EP1201665A4 - Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte - Google Patents

Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte

Info

Publication number
EP1201665A4
EP1201665A4 EP00948257A EP00948257A EP1201665A4 EP 1201665 A4 EP1201665 A4 EP 1201665A4 EP 00948257 A EP00948257 A EP 00948257A EP 00948257 A EP00948257 A EP 00948257A EP 1201665 A4 EP1201665 A4 EP 1201665A4
Authority
EP
European Patent Office
Prior art keywords
protecting group
inorganic acid
group
producing
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00948257A
Other languages
English (en)
French (fr)
Other versions
EP1201665B1 (de
EP1201665A1 (de
Inventor
Akio Kayano
Hiroyuki Chiba
Taiju Nakamura
Shin Sakurai
Hiroyuki Ishizuka
Hiroyuki Saito
Yuuki Komatsu
Manabu Sasho
Nobuaki Sato
Shigeto Negi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of EP1201665A1 publication Critical patent/EP1201665A1/de
Publication of EP1201665A4 publication Critical patent/EP1201665A4/de
Application granted granted Critical
Publication of EP1201665B1 publication Critical patent/EP1201665B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
EP00948257A 1999-07-30 2000-07-27 Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte Expired - Lifetime EP1201665B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP21680699 1999-07-30
JP21680799 1999-07-30
JP21680799 1999-07-30
JP21680699 1999-07-30
PCT/JP2000/005031 WO2001009135A1 (en) 1999-07-30 2000-07-27 Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates

Publications (3)

Publication Number Publication Date
EP1201665A1 EP1201665A1 (de) 2002-05-02
EP1201665A4 true EP1201665A4 (de) 2002-10-23
EP1201665B1 EP1201665B1 (de) 2004-09-29

Family

ID=26521640

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00948257A Expired - Lifetime EP1201665B1 (de) 1999-07-30 2000-07-27 Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte

Country Status (11)

Country Link
US (1) US6642377B1 (de)
EP (1) EP1201665B1 (de)
JP (1) JP4100908B2 (de)
KR (1) KR100694685B1 (de)
CN (1) CN1181072C (de)
AT (1) ATE277930T1 (de)
CA (1) CA2379650C (de)
DE (1) DE60014390T2 (de)
HU (1) HUP0202283A3 (de)
NO (1) NO20020471L (de)
WO (1) WO2001009135A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003016312A1 (en) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Process for preparation of carbapenem antibiotics
DE102004062303A1 (de) 2004-12-23 2006-07-13 BSH Bosch und Siemens Hausgeräte GmbH Linearverdichter
DE102004062300A1 (de) * 2004-12-23 2006-07-13 BSH Bosch und Siemens Hausgeräte GmbH Linearverdichter
US7932381B2 (en) * 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
DE102006009230A1 (de) * 2006-02-28 2007-08-30 BSH Bosch und Siemens Hausgeräte GmbH Verfahren zum Justieren eines Kolbens in einem Linearverdichter
DE102006009231A1 (de) * 2006-02-28 2007-08-30 BSH Bosch und Siemens Hausgeräte GmbH Verfahren und Steuergerät zum Betreiben eines Linearverdichters
CN100457759C (zh) * 2007-01-12 2009-02-04 深圳信立泰药业股份有限公司 头孢吡肟氢卤酸盐的制备方法
CN101041664B (zh) * 2007-04-24 2010-05-26 深圳信立泰药业股份有限公司 钙盐沉淀法制备头孢吡肟氢卤酸盐
JP2011520866A (ja) * 2008-05-14 2011-07-21 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド セフォゾプランの改良した製造方法
ES2527137T3 (es) 2008-07-28 2015-01-21 Pfizer Inc. Compuestos de fenantrenona, composiciones y procedimientos
CN102675343A (zh) * 2011-03-15 2012-09-19 陈婧 一种以盐酸头孢替安制备盐酸头孢替安酯的方法
CN104788470A (zh) * 2015-04-30 2015-07-22 苗怡文 一种治疗敏感菌感染性疾病的盐酸头孢他美酯化合物
CN109384800B (zh) * 2018-11-20 2020-05-22 山东罗欣药业集团股份有限公司 一种盐酸头孢替安的制备方法
CN119390710A (zh) * 2024-10-09 2025-02-07 安徽益普克医药科技发展有限公司 一种高纯度盐酸匹美西林晶型的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1182204A1 (de) * 1999-06-03 2002-02-27 Eisai Co., Ltd. Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektion

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1335718A (en) * 1971-05-05 1973-10-31 Leo Pharm Prod Ltd Penicillin esters salts thereof and methods for their preparation
JP2949363B2 (ja) * 1990-06-05 1999-09-13 サントリー株式会社 アリル基の脱離方法
US5302711A (en) * 1992-02-18 1994-04-12 Eli Lilly And Company Ester cleavage process for use with β-lactams
JPH08502513A (ja) * 1992-10-23 1996-03-19 藤沢薬品工業株式会社 セフェム化合物、およびそれらの医薬組成物
JP3848693B2 (ja) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1182204A1 (de) * 1999-06-03 2002-02-27 Eisai Co., Ltd. Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektion

Also Published As

Publication number Publication date
KR100694685B1 (ko) 2007-03-13
EP1201665B1 (de) 2004-09-29
DE60014390D1 (de) 2004-11-04
CN1365362A (zh) 2002-08-21
US6642377B1 (en) 2003-11-04
WO2001009135A1 (en) 2001-02-08
CN1181072C (zh) 2004-12-22
KR20020033734A (ko) 2002-05-07
ATE277930T1 (de) 2004-10-15
EP1201665A1 (de) 2002-05-02
DE60014390T2 (de) 2005-10-06
NO20020471L (no) 2002-03-22
CA2379650C (en) 2008-09-02
CA2379650A1 (en) 2001-02-08
HUP0202283A3 (en) 2003-10-28
JP4100908B2 (ja) 2008-06-11
NO20020471D0 (no) 2002-01-29
HUP0202283A2 (en) 2002-10-28

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