EP1310552A3 - Posh Nukleinsäure, Polypeptide und darauf bezogene Verfahren - Google Patents

Posh Nukleinsäure, Polypeptide und darauf bezogene Verfahren Download PDF

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Publication number
EP1310552A3
EP1310552A3 EP02257796A EP02257796A EP1310552A3 EP 1310552 A3 EP1310552 A3 EP 1310552A3 EP 02257796 A EP02257796 A EP 02257796A EP 02257796 A EP02257796 A EP 02257796A EP 1310552 A3 EP1310552 A3 EP 1310552A3
Authority
EP
European Patent Office
Prior art keywords
nucleic acids
related methods
polypeptides
posh nucleic
posh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02257796A
Other languages
English (en)
French (fr)
Other versions
EP1310552A2 (de
EP1310552B1 (de
Inventor
Iris Alroy
Shmuel Tuvia
Tsvika Greener
Danny Ben-Avraham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proteologics Inc
Original Assignee
Proteologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteologics Inc filed Critical Proteologics Inc
Publication of EP1310552A2 publication Critical patent/EP1310552A2/de
Publication of EP1310552A3 publication Critical patent/EP1310552A3/de
Priority to AU2003304109A priority Critical patent/AU2003304109A1/en
Priority to PCT/US2003/035712 priority patent/WO2004098492A2/en
Priority to US11/127,559 priority patent/US20060287337A1/en
Application granted granted Critical
Publication of EP1310552B1 publication Critical patent/EP1310552B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y603/00Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02019Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP02257796A 2001-11-09 2002-11-11 Posh Nukleinsäure, Polypeptide und darauf bezogene Verfahren Expired - Lifetime EP1310552B1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003304109A AU2003304109A1 (en) 2002-11-11 2003-11-10 Trans-golgi network-associated processes, methods and compositions related thereto
PCT/US2003/035712 WO2004098492A2 (en) 2002-11-11 2003-11-10 Trans-golgi network-associated processes, methods and compositions related thereto
US11/127,559 US20060287337A1 (en) 2001-11-09 2005-05-11 Trans-golgi network-associated processes, methods and compositions related thereto

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34584601P 2001-11-09 2001-11-09
US345846P 2001-11-09
US36453002P 2002-03-15 2002-03-15
US364530P 2002-03-15

Publications (3)

Publication Number Publication Date
EP1310552A2 EP1310552A2 (de) 2003-05-14
EP1310552A3 true EP1310552A3 (de) 2003-10-08
EP1310552B1 EP1310552B1 (de) 2007-06-13

Family

ID=26994569

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02257796A Expired - Lifetime EP1310552B1 (de) 2001-11-09 2002-11-11 Posh Nukleinsäure, Polypeptide und darauf bezogene Verfahren

Country Status (10)

Country Link
US (4) US7250250B2 (de)
EP (1) EP1310552B1 (de)
JP (1) JP2005519636A (de)
AT (1) ATE364690T1 (de)
AU (1) AU2002365160C1 (de)
CA (1) CA2465973C (de)
DE (1) DE60220621T2 (de)
IL (2) IL161764A0 (de)
NZ (1) NZ532908A (de)
WO (1) WO2003095971A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106754883B (zh) * 2016-12-30 2019-10-29 中山大学 一种一步、无缝、非同源、多片段的基因拼接改造方法及其试剂盒

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE458485T1 (de) 2003-07-11 2010-03-15 Proteologics Inc Ubiquitin-ligase-hemmer und verwandte verfahren
US20060188890A1 (en) * 2003-10-31 2006-08-24 Proteologics, Inc. Ubiquitin-based protein interaction assays and related compositions
WO2006044747A2 (en) * 2004-10-15 2006-04-27 Signal Pharmaceuticals, Llc P27 ubiquitination assay and methods of use
EP1820024B1 (de) 2004-12-01 2012-06-13 Proteologics, Ltd Ubiquitin-ligase-assays und verwandte reagenzien
JP2008092911A (ja) * 2006-10-16 2008-04-24 Univ Of Tokyo タンパク質結合検出方法
EP2196794A4 (de) 2007-08-30 2014-04-02 Mitsui Shipbuilding Eng Fret-nachweisverfahren und -vorrichtung
US8691971B2 (en) 2008-09-23 2014-04-08 Scott G. Petersen Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
US9901617B2 (en) * 2013-08-14 2018-02-27 The Curators Of The University Of Missouri Cell permeable inhibitors of the scaffold protein plenty of SH3 domains (POSH) or Sh3Rfl
WO2018085208A1 (en) 2016-11-02 2018-05-11 The Research Foundation For The State University Of New York Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction
CN112764372A (zh) * 2020-12-25 2021-05-07 天津大学 基于vpx架构的多通道信号采集系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053719A2 (en) * 2001-01-04 2002-07-11 Incyte Genomics, Inc. Cytoskeleton-associated proteins
WO2002079449A2 (en) * 2001-03-28 2002-10-10 Incyte Genomics, Inc. Molecules for disease detection and treatment

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000008181A2 (en) * 1998-08-07 2000-02-17 Onyx Pharmaceuticals, Inc. Chp polypeptide, a ligand of pak65
CN1334875A (zh) * 1998-10-13 2002-02-06 昂尼克斯药物公司 新颖的细胞信号多肽和核酸
WO2000027865A1 (en) 1998-11-06 2000-05-18 The Brigham And Women's Hospital, Inc. CHARACTERIZATION OF NOVEL GENE cbl-SL
WO2001088088A2 (en) 2000-05-18 2001-11-22 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001064835A2 (en) 2000-02-28 2001-09-07 Hyseq, Inc. Novel nucleic acids and polypeptides
EP1074617A3 (de) 1999-07-29 2004-04-21 Research Association for Biotechnology Primers für Synthese von ganzen-Länge cDNS und deren Anwendung
AU7701100A (en) 1999-09-03 2001-04-10 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
WO2001055301A2 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
CA2399776A1 (en) 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001060860A2 (en) 2000-02-17 2001-08-23 Millennium Predictive Medicine, Inc. Genes differentially expressed in human prostate cancer and their use
WO2001070979A2 (en) 2000-03-21 2001-09-27 Millennium Pharmaceuticals, Inc. Genes, compositions, kits, and method for identification, assessment, prevention and therapy of ovarian cancer
AU2001245945A1 (en) 2000-03-23 2001-10-03 Pe Corporation (Ny) Detection kits, such as nucleic acid arrays, for detecting the expression of 10,000 or more drosophila genes and uses thereof
AU2001247899A1 (en) 2000-04-06 2001-10-23 Genetics Institute, Llc Polynucleotides encoding novel secreted proteins
EP1339872A2 (de) 2000-09-19 2003-09-03 Whitehead Institute For Biomedical Research Genetische marker für tumore
EP1629082A4 (de) 2000-10-20 2009-07-22 Univ Massachusetts Mit glucosetransport in zusammenhang stehende gene und deren verwendungen
EP1334113A4 (de) 2000-10-20 2007-08-08 Expression Diagnostics Inc Erstellen von leukozytenexpressionsprofilen
AU2002241520A1 (en) 2000-11-28 2003-03-03 University Of Cincinnati Blood assessment of injury
WO2002077235A2 (en) 2000-12-21 2002-10-03 Incyte Genomics, Inc. Intracellular signaling molecules
JP2005503760A (ja) 2001-01-24 2005-02-10 プロテイン デザイン ラブス, インコーポレイテッド 乳癌の診断方法、組成物および乳癌のモジュレーターのスクリーニング方法
US6743619B1 (en) 2001-01-30 2004-06-01 Nuvelo Nucleic acids and polypeptides
JP2004536575A (ja) 2001-02-28 2004-12-09 コンドロジーン・インコーポレイテッド 変形性関節症に関連する組成物および方法
US20040236091A1 (en) 2001-03-28 2004-11-25 Chicz Roman M. Translational profiling
WO2002085285A2 (en) 2001-04-18 2002-10-31 Wyeth Methods and reagents for regulating bone and cartilage formation
CA2447357A1 (en) 2001-05-22 2002-11-28 Gene Logic, Inc. Molecular toxicology modeling
WO2003022987A2 (en) 2001-07-26 2003-03-20 Eos Biotechnology, Inc. Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection
WO2003033646A2 (en) 2001-07-31 2003-04-24 Proteologics, Inc. Compositions and methods for the modulation of viral maturation
AU2002330039A1 (en) 2001-09-17 2003-04-01 Eos Biotechnology, Inc. Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
MXPA04003382A (es) 2001-10-31 2004-11-22 Pfizer Prod Inc Agentes terapeuticos y diagnostico para transtornos de la eritropoyesis.
WO2003039490A2 (en) 2001-11-09 2003-05-15 Office Of Technology Licensing Stanford University Compositions and methods for diagnosing and treating mental disorders
US20040096828A1 (en) * 2002-01-04 2004-05-20 Lu Dyung Aina M Cytoskeleton-associated proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053719A2 (en) * 2001-01-04 2002-07-11 Incyte Genomics, Inc. Cytoskeleton-associated proteins
WO2002079449A2 (en) * 2001-03-28 2002-10-10 Incyte Genomics, Inc. Molecules for disease detection and treatment

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GENSEQ [online] 12 February 2003 (2003-02-12), DAFFO,A. ET AL.: "Human MDDT polypeptide SEQ ID NO 542", XP002250464, Database accession no. ABU11595 *
TAPON NICOLAS ET AL: "A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 17, no. 5, 2 March 1998 (1998-03-02), pages 1395 - 1404, XP002250463, ISSN: 0261-4189 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106754883B (zh) * 2016-12-30 2019-10-29 中山大学 一种一步、无缝、非同源、多片段的基因拼接改造方法及其试剂盒

Also Published As

Publication number Publication date
AU2002365160A1 (en) 2003-11-11
IL161764A (en) 2010-12-30
WO2003095971A3 (en) 2005-04-28
CA2465973A1 (en) 2003-11-20
US7250250B2 (en) 2007-07-31
EP1310552A2 (de) 2003-05-14
JP2005519636A (ja) 2005-07-07
WO2003095971A2 (en) 2003-11-20
CA2465973C (en) 2013-04-16
AU2002365160B2 (en) 2008-10-30
US7429643B2 (en) 2008-09-30
AU2002365160C1 (en) 2009-08-13
NZ532908A (en) 2008-04-30
HK1055996A1 (en) 2004-01-30
US20040025196A1 (en) 2004-02-05
US7268227B2 (en) 2007-09-11
ATE364690T1 (de) 2007-07-15
US20080187538A1 (en) 2008-08-07
DE60220621D1 (de) 2007-07-26
EP1310552B1 (de) 2007-06-13
IL161764A0 (en) 2005-11-20
DE60220621T2 (de) 2008-03-06
US20060035213A1 (en) 2006-02-16
US20060019240A1 (en) 2006-01-26

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