EP1230353A4 - BIFUNCTIONAL MOLECULES AND THEIR USE FOR INHIBITING PROTEIN-PROTEIN INTERACTIONS - Google Patents

BIFUNCTIONAL MOLECULES AND THEIR USE FOR INHIBITING PROTEIN-PROTEIN INTERACTIONS

Info

Publication number: EP1230353A4
Authority: EP; European Patent Office
Prior art keywords: protein; bifunctional molecules; inhibiting; interactions; protein interactions
Prior art date: 1999-11-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP20000980512

Other languages

German (de)

French (fr)

Other versions

EP1230353A1 (en

Inventor

Gerald R Crabtree

Kryn Stankunas

Roger Briesewitz

Thomas Wandless

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Leland Stanford Junior University

Original Assignee

Leland Stanford Junior University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-19

Filing date

2000-11-17

Publication date

2002-11-06

2000-11-17 Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University

2002-08-14 Publication of EP1230353A1 publication Critical patent/EP1230353A1/en

2002-11-06 Publication of EP1230353A4 publication Critical patent/EP1230353A4/en

Status Withdrawn legal-status Critical Current

Links

230000001588 bifunctional effect Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
230000003993 interaction Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

EP20000980512 1999-11-19 2000-11-17 BIFUNCTIONAL MOLECULES AND THEIR USE FOR INHIBITING PROTEIN-PROTEIN INTERACTIONS Withdrawn EP1230353A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US16667599P	1999-11-19	1999-11-19
US166675P		1999-11-19
PCT/US2000/031695 WO2001036612A1 (en)	1999-11-19	2000-11-17	Bifunctional molecules and their use in the disruption of protein-protein interactions

Publications (2)

Publication Number	Publication Date
EP1230353A1 EP1230353A1 (en)	2002-08-14
EP1230353A4 true EP1230353A4 (en)	2002-11-06

Family

ID=22604262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP20000980512 Withdrawn EP1230353A4 (en)	1999-11-19	2000-11-17	BIFUNCTIONAL MOLECULES AND THEIR USE FOR INHIBITING PROTEIN-PROTEIN INTERACTIONS

Country Status (3)

Country	Link
EP (1)	EP1230353A4 (en)
AU (1)	AU1776501A (en)
WO (1)	WO2001036612A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1229924A4 (en) *	1999-11-19	2004-12-15	Univ Leland Stanford Junior	TARGETED BIFUNCTIONAL MOLECULES AND THERAPIES THEREFORE
US9428845B1 (en)	2010-12-28	2016-08-30	Warp Drive Bio, Inc.	Identifying new therapeutic agents
EP4289950A3 (en)	2015-01-09	2024-01-24	Revolution Medicines, Inc.	Macrocyclic compounds that participate in cooperative binding and medical uses thereof
EP3355930A4 (en)	2015-10-01	2019-03-06	Warp Drive Bio, Inc.	METHODS AND REAGENTS FOR THE ANALYSIS OF PROTEIN-PROTEIN INTERFACES
KR102359972B1 (en)	2016-04-12	2022-02-10	징코 바이오웍스, 인크.	Compositions and methods for the preparation of compounds
WO2018081592A2 (en)	2016-10-28	2018-05-03	Warp Drive Bio, Inc.	Compositions and methods for the production of compounds
PE20221277A1 (en)	2019-11-04	2022-09-05	Revolution Medicines Inc	RAS INHIBITORS
CN114786777A (en)	2019-11-04	2022-07-22	锐新医药公司	RAS inhibitors
CN114867735A (en)	2019-11-04	2022-08-05	锐新医药公司	RAS inhibitors
AU2021345111B2 (en)	2020-09-15	2025-11-27	Revolution Medicines, Inc.	Indole derivatives as Ras inhibitors in the treatment of cancer
CR20230558A (en)	2021-05-05	2024-01-24	Revolution Medicines Inc	RAS INHIBITORS FOR CANCER TREATMENT
AR127308A1 (en)	2021-10-08	2024-01-10	Revolution Medicines Inc	RAS INHIBITORS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999061055A1 (en) *	1998-05-22	1999-12-02	The Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1978095A1 (en) *	1993-02-12	2008-10-08	The Board Of Trustees Of The Leland Stanford Junior University	Chimeric receptor proteins for controlling signal transduction and ligands binding thereto

2000
- 2000-11-17 AU AU17765/01A patent/AU1776501A/en not_active Abandoned
- 2000-11-17 WO PCT/US2000/031695 patent/WO2001036612A1/en not_active Ceased
- 2000-11-17 EP EP20000980512 patent/EP1230353A4/en not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999061055A1 (en) *	1998-05-22	1999-12-02	The Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0136612A1 *

Also Published As

Publication number	Publication date
EP1230353A1 (en)	2002-08-14
WO2001036612A1 (en)	2001-05-25
AU1776501A (en)	2001-05-30

Legal Events

Date	Code	Title	Description
2002-06-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2002-08-14	17P	Request for examination filed	Effective date: 20020506
2002-08-14	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-08-14	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2002-11-06	A4	Supplementary search report drawn up and despatched
2002-11-06	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-12-18	A4	Supplementary search report drawn up and despatched	Effective date: 20021106
2007-02-07	17Q	First examination report despatched	Effective date: 20060524
2007-10-12	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2007-11-14	18D	Application deemed to be withdrawn	Effective date: 20070519

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DE60043067D1 (en)	2009-11-12	QUADRUPOL ION TRAPS AND RELATED USE
DE60029306D1 (en)	2006-08-24	COMPATIBLE CONTAINER AND ASSOCIATED CONNECTING DEVICE
ITMI20000686A0 (en)	2000-03-31	LID HOLDER
DE60015213D1 (en)	2004-12-02	Parallel playback device
ATE219445T1 (en)	2002-07-15	POURING DEVICE
DE69927299D1 (en)	2005-10-20	IMITATOR-CELLULOSE BINDING DOMAIN
DE60120608D1 (en)	2006-07-27	Container arrangement and container
DE60044658D1 (en)	2010-08-26	Media processing device
DE60004748D1 (en)	2003-10-02	Settlement system and card
ATE301223T1 (en)	2005-08-15	COVER DEVICE
NO20005099L (en)	2002-04-11	Liquid storage system
DE69626872D1 (en)	2003-04-24	plate container
EP1229924A4 (en)	2004-12-15	TARGETED BIFUNCTIONAL MOLECULES AND THERAPIES THEREFORE
GB0004823D0 (en)	2000-04-19	Liquid asset
DE59911042D1 (en)	2004-12-16	planar filter
FR2792572B1 (en)	2001-07-06	MATERIAL FOR BOOK COVER
ITUD990125A0 (en)	1999-07-06	COMPACT DISC CONTAINER
IT246484Y1 (en)	2002-04-09	CONTAINER
KR980000393U (en)	1998-03-30	Manicure Removal Liquid Container
ATA7799A (en)	2000-07-15	CD COVER
IT248942Y1 (en)	2003-03-06	CONTAINER FOR COMPACT DISC
ITUD990043U3 (en)	2001-01-08	CONTAINER FOR COMPACT DISC
NO990252D0 (en)	1999-01-20	Information holder device
NO994546D0 (en)	1999-09-17	Device for lid construction