EP1143795A2 - Solutions aqueuses hypertoniques de sels d'acides polybasiques - Google Patents

Solutions aqueuses hypertoniques de sels d'acides polybasiques

Info

Publication number
EP1143795A2
EP1143795A2 EP00908294A EP00908294A EP1143795A2 EP 1143795 A2 EP1143795 A2 EP 1143795A2 EP 00908294 A EP00908294 A EP 00908294A EP 00908294 A EP00908294 A EP 00908294A EP 1143795 A2 EP1143795 A2 EP 1143795A2
Authority
EP
European Patent Office
Prior art keywords
aqueous solution
acid
polybasic acid
solution
polybasic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00908294A
Other languages
German (de)
English (en)
Inventor
Shalaby W. Shalaby
Charles L. Linden, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SteriFx Inc
Original Assignee
Stericon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stericon LLC filed Critical Stericon LLC
Publication of EP1143795A2 publication Critical patent/EP1143795A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/26—Phosphorus; Compounds thereof

Definitions

  • the present invention relates to novel simple salt solutions of one or two polybasic acids with at least three acid functionalities having a pH between about 1 and
  • novel solutions of the present invention are useful for a number of applications, including, but not limited to, use as a cold sterilant, disinfectant and antiviral agent.
  • the present invention overcomes the limitations of existing formulations and provides for simpler solutions with a broader pH range useful in a number of tailored applications. Such solutions are more effective than conventional solutions, at least in part, as a result of controlled use of their hypertonicity.
  • the present invention is directed to simple salt solutions containing one or two polybasic acids with at least three acid functionalities.
  • the solutions of the invention have a pH between about 1.0 and 3.0 and an ionic strength exceeding 5 ⁇ . These solutions are useful for a number of applications, including, but not limited to, use as a cold sterilant, disinfectant, or antiviral agent.
  • one embodiment of the invention is directed to a hypertonic aqueous solution containing one or two polybasic acids and a base.
  • the acids each have at least three acid functionalities per molecule.
  • the base is added in an amount sufficient to at least partially neutralize the solution to achieve a pH of between about 1 to about 3 and an ionic strength of at least 5 ⁇ .
  • Another embodiment is directed to a method for inhibiting viability of biological organisms, such as bacteria, virus or fungus, on a surface comprising contacting the surface with an aqueous solution according to the invention for a period of time effective to sterilize, disinfect or otherwise inhibit the viability of the biological organisms on the surface.
  • biological organisms such as bacteria, virus or fungus
  • the present invention is directed to hypertonic aqueous solutions of polycarboxylic acid salts, and more specifically, to hypertonic aqueous solutions of one or two polybasic acids with three or more acid functionalities per molecule that are partially neutralized with an inorganic or organic base to achieve a pH between about 1 to about 3 and an ionic strength of more than 5 ⁇ .
  • the one or two polybasic acids may be selected from the group consisting of phosphoric acid, citric acid, isocitric acid, polyacrylic acid, an N-succinylated chitosan, hyaluronic acid, alginic acid, and carboxymethyl cellulose.
  • the solution of one or two polybasic acids and a base is a mixture of citric acid or phosphoric acid, partially neutralized with an inorganic base.
  • a preferred composition uses only citric acid and a base, such as zinc oxide.
  • Another preferred solution is a mixture of phosphoric acid and a base, such as zinc oxide. The latter is particularly useful as a cold sterilant.
  • the solution comprises a cationic component of the salt.
  • the cationic component is preferably a monovalent cation such as Na * and K + or a divalent cation such as Mg' 2 and Zn +2 , or mixtures of them.
  • the cationic component is comprised of both Na ⁇ * and Zn 2 .
  • the solution may comprise citrate anions and Zn 12 .
  • the solution comprises 30 percent citric acid by weight/volume that is partially neutralized with zinc oxide. This embodiment is also particularly useful as a cold sterilant.
  • the solutions of the present invention may be used in a number of applications, including, but not limited to, as a cold sterilant, a disinfectant, and an antiviral agent.
  • Suture Loop Carrier Standard loops were prepared by wrapping size 3-0 surgical silk suture (black braided A184. USP. Ethicon, Inc.) around a pencil three times. This loop was then tied and knotted with another piece of suture before slipping off the end of the pencil. The ends of the sutures were cut to within 2mm, and prepared loops were then placed in 300 ml chloroform and incubated at room temperature for 24 hours while rotating at 100 rpm. The loops were then air-dried at room temperature under a hood. After drying, the suture loops were added to 100 ml of 0.5N HC1 and incubated for 10 minutes. After 10 minutes, loops were washed three times with distilled water (15 min. per wash) until the pH was neutral. Loops were finally dried on filter paper at room temperature for 24 hours and then sterilized by autoclave (20 min. 121 °C, 15 psi).
  • NVVR sterile 50 cc centrifuge tubes
  • Suture loops were incubated for 15 minutes at room temperature and then removed with sterile forceps to a Petri dish lined with 2 layers of Whatman #43 filter paper. All suture loops contaminated with B. subtilis were placed in a vacuum oven at room temperature containing calcium chloride for 20 minutes, then dried under vacuum for an additional 24 hours. These loops were used within 24 hours of preparation.
  • Verification of Spore Niability 10 ml of2.5 ⁇ HCl was added to four separate sterile glass vials and five contaminated suture loops were added to each vial. After 2, 5, 10, or 20 minutes, five suture loops were transferred to thioglycolate subculture broth for 20 seconds. Each suture loop was subsequently transferred to 10 ml of fresh sterile thioglycolate broth and incubated at 37°C. Incubation was continued for a total of 21 days.
  • PC-1 The following solutions, referred to as PC-1 , PC-2, and PC-3, were prepared and tested for their ability to act as an aqueous sporicidal agent.
  • the control hydrochloric acid solutions were prepared by diluting commercial 1 ON hydrochloric acid solution with deionized water.
  • the sterilant solutions PC- 1 , PC-2, and PC-3 were prepared as follows: ( 1 ) to prepare sterilant solution PC- 1 , solid citric acid was dissolved in deionized water at about 10% weight/volume, to produce a sterilant solution having a pH of 1.2; (2) to prepare sterilant solution PC-2, approximately 30% weight/volume solution of citric acid was first prepared by dissolving solid citric acid in deionized water, and then dissolving solid sodium hydrogen phosphate in the acid solution in small aliquots until a pH of 1.2 was achieved; and (3) to prepare sterilant solution PC-3, solid citric acid was dissolved in deionized water at 30% level weight/volume, and then small aliquots of zinc oxide were dissolved in the acid solution until a pH of 1.2 was achieved.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des solutions salines simples contenant un ou deux acides polybasiques comportant au moins trois fonctionnalités acide, et présentant un pH compris entre environ 1,0 et 3,0 ainsi qu'une force ionique supérieure à 5ν. Les solutions de la présente invention peuvent être utilisées dans de nombreuses applications, notamment, mais pas seulement, en tant que stérilisant à froid, désinfectant et agent antiviral.
EP00908294A 1999-01-19 2000-01-19 Solutions aqueuses hypertoniques de sels d'acides polybasiques Withdrawn EP1143795A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11632299P 1999-01-19 1999-01-19
US116322P 1999-01-19
PCT/US2000/001106 WO2000043047A2 (fr) 1999-01-19 2000-01-19 Solutions aqueuses hypertoniques de sels d'acides polybasiques

Publications (1)

Publication Number Publication Date
EP1143795A2 true EP1143795A2 (fr) 2001-10-17

Family

ID=22366502

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00908294A Withdrawn EP1143795A2 (fr) 1999-01-19 2000-01-19 Solutions aqueuses hypertoniques de sels d'acides polybasiques

Country Status (4)

Country Link
EP (1) EP1143795A2 (fr)
AU (1) AU2967100A (fr)
CA (1) CA2359292A1 (fr)
WO (1) WO2000043047A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002303210A1 (en) * 2001-04-06 2002-10-21 Cytorex Biosciences, Inc. Pharmacologically active strong acid solutions
MX2007006860A (es) * 2004-12-09 2008-02-15 Dial Corp Composiciones que tienen alta eficacia antiviral y antibacterial.
CN101384171A (zh) * 2004-12-09 2009-03-11 日晷公司 具有高抗病毒和抗菌效力的组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903259A (en) * 1971-01-07 1975-09-02 Una L Hart Method of deodorizing diapers and human excreta
ES8504625A2 (es) * 1972-07-19 1985-05-16 Fisons Iberica S A Mejoras introducidas en el objeto de la patente principal, para: procedimiento para la obtencion de una solucion hipertonica tamponada
JPS6293203A (ja) * 1985-10-21 1987-04-28 Agency Of Ind Science & Technol 多塩基酸アミン塩型殺菌剤
US4784991A (en) * 1986-03-14 1988-11-15 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
DE4200066C2 (de) * 1991-03-27 1994-09-15 Fresenius Ag Verwendung eines wäßrigen zitronensäurehaltigen Desinfektionsmittels zur Inaktivierung von Hepatitis-B-Viren
GB9605247D0 (en) * 1996-03-13 1996-05-15 Giltech Ltd Composition
HU225329B1 (en) * 1996-09-12 2006-09-28 Richter Gedeon Vegyeszet Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity
US6020375A (en) * 1997-06-13 2000-02-01 Senju Pharmaceutical Co., Ltd. Bactericidal composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0043047A3 *

Also Published As

Publication number Publication date
AU2967100A (en) 2000-08-07
WO2000043047A2 (fr) 2000-07-27
WO2000043047A3 (fr) 2000-11-30
CA2359292A1 (fr) 2000-07-27

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