EP1102786A4 - Agent comprenant des oligonucleotides antisens a faible teneur en adenosine, composition, trousse et traitements - Google Patents

Agent comprenant des oligonucleotides antisens a faible teneur en adenosine, composition, trousse et traitements

Info

Publication number
EP1102786A4
EP1102786A4 EP99939006A EP99939006A EP1102786A4 EP 1102786 A4 EP1102786 A4 EP 1102786A4 EP 99939006 A EP99939006 A EP 99939006A EP 99939006 A EP99939006 A EP 99939006A EP 1102786 A4 EP1102786 A4 EP 1102786A4
Authority
EP
European Patent Office
Prior art keywords
kit
preparation
treatment methods
adenosine content
low adenosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99939006A
Other languages
German (de)
English (en)
Other versions
EP1102786A2 (fr
Inventor
Jonathan W Nyce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
East Carolina University
Original Assignee
East Carolina University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by East Carolina University filed Critical East Carolina University
Publication of EP1102786A2 publication Critical patent/EP1102786A2/fr
Publication of EP1102786A4 publication Critical patent/EP1102786A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
EP99939006A 1998-08-03 1999-08-03 Agent comprenant des oligonucleotides antisens a faible teneur en adenosine, composition, trousse et traitements Withdrawn EP1102786A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9521298P 1998-08-03 1998-08-03
US95212P 1998-08-03
PCT/US1999/017712 WO2000009525A2 (fr) 1998-08-03 1999-08-03 Agent comprenant des oligonucleotides antisens a faible teneur en adenosine, composition, trousse et traitements

Publications (2)

Publication Number Publication Date
EP1102786A2 EP1102786A2 (fr) 2001-05-30
EP1102786A4 true EP1102786A4 (fr) 2002-03-06

Family

ID=22250687

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99939006A Withdrawn EP1102786A4 (fr) 1998-08-03 1999-08-03 Agent comprenant des oligonucleotides antisens a faible teneur en adenosine, composition, trousse et traitements

Country Status (6)

Country Link
EP (1) EP1102786A4 (fr)
CN (1) CN1317009A (fr)
AU (1) AU5337499A (fr)
CA (1) CA2333901A1 (fr)
HK (1) HK1042706A1 (fr)
WO (1) WO2000009525A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6825174B2 (en) 1995-06-07 2004-11-30 East Carolina University Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
US7034007B1 (en) 1995-06-07 2006-04-25 East Carolina University Low adenosine anti-sense oligonucleotide, compositions, kit & method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) & surfactant depletion
EP1165123A4 (fr) * 1999-03-26 2002-09-11 Human Genome Sciences Inc 48 proteines humaines secretees
EP1165783A4 (fr) * 1999-03-26 2002-09-11 Human Genome Sciences Inc 47 proteines humaines secretees
WO2000062736A2 (fr) * 1999-04-06 2000-10-26 East Carolina University Oligonucleotide antisens a faible teneur en adenosine, compositions, kit et procede pour le traitement d'affections des voies aeriennes associees a la bronchoconstriction, a l'inflammation pulmonaire, aux allergies et a la depletion de surfactant
US6489151B1 (en) * 2000-03-27 2002-12-03 The Research Foundation Of State University Of New York Biologically active alternative form of the IKKα IκB kinase
DE10019252A1 (de) * 2000-04-18 2001-10-31 Klaus Karl Degitz Polydesoxyribonukleotide zur Hemmung der ICAM-1-Genexpression
DE10049549A1 (de) * 2000-10-06 2002-05-02 Markus Hecker Modulation der Transkription pro-inflammatorischer Genprodukte
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7745420B2 (en) * 2001-07-06 2010-06-29 Topigen Pharmaceutique, Inc. Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US20060088835A1 (en) * 2002-04-05 2006-04-27 Pickard Benjamin S Schizophrenia associated genes
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
CN1322899C (zh) * 2004-02-11 2007-06-27 中国科学院上海生命科学研究院 抗肝癌基因药物组合物、小分子干扰rna及其筛选方法
WO2005105841A2 (fr) 2004-03-12 2005-11-10 Human Genome Sciences, Inc. Récepteur humain (ccr5) hdgnr10 de chimiokine de la protéine g
NZ554723A (en) 2004-10-29 2009-12-24 Topigen Pharmaceuticals Inc Antisense oligonucleotides against CCR3 chemokine receptor
MX2008002101A (es) 2005-08-12 2008-04-19 Schering Corp Fusiones de la proteina-1 quimiotactica de monocito.
US8524217B2 (en) 2010-05-11 2013-09-03 Merck Sharp & Dohme Corp. MCP1-Ig fusion variants
US10017762B2 (en) * 2010-11-24 2018-07-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Compositions and methods for treating or preventing lupus
BR112013032223A2 (pt) * 2011-06-15 2016-12-20 Grifols Therapeutics Inc molécula de ácido nucleico isolada, e, composição
CN102866153B (zh) * 2012-09-29 2014-08-13 郑州安图生物工程股份有限公司 前列腺炎联合检测试剂盒
WO2014164805A1 (fr) * 2013-03-11 2014-10-09 University Of North Carolina At Chapel Hill Compositions et méthodes de ciblage de la n-acétylglucosamine transférase à liaison o et d'accélération de la cicatrisation des plaies
JP2023548597A (ja) * 2020-10-29 2023-11-17 エー． ガルシア－ブランコ，マリアーノ がんを処置するための可溶性インターロイキン－７受容体（ｓＩＬ７Ｒ）変調療法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010820A1 (fr) * 1991-11-26 1993-06-10 Gilead Sciences, Inc. Formation amelioree de triple et double helices a l'aide d'oligomeres contenant des pyrimidines modifiees
WO1993012756A2 (fr) * 1991-12-17 1993-07-08 The Regents Of The University Of California Transfection pulmonaire par administration transgenique aerosol
WO1995035032A1 (fr) * 1992-05-22 1995-12-28 The Scripps Research Institute SUPPRESSION DES PROCESSUS DEPENDANT DU FACTEUR NUCLEAIRE kB AU MOYEN D'OLIGONUCLEOTIDES
WO1996040162A1 (fr) * 1995-06-07 1996-12-19 East Carolina University Procede de traitement de maladies pulmonaires au moyen d'oligonucleotides antisens
WO1998011211A2 (fr) * 1996-09-10 1998-03-19 Hybridon, Inc. METHODES D'UTILISATION D'OLIGONUCLEOTIDES POSSEDANT DES DINUCLEOSIDES CpG MODIFIES
WO1999060166A1 (fr) * 1998-05-21 1999-11-25 Isis Pharmaceuticals, Inc. Compositions et methodes d'administration aux poumons d'acides nucleiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932557A (en) * 1997-08-12 1999-08-03 Mustafa; S. Jamal Adenosine A1 receptor antisense oligonucleotide treatment of alcohol and marijuana-induced psychomotor impairments

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010820A1 (fr) * 1991-11-26 1993-06-10 Gilead Sciences, Inc. Formation amelioree de triple et double helices a l'aide d'oligomeres contenant des pyrimidines modifiees
WO1993012756A2 (fr) * 1991-12-17 1993-07-08 The Regents Of The University Of California Transfection pulmonaire par administration transgenique aerosol
WO1995035032A1 (fr) * 1992-05-22 1995-12-28 The Scripps Research Institute SUPPRESSION DES PROCESSUS DEPENDANT DU FACTEUR NUCLEAIRE kB AU MOYEN D'OLIGONUCLEOTIDES
WO1996040162A1 (fr) * 1995-06-07 1996-12-19 East Carolina University Procede de traitement de maladies pulmonaires au moyen d'oligonucleotides antisens
WO1998011211A2 (fr) * 1996-09-10 1998-03-19 Hybridon, Inc. METHODES D'UTILISATION D'OLIGONUCLEOTIDES POSSEDANT DES DINUCLEOSIDES CpG MODIFIES
WO1999060166A1 (fr) * 1998-05-21 1999-11-25 Isis Pharmaceuticals, Inc. Compositions et methodes d'administration aux poumons d'acides nucleiques

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
LOAKES D ET AL: "5-NITROINDOLE AS AN UNIVERSAL BASE ANALOGUE", NUCLEIC ACIDS RESEARCH, vol. 22, no. 20, 1994, pages 4039 - 4043, XP000999195, ISSN: 0305-1048 *
METZGER W JAMES ET AL: "Oligonucleotide therapy of allergic asthma.", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 104, no. 2 PART 1, August 1999 (1999-08-01), pages 260 - 266, XP001024505, ISSN: 0091-6749 *
NARAYANAN, R.: "The NK-kappaB transcription factor", STEIN, C.A. & KRIEG, A.M. 'APPLIED ANTISENSE OLIGONUCLEOTIDE TECHNOLOGY'. WILEY-LISS, NEW YORK, US; 1998; CHAPTER 12, pages 231 - 243, XP002185125 *
NICHOLS R ET AL: "A UNIVERSAL NUCLEOSIDE FOR USE AT AMBIGOUS SITES IN DNA PRIMERS", NATURE, vol. 369, no. 6480, 9 June 1994 (1994-06-09), pages 492 - 493, XP000560346, ISSN: 0028-0836 *
OHTSUKA E ET AL: "AN ALTERNATIVE APPROACH TO DEOXYOLIGONUCLEOTIDES AS HYBRIDIZATION PROBES BY INSERTION OF DEOXYINOSINE AT AMBIGUOUS CODON POSITIONS", JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS), vol. 260, no. 5, 10 March 1985 (1985-03-10), pages 2605 - 2608, XP002031938 *
RAHMAN M SAYEEDUR ET AL: "Nebularine (9-2'-deoxy-beta-D-ribofuranosylpurine) has the template characteristics of adenine in vivo and in vitro.", MUTATION RESEARCH, vol. 377, no. 2, 1997, pages 263 - 268, XP001024479, ISSN: 0027-5107 *
See also references of WO0009525A3 *

Also Published As

Publication number Publication date
WO2000009525A3 (fr) 2000-05-18
AU5337499A (en) 2000-03-06
WO2000009525A2 (fr) 2000-02-24
CN1317009A (zh) 2001-10-10
CA2333901A1 (fr) 2000-02-24
EP1102786A2 (fr) 2001-05-30
HK1042706A1 (zh) 2002-08-23

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