EP1090843A2 - Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides - Google Patents

Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides Download PDF

Info

Publication number: EP1090843A2
Authority: EP; European Patent Office
Prior art keywords: insulator housing; machine; packaging machine; cover plate; frame
Prior art date: 1999-10-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP00119535A

Other languages

German (de)

English (en)

Other versions

EP1090843A3 (fr

EP1090843B1 (fr

Inventor

Thomas Hertfelder

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Robert Bosch GmbH

Original Assignee

Robert Bosch GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-05

Filing date

2000-09-07

Publication date

2001-04-11

2000-09-07 Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH

2001-04-11 Publication of EP1090843A2 publication Critical patent/EP1090843A2/fr

2002-06-19 Publication of EP1090843A3 publication Critical patent/EP1090843A3/fr

2004-03-24 Application granted granted Critical

2004-03-24 Publication of EP1090843B1 publication Critical patent/EP1090843B1/fr

2020-09-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages

Definitions

the invention relates to a packaging machine, especially for filling and closing liquid Containers containing pharmaceuticals according to the generic term of claim 1.
a packaging machine has a hood-like insulator housing, the one Seals machine plate of a machine frame and thereby form a sterile room in which the containers filled with a filling material and then sealed become.
the insulator housing has the Machine frame facing underside a circumferential, edge drawn inwards with the interposition of a Sealing element, for example silicone, over the entire surface of the Top of the machine plate at its edge areas lies on.
the packaging machine according to the invention in particular for Filling and sealing of liquid pharmaceuticals Containers containing the characteristic features of claim 1 has the advantage that the manufacturing cost both the machine plate and the insulator housing is reduced because the tolerances of the individual components can be larger. Furthermore, both for bottling plants, who use an insulator housing, as well as for such Filling systems without isolator one and the same relatively narrow Machine plate can be used.
the invention Arrangement of the insulator housing also enables easier control and exchange of the Sealing element, since this is no longer the case Insulator housing must be removed.
the packaging machine 10 shown in the figures serves in the pharmaceutical industry for filling and Sealing containers such as ampoules, vials or the like.
the packaging machine 10 is in a so-called Insulator technology built, that is, in the interior 11th the packaging machine has 10 sterile conditions.
the packaging machine 10 has a 12 designated machine frame in which the essential Drive components are arranged.
the top of the Machine frame 12 is at least one Machine plate 13 completed in the illustrated Example of performance of two machine plates 13a, 13b are arranged at different levels ( Figure 2). in the Areas above the one machine plate 13a are located Filling and closing devices for the containers, while in the area above the machine plate 13b a transport device for the containers is located.
the interior 11 is delimited by the machine plate 13 on the one hand and a seal surrounding it Insulator housing 15.
the hood-like insulator housing 15 has side walls 16, in which viewing panels 17 are inserted are. Furthermore, 17 inserts 18 for Example of rubber gloves arranged to be by hand To be able to make manipulations in the interior 11. To the End faces 19, 20 of the insulator housing 15 are also not Locks shown trained to the containers in the interior 11 in or out.
a Blower or air circulation system which is in a box-shaped Area 23 arranged in the upper part of the insulator housing 15 is.
this area 23 there is, for example Circulating air blower and sterile air filter, which from the Clean interior air 11 and in relation to your Flow direction and flow speed again lead specifically into the interior 11.
the suction of the air in the interior 11 preferably takes place in the area of the Edge areas of the insulator housing 15, including the viewing windows 17 are designed as double disks with inner disks 24.
the inner panes 24 extend to just above the Machine plate 13 so that the air over the edge Column 25 is suctioned off.
the machine plate 13c from a solid Base plate 26 and a covering this, made of sheet metal trained cover plate 27 there.
the cover plate 27 has an angled edge 28 which the base plate 26th covers laterally on their circumference.
Machine frame 12 laterally projecting area 29 of the Base plate 26 is formed a through hole 31.
a Threaded bolt 34 arranged, the threaded bolt 34 the Cover plate 27 penetrates in the region of a hole 36 and cooperates with a mother 35.
the threaded bolt 34 is attached to a profile frame 38 made of sheet metal or welded on.
the profile frame 38 is closed Frame or box 39 formed, the viewing panels 17th with the interposition of inflatable molded seals 40 records.
a curved wall 41 of the box 39 runs on the the machine plate 13 facing side in a straight line Edge zone 42 from which the cover plate 27 to approximately in height of the machine frame 12 covered, and on the underside the threaded bolt 34 is attached.
Between edge zone 42 and the cover plate 27 is also a sealing member for Example arranged in the form of a sealing tape 43 to which as a conclusion on the side facing the interior 11 a silicone bead 44 connects.
Insulator housing 15 to the machine frame 12 using the Figure 4 received:
a plurality of holders 45 arranged at the Machine frame 12 is laterally a plurality of holders 45 arranged.
This holder 45 serve as a support surface and Attachment possibility for the insulator housing 15 at the Profile frame 46.
the profile frame 46 has an im Cross section rectangular base profile 47, which with its Narrow side 48 rests on top 49 of carrier 45 and in a suitable manner, for example by means of Screw connections 51, interchangeable with the brackets 45 is attached.
the basic profile 47 is laterally of two Shaped sheets 53, 54 at least partially limited, which on the the side facing away from the carriers 45 together with the Form seal 40 a tight and form-fitting reception of the Allow side wall 16. That of the machine plate 13 facing molding plate 54 has a level with the top of the Cover plate 27 tapering curvature 55 and at least one essentially parallel to the edge 28 of the cover plate 27 arranged, bent portion 56. The distance between the section 56 and the edge 28 of the cover plate 27 about three to ten millimeters, the trained one Gap 57 has a length such that in gap 57 a sealing element 58 can be arranged. In the in the Figure 4 illustrated first embodiment of the Invention, this sealing element 58 is in one piece, for example as a molded seal or inflatable sealing element 58 educated.
the second embodiment shown in Figure 5 differs from the first embodiment according to Figure 4 by the sealing element 58a, which is now made consists of two parts, a sealing tape 59 and one Silicone bead 60.
the sealing tape 59 is in the gap 57, while the silicone bead 60 towards the interior 11 flat transition between the cover plate 27 and the Form sheet 55 allows.

Landscapes

Engineering & Computer Science (AREA)
Mechanical Engineering (AREA)
Vacuum Packaging (AREA)
Basic Packing Technique (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)

EP00119535A 1999-10-05 2000-09-07 Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides Expired - Lifetime EP1090843B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19947786		1999-10-05
DE19947786A DE19947786A1 (de)	1999-10-05	1999-10-05	Verpackungsmaschine, insbesondere zum Abfüllen und Verschliessen von flüssigen Pharmazeutika enthaltenden Behältnissen

Publications (3)

Publication Number	Publication Date
EP1090843A2 true EP1090843A2 (fr)	2001-04-11
EP1090843A3 EP1090843A3 (fr)	2002-06-19
EP1090843B1 EP1090843B1 (fr)	2004-03-24

Family

ID=7924462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP00119535A Expired - Lifetime EP1090843B1 (fr)	1999-10-05	2000-09-07	Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides

Country Status (4)

Country	Link
US (1)	US6651404B1 (fr)
EP (1)	EP1090843B1 (fr)
JP (1)	JP4727803B2 (fr)
DE (2)	DE19947786A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003016139A1 (fr) *	2001-08-14	2003-02-27	The Boc Group, Inc.	Appareil de remplissage aseptique de flacons
WO2009003924A1 (fr) *	2007-07-03	2009-01-08	Robert Bosch Gmbh	Dispositif pour étancher un espace fermé
WO2010119130A3 (fr) *	2009-04-17	2011-04-14	Gerhard Liepold	Appareil de traitement de substance dans une zone fermée

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040020558A1 (en) *	2001-08-14	2004-02-05	Paul Stewart	Filling apparatus
WO2010100234A1 (fr)	2009-03-06	2010-09-10	Disposable-Lab	Isolateur amovible comprenant un moyen pour remplir des récipients
DE102009027452A1 (de) *	2009-07-03	2011-01-05	Robert Bosch Gmbh	Vorrichtung zum Füllen und Verschließen von pharmazeutischen Bahältnissen
CA2782769A1 (fr)	2009-12-21	2011-06-30	Disposable-Lab	Chaine de production jetable
SG10201406761SA (en) *	2013-10-18	2015-05-28	Pall Life Sciences Belgium Bvba	Disposable production line for filling and finishing a product
CN106679297B (zh) *	2017-01-05	2019-07-19	滁州美业机械制造有限公司	一种冰箱门与冲压件连接结构
KR102880992B1 (ko)	2018-11-16	2025-11-03	파티클 머슈어링 시스템즈, 인크.	로봇 제어된 제조 장벽 시스템을 위한 입자 샘플링 시스템 및 방법
DE102019207280A1 (de)	2019-05-18	2020-11-19	Syntegon Technology Gmbh	Anlage zum Handhaben von empfindlichen Produkten, insbesondere Verpackungsanlage
TWI829492B (zh)	2020-01-21	2024-01-11	美商粒子監測系統有限公司	撞擊器及用於對來自一流體流之生物顆粒取樣之方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3337218A1 (de) *	1983-10-13	1985-04-25	Robert Bosch Gmbh, 7000 Stuttgart	Maschinengehaeuse
US4730435A (en) *	1986-04-07	1988-03-15	Aqua-Chem, Inc.	Sterile docking system for filling IV bags
US4803827A (en) *	1987-11-17	1989-02-14	Baxter International Inc.	Means for segregating sterile and nonsterile environments in a packaging machine
FR2651752B1 (fr) *	1989-08-16	1993-12-03	Air Liquide	Boite d'isolation de l'atmosphere ambiante pour traitement de produits.
US5007232A (en) *	1989-11-20	1991-04-16	Abbott Laboratories	Apparatus and method of use of sterilizing containers using hydrogen peroxide vapor
US5117587A (en) *	1991-05-02	1992-06-02	Rjf International Corporation	Sealing structure
US5749203A (en) *	1994-09-23	1998-05-12	Kimberly-Clark Corporation	Method of packaging a medical article
IT1279846B1 (it) *	1995-08-11	1997-12-18	Rossi & Catelli Spa	Impianto di imbottigliamento asettico in continuo
US5878553A (en) *	1995-10-11	1999-03-09	Chronos Richardson Gmbh	Method and device for the spreading and fitting of empty sacks and for grasping and stacking filled sacks and for conveying them into a closure device
US5881535A (en) *	1996-04-09	1999-03-16	Baxter International, Inc.	Apparatus and method for filling and sealing intravenous solution bags
FR2749661B1 (fr) *	1996-06-05	1998-08-14	Tech De La Conservation Des Pr	Dispositif de controle en continu du contenant d'enceintes fermees hermetiquement
AU6775598A (en) *	1997-03-28	1998-10-22	Tetra Laval Holdings & Finance Sa	Filling machine having clean air system
JPH1191701A (ja) *	1997-09-17	1999-04-06	Shikoku Kakoki Co Ltd	液体充填装置
JP4042002B2 (ja) *	1997-09-19	2008-02-06	四国化工機株式会社	包装機械
US6018932A (en) *	1998-01-07	2000-02-01	Premark Feg L.L.C.	Gas exchange apparatus

1999
- 1999-10-05 DE DE19947786A patent/DE19947786A1/de not_active Ceased
2000
- 2000-09-07 EP EP00119535A patent/EP1090843B1/fr not_active Expired - Lifetime
- 2000-09-07 DE DE50005775T patent/DE50005775D1/de not_active Expired - Lifetime
- 2000-09-29 US US09/672,086 patent/US6651404B1/en not_active Expired - Lifetime
- 2000-10-05 JP JP2000306528A patent/JP4727803B2/ja not_active Expired - Fee Related

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003016139A1 (fr) *	2001-08-14	2003-02-27	The Boc Group, Inc.	Appareil de remplissage aseptique de flacons
US6799612B2 (en)	2001-08-14	2004-10-05	The Boc Group, Inc.	Filling apparatus
WO2009003924A1 (fr) *	2007-07-03	2009-01-08	Robert Bosch Gmbh	Dispositif pour étancher un espace fermé
WO2010119130A3 (fr) *	2009-04-17	2011-04-14	Gerhard Liepold	Appareil de traitement de substance dans une zone fermée

Also Published As

Publication number	Publication date
US6651404B1 (en)	2003-11-25
DE50005775D1 (de)	2004-04-29
JP2001158404A (ja)	2001-06-12
DE19947786A1 (de)	2001-04-19
JP4727803B2 (ja)	2011-07-20
EP1090843A3 (fr)	2002-06-19
EP1090843B1 (fr)	2004-03-24

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Publication	Publication Date	Title
EP1090843B1 (fr)	2004-03-24	Machine d'emballage, spécialement pour remplir et fermer des récipients contenant des produits médicamenteux liquides
DE8900273U1 (de)	1990-02-22	Verschluß für Dosendeckel
EP0504675B1 (fr)	1995-05-03	Bande d'étanchéité pour l'enceinte d'une presse à comprimés pharmaceutiques
DE615693C (de)	1935-07-10	Geschlossener Wagenkasten fuer Kraftfahrzeuge
DE102007030789A1 (de)	2009-01-08	Vorrichtung zum Abdichten eines geschlossenen Raumes
EP0609755B1 (fr)	1997-06-18	Dispositif d'étanchéité pour des bas de portes
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EP0169354A2 (fr)	1986-01-29	Plafond à filtre pour filtrer de l'air entrant dans une pièce
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