EP1230353A4 - Bifunktionelle moleküle und deren verwendung bei der zerstörung von protein-protein-interaktionen - Google Patents

Bifunktionelle moleküle und deren verwendung bei der zerstörung von protein-protein-interaktionen

Info

Publication number
EP1230353A4
EP1230353A4 EP20000980512 EP00980512A EP1230353A4 EP 1230353 A4 EP1230353 A4 EP 1230353A4 EP 20000980512 EP20000980512 EP 20000980512 EP 00980512 A EP00980512 A EP 00980512A EP 1230353 A4 EP1230353 A4 EP 1230353A4
Authority
EP
European Patent Office
Prior art keywords
protein
bifunctional molecules
inhibiting
interactions
protein interactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20000980512
Other languages
English (en)
French (fr)
Other versions
EP1230353A1 (de
Inventor
Gerald R Crabtree
Kryn Stankunas
Roger Briesewitz
Thomas Wandless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of EP1230353A1 publication Critical patent/EP1230353A1/de
Publication of EP1230353A4 publication Critical patent/EP1230353A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP20000980512 1999-11-19 2000-11-17 Bifunktionelle moleküle und deren verwendung bei der zerstörung von protein-protein-interaktionen Withdrawn EP1230353A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16667599P 1999-11-19 1999-11-19
US166675P 1999-11-19
PCT/US2000/031695 WO2001036612A1 (en) 1999-11-19 2000-11-17 Bifunctional molecules and their use in the disruption of protein-protein interactions

Publications (2)

Publication Number Publication Date
EP1230353A1 EP1230353A1 (de) 2002-08-14
EP1230353A4 true EP1230353A4 (de) 2002-11-06

Family

ID=22604262

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20000980512 Withdrawn EP1230353A4 (de) 1999-11-19 2000-11-17 Bifunktionelle moleküle und deren verwendung bei der zerstörung von protein-protein-interaktionen

Country Status (3)

Country Link
EP (1) EP1230353A4 (de)
AU (1) AU1776501A (de)
WO (1) WO2001036612A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1229924A4 (de) * 1999-11-19 2004-12-15 Univ Leland Stanford Junior Gezielte bifunctionelle moleküle und darauf gegründete therapien
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
EP4289950A3 (de) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Makrozyklische verbindungen mit beteiligung an einer kooperativen bindung und medizinische verwendungen davon
EP3355930A4 (de) 2015-10-01 2019-03-06 Warp Drive Bio, Inc. Verfahren und reagenzien zur analyse von protein-protein-schnittstellen
KR102359972B1 (ko) 2016-04-12 2022-02-10 징코 바이오웍스, 인크. 화합물의 제조를 위한 조성물 및 방법
WO2018081592A2 (en) 2016-10-28 2018-05-03 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
PE20221277A1 (es) 2019-11-04 2022-09-05 Revolution Medicines Inc Inhibidores de ras
CN114786777A (zh) 2019-11-04 2022-07-22 锐新医药公司 Ras抑制剂
CN114867735A (zh) 2019-11-04 2022-08-05 锐新医药公司 Ras抑制剂
AU2021345111B2 (en) 2020-09-15 2025-11-27 Revolution Medicines, Inc. Indole derivatives as Ras inhibitors in the treatment of cancer
CR20230558A (es) 2021-05-05 2024-01-24 Revolution Medicines Inc Inhibidores de ras para el tratamiento del cáncer
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061055A1 (en) * 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1978095A1 (de) * 1993-02-12 2008-10-08 The Board Of Trustees Of The Leland Stanford Junior University Regulierte Transkription gezielter Gene und anderer biologischer Ereignisse

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061055A1 (en) * 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0136612A1 *

Also Published As

Publication number Publication date
EP1230353A1 (de) 2002-08-14
WO2001036612A1 (en) 2001-05-25
AU1776501A (en) 2001-05-30

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