EP1280930A4 - Substrate der gamma-sekretase und in vitro assays - Google Patents

Substrate der gamma-sekretase und in vitro assays

Info

Publication number
EP1280930A4
EP1280930A4 EP01930748A EP01930748A EP1280930A4 EP 1280930 A4 EP1280930 A4 EP 1280930A4 EP 01930748 A EP01930748 A EP 01930748A EP 01930748 A EP01930748 A EP 01930748A EP 1280930 A4 EP1280930 A4 EP 1280930A4
Authority
EP
European Patent Office
Prior art keywords
dosages
gamma
vitro
secretase substrates
secretase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01930748A
Other languages
English (en)
French (fr)
Other versions
EP1280930A1 (de
Inventor
Yueming Li
Min Xu
Qian Huang
Stephen Gardell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1280930A1 publication Critical patent/EP1280930A1/de
Publication of EP1280930A4 publication Critical patent/EP1280930A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP01930748A 2000-05-01 2001-04-25 Substrate der gamma-sekretase und in vitro assays Withdrawn EP1280930A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20105300P 2000-05-01 2000-05-01
US201053P 2000-05-01
PCT/US2001/013332 WO2001083811A1 (en) 2000-05-01 2001-04-25 Gamma secretase substrates and in vitro assays

Publications (2)

Publication Number Publication Date
EP1280930A1 EP1280930A1 (de) 2003-02-05
EP1280930A4 true EP1280930A4 (de) 2004-05-26

Family

ID=22744277

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01930748A Withdrawn EP1280930A4 (de) 2000-05-01 2001-04-25 Substrate der gamma-sekretase und in vitro assays

Country Status (4)

Country Link
EP (1) EP1280930A4 (de)
JP (1) JP2003531625A (de)
CA (1) CA2408003A1 (de)
WO (1) WO2001083811A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0202276D0 (en) * 2002-01-31 2002-03-20 Eisai London Res Lab Ltd Assays
CN100335500C (zh) * 2003-06-27 2007-09-05 中国科学院上海生命科学研究院 人淀粉样蛋白前体蛋白639、其编码序列及用途
US9023767B2 (en) 2009-05-07 2015-05-05 Memorial Sloan-Kettering Cancer Center γ-Secretase substrates and methods of use
CN103502466A (zh) * 2010-09-07 2014-01-08 斯隆－凯特林纪念癌症中心 用于γ-分泌酶测定的方法和组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187153A (en) * 1986-11-17 1993-02-16 Scios Nova Inc. Methods of treatment using Alzheimer's amyloid polypeptide derivatives

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
LI YUE-MING ET AL: "Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 11, 23 May 2000 (2000-05-23), May 23, 2000, pages 6138 - 6143, XP002275336, ISSN: 0027-8424 *
LICHTENTHALER S F ET AL: "MUTATIONS IN THE TRANSMEMBRANE DOMAIN OF APP ALTERING GAMMA SECRETASE SPECIFICITY", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 36, no. 49, 9 December 1997 (1997-12-09), pages 15396 - 15403, XP002056700, ISSN: 0006-2960 *
MACKAY E A ET AL: "A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 244, no. 2, 1997, pages 414 - 425, XP001155037, ISSN: 0014-2956 *
OSTER-GRANITE MARY LOU ET AL: "Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of they amyloid precursor protein", JOURNAL OF NEUROSCIENCE, vol. 16, no. 21, 1996, pages 6732 - 6741, XP009028576, ISSN: 0270-6474 *
See also references of WO0183811A1 *
SELKOE D.J.: "Translating cell biology into therapeutic advances in Alzheimer's disease", NATURE, vol. 399, 24 June 1999 (1999-06-24), pages A23 - A31 *
XU MIN ET AL: "gamma-Secretase: Characterization and implication for Alzheimer disease therapy.", NEUROBIOLOGY OF AGING, vol. 23, no. 6, pages 1023 - 1030, XP001180539, ISSN: 0197-4580 *

Also Published As

Publication number Publication date
CA2408003A1 (en) 2001-11-08
EP1280930A1 (de) 2003-02-05
WO2001083811A1 (en) 2001-11-08
JP2003531625A (ja) 2003-10-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20021202

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 38/00 B

Ipc: 7C 07K 14/00 B

Ipc: 7G 01N 33/53 A

Ipc: 7C 07H 21/04 B

Ipc: 7C 12N 9/48 B

A4 Supplementary search report drawn up and despatched

Effective date: 20040416

17Q First examination report despatched

Effective date: 20061120

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080305