EP1090928B1 - Polymères chargés avec des agents bioactifs - Google Patents

Polymères chargés avec des agents bioactifs Download PDF

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Publication number
EP1090928B1
EP1090928B1 EP20000203388 EP00203388A EP1090928B1 EP 1090928 B1 EP1090928 B1 EP 1090928B1 EP 20000203388 EP20000203388 EP 20000203388 EP 00203388 A EP00203388 A EP 00203388A EP 1090928 B1 EP1090928 B1 EP 1090928B1
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EP
European Patent Office
Prior art keywords
polymer
solvent
bioactive agent
loaded
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP20000203388
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German (de)
English (en)
Other versions
EP1090928A1 (fr
Inventor
Jeroen Mattijs Bezemer
Jan Feijen
Clemens Antoni Van Blitterswijk
Dirk Wybe Grijpma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chienna BV
Original Assignee
Chienna BV
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Filing date
Publication date
Application filed by Chienna BV filed Critical Chienna BV
Priority to EP20000203388 priority Critical patent/EP1090928B1/fr
Publication of EP1090928A1 publication Critical patent/EP1090928A1/fr
Application granted granted Critical
Publication of EP1090928B1 publication Critical patent/EP1090928B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/04—Peptides being immobilised on, or in, an organic carrier entrapped within the carrier, e.g. gel, hollow fibre
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers

Definitions

  • the loaded polymer may also include, in addition to a hydrophobic antioxidant, a hydrophobic molecule such as cholesterol, ergosterol, litrochohc acid, cholic acid, dinosterol, betuline, or oleanohc acid, which may be employed in order to retard the release rate of the agent from the copolymer.
  • a hydrophobic molecule such as cholesterol, ergosterol, litrochohc acid, cholic acid, dinosterol, betuline, or oleanohc acid, which may be employed in order to retard the release rate of the agent from the copolymer.
  • Such hydrophobic molecules prevent water penetration into the loaded polymer, but do not compromise the degradability of the polymer matrix.
  • such molecules have melting points from 150°C to 200°C or decreases the polymer matrix diffusion coefficient for the biologically active agent, such as drug molecule, to be released.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Claims (14)

  1. Un procédé de préparation d'un polymère chargé d'un ou plusieurs agents bioactifs, comprenant les étapes dans lesquelles :
    a) on prend une solution de polymère dans un premier solvant qui est inmiscible à l'eau ;
    b) on ajoute une solution aqueuse de l'agent bioactif à la solution de polymère pour obtenir une émulsion eau-dans-huile ;
    c) on plonge l'émulsion eau-dans-huile dans un second solvant par injection de l'émulsion par une buse dans le second solvant, le polymère étant sensiblement insoluble dans le second solvant et le second solvant étant miscible avec le premier solvant ;
    d) on laisse le premier solvant migrer dans le second solvant pour obtenir un polymère fibreux, massif, chargé de l'agent bioactif.
  2. Un procédé selon la revendication 1, dans lequel le polymère est biocompatible et biodégradable.
  3. Un procédé selon la revendication 2, dans lequel le polymère est un copolymère séquencé amphiphile, comprenant des séquences hydrophiles et des séquences hydrophobes.
  4. Un procédé selon la revendication 3, dans lequel le polymère est un copolymère d'un polyalkylène glycol et d'un ester aromatique.
  5. Un procédé selon l'une quelconque des revendications précédentes, dans lequel l'agent bioactif est choisi dans le groupe des agents antimicrobiens, tels que les agents antibactériens et anti-fongiques, les agents anti-viraux, les agents anti-tumoraux, les agents immunogènes, les lipides, les lipopolysaccharides, les hormones et les facteurs de croissance.
  6. Un procédé selon l'une quelconque des revendications précédentes, dans lequel l'agent bioactif est choisi dans le groupe des peptides, oligopeptides, polypeptides et protéines.
  7. Un procédé selon la revendication 6, dans lequel le premier solvant se mélange mieux avec le second solvant que le polymère ne se dissout dans le premier solvant.
  8. Un procédé selon l'une quelconque des revendications précédentes, dans lequel on plonge l'émulsion eau-dans-huile dans le second solvant par injection à l'aide d'une seringue ou d'une extrudeuse.
  9. Un polymère chargé d'agent bioactif susceptible d'être obtenu selon l'une quelconque des revendications 1 à 8.
  10. Une fibre de polymère chargée d'agent bioactif obtenue par le procédé selon la revendication 8.
  11. Une fibre de polymère chargée d'agent bioactif selon la revendication 9 ou 10, dans laquelle ledit agent bioactif est un peptide, un oligopeptide, un polypeptide ou une protéine.
  12. Un procédé d'assemblage de fibres selon l'une quelconque des revendications 10 ou 11 pour former un treillis fibreux, dans lequel on recueille les fibres et on les réunit ensemble en utilisant des mélanges de solvants appropriés.
  13. Un treillis fibreux susceptible d'être obtenu par un procédé selon la revendication 12.
  14. L'utilisation d'un polymère chargé d'agent bioactif selon l'une quelconque des revendications 9 à 11 ou d'un treillis fibreux selon la revendication 13, en tant que support pour la libération contrôlée de médicament ou en tant que support de greffe pour la réparation des tissus.
EP20000203388 1999-09-30 2000-09-28 Polymères chargés avec des agents bioactifs Expired - Lifetime EP1090928B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20000203388 EP1090928B1 (fr) 1999-09-30 2000-09-28 Polymères chargés avec des agents bioactifs

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99203195 1999-09-30
EP99203195 1999-09-30
EP20000203388 EP1090928B1 (fr) 1999-09-30 2000-09-28 Polymères chargés avec des agents bioactifs

Publications (2)

Publication Number Publication Date
EP1090928A1 EP1090928A1 (fr) 2001-04-11
EP1090928B1 true EP1090928B1 (fr) 2004-05-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP20000203388 Expired - Lifetime EP1090928B1 (fr) 1999-09-30 2000-09-28 Polymères chargés avec des agents bioactifs

Country Status (1)

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EP (1) EP1090928B1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351423B2 (en) 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
US9801830B2 (en) 2010-07-02 2017-10-31 The Procter & Gamble Company Methods of delivering a health care active by administering personal health care articles comprising a filmament

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0208418D0 (en) * 2002-04-11 2002-05-22 Univ Aston Polymeric fibre
EP1679065A1 (fr) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Formulation destinée à la libération contrôlée d'interferone par un copolymère bloc PEGT/PBT
EP2055299A1 (fr) 2007-10-23 2009-05-06 Koninklijke Philips Electronics N.V. Procédé de préparation de microparticules en polymère
EP2205221A2 (fr) 2007-10-23 2010-07-14 Koninklijke Philips Electronics N.V. Procédés de préparation de microparticules de polymère
CN107496992B (zh) * 2017-08-30 2020-05-22 华南理工大学 一种三维图案化Fe3O4/医用高分子材料复合纳米纤维及其制备方法
CN116492450B (zh) * 2023-06-25 2023-10-10 朗肽生物制药股份有限公司 重组人碱性成纤维细胞生长因子口腔凝胶及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
EP0891783B1 (fr) * 1997-07-16 2002-06-12 IsoTis N.V. Dispositif pour la régénération osseuse consistant d'un copolyester thermoplastique biodégradable et de cellules cultivées

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351423B2 (en) 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
US9801830B2 (en) 2010-07-02 2017-10-31 The Procter & Gamble Company Methods of delivering a health care active by administering personal health care articles comprising a filmament
US10449163B2 (en) 2010-07-02 2019-10-22 The Procter & Gamble Company Methods of delivering a health care active by administering personal health care articles comprising a filament
US10517836B2 (en) 2010-07-02 2019-12-31 The Procter & Gamble Company Methods of delivering a health care active by administering personal health care articles comprising a filmament
US10912738B2 (en) 2010-07-02 2021-02-09 The Procter & Gamble Company Methods of delivering an oral care active by administering oral care articles comprising a filament
US11964059B2 (en) 2010-07-02 2024-04-23 The Procter & Gamble Company Methods of delivering an oral care active by administering oral care articles comprising a filament

Also Published As

Publication number Publication date
EP1090928A1 (fr) 2001-04-11

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