EP1132135A2 - Fermeture individuelle et support de fermetures pour récipients de réaction, et dispositif de stockage et de distribution de telles fermetures - Google Patents

Fermeture individuelle et support de fermetures pour récipients de réaction, et dispositif de stockage et de distribution de telles fermetures Download PDF

Info

Publication number: EP1132135A2
Authority: EP; European Patent Office
Prior art keywords: closure; individual; carrier; section; closures
Prior art date: 2000-03-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP01104986A

Other languages

German (de)

English (en)

Other versions

EP1132135B1 (fr

EP1132135A3 (fr

Inventor

Günter Kohrmann

Antonio Dr. Romaguera

Peter Mahler

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Brand GmbH and Co KG

Original Assignee

Brand GmbH and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-09

Filing date

2001-03-01

Publication date

2001-09-12

2001-03-01 Application filed by Brand GmbH and Co KG filed Critical Brand GmbH and Co KG

2001-09-12 Publication of EP1132135A2 publication Critical patent/EP1132135A2/fr

2003-06-25 Publication of EP1132135A3 publication Critical patent/EP1132135A3/fr

2005-08-03 Application granted granted Critical

2005-08-03 Publication of EP1132135B1 publication Critical patent/EP1132135B1/fr

2021-03-01 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

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Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Rigid containers without fluid transport within
- B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
- B01L3/50853—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates with covers or lids

Definitions

the invention relates to an arrangement for contamination-free processing of in particular molecular biological reaction processes with the Features of the preamble of claim 1.
the subject of the invention also a corresponding closure carrier for such an arrangement, a single closure for such an arrangement and a supply and dispensing arrangement for such individual closures.
nucleic acid diagnostics A particularly problematic area is nucleic acid diagnostics, in which avoiding contamination is very important.
special Importance of modern reproduction methods such as the polymerase chain reaction, which significantly lowers the detection limit becomes.
the risk of falsifying the measurement results increases due to the contamination mentioned above.
nucleic acid diagnostics may overall Reference is made to EP 0 676 643 A2, from which extensive have other versions removed.
the individual closures are here on the closure carrier a one-piece or multi-piece adhesive film held and can be together with the closure carrier all together sealing the reaction vessels put on, but also together or in groups together with the closure carrier be subtracted from these. If you remove the adhesive film, the respective individual closure remains sealed on the reaction vessel.
the individual closures are in the previously explained prior art as comprehensive lid executed, so that the respective closure section the edge of the open end of the reaction vessel is covered.
the Reaction vessels one from the connection level of the reaction vessels have a protruding edge at the top. So it is the arrangement with the reaction vessels in this prior art is not a typical one Microtiter plate, which is flat on the top.
the invention also relates to the individual parts of a Arrangement of the type in question, in particular the closure carrier and the individual locks.
the invention also relates to a supply and dispensing arrangement for individual closures, since it has been shown according to the invention that the Individual closures also individually, that is to say without the closure carrier, on the reaction vessels can be used like that of course from the is known prior art (EP 0 676 643 A 2, EP 0 734 769 A 1).
the teaching of the invention is particularly useful in connection use with an industrial robot system or for such an industrial robot system use.
microtiter plate shown in Fig. 1 for 96 reaction vessels for small and smallest amounts of sample liquid is an example of an arrangement interconnected reaction vessels, which is not restrictive understand is. Also strip-like arrangements of several with one another connected reaction vessels are the subject of the invention.
microtiter plate 1 shown in perspective in FIG. 1 as an arrangement of small, interconnected, upwardly open reaction vessels 2 is well suited, for example, to carry out PCR technology as has been explained extensively in the prior art (see, for example, EP 0 676 643 A2).
the capacity of a reaction vessel 2 is included this application example at about 200 to 400 ⁇ l. But that is not the case either to be understood restrictively.
Fig. 2 shows that in the arrangement according to the invention each reaction vessel 2 an individual closure 3 is assigned.
Fig. 4 shows such an individual closure 3 in a side view. It can be seen that the individual closure 3 a closure section 4 for sealingly closing the opening of the reaction vessel 2 and an actuating section 5 for engaging the individual lock 3 for the purpose of handling it.
closure carrier 6 can also only cover a group of reaction vessels 2 of the overall arrangement, so that the overall arrangement then has a plurality of closure supports 6.
the individual closures 3 fastened to the closure carrier 6, as shown in FIG. 2, are together with the closure carrier 6 on the reaction vessels 2, that is Microtiter plate 1, sealable, but also together with the closure carrier 6 of them removable.
closure sections 4 of the individual closures 3 can be inserted through the receptacles 7 in the closure carrier 6, so when inserting and removing from the closure carrier 6 not collide with the closure carrier 6.
actuating sections 5 are the individual closures 3 further attached to the closure carrier 6 that at on the reaction vessels 2 placed closure carrier 6 together with individual closures 3 each individual closure 3 individually from the closure carrier 6 and can be removed from the assigned reaction vessel 2.
the closure carrier 6 is an independent "lid carrier" which the individual closures 3 are so releasably attached that they also individually removed when the closure carrier 6 is in contact with the reaction vessels 2 can be. This allows the individual opening of each reaction vessel 2 in the case of other sealed reaction vessels 2. This has the handling technology explained in the general part of the description Advantages and in particular avoids any cross-contamination.
This slight translational relocation option allows an exact positioning of the closure sections 4 of all individual closures 3 in the respective reaction vessels 2. This applies in particular also when if you put on the closure carrier equipped with the individual closures 3 6 progressively closes the reaction vessels 2 in rows.
the slight permissible relative displacement between the closure carrier 6 and individual closure 3 facilitates this procedure in particular if you have a relatively rigid plastic material for the closure carrier 6 used.
the positive connection 8, 9 in detail, that this is designed like a bayonet, the Pin part 8 of the positive connection 8, 9 arranged on the individual lock 3 is, while the setting part 9 of the positive connection 8, 9, the recording 7 of the closure carrier 6 forms.
the scenery parts 9 As Edges of the receptacles 7 in the closure carrier 6 in Fig. 3.
a normal bayonet lock reaches its closed position through a Rotary movement in one direction and its opening position by one Rotation in the opposite direction.
a bayonet catch can also be used in the invention for the positive connection 8, 9 become.
the preferred embodiment shows a construction in which the bayonet lock can be operated in both directions is and does not have a stop, but has a detachable catch 8a.
the catch 8a can be seen on each pin part 8 in FIG. 5. With this construction the operator is free in which direction of rotation the bayonet lock wants to operate, it always reaches the other function position of the bayonet catch.
a quick screw connection comes as an alternative a quarter-circle screw connection, as a positive connection 8, 9 as well like a kind of snap lock.
Fig. 2 indicates and Fig. 5 shows more clearly that the individual closure 3 the individual closure 3, in particular and shown here on the actuating section 5, a locking handle 10 for attacking one of the handles of a single single lock 3 serving operating tool 11 has.
the operating tool 11 indicated as a pen-like hand tool. But one becomes for more extensive ones Handling often also moved and operated automatically Use actuating tools 11, such as that from the prior art Technology is known.
the closure handling means 10 is designed as a form-locking element, to which a corresponding Form-locking element 12 on the actuating tool 11 corresponds. More specifically, in the illustrated embodiment, the closure handling means 10 as a part, namely here as a backdrop part, of a bayonet catch executed. The positive locking element 12 on the operating tool 11 is than the other part, in particular the pin part of the bayonet catch executed.
the illustrated and preferred embodiment shows in particular in 4 and 5 that on the individual closure 3, the positive connection 8, 9th or frictional connection is arranged on the outside of the actuating section 5, while the closure handling means 10 of the single closure 3 inside is arranged.
the closure portion 4 of the individual closure 3 covers the reaction vessel 2.
the illustrated and preferred embodiment shows an embodiment that characterized in that the closure section 4 of the individual closure 3 enters the open end of the reaction vessel 2 in a plug-like manner.
This is also known per se from the prior art. That allows one particularly useful, also realized here in the embodiment Concept in such a way that the fastening sections 5 of the individual closures 3 consist of a relatively hard, rigid plastic material, the Closure sections 4 are integrally formed thereon and from one relatively soft, rubber-elastic plastic material. Fig. 4 shows this is indicated by the different gray levels of the two sections 4, 5.
closure section 4 An optimal sealing effect in the closure section 4 is achieved and at the same time simple, practical handling of the individual closures 3 guaranteed in connection with the closure carrier 6.
FIG. 5 shows both Execution of the closure section 4 from a relatively soft, rubber-elastic Plastic material, in particular of a thermoplastic elastomer, offers the appropriate possibility that a puncture in the Membrane section 4a of the closure section 4 closes again by itself, because the thermoplastic elastomer has a sufficient restoring force.
the individual closures 3 can also be used have different colors, for example for information to connect via the content of the respective reaction vessel 2. 2 interprets the latter with the different gray levels of the two there recognizable individual closures 3.
FIG. 3 shows the closure carrier 6 of an arrangement for itself
FIG. 2 shows the closure carrier 6 equipped with individual closures 3.
Such closure carriers are also marketable elements for themselves therefore subject to independent protection. The same applies to the Single locks 3.
FIG. 7 schematically shows an example of a storage and dispensing arrangement 14 for individual closures 3 of the type in question.
This is equipped with its own form-fitting training 15, which with the form-fitting training, namely the pin parts 8 on the actuating section 5 of the individual lock 3 interacts in such a way that the individual locks 3 in a precisely predetermined, specific lateral orientation from the Supply and dispensing arrangement 14 are dispensable. So you can target one Equipping either the closure carrier 6 with the individual closures 3 accomplish or even equip the reaction vessels 2 without closure carrier 6.
the arrangement according to the invention can be particularly convenient within of an industrial robot system with which the reaction sequences of the The type in question is tested in series and essentially automatically become.
the actuating tool 11 for example Be part of the industrial robot system, for example on an operating arm arranged
the industrial robot system also the reaction vessels 2 and the closure carrier 3 automatically handles, at least operable fixed.
the teaching also relates to the use of an arrangement in Type in question in an industrial robot system.

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Clinical Laboratory Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Closures For Containers (AREA)
Sampling And Sample Adjustment (AREA)
Investigating Or Analysing Biological Materials (AREA)
Automatic Analysis And Handling Materials Therefor (AREA)
Devices For Use In Laboratory Experiments (AREA)

EP01104986A 2000-03-09 2001-03-01 Fermeture individuelle et support de fermetures pour récipients de réaction, et dispositif de stockage et de distribution de telles fermetures Expired - Lifetime EP1132135B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10013240A DE10013240A1 (de)	2000-03-09	2000-03-09	Anordnung zu kontaminationsfreier Bearbeitung von insbesondere molekularbiologischen Reaktionsabläufen, Verschlußträger und Einzelverschluß für eine solche Anordnung sowie Vorrats-und Abgabeanordnung für Einzelverschlüsse
DE10013240		2000-03-09

Publications (3)

Publication Number	Publication Date
EP1132135A2 true EP1132135A2 (fr)	2001-09-12
EP1132135A3 EP1132135A3 (fr)	2003-06-25
EP1132135B1 EP1132135B1 (fr)	2005-08-03

Family

ID=7635258

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP01104986A Expired - Lifetime EP1132135B1 (fr)	2000-03-09	2001-03-01	Fermeture individuelle et support de fermetures pour récipients de réaction, et dispositif de stockage et de distribution de telles fermetures

Country Status (5)

Country	Link
US (1)	US20010036426A1 (fr)
EP (1)	EP1132135B1 (fr)
JP (1)	JP2001330537A (fr)
AT (1)	ATE301000T1 (fr)
DE (2)	DE10013240A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10142960A1 (de) *	2001-09-01	2003-04-03	Eppendorf Ag	Vorrichtung zur Erzeugung eines Vakuums in mehreren in einer Mikrotiterfilterplatte vorgesehenen Kavitäten sowie ein entsprechendes Verfahren
EP2098295A1 (fr)	2008-03-05	2009-09-09	Tsubakimoto Chain Co.	Capuchon pour microtube pour le développement pharmaceutique

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006001882A1 (de) *	2006-01-13	2007-07-19	Roche Diagnostics Gmbh	Zu einem Verbund zusammengefasste Gruppe von Reagenzienträgern
FR2942239B1 (fr) *	2009-02-18	2013-07-26	Oreal	Dispositif de culture cellulaire ou tissulaire et ensemble associe
CN113474083A (zh) *	2019-01-04	2021-10-01	仪器实验室公司	用于高刺穿计数应用的容器塞子

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US3107810A (en) *	1962-02-08	1963-10-22	Toronto Iron Works Ltd	Door locking mechanism for high pressure autoclaves
US3215304A (en) *	1963-06-21	1965-11-02	Walter Glass	Battery case
US3888045A (en) *	1974-05-30	1975-06-10	Wsf Ind Inc	Construction for mounting a door of a pit mounted pressure vessel
US4022352A (en) *	1976-04-26	1977-05-10	Pehr Harold T	Container cover and safety closure
US4599314A (en) *	1983-06-14	1986-07-08	Hsc Research Development Corporation	Multiple vessel specimen tray with lid for releasably adhering vessel covers
DE3402276C1 (de) *	1984-01-24	1985-02-21	Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg	Reaktionsgefaess aus Kunststoff fuer kleine Fluessigkeitsmengen
US5247015A (en) *	1988-12-22	1993-09-21	The West Company, Incorporated	Molded thermoplastic elastomer
US5112574A (en) *	1991-04-26	1992-05-12	Imanigation, Ltd.	Multititer stopper array for multititer plate or tray
CA2130517C (fr) *	1993-09-10	1999-10-05	Walter Fassbind	Reseau de microplateaux pour appareil de production automatique de cycles de temperatures
DE4412286A1 (de) *	1994-04-09	1995-10-12	Boehringer Mannheim Gmbh	System zur kontaminationsfreien Bearbeitung von Reaktionsabläufen
US5683659A (en) *	1995-02-22	1997-11-04	Hovatter; Kenneth R.	Integral assembly of microcentrifuge strip tubes and strip caps
EP0734769B1 (fr) *	1995-03-31	2002-11-27	Roche Diagnostics GmbH	Système et procédé pour la fermeture de récipients
DE19511841B4 (de) *	1995-03-31	2005-09-08	Roland Stecher	Verpackungsbehälter
US5603899A (en) *	1995-04-12	1997-02-18	Pharmacia Biotech, Inc.	Multiple column chromatography assembly
US6074614A (en) *	1995-06-07	2000-06-13	Molecular Devices Corporation	Multi-assay plate cover for elimination of meniscus
US5538134A (en) *	1995-07-25	1996-07-23	Pitesky; Isadore	Disposable allergen container and pick apparatus
US6193088B1 (en) *	1996-02-26	2001-02-27	Monty E. Vincent	Flask vent and method of making same
US5632399A (en) *	1996-06-28	1997-05-27	Dpc Cirrus Inc.	Self-sealing reagent container and reagent container system
SE9702005D0 (sv) *	1997-05-28	1997-05-28	Alphahelix Ab	New reaction vessel and method for its use
US6251343B1 (en) *	1998-02-24	2001-06-26	Caliper Technologies Corp.	Microfluidic devices and systems incorporating cover layers
GB9804383D0 (en) *	1998-03-03	1998-04-22	Chromacol Ltd	Closures
US6106783A (en) *	1998-06-30	2000-08-22	Microliter Analytical Supplies, Inc.	Microplate assembly and closure
FR2780903B1 (fr) *	1998-07-13	2000-09-29	Central Labo Europ	Plaque destinee notamment au microtitrage, presentant une pluralite de godets pour recevoir des echantillons d'un liquide biologique

2000
- 2000-03-09 DE DE10013240A patent/DE10013240A1/de not_active Withdrawn
2001
- 2001-03-01 EP EP01104986A patent/EP1132135B1/fr not_active Expired - Lifetime
- 2001-03-01 DE DE50106928T patent/DE50106928D1/de not_active Expired - Lifetime
- 2001-03-01 AT AT01104986T patent/ATE301000T1/de not_active IP Right Cessation
- 2001-03-09 US US09/801,930 patent/US20010036426A1/en not_active Abandoned
- 2001-03-09 JP JP2001065881A patent/JP2001330537A/ja active Pending

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10142960A1 (de) *	2001-09-01	2003-04-03	Eppendorf Ag	Vorrichtung zur Erzeugung eines Vakuums in mehreren in einer Mikrotiterfilterplatte vorgesehenen Kavitäten sowie ein entsprechendes Verfahren
DE10142960C2 (de) *	2001-09-01	2003-12-04	Eppendorf Ag	Verwendung einer Platte aus elastisch verformbaren Kunststoff oder Gummi zur Abdeckung einer zum Teil befüllten Mikrofiltrationsplatte während der Filtration
US6666978B2 (en)	2001-09-01	2003-12-23	Eppendorf Ag	Apparatus producing a vacuum in several cavities of a microtitration filter plate, and corresponding method
EP2098295A1 (fr)	2008-03-05	2009-09-09	Tsubakimoto Chain Co.	Capuchon pour microtube pour le développement pharmaceutique
US8206665B2 (en)	2008-03-05	2012-06-26	Tsubakimoto Chain Co.	Cap for microtube for pharmaceutical development

Also Published As

Publication number	Publication date
DE10013240A1 (de)	2001-10-11
EP1132135B1 (fr)	2005-08-03
JP2001330537A (ja)	2001-11-30
EP1132135A3 (fr)	2003-06-25
US20010036426A1 (en)	2001-11-01
DE50106928D1 (de)	2005-09-08
ATE301000T1 (de)	2005-08-15

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Publication	Publication Date	Title
EP2030684B1 (fr)	2019-04-10	Dispositif de préparation de substances pouvant être pipetées
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DE69831830T2 (de)	2006-06-22	Einweg-Analysevorrichtung
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EP3120929B1 (fr)	2018-11-07	Soupape d'admission pour systemes de chambres et recipients a echantillons ainsi que systemes de chambres dotes de recipients a echantillons dotes de telles soupapes d'admission
DE60012817T2 (de)	2005-08-18	Verbesserte Titrationsplatten
EP3083053B1 (fr)	2019-12-18	Dispositif de recouvrement, en particulier couvercle servant à couvrir des récipients réactionnels
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DE10308362A1 (de)	2004-09-09	System zum automatischen Öffnen von Reagenzgefäßen
EP3025780B1 (fr)	2018-06-06	Plateau d'incubation
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DE69902235T2 (de)	2002-11-14	Verschlusskappen-array mit blindbohrungen
EP1132135B1 (fr)	2005-08-03	Fermeture individuelle et support de fermetures pour récipients de réaction, et dispositif de stockage et de distribution de telles fermetures
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DE102020134318A1 (de)	2021-06-24	Handhabung von Laborelementen
EP0896662B1 (fr)	2000-10-18	Barre a cuvettes