EP1126831A4 - Methoden zur behandlung der insulinresistenz durch stickstoffmonoxyd der leber - Google Patents

Methoden zur behandlung der insulinresistenz durch stickstoffmonoxyd der leber

Info

Publication number
EP1126831A4
EP1126831A4 EP99951765A EP99951765A EP1126831A4 EP 1126831 A4 EP1126831 A4 EP 1126831A4 EP 99951765 A EP99951765 A EP 99951765A EP 99951765 A EP99951765 A EP 99951765A EP 1126831 A4 EP1126831 A4 EP 1126831A4
Authority
EP
European Patent Office
Prior art keywords
nitric oxide
insulin resistance
treating insulin
hepatic nitric
hepatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99951765A
Other languages
English (en)
French (fr)
Other versions
EP1126831A1 (de
Inventor
Wilfred Wayne Lautt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diamedica Therapeutics Inc
Original Assignee
Diamedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diamedica Inc filed Critical Diamedica Inc
Publication of EP1126831A1 publication Critical patent/EP1126831A1/de
Publication of EP1126831A4 publication Critical patent/EP1126831A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99951765A 1998-10-06 1999-10-05 Methoden zur behandlung der insulinresistenz durch stickstoffmonoxyd der leber Withdrawn EP1126831A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10317098P 1998-10-06 1998-10-06
US103170P 1998-10-06
PCT/US1999/023098 WO2000019992A1 (en) 1998-10-06 1999-10-05 Method for treating insulin resistance through hepatic nitric oxide

Publications (2)

Publication Number Publication Date
EP1126831A1 EP1126831A1 (de) 2001-08-29
EP1126831A4 true EP1126831A4 (de) 2004-10-06

Family

ID=22293754

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99951765A Withdrawn EP1126831A4 (de) 1998-10-06 1999-10-05 Methoden zur behandlung der insulinresistenz durch stickstoffmonoxyd der leber

Country Status (3)

Country Link
EP (1) EP1126831A4 (de)
CA (1) CA2381095C (de)
WO (1) WO2000019992A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2514090C (en) 2002-01-25 2012-08-21 Diamedica Inc. Use of glutathione synthesis stimulating compounds in reducing insulin resistance
JP5000493B2 (ja) 2004-05-20 2012-08-15 ディアメディカ インコーポレイテッド インスリン抵抗性を治療するための製薬組成物、同製薬組成物の調製においてベタネコール及びｎ−アセチルシステインを使用する方法及び同製薬組成物を含むキット
CA2856732A1 (en) 2011-12-09 2013-06-13 Metavention, Inc. Therapeutic neuromodulation of the hepatic system
WO2013134543A1 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg Sarl Immune system neuromodulation and associated systems and methods
WO2013173923A1 (en) 2012-05-25 2013-11-28 Diamedica, Inc. Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
ES2625548T3 (es) 2012-06-04 2017-07-19 DiaMedica Therapeutics Inc. Isoformas de glicosilación de la calicreína-1 tisular humana
CA2913346A1 (en) 2013-06-05 2014-12-11 Metavention, Inc. Modulation of targeted nerve fibers
WO2016090175A1 (en) 2014-12-03 2016-06-09 Metavention, Inc. Systems and methods for modulating nerves or other tissue
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
CA3054962A1 (en) 2017-03-09 2018-09-13 Diamedica Inc. Dosage forms of tissue kallikrein 1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910316A (en) * 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
GB9510037D0 (en) * 1995-05-18 1995-07-12 Sandoz Nutrition Ltd Improvements in or relating to organic compounds
US5906987A (en) * 1997-03-10 1999-05-25 Schering Aktiengesellschaft And Board Of Regents Treatment of male climacteric disorders with nitric oxide synthase substrates and/or donors, in combination with androgens and/or aromatase inhibitors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GOTOH M ET AL: "VAGALLY MEDIATED INSULIN SECRETION BY STIMULATION OF BRAIN CHOLINERGIC NEURONS WITH NEOSTIGMINE IN BILATERAL ADRENALECTOMIZED RATS", BRAIN RESEARCH, AMSTERDAM, NL, vol. 493, no. 1, 24 July 1989 (1989-07-24), pages 97 - 102, XP009011022, ISSN: 0006-8993 *
PARISSA SANDRI AND ALL.: "Blockade of Nitric Oxide Production in the Liver Causes Insulin Resistance", PROCEEDINGS OF THE WESTERN PHARMACOLOGICAL SOCIETY, vol. 41, 1 August 1998 (1998-08-01), pages 37 - 38, XP002292125 *
RIO DEL G ET AL: "CHOLINERGIC ENHANCEMENT BY PYRIDOSTIGMINE INCREASES THE INSULIN RESPONSE TO GLUCOSE LOAD IN OBESE PATIENTS BUT NOT IN NORMAL SUBJECTS", INTERNATIONAL JOURNAL OF OBESITY, NEWMAN PUBLISHING, LONDON, GB, vol. 21, no. 12, December 1997 (1997-12-01), pages 1111 - 1114, XP009011020, ISSN: 0307-0565 *
See also references of WO0019992A1 *
SZABO O ET AL: "NEUROPHARMACOLOGICAL CHARACTERIZATION OF INSULIN-SENSITIVE CNS GLUCOREGULATOR", AMERICAN JOURNAL OF PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, vol. 229, no. 3, September 1975 (1975-09-01), pages 663 - 668, XP009011092, ISSN: 0002-9513 *
XIE H ET AL: "INSULIN RESISTANCE CAUSED BY HEPATIC CHOLINERGIC INTERRUPTION AN REVERSED BY ACETYLCHOLINE ADMINISTRATION", AMERICAN JOURNAL OF PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, vol. 271, no. 3, PART 1, 1996, pages E587 - E592, XP009011012, ISSN: 0002-9513 *

Also Published As

Publication number Publication date
EP1126831A1 (de) 2001-08-29
WO2000019992A1 (en) 2000-04-13
WO2000019992A9 (en) 2000-09-21
CA2381095A1 (en) 2000-04-13
CA2381095C (en) 2012-08-14

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: KOHN, KENNETH I.

Owner name: DIAMEDICA INC.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: DIAMEDICA INC.

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