EP1043071A1 - Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung - Google Patents

Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung Download PDF

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Publication number
EP1043071A1
EP1043071A1 EP99810294A EP99810294A EP1043071A1 EP 1043071 A1 EP1043071 A1 EP 1043071A1 EP 99810294 A EP99810294 A EP 99810294A EP 99810294 A EP99810294 A EP 99810294A EP 1043071 A1 EP1043071 A1 EP 1043071A1
Authority
EP
European Patent Office
Prior art keywords
centrifuge
piston
passage
tubular
drive member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99810294A
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English (en)
French (fr)
Inventor
Jean-Denis Rochat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP99810294A priority Critical patent/EP1043071A1/de
Priority to PCT/IB2000/000436 priority patent/WO2000061294A1/fr
Priority to US09/958,468 priority patent/US6709377B1/en
Priority to EP00912863A priority patent/EP1171242B1/de
Priority to JP2000610615A priority patent/JP4463997B2/ja
Priority to AU34504/00A priority patent/AU3450400A/en
Priority to DE60003656T priority patent/DE60003656T2/de
Publication of EP1043071A1 publication Critical patent/EP1043071A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/08—Arrangement or disposition of transmission gearing ; Couplings; Brakes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Program control of centrifuges
    • B04B2013/006—Interface detection or monitoring of separated components

Definitions

  • the present invention relates to a centrifuge apparatus liquid, especially blood, containing suspended particles comprising a first drive member rotatably mounted, a second drive member rotatably mounted, coaxial with the first drive member, means for training said first and said second drive member, with a rotation ratio of 2/1 between them, a member for centrifuging said liquid, with at least three channels connecting its center to a room separation device, means for rendering said centrifuge member integral with said first member drive, three conduits made of elastically deformable material, each having a first integral end from the central end of one of the three channels of said centrifuge member, these conduits each forming a open loop around said centrifuge member, the second end of this loop being substantially coaxial at the first and angularly fixed, a portion of each loop being kinematically integral with said second member one of said conduits being connected to a power source for said liquid to be centrifuged, both others used to recover components of different densities from centrifugation.
  • This invention relates also to use
  • centrifuge devices are well known especially in the field of blood centrifugation, since they allow to connect the centrifuge rotor outside to supply it with liquid to be centrifuged and remove the separate components without using seal. Indeed, it is known from US 3,586,413 that if you have a flexible duct forming an open loop and whose two ends are coaxial, that one is fixed while the other rotates at 2 ⁇ speed around the axis common to these two ends and that the loop is driven at speed ⁇ , the flexible conduit rotates around its own axis at speed - ⁇ , canceling the induced twist by the rotation of the rotor.
  • the centrifuge rotor In the case of blood centrifugation, the separation must be changed for each donor or each different patient. Given the centrifugal forces required to obtain the desired separation of the constituents, the centrifuge rotor must be able to withstand the forces centrifugal to which it is subjected, it must be sized appropriately, it must be balanced to avoid unbalance and it must be fixed securely on the axle of rotation.
  • US 4,790,807 relates to a rigid enclosure but flexible formed by a split ring, both of which end are spread apart. To set up this speaker in the support rotor, the two ends are brought together of the split ring which is then retained in a housing of the rotor by its elasticity.
  • the drive shaft of this rotor is constituted by a tubular element allowing the passage of the liquid conduits to centrifuge and constituents from the separation.
  • the outside of the tube has an annular surface gear intended to engage a pinion of the mechanism device drive, a first profile disc convex is placed on one side of the annular toothed surface and is intended to engage with three guide pulleys with concave profiles.
  • a second disc, placed on the other side of this toothed annular surface is engaged with three other guide rollers.
  • the object of the present invention is to remedy, less in part to the disadvantages of the above-mentioned solutions.
  • this invention relates to an apparatus for centrifuging liquid, especially blood, of the type above, as defined by claim 1.
  • This invention also relates to a use of this centrifuge, as defined by claim 15.
  • the apparatus according to the invention is therefore of the type in which the circular centrifuge member forms a single disposable member, integral with the conduits used for feeding and the collection of liquids.
  • the fixation of the organ circular centrifugation on its drive member is obtained by manual latching.
  • the fixing system is not subject to centrifugal forces since it works axially. Once the attachment is obtained, there is therefore no risk of untimely separation.
  • the dropout of the centrifuge unit requires only a simple pull axial against spring elastic pressure holding. No other mechanical element than the second coupling element is not located on the centrifuge member, so this one constitutes a simple piece and cheap to make.
  • the centrifuge apparatus illustrated in FIG. 1, intended in particular for plasmapheresis, comprises a rotor centrifugation, having the shape of a disc 1 arranged at the end of a tubular body 1a, pivotally mounted in two ball bearings P1, P2.
  • This centrifuge rotor 1 carries a disposable centrifuge bowl 2, formed itself by the union of two parts welded or glued one to the other, the lower one, formed by a disc 2a and the other upper 2b, having two cylindrical side walls and concentric, one inside 2c and the other 2d exterior between which an enclosure is formed separation ring 3 ( Figures 1 and 2).
  • Channel 4 constitutes the blood supply channel to be centrifuged.
  • he has a partition 7 which joins the side wall 2d of the annular separation enclosure 3, while the other wall of this feed channel 4 stops at the side wall internal 2c of
  • the partition 7 also serves to separate the channel 4 from the channel 5 intended for the recovery of blood cells, of which the other partition 8 stops at a certain distance from the 2d external side wall of the annular enclosure of separation 3.
  • This partition 8 therefore separates channels 5 and 6 and communicates them respectively with the external party of the annular separation enclosure 3, that is to say that where the blood cells are concentrated, that of lower density where the plasma is concentrated.
  • subsequent separation of the recovered blood cells is possible to separate red blood cells, red blood cells blanks and pads.
  • These three channels 4, 5 and 6 lead to the center of the bowl 2 where they are connected to three conduits 4a, 5a, respectively 6a ( Figure 4) which are preferably arranged parallel in the same flexible tubular element 9.
  • the portion of this tubular element 9, adjacent to its end connected to channels 4, 5 and 6 is held in a housing tubular 10 formed coaxially with the axis of rotation of the bowl 2, on the upper part 2b thereof.
  • the sections of the three conduits 4a, 5a, 6a are elliptical, the major axes of these ellipses being tangent to at least one circle concentric with the longitudinal axis of the tubular element 9. This orientation of the elliptical sections of the conduits 4a, 5a, 6a, facilitates the rotation of the tubular element around its longitudinal axis.
  • the movable part called to be discarded after each use does not consist that of three parts, the bowl 2 formed of two parts 2a, 2b welded or glued to each other and the tubular element 9. In addition, this set does not require any seal sealing. This set is removably connected to the centrifuge rotor 1 as described below.
  • the bottom of the disc forming the lower part 2a of the bowl 2 carries a coupling element constituted by a tenon or a cylindrical rod 11, having a groove 11a of semi-circular section, adjacent to one end frustoconical llb.
  • This coupling rod 11 is engaged in a coupling element formed by a ring 12, of a coupling mechanism 13, this ring and this mechanism of coupling being housed in the tubular part la of the rotor 1.
  • the coupling mechanism 13 includes a coupling means which, in this embodiment, consists by a ring of balls 16 which is located at the end internal of the axial passage formed by the ring 12 secured to the tubular part 1a of the rotor 1.
  • a tubular piston 17 is slidably mounted in the tubular part 1a. Its end upper ends with a funnel-shaped surface 17a.
  • This tubular piston 17 is pressed axially against the inner end of the ring 12 by a spring helical 18 compressed between one end of the part the la of the rotor 1 and a bearing of the tubular piston 17.
  • This axial pressure in the direction of the ring 12 and the funnel shape 17a have the effect of exerting forces centripetals on the crown of balls 16 which presses them into the groove 11a of the coupling stud 11 of the bowl 2.
  • a second piston 14 is slidably mounted inside the tubular piston 17 and a second spring helical 19 pushes it axially against the end of the coupling member 11.
  • the ring of balls 16 could be replaced by a split ring-type spring piano, or by a coil spring forming a O-ring spring, both ends of which would then brought together by the funnel 17a under the coil spring pressure 18, thereby reducing its diameter to keep it engaged with the throat of the coupling stud.
  • the outer end of the tubular piston 17 is integral a gripping member 20 intended to allow exercise an axial traction opposite to the pressure of the spring 18, to allow the balls 16 to move outward.
  • the piston 14 subjected to the axial pressure of the spring 19 can then eject the bowl 2 upwards and maintain simultaneously the spaced balls 16.
  • the upper surface of the disc carrying this bowl 2 has a slight clearance 1b, which ensures good contact with the peripheral annular surface of this disc.
  • the axial position of the groove lla of the coupling stud 11 can be chosen to be normally still very partially in the axial passage of the ring 12 of so that the engagement of the balls 16 in this groove 11a induce a very slight deflection of the center of the bottom of the bowl 2, which allows the disengagement 1b of the rotor disk 1, thus ensuring sufficient contact between this disc and the bowl 2 to guarantee a friction drive of the latter. In case this friction is not sufficient, radial grooves could be provided for prevent the bowl 2 from sliding relative to the disc rotor 1.
  • the ball bearings P1, P2 of the tubular part la of the rotor are mounted in a support element 21 fixed to a plate 22, itself fixed to an upper disc 26 by four columns 15, two of which are located behind bowl 2 are visible in Figures 1 and 3, the other two being arranged symmetrically with respect to a drive shaft 23 parallel to the axis of the rotor 1. Thanks to this arrangement, the side of the centrifuge opposite the shaft training is free, allowing the introduction side of the bowl 2 and the positioning of the element tubular 9. This allows easy access to the centrifugation 2 and easily carry it out and its removal.
  • the drive shaft 23 is pivotally mounted through two ball bearings 24, 25, respectively integral with the plate 22 and the upper disc 26 located above the bowl 2.
  • This upper disc 26 is integral with the drive shaft 27 of a motor 28, coaxial to the axis of rotation of the rotor 1.
  • the end of the shaft 23 which extends above the disc 26 is integral with a satellite pinion 29 in engagement with a fixed pinion 30.
  • the ratio between the diameters of the satellite pinion 29 and the fixed gear 30 is 1/1, so that if the speed of rotation of the plate 26 is ⁇ , that of the shaft 23 around its axis is 2 ⁇ .
  • the lower end of this shaft 23 carries a toothed pinion 31 connected by a toothed belt 32 to a toothed pinion 33, of the same diameter as the toothed pinion 31, so that the rotor 1 is driven at speed 2 ⁇ .
  • the flexible tubular element 9 forms an open loop one end of which 9a is fixed and coaxial with the pivot axis of the rotor 1. This end 9a is fixed and held in a 10 'tubular connector housing similar to housing 10 supporting the other end of this element tubular 9.
  • Each of these tubular elements 10 and 10 ' presents a sort of funnel 10a, respectively 10'a (fig. 5) which gives support to this part of the element tubular 9 when subjected to centrifugal force.
  • This loop passes through an opening 22a formed in the plate 22, so that it is driven around the pivot axis of rotor 1 at speed ⁇ , while its end secured to the center of the bowl 2 is driven at speed 2 ⁇ and that the other end 9a is fixed, from so that the flexible element is entrained between these two ends at speed - ⁇ around its longitudinal axis canceling out any accumulation of torsion between these two extremities.
  • a support surface 22b secured to the plate 22 serves to limit the deformation of the tubular element 9 under the effect of centrifugal force.
  • Guide parts of the tubular element 9 are preferably made of a material self-lubricating or low friction, such as as Oilamid®, bronze-Teflon® or Valflon®.
  • the three conduits 4a, 5a, 6a separate and the conduit of plasma 6a is associated with a flow control valve 34 depending on the position of the separation surface between plasma and blood cells in the separation chamber 3.
  • a double prism 3a is formed at the end top of the separation enclosure 3 and came in one piece with the upper part 2b of the bowl 2 during its injection.
  • the portion of this double prism 3a which is covered by the separated blood cells of plasma by centrifugal force following rotation of bowl 2 is opaque, while the part which emerges in the plasma is transparent.
  • An optical device 35 comprising a laser and a photoelectric detector is arranged opposite this prism 3a, so that the detector photoelectric receives the light reflected by the part of the double prism 3a which emerges in the transparent plasma.
  • a proportional duration signal at the angular value of the transparent area of double prism 3a is thus supplied to an amplifier 36 whose outlet is connected to the proportional valve 34.
  • the amplifier 36 will control the proportional valve 34 so that it reduces, respectively so that it increases the section of the plasma evacuation duct 6a, making it possible to maintain by this adjustment, the balance between the flows in the outlet conduits 5a and 6a, depending on a flow rate input determined by the blood supply pump into the conduit 4a, itself determined by the venous pressure from the donor arm.
  • the dimensioning of the centrifuge bowl 2 and of the tubular element 9 forming the open loop are chosen to reduce the size, weight, the price and volume, both of this bowl 2 and of the whole centrifuge, including the dimensioning is essentially dependent on the diameter of the centrifuge bowl. If the diameter decreases, it is necessary to increase speed. The increase in this may be limited by increasing the height of the centrifuge chamber 3, so that the maximum flow resulting remains practically constant, this being determined by obtaining good cell sedimentation blood.
  • the diameter of the bowl is 80 mm and its height is substantially equal to its radius.
  • Such diameter corresponds to about a third of that of the rotors of separation of the state of the art. Therefore, the length of the open loop formed by the tubular conduit 9 therefore corresponds substantially to one third of the loops of the state of the art.
  • the tensile force exerted on it by the centrifugal force to which it is subjected can be kept at a constant value.
  • the material of the tubular element is plasticized PVC or silicone, the specific weight of which is 1.2 g / cm 3 , as in the prior art.
  • This sizing example shows that it is completely made possible to very significantly reduce the diameter of the separation enclosure without loss of performance and without increased constraints as far as some measures are taken to this effect. Now, this reduction in diameter reduces the size of the device so extremely important. This allows to have a device much more compact, lighter and less expensive to manufacture. This device taking up little space, we can install more devices on the same surface, which is important, especially in the case of trucks used for the plasma collection where space is limited.
  • the rotating part according to the invention weighs about 600 g while the rotors of the devices of the state of the art weigh almost five times what weight. This is the reason why in the collection of blood, plasmapheresis is generally not performed directly, but the blood is collected in pockets flexible tubes which are then placed in very large centrifuges. In this case, it is no longer possible to return the donor has red blood cells. However, the time for the body reproduce the amount of red blood cells is long, which is why several months must necessarily separate two blood donations for the same donor, this which would not be necessary if red blood cells could be reinjected after separation. This is not possible only if the separation is done simultaneously with the blood test.
  • Another important aspect of this invention is in that the complete circulation of the liquid is obtained by the overpressure with which the blood is brought in the centrifuge dish 2.
  • This overpressure must compensate for the pressure losses induced in the duct supply 4a as well as in the recovery conduits blood cells 5a and plasma 6a.
  • a pump peristaltic intended to ensure the desired flow downstream of the separation. No peristaltic suction pump outgoing components is therefore not necessary, the regulation of the plasma flow being obtained by the regulating valve 34, controlled by its servo system according to the variation of position of the border between the plasma and blood cells.
  • this device is particularly suitable for use to perform online plasmapheresis with the blood test, it can of course also be used in therapeutic applications.
  • the tubular element 9 containing the three conduits 4a, 5a, 6a is calculated with a factor of security of 5 for continuous use exceeding 5 hours, which allows its use in all applications possible.
  • the apparatus which is the subject of the present invention can also be used for washing blood cells by introducing alternatively with suitable means known in the domain, the cells to be washed and a washing liquid.
  • the washing liquid could be introduced by an additional conduit, allowing to simultaneously perform separation and washing.
  • the element tubular 9 should then have four conduits instead of the three represented.
  • the two discs 22 and 26 of the previous embodiment are replaced by two diametrical arms 22 ', 26' which are come from a single piece of aluminum with two pillars 37 and 38 diametrically opposed.
  • the arm 26 ' has a hub 26 'which is driven on the shaft 27 of the motor 28.
  • the pillar 37 has a cylindrical passage 39 intended for the passage of the drive shaft 23.
  • the other pillar 38 is integral a support 40 having a guide chute 41 of the tubular element 9.
  • Support 40 is designed to support the element flexible tubular 9 in the area where its radius is greatest large, therefore where the centrifugal force is most important.
  • the funnel 10a supports the central part of the element tubular 9.
  • the support 40 is made, like the support 22b of the embodiment of FIG. 1, made of a material with low coefficient of friction.
  • a high weight polyethylene molecular (PEHMW) we could also use a high weight polyethylene molecular (PEHMW).
  • PEHMW polyethylene molecular
  • rollers 42 have the support 40 in the chute freely rotated around axes parallel to that of the element tubular 9. These rollers 42 are driven by the rotation of the tubular element 9 on itself.
  • the rest of the centrifuge corresponds to the embodiment described above.
  • the variant described in relation to Figures 5 and 6 facilitates balancing and increases the security of the device when rotates at centrifugation speed. It improves also guiding and supporting the tubular element 9, which is thus very little subjected to centrifugal force.

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  • Centrifugal Separators (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)
EP99810294A 1999-04-09 1999-04-09 Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung Withdrawn EP1043071A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP99810294A EP1043071A1 (de) 1999-04-09 1999-04-09 Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung
PCT/IB2000/000436 WO2000061294A1 (fr) 1999-04-09 2000-04-07 Appareil de centrifugation de liquide et utilisation de cet appareil
US09/958,468 US6709377B1 (en) 1999-04-09 2000-04-07 System and method for quick disconnect centrifuge unit
EP00912863A EP1171242B1 (de) 1999-04-09 2000-04-07 Vorrichtung zum zentrifugieren einer flüssigkeit und verwendung einer solchen vorrichtung
JP2000610615A JP4463997B2 (ja) 1999-04-09 2000-04-07 遠心分離装置および使用方法
AU34504/00A AU3450400A (en) 1999-04-09 2000-04-07 Liquid centrifuging apparatus and use of same
DE60003656T DE60003656T2 (de) 1999-04-09 2000-04-07 Vorrichtung zum zentrifugieren einer flüssigkeit und verwendung einer solchen vorrichtung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99810294A EP1043071A1 (de) 1999-04-09 1999-04-09 Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung

Publications (1)

Publication Number Publication Date
EP1043071A1 true EP1043071A1 (de) 2000-10-11

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Family Applications (2)

Application Number Title Priority Date Filing Date
EP99810294A Withdrawn EP1043071A1 (de) 1999-04-09 1999-04-09 Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung
EP00912863A Expired - Lifetime EP1171242B1 (de) 1999-04-09 2000-04-07 Vorrichtung zum zentrifugieren einer flüssigkeit und verwendung einer solchen vorrichtung

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP00912863A Expired - Lifetime EP1171242B1 (de) 1999-04-09 2000-04-07 Vorrichtung zum zentrifugieren einer flüssigkeit und verwendung einer solchen vorrichtung

Country Status (6)

Country Link
US (1) US6709377B1 (de)
EP (2) EP1043071A1 (de)
JP (1) JP4463997B2 (de)
AU (1) AU3450400A (de)
DE (1) DE60003656T2 (de)
WO (1) WO2000061294A1 (de)

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WO2003075983A3 (en) * 2002-03-04 2004-02-05 Therakos Inc Method and apparatus for the continuous fractionation of biological fluids
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7476209B2 (en) 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
CN109395894A (zh) * 2018-12-14 2019-03-01 中国科学院沈阳自动化研究所 一种小型立式高速离心机
CN118954939A (zh) * 2024-10-17 2024-11-15 常州英来机械有限公司 一种应用于岩棉生产离心机的导流驱动装置

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EP1043071A1 (de) 1999-04-09 2000-10-11 Jean-Denis Rochat Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung
EP1043072A1 (de) * 1999-04-09 2000-10-11 Jean-Denis Rochat Zentrifugationsvorrichtung und Verwendung dieser Vorrichtung
US6524231B1 (en) * 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US6890728B2 (en) * 2001-04-09 2005-05-10 Medtronic, Inc. Methods of isolating blood components using a microcentrifuge and uses thereof
US20040127840A1 (en) * 2002-03-04 2004-07-01 Steve Gara Blood separation apparatus and method of using the same
US7297272B2 (en) * 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
US20050049539A1 (en) * 2003-09-03 2005-03-03 O'hara Gerald P. Control system for driving fluids through an extracorporeal blood circuit
ES2640216T3 (es) 2007-12-07 2017-11-02 Miltenyi Biotec Gmbh Sistemas y métodos para procesamiento de células
US8075468B2 (en) 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
US8685258B2 (en) * 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
EP2731724B1 (de) * 2011-09-22 2015-01-14 Fenwal, Inc. Antriebssystem für eine zentrifuge
EP2731725B1 (de) * 2011-09-22 2015-01-14 Fenwal, Inc. Antriebssystem für eine zentrifuge
EP2597153B1 (de) 2011-11-25 2016-10-05 Miltenyi Biotec GmbH Zelltrennverfahren
US9101944B2 (en) 2012-01-04 2015-08-11 Fenwal, Inc. Drive system for centrifuge
US8986238B2 (en) 2012-08-15 2015-03-24 Cyclone Medtech, Inc. Systems and methods for salvaging red blood cells for autotransfusion
US10099228B2 (en) 2015-10-09 2018-10-16 Invetech, Inc. Apparatus for performing counter flow centrifugation and method of using same
EP3666384B1 (de) 2018-12-10 2021-08-18 Alfa Laval Corporate AB Zentrifugalabscheider und verfahren zur beseitigung von luftschleusen in einem zentrifugalabscheider
EP3666394B1 (de) 2018-12-10 2026-02-25 Alfa Laval Corporate AB Modularer zentrifugalabscheider und basiseinheit davon und system
EP3666389B1 (de) 2018-12-10 2021-08-04 Alfa Laval Corporate AB Zentrifugalabscheider
EP3666385B1 (de) 2018-12-10 2021-07-14 Alfa Laval Corporate AB Austauschbare trennfolie und modularer zentrifugalabscheider und verfahren

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US9238097B2 (en) 2002-03-04 2016-01-19 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US10556055B2 (en) 2002-03-04 2020-02-11 Mallinckrodt Hospital Products IP Limited Method for collecting a desired blood component and performing a photopheresis treatment
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US7914477B2 (en) 2002-03-04 2011-03-29 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
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JP2006513019A (ja) * 2002-03-04 2006-04-20 セラコス・インコーポレイテッド 成分への生物学的流体の連続的分離のための改良型方法及び装置
WO2003075983A3 (en) * 2002-03-04 2004-02-05 Therakos Inc Method and apparatus for the continuous fractionation of biological fluids
US7850634B2 (en) 2002-03-04 2010-12-14 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7476209B2 (en) 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
WO2020118775A1 (zh) * 2018-12-14 2020-06-18 中国科学院沈阳自动化研究所 一种小型立式高速离心机
CN109395894A (zh) * 2018-12-14 2019-03-01 中国科学院沈阳自动化研究所 一种小型立式高速离心机
CN118954939A (zh) * 2024-10-17 2024-11-15 常州英来机械有限公司 一种应用于岩棉生产离心机的导流驱动装置

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JP2002541467A (ja) 2002-12-03
EP1171242A1 (de) 2002-01-16
EP1171242B1 (de) 2003-07-02
US6709377B1 (en) 2004-03-23
DE60003656T2 (de) 2004-07-29
JP4463997B2 (ja) 2010-05-19
AU3450400A (en) 2000-11-14
DE60003656D1 (de) 2003-08-07

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