EP1140897A4 - Protease inhibitoren - Google Patents

Protease inhibitoren

Info

Publication number: EP1140897A4
Authority: EP; European Patent Office
Prior art keywords: protease inhibitors; protease; inhibitors
Prior art date: 1998-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99968936A

Other languages

English (en)

French (fr)

Other versions

EP1140897A1 (de

Inventor

Robert Wells Marquis Jr

Daniel Frank Veber

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-23

Filing date

1999-12-21

Publication date

2002-04-03

1999-12-21 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

2001-10-10 Publication of EP1140897A1 publication Critical patent/EP1140897A1/de

2002-04-03 Publication of EP1140897A4 publication Critical patent/EP1140897A4/de

Status Withdrawn legal-status Critical Current

Links

229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP99968936A 1998-12-23 1999-12-21 Protease inhibitoren Withdrawn EP1140897A4 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11414398P	1998-12-23	1998-12-23
US114143P		1998-12-23
PCT/US1999/030602 WO2000039115A1 (en)	1998-12-23	1999-12-21	Protease inhibitors

Publications (2)

Publication Number	Publication Date
EP1140897A1 EP1140897A1 (de)	2001-10-10
EP1140897A4 true EP1140897A4 (de)	2002-04-03

Family

ID=22353596

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99968936A Withdrawn EP1140897A4 (de)	1998-12-23	1999-12-21	Protease inhibitoren

Country Status (9)

Country	Link
EP (1)	EP1140897A4 (de)
JP (1)	JP2002533452A (de)
AR (1)	AR021970A1 (de)
AU (1)	AU2713100A (de)
CO (1)	CO5180541A1 (de)
DZ (1)	DZ2976A1 (de)
HK (1)	HK1041690A1 (de)
PE (1)	PE20001355A1 (de)
WO (1)	WO2000039115A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030144175A1 (en)	1998-12-23	2003-07-31	Smithkline Beecham Corporation	Protease inhibitors
US6583137B1 (en)	1999-11-10	2003-06-24	Smithkline Beecham Corporation	Protease inhibitors
US6596715B1 (en)	1999-11-10	2003-07-22	Smithkline Beecham Corporation	Protease inhibitors
EP1229914A4 (de)	1999-11-10	2004-06-23	Smithkline Beecham Corp	Proteasehemmer
AU4344101A (en)	2000-03-21	2001-10-03	Smithkline Beecham Corp	Protease inhibitors
US6982263B2 (en)	2001-06-08	2006-01-03	Boehringer Ingelheim Pharmaceuticals, Inc.	Nitriles useful as reversible inhibitors of cysteine proteases
WO2003075853A2 (en)	2002-03-08	2003-09-18	Bristol-Myers Squibb Company	Cyclic derivatives as modulators of chemokine receptor activity
EP1796793A4 (de) *	2004-09-07	2009-08-05	Smithkline Beecham Corp	Neue verbindungen
JP5236293B2 (ja) *	2005-01-13	2013-07-17	ブリストル−マイヤーズスクイブカンパニー	Ｘｉａ因子阻害剤としての置換ビアリール化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998005336A1 (en) *	1996-08-08	1998-02-12	Smithkline Beecham Corporation	Inhibitors of cysteine protease
WO1998050534A1 (en) *	1997-05-08	1998-11-12	Smithkline Beecham Corporation	Protease inhibitors

1999
- 1999-12-16 CO CO99078651A patent/CO5180541A1/es not_active Application Discontinuation
- 1999-12-21 AR ARP990106647A patent/AR021970A1/es unknown
- 1999-12-21 AU AU27131/00A patent/AU2713100A/en not_active Abandoned
- 1999-12-21 EP EP99968936A patent/EP1140897A4/de not_active Withdrawn
- 1999-12-21 HK HK02101209.3A patent/HK1041690A1/zh unknown
- 1999-12-21 WO PCT/US1999/030602 patent/WO2000039115A1/en not_active Ceased
- 1999-12-21 JP JP2000591026A patent/JP2002533452A/ja not_active Withdrawn
- 1999-12-22 DZ DZ990276A patent/DZ2976A1/xx active
- 1999-12-23 PE PE1999001311A patent/PE20001355A1/es not_active Application Discontinuation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998005336A1 (en) *	1996-08-08	1998-02-12	Smithkline Beecham Corporation	Inhibitors of cysteine protease
WO1998050534A1 (en) *	1997-05-08	1998-11-12	Smithkline Beecham Corporation	Protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0039115A1 *

Also Published As

Publication number	Publication date
HK1041690A1 (zh)	2002-07-19
EP1140897A1 (de)	2001-10-10
PE20001355A1 (es)	2001-01-28
AU2713100A (en)	2000-07-31
WO2000039115A1 (en)	2000-07-06
JP2002533452A (ja)	2002-10-08
AR021970A1 (es)	2002-09-04
DZ2976A1 (fr)	2004-03-15
CO5180541A1 (es)	2002-07-30

Legal Events

Date	Code	Title	Description
2001-08-24	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-10-10	17P	Request for examination filed	Effective date: 20010710
2001-10-10	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-10-10	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2002-04-03	A4	Supplementary search report drawn up and despatched	Effective date: 20020219
2002-04-03	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-04-03	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 07D 401/02 A, 7C 07D 401/14 B, 7C 07D 225/02 B, 7A 61K 31/33 B, 7A 61K 31/44 B, 7A 61K 31/47 B, 7A 61P 19/02 B, 7A 61P 19/10 B, 7C 07D 405/14 B, 7C 07D 401/12 B, 7A 61K 31/395 B
2002-08-28	17Q	First examination report despatched	Effective date: 20020716
2003-04-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2003-06-11	18D	Application deemed to be withdrawn	Effective date: 20021127
2008-08-01	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1041690 Country of ref document: HK

Publication	Publication Date	Title
PL349192A1 (en)	2002-07-01	Protease inhibitors
IL131661A0 (en)	2001-01-28	Protease inhibitors
PL336589A1 (en)	2000-07-03	Serinic protease inhibitors
IL132630A0 (en)	2001-03-19	Protease inhibitors
EP1093367A4 (de)	2003-03-05	Proteaseinhibitoren
IL132629A0 (en)	2001-03-19	Protease inhibitors
IL132088A0 (en)	2001-03-19	Protease inhibitors
ZA988479B (en)	1998-10-26	Protease inhibitors
EP1067894A4 (de)	2004-09-08	Protheaseinhibitoren
IL139187A0 (en)	2001-11-25	Cysteine protease inhibitors
EP1079821A4 (de)	2001-08-29	Protease inhibitoren
EP1235577A4 (de)	2003-04-09	Proteaseinhibitoren
AU1393900A (en)	2000-06-05	Morpholino-ethoxybenzofuran protease inhibitors
GB9800817D0 (en)	1998-03-11	Serine protease inhibitors
EP1232155A4 (de)	2002-11-20	Protease inhibitoren
EP1086083A4 (de)	2001-09-26	Proteaseinhibitoren
ZA988064B (en)	1999-05-28	Protease inhibitors
EP1229912A4 (de)	2003-05-07	Proteaseinhibitoren
EP1231921A4 (de)	2004-06-23	Proteaseinhibitoren
EP1229915A4 (de)	2003-05-14	Proteasehemmer
EP1229914A4 (de)	2004-06-23	Proteasehemmer
AU2713100A (en)	2000-07-31	Protease inhibitors
EP1161237A4 (de)	2002-03-27	Protease-inhibitoren
EP1233771A4 (de)	2003-05-14	Proteasehemmer
EP1229911A4 (de)	2003-05-07	Proteaseinhibitoren