EP1157110A4 - Neutrokin-alpha und Neutrokin-alpha Spleissvarianten - Google Patents

Neutrokin-alpha und Neutrokin-alpha Spleissvarianten

Info

Publication number: EP1157110A4
Authority: EP; European Patent Office
Prior art keywords: neutrokine; alpha; splice variant; variant; alpha splice
Prior art date: 1999-02-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP00908739A

Other languages

English (en)

French (fr)

Other versions

EP1157110A1 (de

Inventor

Craig A Rosen

Jian Ni

Reinhard Ebner

Guo-Liang Yu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Human Genome Sciences Inc

Original Assignee

Human Genome Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-23

Filing date

2000-02-22

Publication date

2006-05-10

1999-02-23 Priority claimed from US09/255,794 external-priority patent/US6716576B1/en

2000-02-22 Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc

2000-02-22 Priority to EP07012741A priority Critical patent/EP1860190A3/de

2001-11-28 Publication of EP1157110A1 publication Critical patent/EP1157110A1/de

2006-05-10 Publication of EP1157110A4 publication Critical patent/EP1157110A4/de

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Communicable Diseases (AREA)
Cell Biology (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP00908739A 1999-02-23 2000-02-22 Neutrokin-alpha und Neutrokin-alpha Spleissvarianten Withdrawn EP1157110A4 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP07012741A EP1860190A3 (de)	1999-02-23	2000-02-22	Neutrokin-alpha und Neutrokin-alpha-Fugenvarianten

Applications Claiming Priority (35)

Application Number	Priority Date	Filing Date	Title
US255794		1988-10-11
US09/255,794 US6716576B1 (en)	1996-10-25	1999-02-23	Method of assaying Neutrokine-α mRNA level
US12238899P	1999-03-02	1999-03-02
US122388P		1999-03-02
US12409799P	1999-03-12	1999-03-12
US124097P		1999-03-12
US12659999P	1999-03-26	1999-03-26
US126599P		1999-03-26
US12759899P	1999-04-02	1999-04-02
US127598P		1999-04-02
US13041299P	1999-04-16	1999-04-16
US130412P		1999-04-16
US13069699P	1999-04-23	1999-04-23
US130696P		1999-04-23
US13127899P	1999-04-27	1999-04-27
US131278P		1999-04-27
US13167399P	1999-04-29	1999-04-29
US131673P		1999-04-29
US13678499P	1999-05-28	1999-05-28
US136784P		1999-05-28
US14265999P	1999-07-06	1999-07-06
US142659P		1999-07-06
US14582499P	1999-07-27	1999-07-27
US145824P		1999-07-27
US16723999P	1999-11-24	1999-11-24
US167239P		1999-11-24
US16862499P	1999-12-03	1999-12-03
US168624P		1999-12-03
US17110899P	1999-12-16	1999-12-16
US171108P		1999-12-16
US17162699P	1999-12-23	1999-12-23
US171626P		1999-12-23
US17601500P	2000-01-14	2000-01-14
US176015P		2000-01-14
PCT/US2000/004336 WO2000050597A2 (en)	1999-02-23	2000-02-22	Neutrokine-alpha and neutrokine-alpha splice variant

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
EP07012741A Division EP1860190A3 (de)	1999-02-23	2000-02-22	Neutrokin-alpha und Neutrokin-alpha-Fugenvarianten

Publications (2)

Publication Number	Publication Date
EP1157110A1 EP1157110A1 (de)	2001-11-28
EP1157110A4 true EP1157110A4 (de)	2006-05-10

Family

ID=27586018

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP07012741A Withdrawn EP1860190A3 (de)	1999-02-23	2000-02-22	Neutrokin-alpha und Neutrokin-alpha-Fugenvarianten
EP00908739A Withdrawn EP1157110A4 (de)	1999-02-23	2000-02-22	Neutrokin-alpha und Neutrokin-alpha Spleissvarianten

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
EP07012741A Withdrawn EP1860190A3 (de)	1999-02-23	2000-02-22	Neutrokin-alpha und Neutrokin-alpha-Fugenvarianten

Country Status (6)

Country	Link
EP (2)	EP1860190A3 (de)
JP (2)	JP2003526330A (de)
AU (2)	AU777536B2 (de)
CA (1)	CA2363112A1 (de)
NZ (2)	NZ513290A (de)
WO (1)	WO2000050597A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7217788B2 (en)	1996-03-14	2007-05-15	Human Genome Sciences, Inc.	Human tumor necrosis factor delta polypeptides
US6541224B2 (en)	1996-03-14	2003-04-01	Human Genome Sciences, Inc.	Tumor necrosis factor delta polypeptides
US8212004B2 (en)	1999-03-02	2012-07-03	Human Genome Sciences, Inc.	Neutrokine-alpha fusion proteins
US6812327B1 (en)	1996-10-25	2004-11-02	Human Genome Sciences, Inc.	Neutrokine-alpha polypeptides
US6689579B1 (en)	1996-10-25	2004-02-10	Human Genome Sciences, Inc.	Polynucleotides encoding neutrokine-α
US7833529B1 (en)	1999-01-07	2010-11-16	Zymogenetics, Inc.	Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
US20030095967A1 (en)	1999-01-25	2003-05-22	Mackay Fabienne	BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
BR0007719A (pt)	1999-01-25	2001-11-13	Biogen Inc	Baff, agentes de bloqueio relacionados e uso dosmesmos no estìmulo e na inibição de células b e deimunoglobulinas em respostas imunológicas
NZ513290A (en) *	1999-02-23	2004-05-28	Human Genome Sciences Inc	Neutrokine-alpha and neutrokine-alpha splice variant
WO2000068378A1 (en)	1999-05-06	2000-11-16	National Jewish Medical And Research Center	Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof
UA74798C2 (uk)	1999-10-06	2006-02-15	Байоджен Айдек Ма Інк.	Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
JP2003521931A (ja)	2000-02-11	2003-07-22	バイオジェンインコーポレイテッド	Ｔｎｆファミリーの異種ポリペプチド
US6969519B2 (en)	2000-03-10	2005-11-29	Human Genome Sciences, Inc.	Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17)
AU2001268427B2 (en)	2000-06-16	2007-03-29	Glaxosmithkline Intellectual Property Limited	Antibodies that immunospecifically bind to blys
US7220840B2 (en)	2000-06-16	2007-05-22	Human Genome Sciences, Inc.	Antibodies that immunospecifically bind to B lymphocyte stimulator protein
US7879328B2 (en)	2000-06-16	2011-02-01	Human Genome Sciences, Inc.	Antibodies that immunospecifically bind to B lymphocyte stimulator
WO2002016411A2 (en)	2000-08-18	2002-02-28	Human Genome Sciences, Inc.	Binding polypeptides and methods based thereon
UA83458C2 (uk)	2000-09-18	2008-07-25	Байоджен Айдек Ма Інк.	Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
JP2004537290A (ja)	2001-05-24	2004-12-16	ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド	腫瘍壊死因子δ（ＡＰＲＩＬ）に対する抗体
MXPA03010747A (es)	2001-05-25	2004-03-02	Human Genome Sciences Inc	Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral.
AR035119A1 (es)	2001-08-16	2004-04-14	Lilly Co Eli	Anticuerpos humanos antagonistas anti-htnfsf13b
WO2004094620A2 (en)	2003-03-28	2004-11-04	Biogen Idec Ma Inc.	Truncated baff receptors
JP2008528633A (ja) *	2005-02-01	2008-07-31	リサーチディベロップメントファウンデーション	Ｂｌｙｓレセプターを標的化するためのｂｌｙｓ融合タンパク質およびｂ細胞増殖性疾患の処置方法
EP1922079A2 (de)	2005-08-09	2008-05-21	ZymoGenetics, Inc.	Verfahren zur behandlung und prävention abnormaler zellproliferation mittels taci-fusionsmolekülen
AU2006278229B2 (en)	2005-08-09	2011-10-27	Ares Trading S.A.	Methods for treating B-cell malignancies using TACI-Ig fusion molecule
US9168286B2 (en)	2005-10-13	2015-10-27	Human Genome Sciences, Inc.	Methods and compositions for use in treatment of patients with autoantibody positive disease
EA015860B1 (ru)	2005-10-13	2011-12-30	Хьюман Дженом Сайенсиз, Инк.	Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа
WO2007062090A2 (en)	2005-11-23	2007-05-31	Genentech, Inc.	Methods and compositions related to b cell assays
US8211649B2 (en)	2006-03-31	2012-07-03	Human Genome Sciences, Inc.	Methods of diagnosing and prognosing hodgkin's lymphoma
JP2009537563A (ja)	2006-05-15	2009-10-29	アレストレーディングソシエテアノニム	Ｔａｃｉ融合分子を使用する自己免疫疾患を治療するための方法
CA2667802A1 (en) *	2006-11-03	2008-05-29	Northwestern University	Multiple sclerosis therapy
WO2009017620A1 (en) *	2007-07-26	2009-02-05	Ipsen Pharma S.A.S.	Chemokine analogs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998018921A1 (en) *	1996-10-25	1998-05-07	Human Genome Sciences, Inc.	NEUTROKINE $g(a)
WO2000050597A2 (en) *	1999-02-23	2000-08-31	Human Genome Sciences, Inc.	Neutrokine-alpha and neutrokine-alpha splice variant
US6403770B1 (en) *	1996-10-25	2002-06-11	Human Genome Sciences, Inc.	Antibodies to neutrokine-alpha

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Publication number	Priority date	Publication date	Assignee	Title
AU5705898A (en) *	1996-12-17	1998-07-15	Schering Corporation	Mammalian cell surface antigens; related reagents
CA2232743A1 (en) *	1997-04-02	1998-10-02	Smithkline Beecham Corporation	A tnf homologue, tl5
CA2303424A1 (en) *	1997-09-12	1999-03-18	Jurg Tschopp	Kay - a novel immune system protein
WO1999033980A2 (en) *	1997-12-30	1999-07-08	Chiron Corporation	Members of tnf and tnfr families

2000
- 2000-02-22 NZ NZ513290A patent/NZ513290A/en not_active IP Right Cessation
- 2000-02-22 JP JP2000601161A patent/JP2003526330A/ja active Pending
- 2000-02-22 EP EP07012741A patent/EP1860190A3/de not_active Withdrawn
- 2000-02-22 WO PCT/US2000/004336 patent/WO2000050597A2/en not_active Ceased
- 2000-02-22 AU AU30028/00A patent/AU777536B2/en not_active Expired
- 2000-02-22 EP EP00908739A patent/EP1157110A4/de not_active Withdrawn
- 2000-02-22 CA CA002363112A patent/CA2363112A1/en not_active Abandoned
2003
- 2003-11-14 NZ NZ529555A patent/NZ529555A/en not_active IP Right Cessation
2005
- 2005-01-20 AU AU2005200237A patent/AU2005200237B2/en not_active Expired
2007
- 2007-04-19 JP JP2007111070A patent/JP2007277249A/ja active Pending

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998018921A1 (en) *	1996-10-25	1998-05-07	Human Genome Sciences, Inc.	NEUTROKINE $g(a)
US6403770B1 (en) *	1996-10-25	2002-06-11	Human Genome Sciences, Inc.	Antibodies to neutrokine-alpha
WO2000050597A2 (en) *	1999-02-23	2000-08-31	Human Genome Sciences, Inc.	Neutrokine-alpha and neutrokine-alpha splice variant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200053, Derwent World Patents Index; Class B04, AN 2000-572093, XP002331367 *

Also Published As

Publication number	Publication date
AU777536B2 (en)	2004-10-21
JP2003526330A (ja)	2003-09-09
EP1860190A3 (de)	2008-03-12
WO2000050597A2 (en)	2000-08-31
AU2005200237A1 (en)	2005-02-17
JP2007277249A (ja)	2007-10-25
AU2005200237B2 (en)	2007-11-29
CA2363112A1 (en)	2000-08-31
EP1860190A2 (de)	2007-11-28
NZ513290A (en)	2004-05-28
EP1157110A1 (de)	2001-11-28
AU3002800A (en)	2000-09-14
NZ529555A (en)	2005-09-30

Legal Events

Date	Code	Title	Description
2001-10-12	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-11-28	17P	Request for examination filed	Effective date: 20010924
2001-11-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-11-28	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2006-05-10	A4	Supplementary search report drawn up and despatched	Effective date: 20060328
2007-01-17	17Q	First examination report despatched	Effective date: 20061219
2007-11-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2007-12-19	18D	Application deemed to be withdrawn	Effective date: 20070630
2008-10-03	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1046707 Country of ref document: HK

Publication	Publication Date	Title
EP1157110A4 (de)	2006-05-10	Neutrokin-alpha und Neutrokin-alpha Spleissvarianten
LU91437I2 (fr)	2008-07-14	"dabigatran-etexilate et ses sels- particulièrement dabigatran-etexilate-mésilate (PRADAXA)"
FI20000038A7 (fi)	2000-03-10	Tiadiatsolyyli- ja oksadiatsolyylifenyylioksatsolidinonit antibakteerisina aineina
EP1507793A4 (de)	2006-02-01	Neutrokin-alpha und neutrokin-alpha-spleissvariante
FI971627L (fi)	1998-10-18	Luistimilla liikkuvan pelaajan suojus
FR2793061B1 (fr)	2001-07-27	Panneau d'affichage
ID19801A (id)	1998-08-06	Turunan-turunan 5'-deoksi-sitidina
BR9709521A (pt)	1999-08-10	"3-Cianoaril-pirazóis"
FR2789816B1 (fr)	2001-03-30	Dispositif de protection d'epissures
FR2796747B1 (fr)	2003-06-13	Panneau d'affichage
LU90452B1 (fr)	2001-03-28	Dispositif d'-tanch-it-
NO996127L (no)	1999-12-10	13-dihydro-3'-aziridino-antracykliner
FR2781913B1 (fr)	2001-02-16	Support d'enseigne
FI972010A0 (fi)	1997-05-13	Arrangemang i en borrningsanordning
UA3603S (uk)	2000-09-15	Комплект етикеток "лонгер"
SE9903973D0 (sv)	1999-11-02	"ADSPLIT" System
UA1815S (uk)	1998-02-27	Набір етикеток "академічна"
ITCS970006V0 (it)	1997-10-09	"1 m"
FR2761390B1 (fr)	1999-06-04	Element d'echafaudage
UA3466S (uk)	2000-02-28	Пам'ятник
FR2761928B1 (fr)	1999-05-14	Dispositif d'application de tatouage temporaire
UA2436S (uk)	1998-12-25	Пам'ятник
UA2238S (uk)	1998-10-30	Пляшка "державна"
UA3704S (uk)	2000-10-16	Наліпка "аверс-плюс"
HK1046707A1 (zh)	2003-01-24	中性活動(NEUTROKINE)-α與中性活動-α粘接變異