EP1174182A4 - Microcircuit integre pour reaction chimique - Google Patents

Microcircuit integre pour reaction chimique

Info

Publication number
EP1174182A4
EP1174182A4 EP00903980A EP00903980A EP1174182A4 EP 1174182 A4 EP1174182 A4 EP 1174182A4 EP 00903980 A EP00903980 A EP 00903980A EP 00903980 A EP00903980 A EP 00903980A EP 1174182 A4 EP1174182 A4 EP 1174182A4
Authority
EP
European Patent Office
Prior art keywords
chemical reaction
reaction pool
pool parts
micro
chip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00903980A
Other languages
German (de)
English (en)
Other versions
EP1174182A1 (fr
Inventor
Michifumi Tanga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Kohan Co Ltd
Original Assignee
Toyo Kohan Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Kohan Co Ltd filed Critical Toyo Kohan Co Ltd
Publication of EP1174182A1 publication Critical patent/EP1174182A1/fr
Publication of EP1174182A4 publication Critical patent/EP1174182A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0661—Valves, specific forms thereof with moving parts shape memory polymer valves
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S257/00—Active solid-state devices, e.g. transistors, solid-state diodes
    • Y10S257/93—Thermoelectric, e.g. peltier effect cooling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

L'invention se rapporte à un microcircuit intégré pour réaction chimique permettant la mise en oeuvre rapide d'une expérience quels que soient les types de substances chimiques mises en jeu dans l'expérience et dans diverses conditions expérimentales. Ce microcircuit comporte un chemin de communication horizontale (13) comprenant une pluralité de parties (11, 12) regroupées et destinées à la réaction chimique et de rainures assurant la communication entre lesdites parties (11, 12), ledit chemin étant formé à la surface d'un substrat en diamant (10) de petite taille; un chemin de communication verticale (20) comportant des trous traversants assurant la communication verticale entre lesdites parties (11, 12), ledit chemin étant ménagé dans le substrat en diamant (10); une soupape d'arrêt (21) installée au niveau d'une section de communication, et en outre des organes de chauffage et de refroidissement (23, 24), du type élément à effet Peltier, installés en des emplacements correspondant respectivement aux parties (11, 12) regroupées et destinées à la réaction chimique. Ce microcircuit permet la mise en oeuvre d'une variété d'expériences dans un espace limité sans restriction sur le type des substances chimiques et dans des conditions expérimentales variées.
EP00903980A 1999-02-18 2000-02-16 Microcircuit integre pour reaction chimique Withdrawn EP1174182A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4068999 1999-02-18
JP4068999 1999-02-18
PCT/JP2000/000867 WO2000048724A1 (fr) 1999-02-18 2000-02-16 Microcircuit integre pour reaction chimique

Publications (2)

Publication Number Publication Date
EP1174182A1 EP1174182A1 (fr) 2002-01-23
EP1174182A4 true EP1174182A4 (fr) 2003-07-23

Family

ID=12587534

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00903980A Withdrawn EP1174182A4 (fr) 1999-02-18 2000-02-16 Microcircuit integre pour reaction chimique

Country Status (7)

Country Link
US (1) US6525343B1 (fr)
EP (1) EP1174182A4 (fr)
KR (1) KR100630297B1 (fr)
CN (1) CN1150059C (fr)
AU (1) AU2571600A (fr)
CA (1) CA2371767C (fr)
WO (1) WO2000048724A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10041853C1 (de) * 2000-08-25 2002-02-28 Gmd Gmbh Konfigurierbares Mikroreaktornetzwerk
GB2368809B (en) * 2000-09-15 2004-09-29 Norchip As Microfabricated reaction chamber system
WO2002043853A1 (fr) * 2000-11-29 2002-06-06 Merck Patent Gmbh Dispositif pour equilibrer la temperature de microcomposants
JP4954386B2 (ja) * 2001-05-07 2012-06-13 財団法人神奈川科学技術アカデミー 電場または磁場印加によるマイクロチップ液液界面反応方法とそのためのマイクロチップ
EP2719756B1 (fr) * 2002-10-04 2017-04-05 The Regents of the University of California Dispositif à plusieurs compartiments microfluidiques pour la recherche de neuroscience
US20080047836A1 (en) * 2002-12-05 2008-02-28 David Strand Configurable Microfluidic Substrate Assembly
JP4695851B2 (ja) * 2003-07-10 2011-06-08 シチズンホールディングス株式会社 マイクロ化学チップ温度調節装置
EP1510253A1 (fr) * 2003-08-21 2005-03-02 Yamaha Corporation Microreacteur et procédé de production de substance avec un tel microreacteur
JP2005114298A (ja) * 2003-10-10 2005-04-28 Citizen Watch Co Ltd 温度調節装置
EP1711264B1 (fr) * 2004-02-02 2010-03-31 Silicon Valley Scientific, Inc. Systeme integre equipe de composants microfluidiques modulaires
EP1728062A4 (fr) * 2004-03-26 2012-12-26 Univ Laval Pile amovible a ecoulement microfluidique
DE102004050510B4 (de) 2004-10-15 2012-01-12 Siemens Ag Verfahren zur Ventilsteuerung bei der Thermozyklisierung einer Substanz zwecks PCR und zugehörige Anordnung
US7691334B2 (en) * 2005-09-20 2010-04-06 Yamaha Corporation Temperature control apparatus for microchemical chip
US9618132B2 (en) * 2011-07-13 2017-04-11 GM Global Technology Operations LLC Temperature dependent variable flow orifice
US10086370B2 (en) * 2013-02-08 2018-10-02 Infineon Technologies Ag Microfluidic device and method
USD844805S1 (en) 2016-02-29 2019-04-02 President And Fellows Of Harvard College Holder
USD846755S1 (en) * 2016-12-07 2019-04-23 President And Fellows Of Harvard College Holder
CN107715930B (zh) * 2017-09-22 2020-03-17 华中科技大学同济医学院附属协和医院 芯片结构
JP7668523B2 (ja) * 2021-06-04 2025-04-25 国立研究開発法人産業技術総合研究所 マイクロチャンバ、マイクロチャンバ装置、及びマイクロチャンバの製造方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
EP0697726A2 (fr) * 1994-08-03 1996-02-21 Sumitomo Electric Industries, Ltd. Dissipateur de chaleur fabriqué d'une couche en diamant synthétique
WO1996014933A1 (fr) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Dispositifs a meso-echelle pour analyse de cellules mobiles
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5690763A (en) * 1993-03-19 1997-11-25 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof

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US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
DE69333601T2 (de) * 1993-04-15 2005-09-15 Zeptosens Ag Verfahren zur Steuerung der Probeneinführung bei Mikrosäulentrennungstechniken und Probenentnahmevorrichtungen
US5821399A (en) * 1993-07-16 1998-10-13 I-Stat Corporation Automatic test parameters compensation of a real time fluid analysis sensing device
JPH07232056A (ja) 1994-02-23 1995-09-05 Hitachi Ltd 微量反応装置
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5690763A (en) * 1993-03-19 1997-11-25 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
EP0697726A2 (fr) * 1994-08-03 1996-02-21 Sumitomo Electric Industries, Ltd. Dissipateur de chaleur fabriqué d'une couche en diamant synthétique
WO1996014933A1 (fr) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Dispositifs a meso-echelle pour analyse de cellules mobiles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0048724A1 *

Also Published As

Publication number Publication date
KR20020003368A (ko) 2002-01-12
EP1174182A1 (fr) 2002-01-23
AU2571600A (en) 2000-09-04
KR100630297B1 (ko) 2006-09-29
US6525343B1 (en) 2003-02-25
CA2371767C (fr) 2007-05-08
CN1341041A (zh) 2002-03-20
WO2000048724A1 (fr) 2000-08-24
CA2371767A1 (fr) 2000-08-24
CN1150059C (zh) 2004-05-19

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