EP1110532A2 - Schlankheitsvorrichtung - Google Patents

Schlankheitsvorrichtung Download PDF

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Publication number
EP1110532A2
EP1110532A2 EP00128078A EP00128078A EP1110532A2 EP 1110532 A2 EP1110532 A2 EP 1110532A2 EP 00128078 A EP00128078 A EP 00128078A EP 00128078 A EP00128078 A EP 00128078A EP 1110532 A2 EP1110532 A2 EP 1110532A2
Authority
EP
European Patent Office
Prior art keywords
uncoupling protein
stimulation
physical stimulation
ultrasonic
slimming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00128078A
Other languages
English (en)
French (fr)
Other versions
EP1110532A3 (de
EP1110532B1 (de
Inventor
Toshihide Yoshida
Yuko Matsumura
Yasuhiro Sato
Hideo Iwata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
YOSHIDA, TOSHIHIDE
Panasonic Electric Works Co Ltd
Original Assignee
Matsushita Electric Works Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsushita Electric Works Ltd filed Critical Matsushita Electric Works Ltd
Publication of EP1110532A2 publication Critical patent/EP1110532A2/de
Publication of EP1110532A3 publication Critical patent/EP1110532A3/de
Application granted granted Critical
Publication of EP1110532B1 publication Critical patent/EP1110532B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • A61H23/0245—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with ultrasonic transducers, e.g. piezoelectric

Definitions

  • This invention relates to a slimming device capable of providing a slimming action by a physical stimulation applied to the body.
  • the primary purpose in obtaining a slimming action is to lower a superflux of adipose stored in the body, or to optimize the level of the adipose.
  • a superflux of adipose from an adipocyte is firstly allowed to dissolve in blood (referred to as lipolysis), and then the lipid components produced by lipolysis are required to be combusted in a muscle tissue.
  • lipolysis a superflux of adipose from an adipocyte
  • the present invention has been developed in view of the foregoing background, and is directed to provide a slimming device capable of activating successfully an uncoupling protein so as to obtain an effective slimming action.
  • the present invention relates to a slimming device which comprises a means for a physical stimulation wherein the means for a physical stimulation comprises physically stimulating an uncoupling protein that is responsible for thermogenesis to activate the same, thereby generating and/or dissipating the heat.
  • the means for a physical stimulation is herein referred to as at least one of a thermal stimulation, an electrical stimulation, and a mechanical stimulation applied to a part to be stimulated, and specifically include an ultrasonic, a high frequency, a middle frequency, a low frequency, a vibration, a heating, a cooling, an electric, a pressure, a massage, a kneading, a clapping, and the like.
  • the means for a physical stimulation may comprise stimulating an uncoupling protein in at least one of a brown adipocyte, a white adipocyte, and a skeletal muscle.
  • Brown adipocyte refers to a constituent cell in a thermogenesis tissue, brown adipose tissue, which is acknowledged to cause obesity when the function of the tissue lowers, and is located at the interscapular region, the axilla, the nape of the neck, the surrounding artery, the surrounding kidney, and the like.
  • White adipocyte refers to a constituent cell in white adipose tissue that constructs a majority of body adipose and determines a physical feature by forming a thick fat build-up at any part of the body.
  • Skeletal muscle is a general word showing a muscle for moving skeletons of the body, and is located systemically such as at arms, legs, and bulges.
  • the present invention encompasses the slimming device which comprises a means for a physical stimulation, wherein the means for a physical stimulation comprises stimulating exclusively an uncoupling protein in a brown adipocyte particularly located at the interscapular region, the axilla, or the nape of the neck, and the slimming device which comprises a means for a physical stimulation, wherein the means for a physical stimulation comprises stimulating exclusively an uncoupling protein in a white adipocyte or a skeletal muscle located at a part to be slimmed.
  • the invention relates to the slimming device which comprises a means for a physical stimulation, wherein the means for a physical stimulation comprises stimulating an uncoupling protein in a brown adipocyte located at the interscapular region, the axilla, or the nape of the neck, as well as stimulating an uncoupling protein in a white adipocyte or a skeletal muscle located at a part to be slimmed.
  • the slimming device includes an embodiment wherein a part to be slimmed and a brown adipocyte are simultaneously stimulated, and an embodiment wherein a part to be slimmed is firstly stimulated, and subsequently a brown adipocyte is stimulated within a defined period of time after the first stimulation, or vice versa.
  • the invention relates to the slimming device wherein the means for a physical stimulation also comprises stimulating physically a sympathetic nerve to secrete a catecholamine at a part to be slimmed. More preferably, the invention relates to the slimming device that comprises, as the means for a physical stimulation, an ultrasonic stimulation in which the ultrasonic stimulation not only secretes a catecholamine from the terminus of a sympathetic nerve and the adrenal medulla to induce lipolysis of a white adipose, but also activates an uncoupling protein in a white adipose or a skeletal muscle to decay locally the free fatty acids released by lipolysis with energy dissipation in the form of heat.
  • the present invention relates to a method for slimming down or reducing a weight, which comprises physically stimulating an uncoupling protein that is responsible for thermogenesis to activate the same, thereby generating and/or dissipating the heat.
  • This embodiment includes the embodiments as mentioned above with respect to the slimming device of the present invention.
  • the present invention relates to a slimming device which comprises a means for a physical stimulation, wherein the means for a physical stimulation comprises an ultrasonic stimulation in which the ultrasonic stimulation activates a sympathetic nerve to secrete a catecholamine, thereby inducing lipolysis of a white adipose, as well as a method therefor.
  • Figure 1 depicts one embodiment for conducting the present invention.
  • A represents a slimming device.
  • Symbols 1, 3, and 4 represent an ultrasonic irradiator, a medium for ultrasonic irradiation, and the body, respectively.
  • Figure 2 depicts a further embodiment for conducting the present invention.
  • A represents a slimming device.
  • Symbols 1, 2, 5, 6, 7, and 8 represent ultrasonic irradiator, low frequency oscillator, scapula underpart, cervical rear, axilla, and leg, respectively.
  • Figure 3 depicts a still further embodiment for conducting the present invention.
  • Figure 4 is a block diagram showing an embodiment for a slimming device of the present invention.
  • Figure 5 is a graph showing a relationship between a physical stimulation by ultrasonic irradiation and an activity of UPC3.
  • * means 95% confidence limits
  • ** means 99% confidence limits.
  • Figure 6 is a graph showing a relationship between a physical stimulation by ultrasonic irradiation and a weight of adipose.
  • Figure 7 is a graph showing a relationship between a physical stimulation by ultrasonic irradiation and an amount of free fatty acids.
  • Lipolysis can be induced by secretion of a catecholamine, which is a general name of three substances, dopamine, noradrenaline, and adrenaline.
  • a means for a physical stimulation comprising stimulating physically a sympathetic nerve at a part to be slimmed enables secretion of a catecholamine from the terminus of a sympathetic nerve and the adrenal medulla, and also enables acceleration of the secretion.
  • a direct secretion of a catecholamine or an acceleration of the secretion may be accomplished by internal or external administration of a chemical stimulant such as caffeine and nicotine.
  • an ultrasonic successfully stimulates a sympathetic nerve to secrete a catecholamine, thereby inducing lipolysis.
  • the embodiment may constitute the invention. This is demonstrated in Example 2 hereinafter.
  • other physical stimulation such as a massage, and a heating may be combined with an ultrasonic stimulation
  • two or more ultrasonic probes may be used alternately
  • two or more ultrasonic probes may be slid on the skins, providing a massage stimulation as well as the ultrasonic stimulation
  • an ultrasonic stimulation may be effected at intervals to avoid any tolerance of the body to the ultrasonic radiation, thus increasing in the release of free fatty acids.
  • the combustion of the lipid components produced by lipolysis can be attained by using a means for a physical stimulation to stimulate physically the body and activate an uncoupling protein (UCP) that is responsible for thermogenesis, thereby generating and/or dissipating the heat.
  • UCP1, UCP2, and UCP3 have been known as an uncoupling protein, and studies on these uncoupling proteins have revealed that they exist in a brown adipocyte located at the interscapular region, the axilla, the nape of the neck, and the like tissue; a white adipocyte so-called adipose; and a skeletal muscle; or the like.
  • the uncoupling protein may be physically stimulated by a physical stimulation of at least one of a brown adipocyte located at the interscapular region, the axilla, or the nape of the neck; or a white adipocyte or a skeletal muscle which are located at a part to be slimmed.
  • the stimulation activates the uncoupling protein to generate and/or dissipate the heat, thereby obtaining a slimming action.
  • the physical stimulation to be applied to the body in order not only to activate the uncoupling protein but also to secrete a catecholamine includes a thermal stimulation, an electrical stimulation, and a mechanical stimulation, and specifically includes an ultrasonic, a high frequency, a middle frequency, a low frequency, a vibration, a heating, a cooling, an electric, a pressure, a massage, a kneading, and a clapping, and the like.
  • the slimming device of the present invention comprises a means for at least one physical stimulation selected from a group consisting of these stimulations, which means is to be applied to the body.
  • a sympathetic nerve can be stimulated to secrete a catecholamine from the terminus of a sympathetic nerve and the adrenal medulla, which catecholamine can induce lipolysis of an adipose from a white adipocyte, and besides an uncoupling protein in a white adipocyte and a skeletal muscle to be irradiated can be activated to decay the free fatty acids released by lipolysis at the irradiated part with energy dissipation in the form of heat. Accordingly, this embodiment makes it possible to securely reduce an adipose leading to an effective slimming action.
  • the slimming device of the present invention can be used to obtain a partial slimming action at the stimulated part by stimulating exclusively a part of the body to be slimmed to activate exclusively an uncoupling protein in a white adipocyte and a skeletal muscle at the part, thereby generating and dissipating the heat.
  • the slimming device of the present invention can be also used to obtain a general slimming action. This is accomplished by stimulating exclusively a brown adipocyte located at the interscapular region, the axilla, or the nape of the neck to activate an uncoupling protein in the brown adipocyte. This physical stimulation of the brown adipocyte enables activation of uncoupling proteins that are spread over the systemic body, and generation and/or dissipation of the heat, thereby providing the general slimming action.
  • the slimming device may comprise both a means for a physical stimulation which comprises stimulating exclusively an uncoupling protein at a part to be slimmed, and a means for a physical stimulation which comprises stimulating exclusively an uncoupling protein at a brown adipocyte located at the interscapular region, the axilla, or the nape of the neck.
  • both means for a physical stimulation can be set up to effect the stimulations at the same time.
  • Each means for a physical stimulation may be the same kind of stimulation or different each other.
  • an uncoupling protein at a part to be slimmed is exclusively stimulated firstly, and subsequently an uncoupling protein at a brown adipocyte is exclusively stimulated within a defined period of time after the first stimulation, or vice versa.
  • the defined period of time is a period of time for completing an activation of an uncoupling protein at a part to be slimmed, and preferably about 30 minutes or less.
  • each means for a physical stimulation may be the same kind of stimulation or different each other.
  • the present invention simultaneously provides a general slimming action, and a partial slimming action at a part to be slimmed, by stimulating exclusively an uncoupling protein at a brown adipocyte, and stimulating exclusively an uncoupling protein at a part to be slimmed.
  • ultrasonic irradiators can be used to stimulate many parts to be slimmed at the same time.
  • Ultrasonic irradiator having an ultrasonic oscillator was used as a means for a physical stimulation to stimulate a sympathetic nerve, thereby secreting a catecholamine leading to induction of lipolysis.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Electrotherapy Devices (AREA)
  • Massaging Devices (AREA)
  • Specific Sealing Or Ventilating Devices For Doors And Windows (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP00128078A 1999-12-22 2000-12-21 Schlankheitsvorrichtung Expired - Lifetime EP1110532B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP36432499A JP4723707B2 (ja) 1999-12-22 1999-12-22 痩身器具
JP36432499 1999-12-22

Publications (3)

Publication Number Publication Date
EP1110532A2 true EP1110532A2 (de) 2001-06-27
EP1110532A3 EP1110532A3 (de) 2003-04-16
EP1110532B1 EP1110532B1 (de) 2006-11-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP00128078A Expired - Lifetime EP1110532B1 (de) 1999-12-22 2000-12-21 Schlankheitsvorrichtung

Country Status (6)

Country Link
US (1) US6645229B2 (de)
EP (1) EP1110532B1 (de)
JP (1) JP4723707B2 (de)
AT (1) ATE343997T1 (de)
DE (1) DE60031638T2 (de)
ES (1) ES2275471T3 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
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US6645229B2 (en) * 1999-12-22 2003-11-11 Matsushita Electric Works, Ltd. Slimming device
EP1874241A4 (de) * 2005-04-29 2011-06-22 Medicis Technologies Corp Gerät und verfahren zur zerstörung von fettgewebe

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
US6645229B2 (en) * 1999-12-22 2003-11-11 Matsushita Electric Works, Ltd. Slimming device
EP1874241A4 (de) * 2005-04-29 2011-06-22 Medicis Technologies Corp Gerät und verfahren zur zerstörung von fettgewebe

Also Published As

Publication number Publication date
US20010014815A1 (en) 2001-08-16
EP1110532A3 (de) 2003-04-16
ATE343997T1 (de) 2006-11-15
JP4723707B2 (ja) 2011-07-13
ES2275471T3 (es) 2007-06-16
EP1110532B1 (de) 2006-11-02
DE60031638T2 (de) 2007-09-06
US6645229B2 (en) 2003-11-11
JP2001170128A (ja) 2001-06-26
HK1036927A1 (en) 2002-01-25
DE60031638D1 (de) 2006-12-14

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