
WO (1) WO1999016750A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US7857522B2 (en) * 2007-01-31 2010-12-28 Siemens Industry, Inc. Rolling mill oil film bearing

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4306873A1 (de) * 1993-03-05 1994-09-08 Boehringer Mannheim Gmbh Neue 4-Aminopyridine-Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US5668289A (en) * 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE79635T1 (de) * 1986-04-01 1992-09-15 Wako Pure Chem Ind Ltd Peptid-derivate und methode zur messung der wirksamkeit von physiologisch aktiven verbindungen, die dieselben als substraten benuetzen.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4306873A1 (de) * 1993-03-05 1994-09-08 Boehringer Mannheim Gmbh Neue 4-Aminopyridine-Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US5668289A (en) * 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9916750A1 *

Also Published As

Publication number Publication date
AU740170B2 (en) 2001-11-01
JP2001518466A (ja) 2001-10-16
AU9583998A (en) 1999-04-23
EP1027333A1 (fr) 2000-08-16
CA2303832A1 (fr) 1999-04-08
WO1999016750A1 (fr) 1999-04-08

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