EP1086083A4 - Inhibiteurs de proteases - Google Patents

Inhibiteurs de proteases

Info

Publication number: EP1086083A4
Authority: EP; European Patent Office
Prior art keywords: protease inhibitors; protease; inhibitors
Prior art date: 1998-06-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99928614A

Other languages

German (de)

English (en)

Other versions

EP1086083A1 (fr

Inventor

Ashley E Fenwick

Andrew D Gribble

Robert W Marquis Jr

Jason Witherington

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Ltd

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Ltd

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-12

Filing date

1999-06-11

Publication date

2001-09-26

1999-06-11 Application filed by SmithKline Beecham Ltd, SmithKline Beecham Corp filed Critical SmithKline Beecham Ltd

2001-03-28 Publication of EP1086083A1 publication Critical patent/EP1086083A1/fr

2001-09-26 Publication of EP1086083A4 publication Critical patent/EP1086083A4/fr

Status Withdrawn legal-status Critical Current

Links

229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Cosmetics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

EP99928614A 1998-06-12 1999-06-11 Inhibiteurs de proteases Withdrawn EP1086083A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US8905698P	1998-06-12	1998-06-12
US89056P		1998-06-12
PCT/US1999/013334 WO1999064399A1 (fr)	1998-06-12	1999-06-11	Inhibiteurs de proteases

Publications (2)

Publication Number	Publication Date
EP1086083A1 EP1086083A1 (fr)	2001-03-28
EP1086083A4 true EP1086083A4 (fr)	2001-09-26

Family

ID=22215426

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99928614A Withdrawn EP1086083A4 (fr)	1998-06-12	1999-06-11	Inhibiteurs de proteases

Country Status (10)

Country	Link
EP (1)	EP1086083A4 (fr)
JP (1)	JP2002517485A (fr)
AR (1)	AR018652A1 (fr)
AU (1)	AU4564499A (fr)
CA (1)	CA2334652A1 (fr)
CO (1)	CO5040090A1 (fr)
DZ (1)	DZ2815A1 (fr)
MA (1)	MA24877A1 (fr)
PE (1)	PE20000725A1 (fr)
WO (1)	WO1999064399A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030144175A1 (en)	1998-12-23	2003-07-31	Smithkline Beecham Corporation	Protease inhibitors
WO2001034600A1 (fr)	1999-11-10	2001-05-17	Smithkline Beecham Corporation	Inhibiteurs de protease
JP2003513924A (ja)	1999-11-10	2003-04-15	スミスクライン・ビーチャム・コーポレイション	プロテア−ゼ阻害剤
AU1588901A (en)	1999-11-10	2001-06-06	Smithkline Beecham Corporation	Protease inhibitors
OA12323A (en)	2000-03-21	2006-05-15	Smithkline Beecham Corp	Protease inhibitors.
WO2002080920A1 (fr) *	2001-04-06	2002-10-17	Axys Pharmaceuticals, Inc.	Arylacetamido-cetobenzoxazole comme inhibiteurs de la cysteine protease
US7282512B2 (en)	2002-01-17	2007-10-16	Smithkline Beecham Corporation	Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
JP5587790B2 (ja)	2008-01-09	2014-09-10	アミュラセラピューティクスリミティド	化合物
WO2023041432A1 (fr)	2021-09-14	2023-03-23	Boehringer Ingelheim International Gmbh	Dérivés de 3-phénoxyazétidin-1-yl-hétéroaryl-pyrrolidine et leur utilisation en tant que médicament

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995013069A1 (fr) *	1993-11-09	1995-05-18	Merck & Co., Inc.	Piperidines, pyrrolidines et hexahydro-1h-azepines favorisant la liberation de l'hormone de croissance
WO1996016080A1 (fr) *	1994-11-21	1996-05-30	Cortech, Inc.	Inhibiteurs d'elastase neutrophile humaine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5770573A (en) *	1993-12-06	1998-06-23	Cytel Corporation	CS-1 peptidomimetics, compositions and methods of using the same

1999
- 1999-06-09 DZ DZ990115A patent/DZ2815A1/fr active
- 1999-06-10 AR ARP990102767A patent/AR018652A1/es unknown
- 1999-06-10 MA MA25619A patent/MA24877A1/fr unknown
- 1999-06-10 CO CO99036559A patent/CO5040090A1/es unknown
- 1999-06-11 EP EP99928614A patent/EP1086083A4/fr not_active Withdrawn
- 1999-06-11 AU AU45644/99A patent/AU4564499A/en not_active Abandoned
- 1999-06-11 PE PE1999000518A patent/PE20000725A1/es not_active Application Discontinuation
- 1999-06-11 CA CA002334652A patent/CA2334652A1/fr not_active Abandoned
- 1999-06-11 JP JP2000553408A patent/JP2002517485A/ja not_active Withdrawn
- 1999-06-11 WO PCT/US1999/013334 patent/WO1999064399A1/fr not_active Ceased

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995013069A1 (fr) *	1993-11-09	1995-05-18	Merck & Co., Inc.	Piperidines, pyrrolidines et hexahydro-1h-azepines favorisant la liberation de l'hormone de croissance
WO1996016080A1 (fr) *	1994-11-21	1996-05-30	Cortech, Inc.	Inhibiteurs d'elastase neutrophile humaine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO9964399A1 *
T.HOEG-JENSEN ET AL.: "Peptide Thioacylation with High Stereochemical Preservation", SYNTHESIS, vol. 3, 1996, pages 383 - 387, XP002173434 *
THOMPSON S K ET AL: "DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN K INHIBITORS THAT SPAN THE ACTIVE SITE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 94, no. 26, 23 December 1997 (1997-12-23), pages 14249 - 14254, XP002913847, ISSN: 0027-8424 *

Also Published As

Publication number	Publication date
MA24877A1 (fr)	1999-12-31
WO1999064399A1 (fr)	1999-12-16
PE20000725A1 (es)	2000-09-28
CA2334652A1 (fr)	1999-12-16
JP2002517485A (ja)	2002-06-18
AR018652A1 (es)	2001-11-28
DZ2815A1 (fr)	2003-12-01
EP1086083A1 (fr)	2001-03-28
CO5040090A1 (es)	2001-05-29
AU4564499A (en)	1999-12-30

Legal Events

Date	Code	Title	Description
2001-02-09	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-03-28	17P	Request for examination filed	Effective date: 20001108
2001-03-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL
2001-09-19	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 07D 215/14 A, 7C 07D 261/08 B, 7C 07D 207/12 B, 7C 07D 207/24 B, 7C 07D 401/12 B, 7C 07D 413/14 B, 7A 61K 31/40 B
2001-09-26	A4	Supplementary search report drawn up and despatched	Effective date: 20010810
2001-09-26	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): BE CH DE ES FR GB IT LI NL
2002-09-04	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: SMITHKLINE BEECHAM PLC Owner name: SMITHKLINE BEECHAM CORPORATION
2004-04-28	17Q	First examination report despatched	Effective date: 20040312
2004-12-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2005-01-26	18D	Application deemed to be withdrawn	Effective date: 20040723

Publication	Publication Date	Title
PL349192A1 (en)	2002-07-01	Protease inhibitors
ZA983843B (en)	1998-11-09	Protease inhibitors
PL336589A1 (en)	2000-07-03	Serinic protease inhibitors
EP1307203A4 (fr)	2005-08-17	Inhibiteur de proteinase
IL132630A0 (en)	2001-03-19	Protease inhibitors
EP1093367A4 (fr)	2003-03-05	Inhibiteurs de proteases
ZA983522B (en)	1998-10-29	Protease inhibitors
PL336856A1 (en)	2000-07-17	Protease inhibitors
ZA988479B (en)	1998-10-26	Protease inhibitors
EP1067894A4 (fr)	2004-09-08	Inhibiteurs de protease
IL139187A0 (en)	2001-11-25	Cysteine protease inhibitors
EP1079821A4 (fr)	2001-08-29	Inhibiteurs de la protease
EP1235577A4 (fr)	2003-04-09	Inhibiteurs de protease
GB9800817D0 (en)	1998-03-11	Serine protease inhibitors
AU1393900A (en)	2000-06-05	Morpholino-ethoxybenzofuran protease inhibitors
EP1232155A4 (fr)	2002-11-20	Inhibiteurs de protease
EP1140897A4 (fr)	2002-04-03	Inhibiteurs de proteases
ZA988064B (en)	1999-05-28	Protease inhibitors
EP1231921A4 (fr)	2004-06-23	Inhibiteurs de proteases
EP1229914A4 (fr)	2004-06-23	Inhibiteurs de protease
EP1229915A4 (fr)	2003-05-14	Inhibiteurs de protease
EP1229912A4 (fr)	2003-05-07	Inhibiteurs de protease
AU4564499A (en)	1999-12-30	Protease inhibitors
EP1173429A4 (fr)	2002-06-19	Inhibiteurs de protease
EP1161237A4 (fr)	2002-03-27	Inhibiteurs de protease