EP1090146A4 - Verwendung von dna-pk - Google Patents

Verwendung von dna-pk

Info

Publication number
EP1090146A4
EP1090146A4 EP99937188A EP99937188A EP1090146A4 EP 1090146 A4 EP1090146 A4 EP 1090146A4 EP 99937188 A EP99937188 A EP 99937188A EP 99937188 A EP99937188 A EP 99937188A EP 1090146 A4 EP1090146 A4 EP 1090146A4
Authority
EP
European Patent Office
Prior art keywords
protein kinase
dependent protein
dna dependent
subunit
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99937188A
Other languages
English (en)
French (fr)
Other versions
EP1090146A1 (de
EP1090146B1 (de
Inventor
Gloria C Li
Paul J J Burgman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Priority to EP07010186A priority Critical patent/EP1832663A3/de
Publication of EP1090146A1 publication Critical patent/EP1090146A1/de
Publication of EP1090146A4 publication Critical patent/EP1090146A4/de
Application granted granted Critical
Publication of EP1090146B1 publication Critical patent/EP1090146B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP99937188A 1998-06-30 1999-06-30 Verwendung von dna-pk Expired - Lifetime EP1090146B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07010186A EP1832663A3 (de) 1998-06-30 1999-06-30 Verwendungen von DNA-PK

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9118198P 1998-06-30 1998-06-30
US91181P 1998-06-30
PCT/US1999/014702 WO2000000644A1 (en) 1998-06-30 1999-06-30 Uses of dna-pk

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP07010186A Division EP1832663A3 (de) 1998-06-30 1999-06-30 Verwendungen von DNA-PK

Publications (3)

Publication Number Publication Date
EP1090146A1 EP1090146A1 (de) 2001-04-11
EP1090146A4 true EP1090146A4 (de) 2002-04-17
EP1090146B1 EP1090146B1 (de) 2007-05-23

Family

ID=22226489

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99937188A Expired - Lifetime EP1090146B1 (de) 1998-06-30 1999-06-30 Verwendung von dna-pk

Country Status (8)

Country Link
EP (1) EP1090146B1 (de)
JP (1) JP2002519010A (de)
AT (1) ATE362994T1 (de)
AU (1) AU5206899A (de)
CA (1) CA2332179C (de)
DE (1) DE69936141T2 (de)
ES (1) ES2288318T3 (de)
WO (1) WO2000000644A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9907687D0 (en) 1999-04-01 1999-05-26 Kudos Pharm Ltd Assays methods and means
WO2002020500A2 (en) * 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
AU2001221607A1 (en) 2000-11-20 2002-05-27 Ecole Polytechnique Federale De Lausanne (Epfl) Endosseous implant
EP1436406A4 (de) * 2001-09-24 2004-10-13 Blood Ct Res Foundation Verfahren zur modulation oder untersuchung des ku70-spiegels in zellen
WO2004085418A2 (en) 2003-03-24 2004-10-07 Luitpold Pharmaceuticals, Inc. Xanthones, thioxanthones and acridinones as dna-pk inhibitors
CA2559652C (en) * 2004-03-15 2017-02-14 Sunesis Pharmaceuticals, Inc. Methods of using sns-595 in treating cancer
GB201022007D0 (en) * 2010-12-24 2011-02-02 Imp Innovations Ltd DNA-sensor
EP3662922B1 (de) * 2017-07-30 2025-03-05 Tsinghua University Eine kombination aus endostatin und einem dna-doppelstrangbruch-induzierenden chemotherapeutischen mittel zur behandlung von p53(-)-melanom und p53(-)-nicht-kleinzelligem lungenkrebs

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997008184A1 (en) * 1995-08-30 1997-03-06 Arch Development Corporation Methods and compositions including dna damaging agents and tyrosine kinase inhibitors or activators
US5641754A (en) * 1994-01-10 1997-06-24 The Board Of Regents Of The University Of Nebraska Antisense oligonucleotide compositions for selectively killing cancer cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955644A (en) * 1996-08-08 1999-09-21 M.D. Anderson Cancer Center Ku deficient cells and non-human transgenic animals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641754A (en) * 1994-01-10 1997-06-24 The Board Of Regents Of The University Of Nebraska Antisense oligonucleotide compositions for selectively killing cancer cells
WO1997008184A1 (en) * 1995-08-30 1997-03-06 Arch Development Corporation Methods and compositions including dna damaging agents and tyrosine kinase inhibitors or activators

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JACKSON STEPHEN P: "DNA-dependent protein kinase.", INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 29, no. 7, July 1997 (1997-07-01), pages 935 - 938, XP001055924, ISSN: 1357-2725 *
LI G C ET AL.: "Ku70: A Candidate Tumor Suppressor Gene for Murine T Cell Lymphoma", MOLECULAR CELL, vol. 2, July 1998 (1998-07-01), pages 1 - 8, XP002188644 *
SHIN EUY KYUN ET AL: "Evaluation of a test for identification of Arabian horses heterozygous for the severe combined immunodeficiency trait.", JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, vol. 211, no. 10, 15 November 1997 (1997-11-15), pages 1268 - 1270, XP002189151, ISSN: 0003-1488 *
TSENG B Y ET AL: "ANTISENSE OLIGONUCLEOTIDE TECHNOLOGY IN THE DEVELOPMENT OF CANCER THERAPEUTICS", CANCER GENE THERAPY, NORWALK, CT, US, vol. 1, no. 1, 1994, pages 65 - 71, XP000654091, ISSN: 0929-1903 *
UHLMANN E ET AL: "ANTISENSE OLIGONUCLEOTIDES: A NEW THERAPEUTIC PRINCIPLE", CHEMICAL REVIEWS, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 90, no. 4, June 1990 (1990-06-01), pages 543 - 584, XP002924457, ISSN: 0009-2665 *

Also Published As

Publication number Publication date
AU5206899A (en) 2000-01-17
EP1090146A1 (de) 2001-04-11
CA2332179A1 (en) 2000-01-06
DE69936141T2 (de) 2008-01-31
WO2000000644A1 (en) 2000-01-06
DE69936141D1 (de) 2007-07-05
ATE362994T1 (de) 2007-06-15
JP2002519010A (ja) 2002-07-02
HK1036483A1 (en) 2002-01-04
EP1090146B1 (de) 2007-05-23
CA2332179C (en) 2011-06-28
ES2288318T3 (es) 2008-01-01

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