EP1192174A4 - Antagonisten von bmp- und tgf-beta signalwegen - Google Patents

Antagonisten von bmp- und tgf-beta signalwegen

Info

Publication number
EP1192174A4
EP1192174A4 EP00941398A EP00941398A EP1192174A4 EP 1192174 A4 EP1192174 A4 EP 1192174A4 EP 00941398 A EP00941398 A EP 00941398A EP 00941398 A EP00941398 A EP 00941398A EP 1192174 A4 EP1192174 A4 EP 1192174A4
Authority
EP
European Patent Office
Prior art keywords
smurf1
bmp
tgfβ
signalling
smurf2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00941398A
Other languages
English (en)
French (fr)
Other versions
EP1192174A2 (de
Inventor
Gerald H Thomsen
Jeffrey Wrana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HSC Research and Development LP
Research Foundation of the State University of New York
Original Assignee
HSC Research and Development LP
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HSC Research and Development LP, Research Foundation of the State University of New York filed Critical HSC Research and Development LP
Publication of EP1192174A2 publication Critical patent/EP1192174A2/de
Publication of EP1192174A4 publication Critical patent/EP1192174A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP00941398A 1999-06-11 2000-06-12 Antagonisten von bmp- und tgf-beta signalwegen Withdrawn EP1192174A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13896999P 1999-06-11 1999-06-11
US138969P 1999-06-11
PCT/US2000/016250 WO2000077168A2 (en) 1999-06-11 2000-06-12 ANTAGONISTS OF BMP AND TGFβ SIGNALLING PATHWAYS

Publications (2)

Publication Number Publication Date
EP1192174A2 EP1192174A2 (de) 2002-04-03
EP1192174A4 true EP1192174A4 (de) 2002-08-28

Family

ID=22484504

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00941398A Withdrawn EP1192174A4 (de) 1999-06-11 2000-06-12 Antagonisten von bmp- und tgf-beta signalwegen

Country Status (7)

Country Link
EP (1) EP1192174A4 (de)
JP (1) JP2003502064A (de)
CN (1) CN100379752C (de)
AU (1) AU782355B2 (de)
CA (1) CA2376675A1 (de)
IL (1) IL147005A0 (de)
WO (1) WO2000077168A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7358056B1 (en) 1999-08-30 2008-04-15 Signal Pharmaceuticals Methods for modulating signal transduction mediated by TGF-β and related proteins
WO2003030924A1 (en) * 2001-10-09 2003-04-17 Osteoscreen, Inc. Identification of specific modulators of bone formation
WO2005003167A1 (en) * 2003-07-01 2005-01-13 Vib Vzw Ubiquitinated tnf receptor 2 and its uses
US7901874B2 (en) * 2003-09-11 2011-03-08 Hubit Genomix, Inc. Methods for identifying agents for preventing or treating proliferative diseases, and for inhibiting extracellular matrix or α1 type IV collagen
GB0526664D0 (en) * 2005-11-30 2006-02-08 Plasticell Ltd Method
KR100959050B1 (ko) 2006-03-01 2010-05-20 소프트맥스 인코퍼레이티드 분리된 신호를 생성하는 시스템 및 방법
EP2117583B1 (de) 2007-02-21 2013-05-22 Vib Vzw Kombinationstherapie mit TNF und alpha-Galactosylceramid
US20100183514A1 (en) * 2007-05-29 2010-07-22 President And Fellows Of Harvard College Molecules involved in regulation of osteoblast activity and osteoclast activity, and methods of use thereof
WO2011088163A1 (en) 2010-01-14 2011-07-21 President And Fellows Of Harvard College Methods for modulating skeletal remodeling and patterning by modulating shn2 activity, shn3 activity, or shn2 and shn3 activity in combination
US9403810B2 (en) * 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
US9403833B2 (en) * 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
KR102360028B1 (ko) * 2014-12-26 2022-02-08 삼성전자주식회사 Smurf2의 저해제를 포함하는 세포 또는 개체의 노화를 감소시키기 위한 조성물 및 그의 용도
CN110196326A (zh) * 2019-06-05 2019-09-03 武汉合研生物医药科技有限公司 一种TGFβR1（T204D）酶活性的快速检测方法及其应用
CN110592032B (zh) * 2019-10-14 2021-04-13 北京理工大学 泛素连接酶Smurf1突变体、编码基因及用途
US12098384B2 (en) 2021-01-21 2024-09-24 Cellid Co., Ltd. Adenoviral vector not including replication competent adenovirus, and use thereof
CN117721131A (zh) * 2023-12-19 2024-03-19 吉林大学 一种重组骨形态发生蛋白突变体的制备方法和应用
CN119386159B (zh) * 2024-12-31 2025-04-22 温州医科大学 一种mRNA-多肽复合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012962A1 (en) * 1995-10-04 1997-04-10 Cold Spring Harbor Laboratory Ubiquitin ligases, and uses related thereto

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU741242B2 (en) * 1997-05-20 2001-11-29 Ludwig Institute For Cancer Research Smad2 phosphorylation and interaction with Smad4
US5976849A (en) * 1998-02-05 1999-11-02 Zeneca Limited Human E3 ubiquitin protein ligase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012962A1 (en) * 1995-10-04 1997-04-10 Cold Spring Harbor Laboratory Ubiquitin ligases, and uses related thereto

Also Published As

Publication number Publication date
WO2000077168A2 (en) 2000-12-21
CN1409722A (zh) 2003-04-09
CN100379752C (zh) 2008-04-09
IL147005A0 (en) 2002-08-14
EP1192174A2 (de) 2002-04-03
AU5610700A (en) 2001-01-02
WO2000077168A3 (en) 2001-05-03
CA2376675A1 (en) 2000-12-21
AU782355B2 (en) 2005-07-21
JP2003502064A (ja) 2003-01-21

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