EP1292279A4 - Verwendung von glatiramer acetat (copolymer 1) zur behandlung von störungen des zentralen nervensystems - Google Patents

Verwendung von glatiramer acetat (copolymer 1) zur behandlung von störungen des zentralen nervensystems

Info

Publication number
EP1292279A4
EP1292279A4 EP01941973A EP01941973A EP1292279A4 EP 1292279 A4 EP1292279 A4 EP 1292279A4 EP 01941973 A EP01941973 A EP 01941973A EP 01941973 A EP01941973 A EP 01941973A EP 1292279 A4 EP1292279 A4 EP 1292279A4
Authority
EP
European Patent Office
Prior art keywords
copolymer
treatment
nervous system
central nervous
system disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01941973A
Other languages
English (en)
French (fr)
Other versions
EP1292279A1 (de
Inventor
V Wee Yong
Sophie Chabot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of EP1292279A1 publication Critical patent/EP1292279A1/de
Publication of EP1292279A4 publication Critical patent/EP1292279A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP01941973A 2000-06-05 2001-06-05 Verwendung von glatiramer acetat (copolymer 1) zur behandlung von störungen des zentralen nervensystems Withdrawn EP1292279A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58752300A 2000-06-05 2000-06-05
US587523 2000-06-05
PCT/US2001/018248 WO2001093828A1 (en) 2000-06-05 2001-06-05 The use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders

Publications (2)

Publication Number Publication Date
EP1292279A1 EP1292279A1 (de) 2003-03-19
EP1292279A4 true EP1292279A4 (de) 2005-01-12

Family

ID=24350145

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01941973A Withdrawn EP1292279A4 (de) 2000-06-05 2001-06-05 Verwendung von glatiramer acetat (copolymer 1) zur behandlung von störungen des zentralen nervensystems

Country Status (9)

Country Link
EP (1) EP1292279A4 (de)
JP (1) JP2003535118A (de)
AU (2) AU7528001A (de)
CA (1) CA2411536A1 (de)
HU (1) HUP0302333A3 (de)
IL (1) IL153236A0 (de)
PL (1) PL363431A1 (de)
WO (1) WO2001093828A1 (de)
ZA (1) ZA200210084B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005250A1 (en) 1998-07-23 2000-02-03 Yeda Research And Development Co., Ltd Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides
ES2527760T3 (es) 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
ZA200206457B (en) 2000-02-18 2003-08-13 Yeda Res & Dev Oral, nasal and pulmonary dosage formulations of copolymer 1.
US20020077278A1 (en) 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
CA2469393C (en) 2001-12-04 2010-05-25 Teva Pharmaceutical Industries, Ltd. Processes for the measurement of the potency of glatiramer acetate
DK1797109T3 (en) 2004-09-09 2016-04-11 Yeda Res & Dev MIXTURES OF POLYPEPTIDES, compositions containing them and methods for their preparation, and uses thereof
SG10201405806SA (en) 2009-08-20 2014-11-27 Yeda Res & Dev Low Frequency Glatiramer Acetate Therapy
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en) 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
ES2602977T3 (es) 2010-10-11 2017-02-23 Teva Pharmaceutical Industries Ltd. Biomarcadores de citocinas como biomarcadores predictivos de la respuesta clínica para acetato de glatirámero
AU2012323345A1 (en) 2011-10-10 2014-05-22 Teva Pharmaceutical Industries Ltd. Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate
MX2015004563A (es) 2012-10-10 2015-07-14 Teva Pharma Biomarcadores predictivos para respuesta clinica para acetato de glatiramero.
UY35790A (es) 2013-10-21 2015-05-29 Teva Pharma Marcadores genéticos que predicen la respuesta al acetato de glatiramer
DK3185882T3 (da) 2014-08-29 2020-01-27 Region Midtjylland Positivt ladede copolymerer til anvendelse som antimikrobielle midler
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
CN106924175B (zh) * 2015-12-29 2020-07-03 深圳翰宇药业股份有限公司 一种治疗多发性硬化症的药物组合物
EP3458036B1 (de) * 2016-05-20 2023-08-23 Cedars-Sinai Medical Center Behandlung oder vorbeugung von morbus alzheimer und verwandten erkrankungen
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN109982712A (zh) 2016-08-31 2019-07-05 Mapi医药公司 包含醋酸格拉替雷的储库系统
BR112019017724A2 (pt) 2017-03-26 2020-03-31 Mapi Pharma Ltd. Sistemas depot de glatiramer para tratar formas progressivas de esclerose múltipla
CN115151271A (zh) * 2020-09-27 2022-10-04 长沙英奈发药业有限公司 醋酸格拉替雷在制备Aβ42毒性抑制剂和清除剂中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031990A1 (en) * 1994-05-24 1995-11-30 Yeda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
WO2001052878A2 (en) * 2000-01-20 2001-07-26 Yeda Research And Development Co. Ltd. The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy
WO2001093893A2 (en) * 2000-06-07 2001-12-13 Yeda Research And Development Co. Ltd. The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411292D0 (en) * 1994-06-06 1994-07-27 Teva Pharma Pharmaceuticals compositions
US5665764A (en) * 1995-06-02 1997-09-09 Warner-Lambert Company Tricyclic inhibitors of matrix metalloproteinases
IL119989A0 (en) * 1997-01-10 1997-04-15 Yeda Res & Dev Pharmaceutical compositions for oral treatment of multiple sclerosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031990A1 (en) * 1994-05-24 1995-11-30 Yeda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
WO2001052878A2 (en) * 2000-01-20 2001-07-26 Yeda Research And Development Co. Ltd. The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy
WO2001093893A2 (en) * 2000-06-07 2001-12-13 Yeda Research And Development Co. Ltd. The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AHARONI R ET AL: "COP 1 SPECIFIC SUPPRESSOR CELLS INHIBIT EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS INDUCED BY EITHER MOUSE SPINAL CORD HOMOGENATE ORPROTEOLIPID PROTEIN PEPTIDE 139-151", NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA, US, vol. 48, no. 3, SUPPL 2, 12 April 1997 (1997-04-12), pages A422, XP001029141, ISSN: 0028-3878 *
AHARONI R ET AL: "COPOLYMER 1 INDUCES T CELLS OF THE T HELPER TYPE 2 THAT CROSSREACT WITH MYELIN BASIC PROTEIN AND SUPPRESS EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, September 1997 (1997-09-01), pages 10821 - 10826, XP002918836, ISSN: 0027-8424 *
See also references of WO0193828A1 *
TEVA ET AL: "COPOLYMER-1 GLATIRAMER ACETATE COPAXONE(R) AGENT FOR MULTIPLE SCLEROSIS", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 23, no. 2, 1998, pages 213 - 214, XP001029138, ISSN: 0377-8282 *

Also Published As

Publication number Publication date
WO2001093828A1 (en) 2001-12-13
HUP0302333A3 (en) 2005-07-28
HUP0302333A2 (hu) 2003-11-28
AU7528001A (en) 2001-12-17
IL153236A0 (en) 2003-07-06
EP1292279A1 (de) 2003-03-19
AU2001275280B2 (en) 2006-03-16
PL363431A1 (en) 2004-11-15
JP2003535118A (ja) 2003-11-25
CA2411536A1 (en) 2001-12-13
ZA200210084B (en) 2003-12-12

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Legal Events

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Effective date: 20041126

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