EP1140975A4 - Subtiline stable et ses procedes de preparation - Google Patents

Subtiline stable et ses procedes de preparation

Info

Publication number
EP1140975A4
EP1140975A4 EP99967636A EP99967636A EP1140975A4 EP 1140975 A4 EP1140975 A4 EP 1140975A4 EP 99967636 A EP99967636 A EP 99967636A EP 99967636 A EP99967636 A EP 99967636A EP 1140975 A4 EP1140975 A4 EP 1140975A4
Authority
EP
European Patent Office
Prior art keywords
subtilin
manufacture
stable
methods
stable subtilin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99967636A
Other languages
German (de)
English (en)
Other versions
EP1140975A1 (fr
Inventor
Norman J Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Maryland Baltimore
University of Maryland College Park
Original Assignee
University of Maryland Baltimore
University of Maryland College Park
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Maryland Baltimore, University of Maryland College Park filed Critical University of Maryland Baltimore
Publication of EP1140975A1 publication Critical patent/EP1140975A1/fr
Publication of EP1140975A4 publication Critical patent/EP1140975A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/7295—Antibiotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP99967636A 1998-12-24 1999-12-23 Subtiline stable et ses procedes de preparation Withdrawn EP1140975A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11384398P 1998-12-24 1998-12-24
US113843P 1998-12-24
PCT/US1999/030938 WO2000039152A1 (fr) 1998-12-24 1999-12-23 Subtiline stable et ses procedes de preparation

Publications (2)

Publication Number Publication Date
EP1140975A1 EP1140975A1 (fr) 2001-10-10
EP1140975A4 true EP1140975A4 (fr) 2003-01-08

Family

ID=22351844

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99967636A Withdrawn EP1140975A4 (fr) 1998-12-24 1999-12-23 Subtiline stable et ses procedes de preparation

Country Status (4)

Country Link
EP (1) EP1140975A4 (fr)
AU (1) AU2388800A (fr)
CA (1) CA2356955A1 (fr)
WO (1) WO2000039152A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8484798A (en) 1997-07-18 1999-02-10 University Of Maryland Sublancin lantibiotic produced by (bacillus subtilis) 168
US6953683B2 (en) 1997-07-18 2005-10-11 University Of Maryland Compositions and methods of inhibiting bacterial spore germination
US6846804B2 (en) 2000-06-29 2005-01-25 University Of Maryland, College Park Office Of Technology Commercialization Construction of a structural variant of sublancin to facilitate its isolation and use in bioremediation of environmental contamination by gram-positive spore formers such as bacillus anthrasis
US6759205B2 (en) 2000-06-29 2004-07-06 University Of Maryland Construction of a strain of Bacillus subtilis 168 that displays the sublancin lantibiotic on the surface of the cell
US7033766B2 (en) 2000-06-29 2006-04-25 University Of Maryland Office Of Technology Commercialization Construction and screening of lantibody display libraries
CN101776665B (zh) * 2009-01-13 2013-09-11 上海医药工业研究院 一种乳酸链球菌素的hplc检测方法
WO2020185562A1 (fr) * 2019-03-08 2020-09-17 Fraunhofer Usa, Inc. Nouveau peptide lantibiotique antimicrobien et utilisations associées

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011713A1 (fr) * 1995-09-28 1997-04-03 The University Of Maryland College Park Mutants lantibiotiques et chimeres a stabilite et activite renforcees

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516682A (en) * 1988-07-05 1996-05-14 University Of Maryland Subtilin variant of enhanced stability and activity
US5218101A (en) * 1988-07-05 1993-06-08 The University Of Maryland Leader sequence inducing a post-translational modification of polypeptides in bacteria, and gene therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011713A1 (fr) * 1995-09-28 1997-04-03 The University Of Maryland College Park Mutants lantibiotiques et chimeres a stabilite et activite renforcees

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAKICHERLA A ET AL: "ROLE OF THE LEADER AND STRUCTURAL REGIONS OF PRELANTIBIOTIC PEPTIDES AS ASSESSED BY EXPRESSING NISIN-SUBTILIN CHIMERAS IN BACILLUS SUBTILIS 168, AND CHARACTERIZATION OF THEIR PHYSICAL, CHEMICAL, AND ANTIMICROBIAL PROPERTIES*", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 270, no. 40, October 1995 (1995-10-01), pages 23533 - 23539, XP002912807, ISSN: 0021-9258 *
PANTOLIANO M W ET AL: "PROTEIN ENGINEERING OF SUBTILISIN BPN' ENHANCED STABILIZATION THROUGH THE INTRODUCTION OF TWO CYSTEINES TO FORM A DISULFIDE BOND", BIOCHEMISTRY, vol. 26, no. 8, 1987, pages 2077 - 2082, XP002219538, ISSN: 0006-2960 *
See also references of WO0039152A1 *

Also Published As

Publication number Publication date
CA2356955A1 (fr) 2000-07-06
WO2000039152A1 (fr) 2000-07-06
AU2388800A (en) 2000-07-31
EP1140975A1 (fr) 2001-10-10

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