EP1105734A4 - Mit 'homer' interagierende proteine - Google Patents

Mit 'homer' interagierende proteine

Info

Publication number
EP1105734A4
EP1105734A4 EP99945113A EP99945113A EP1105734A4 EP 1105734 A4 EP1105734 A4 EP 1105734A4 EP 99945113 A EP99945113 A EP 99945113A EP 99945113 A EP99945113 A EP 99945113A EP 1105734 A4 EP1105734 A4 EP 1105734A4
Authority
EP
European Patent Office
Prior art keywords
interacting proteins
homer interacting
homer
proteins
interacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99945113A
Other languages
English (en)
French (fr)
Other versions
EP1105734A2 (de
Inventor
Paul F Worley
Jian Cheng Tu
Bo Xiao
Daniel Leahy
Jutta Beneken
Anthony A Lanahan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Priority to EP06003521A priority Critical patent/EP1662255A3/de
Publication of EP1105734A2 publication Critical patent/EP1105734A2/de
Publication of EP1105734A4 publication Critical patent/EP1105734A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99945113A 1998-08-18 1999-08-18 Mit 'homer' interagierende proteine Withdrawn EP1105734A4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06003521A EP1662255A3 (de) 1998-08-18 1999-08-18 Homer interagierende Proteine

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US9733498P 1998-08-18 1998-08-18
US13842699P 1999-06-09 1999-06-09
US13849499P 1999-06-09 1999-06-09
US13849399P 1999-06-09 1999-06-09
US138426P 1999-06-09
US138493P 1999-06-09
US138494P 1999-06-10
PCT/US1999/018973 WO2000011204A2 (en) 1998-08-18 1999-08-18 Homer interacting proteins
US97334P 2008-09-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP06003521A Division EP1662255A3 (de) 1998-08-18 1999-08-18 Homer interagierende Proteine

Publications (2)

Publication Number Publication Date
EP1105734A2 EP1105734A2 (de) 2001-06-13
EP1105734A4 true EP1105734A4 (de) 2005-04-13

Family

ID=27492912

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99945113A Withdrawn EP1105734A4 (de) 1998-08-18 1999-08-18 Mit 'homer' interagierende proteine

Country Status (4)

Country Link
EP (1) EP1105734A4 (de)
JP (1) JP2002523056A (de)
AU (1) AU772105B2 (de)
WO (1) WO2000011204A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
AU2002357449A1 (en) * 2001-12-21 2003-07-15 7Tm Pharma A/S Use of a signal transduction complex in drug discovery processes
JP2007524566A (ja) 2002-12-20 2007-08-30 エンカム ファーマシューティカルズ アクティーゼルスカブ レセプターとリガンドの間の相互作用の調節の方法
DE102006030366A1 (de) * 2006-06-27 2008-01-03 Universität Rostock Pharmazeutisches Mittel zur Behandlung des Parkinson-Syndroms und ein Verfahren zum Screening von Substanzen zur Verminderung der Parkinson-Symptomatik
EP2297325A4 (de) * 2008-05-29 2011-10-05 Chum Verfahren zur stratifizierung, prognose und diagnose von schizophrenie, mutierte nukleinsäuremoleküle und polypeptide
CN108004214B (zh) * 2017-11-29 2020-10-13 武汉大学 Homer2单克隆抗体及其应用
CN111141912A (zh) * 2020-03-02 2020-05-12 南通大学 Gabarap与optn结合在optn蓄积导致的神经元病变中的作用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048724A2 (en) * 1996-02-21 1997-12-24 Nps Pharmaceuticals, Inc. Human metabotropic glutamate receptor
US5721107A (en) * 1990-12-12 1998-02-24 The Board Of Regents Of The University Of Washington Antibodies to G protein coupled glutamate receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721107A (en) * 1990-12-12 1998-02-24 The Board Of Regents Of The University Of Washington Antibodies to G protein coupled glutamate receptors
WO1997048724A2 (en) * 1996-02-21 1997-12-24 Nps Pharmaceuticals, Inc. Human metabotropic glutamate receptor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALLISON DANIEL W ET AL: "Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: Differential attachment of NMDA versus AMPA receptors", JOURNAL OF NEUROSCIENCE, vol. 18, no. 7, 1 April 1998 (1998-04-01), pages 2423 - 2436, XP002303914, ISSN: 0270-6474 *
BENEKEN JUTTA ET AL: "Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition", NEURON, vol. 26, no. 1, April 2000 (2000-04-01), pages 143 - 154, XP002303917, ISSN: 0896-6273 *
BRAKEMAN P R ET AL: "HOMER: A PROTEIN THAT SELECTIVELY BINDS METABOTROPIC GLUTAMATE RECEPTORS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 386, 20 March 1997 (1997-03-20), pages 284 - 288, XP002912002, ISSN: 0028-0836 *
See also references of WO0011204A3 *
TU JIAN CHENG ET AL: "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors", NEURON, vol. 21, no. 4, October 1998 (1998-10-01), pages 717 - 726, XP002303916, ISSN: 0896-6273 *
XIAO BO ET AL: "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins", NEURON, vol. 21, no. 4, October 1998 (1998-10-01), pages 707 - 716, XP002303915, ISSN: 0896-6273 *

Also Published As

Publication number Publication date
WO2000011204A3 (en) 2001-02-15
WO2000011204A2 (en) 2000-03-02
JP2002523056A (ja) 2002-07-30
EP1105734A2 (de) 2001-06-13
AU5779899A (en) 2000-03-14
AU772105B2 (en) 2004-04-08

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