EP1034290A4 - Flavivirus expressions- und verabreichungssystem - Google Patents

Flavivirus expressions- und verabreichungssystem

Info

Publication number
EP1034290A4
EP1034290A4 EP98959672A EP98959672A EP1034290A4 EP 1034290 A4 EP1034290 A4 EP 1034290A4 EP 98959672 A EP98959672 A EP 98959672A EP 98959672 A EP98959672 A EP 98959672A EP 1034290 A4 EP1034290 A4 EP 1034290A4
Authority
EP
European Patent Office
Prior art keywords
delivery system
flavivirus expression
flavivirus
expression
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98959672A
Other languages
English (en)
French (fr)
Other versions
EP1034290A1 (de
Inventor
Edwin G Westaway
Alexander Khromykh
Andrei Varnavski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QIMR Berghofer Medical Research Institute
Original Assignee
Queensland Institute of Medical Research QIMR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPP0627A external-priority patent/AUPP062797A0/en
Priority claimed from AUPP6096A external-priority patent/AUPP609698A0/en
Application filed by Queensland Institute of Medical Research QIMR filed Critical Queensland Institute of Medical Research QIMR
Publication of EP1034290A1 publication Critical patent/EP1034290A1/de
Publication of EP1034290A4 publication Critical patent/EP1034290A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP98959672A 1997-11-28 1998-11-30 Flavivirus expressions- und verabreichungssystem Withdrawn EP1034290A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPP062797 1997-11-28
AUPP0627A AUPP062797A0 (en) 1997-11-28 1997-11-28 Flavivirus expression system
AUPP609698 1998-09-23
AUPP6096A AUPP609698A0 (en) 1998-09-23 1998-09-23 Flavivirus expression system
PCT/AU1998/000993 WO1999028487A1 (en) 1997-11-28 1998-11-30 Flavivirus expression and delivery system

Publications (2)

Publication Number Publication Date
EP1034290A1 EP1034290A1 (de) 2000-09-13
EP1034290A4 true EP1034290A4 (de) 2004-09-15

Family

ID=25645666

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98959672A Withdrawn EP1034290A4 (de) 1997-11-28 1998-11-30 Flavivirus expressions- und verabreichungssystem

Country Status (5)

Country Link
EP (1) EP1034290A4 (de)
JP (2) JP2002500003A (de)
CA (1) CA2311395C (de)
NZ (1) NZ504725A (de)
WO (1) WO1999028487A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1035205A1 (de) * 1999-03-08 2000-09-13 Stichting Dienst Landbouwkundig Onderzoek Sich nicht verbreitendes Pestivirus
US6589531B1 (en) 2000-01-21 2003-07-08 The Regents Of The University Of California Recombinant yellow fever virus and method of use thereof
EP1195438A1 (de) * 2000-10-06 2002-04-10 Rijksuniversiteit te Groningen Genetische Immunisierung gegen Zervixkarzinom
KR20020059856A (ko) * 2001-01-08 2002-07-16 김철중 에이치아이브이 유사입자의 제조
GB2372991B (en) * 2001-03-09 2004-11-17 Fiocruz Fundacao Oswaldo Cruz Flavivirus expression vector
WO2002072803A2 (en) * 2001-03-09 2002-09-19 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Subgenomic replicons of the flavivirus dengue
FR2829149B1 (fr) * 2001-09-06 2004-09-24 Pasteur Institut Souche neurovirulente du virus west nile et ses applications
WO2002089840A1 (en) 2001-05-10 2002-11-14 The Regents Of The University Of California Recombinant bicistronic flaviviruses and methods of use thereof
CA2467397A1 (en) * 2001-11-26 2003-06-05 Replikun Biotech Pty Ltd Flavivirus vaccine delivery system
EP1593738A4 (de) * 2003-01-30 2006-05-31 Shanghai Tengen Biomedical Co Virusähnlicher partikelimpfstoff mit rekombinantem denguevirus-replikon als seinem träger
CN103088038B (zh) * 2004-07-12 2015-06-24 美国天甲生物医药有限公司 黄病毒疫苗
BRPI0504945B8 (pt) * 2005-10-31 2022-08-02 Fundacao Oswaldo Cruz Método para a produção de flavivirus recombinante contendo sequências de nucleotídeos codificantes de uma proteína heteróloga, constructo de dna, flavivirus, e, composição vacinal para imunizar contra flavivirus e/ou outros patógenos.
AP2008004629A0 (en) 2006-02-27 2008-10-31 Univ Texas Pseudoinfectious flavivirus and uses thereof
JP5779352B2 (ja) 2008-03-14 2015-09-16 サノフィ パスツール バイオロジクス リミテッド ライアビリティ カンパニー 複製欠損フラビウイルスワクチンおよびワクチンベクター
AU2011276234B2 (en) 2010-07-06 2016-02-25 Glaxosmithkline Biologicals S.A. Liposomes with lipids having an advantageous pKa- value for RNA delivery
SI2591114T1 (sl) * 2010-07-06 2016-10-28 Glaxosmithkline Biologicals S.A. Imunizacija velikih sesalcev z majhnimi odmerki RNA
ES2646669T3 (es) 2010-07-06 2017-12-14 Glaxosmithkline Biologicals Sa Procedimientos de aumento de una respuesta inmunitaria mediante el suministro de ARN
WO2012031043A1 (en) 2010-08-31 2012-03-08 Novartis Ag Pegylated liposomes for delivery of immunogen-encoding rna
EP3520813B1 (de) 2010-10-11 2023-04-19 GlaxoSmithKline Biologicals S.A. Antigenfreisetzungsplattformen
US10494421B2 (en) 2014-02-10 2019-12-03 Univercells Nv System, apparatus and method for biomolecules production
EP3061826A1 (de) 2015-02-27 2016-08-31 Novartis AG Flavivirus-replikons

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FROLOV ILYA ET AL: "Sindbis virus replicons and Sindbis virus: Assembly of chimeras and of particles deficient in virus RNA", JOURNAL OF VIROLOGY, vol. 71, no. 4, April 1997 (1997-04-01), pages 2819 - 2829, XP002289356, ISSN: 0022-538X *
FROLOVA ELENA ET AL: "Packaging signals in alphaviruses", JOURNAL OF VIROLOGY, vol. 71, no. 1, January 1997 (1997-01-01), pages 248 - 258, XP002289429, ISSN: 0022-538X *
KHROMYKH A A ET AL: "SUBGENOMIC REPLICONS OF THE FLAVIVIRUS KUNJIN: CONSTRUCTION AND APPLICATIONS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 2, February 1997 (1997-02-01), pages 1497 - 1505, XP000938940, ISSN: 0022-538X *
See also references of WO9928487A1 *

Also Published As

Publication number Publication date
NZ504725A (en) 2003-02-28
JP2008113666A (ja) 2008-05-22
JP2002500003A (ja) 2002-01-08
WO1999028487A1 (en) 1999-06-10
CA2311395C (en) 2006-11-28
CA2311395A1 (en) 1999-06-10
EP1034290A1 (de) 2000-09-13

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Owner name: THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL

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Effective date: 20040803

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Effective date: 20060831

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Owner name: REPLIKUN BIOTECH PTY LTD

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