EP1139972A4 - Dihydropyrimidines et leurs utilisations - Google Patents

Dihydropyrimidines et leurs utilisations

Info

Publication number
EP1139972A4
EP1139972A4 EP99967609A EP99967609A EP1139972A4 EP 1139972 A4 EP1139972 A4 EP 1139972A4 EP 99967609 A EP99967609 A EP 99967609A EP 99967609 A EP99967609 A EP 99967609A EP 1139972 A4 EP1139972 A4 EP 1139972A4
Authority
EP
European Patent Office
Prior art keywords
dihydropyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99967609A
Other languages
German (de)
English (en)
Other versions
EP1139972A1 (fr
Inventor
Donghui Cui
Margaret R Davis
Hanumath P Kari
Kamlesh P Vyas
Kanyin Zhang
Benjamin Evans
Michael Dunn
Dhanapalan Nagarathnam
Bharat Lagu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lundbeck Research USA Inc
Merck and Co Inc
Original Assignee
Synaptic Pharmaceutical Corp
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synaptic Pharmaceutical Corp, Merck and Co Inc filed Critical Synaptic Pharmaceutical Corp
Publication of EP1139972A1 publication Critical patent/EP1139972A1/fr
Publication of EP1139972A4 publication Critical patent/EP1139972A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99967609A 1998-12-23 1999-12-23 Dihydropyrimidines et leurs utilisations Withdrawn EP1139972A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22166898A 1998-12-23 1998-12-23
US11361298P 1998-12-23 1998-12-23
US113612P 1998-12-23
US221668 1998-12-23
PCT/US1999/030868 WO2000037026A1 (fr) 1998-12-23 1999-12-23 Dihydropyrimidines et leurs utilisations

Publications (2)

Publication Number Publication Date
EP1139972A1 EP1139972A1 (fr) 2001-10-10
EP1139972A4 true EP1139972A4 (fr) 2002-03-27

Family

ID=26811252

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99967609A Withdrawn EP1139972A4 (fr) 1998-12-23 1999-12-23 Dihydropyrimidines et leurs utilisations

Country Status (5)

Country Link
EP (1) EP1139972A4 (fr)
JP (1) JP2002532525A (fr)
AU (1) AU2386800A (fr)
CA (1) CA2355848A1 (fr)
WO (1) WO2000037026A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007124A2 (fr) 2003-07-23 2005-01-27 Bristol-Myers Squibb Company Inhibiteurs dihydropyrimidine substituee de la fonction canaux calciques
US7166603B2 (en) 2003-07-23 2007-01-23 Bristol-Myers Squibb Co. Dihydropyrimidone inhibitors of calcium channel function
WO2025141607A1 (fr) * 2023-12-26 2025-07-03 Heterochem Innotech Private Limited Nouveaux composés phtalimide pour la régénération tissulaire/cellulaire et compositions les contenant

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014846A1 (fr) * 1994-11-16 1996-05-23 Synaptic Pharmaceutical Corporation Dihydropyrimidines et leurs utilisations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245773B1 (en) * 1996-05-16 2001-06-12 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
WO1997042956A1 (fr) * 1996-05-16 1997-11-20 Synaptic Pharmaceutical Corporation Dihydropyrimidines et leurs emplois
EP1003734A2 (fr) * 1997-08-05 2000-05-31 Merck & Co., Inc. ANTAGONISTE DE RECEPTEUR ADRENERGIQUE ALPHA 1a
WO1999048530A1 (fr) * 1998-03-23 1999-09-30 Merck & Co., Inc. Therapie combinee pour le traitement de l'hyperplasie prostatique benigne

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014846A1 (fr) * 1994-11-16 1996-05-23 Synaptic Pharmaceutical Corporation Dihydropyrimidines et leurs utilisations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Medicinal Chemistry", 1979, WILEY *
See also references of WO0037026A1 *

Also Published As

Publication number Publication date
JP2002532525A (ja) 2002-10-02
CA2355848A1 (fr) 2000-06-29
WO2000037026A1 (fr) 2000-06-29
AU2386800A (en) 2000-07-12
EP1139972A1 (fr) 2001-10-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20010723

AK Designated contracting states

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Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: NAGARATHNAM, DHANAPALAN

Inventor name: DUNN, MICHAEL

Inventor name: EVANS, BENJAMIN

Inventor name: ZHANG, KANYIN

Inventor name: VYAS, KAMLESH, P.

Inventor name: KARI, HANUMATH, P.

Inventor name: DAVIS, MARGARET, R.

Inventor name: CUI, DONGHUI

A4 Supplementary search report drawn up and despatched

Effective date: 20020211

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Effective date: 20021223

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18D Application deemed to be withdrawn

Effective date: 20050216