EP1315510A4 - Verfahren und zusammensetzungen zur reparatur und/oder regeneration des beschädigten herzmuskels - Google Patents

Verfahren und zusammensetzungen zur reparatur und/oder regeneration des beschädigten herzmuskels

Info

Publication number
EP1315510A4
EP1315510A4 EP01961855A EP01961855A EP1315510A4 EP 1315510 A4 EP1315510 A4 EP 1315510A4 EP 01961855 A EP01961855 A EP 01961855A EP 01961855 A EP01961855 A EP 01961855A EP 1315510 A4 EP1315510 A4 EP 1315510A4
Authority
EP
European Patent Office
Prior art keywords
myocarde
regeneration
repair
damaged
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01961855A
Other languages
English (en)
French (fr)
Other versions
EP1315510A2 (de
Inventor
Piero Anversa
Donald Orlic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Medical College
Government of the United States of America
Original Assignee
New York Medical College
United States Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Medical College, United States Department of Health and Human Services filed Critical New York Medical College
Publication of EP1315510A2 publication Critical patent/EP1315510A2/de
Publication of EP1315510A4 publication Critical patent/EP1315510A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Dental Preparations (AREA)
EP01961855A 2000-07-31 2001-07-31 Verfahren und zusammensetzungen zur reparatur und/oder regeneration des beschädigten herzmuskels Withdrawn EP1315510A4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22190200P 2000-07-31 2000-07-31
US221902P 2000-07-31
US25856400P 2000-12-29 2000-12-29
US258564P 2000-12-29
US25880501P 2001-01-02 2001-01-02
US258805P 2001-01-02
PCT/US2001/024223 WO2002013760A2 (en) 2000-07-31 2001-07-31 Methods and compositions for the repair and/or regeneration of damaged myocardium

Publications (2)

Publication Number Publication Date
EP1315510A2 EP1315510A2 (de) 2003-06-04
EP1315510A4 true EP1315510A4 (de) 2005-08-03

Family

ID=27397004

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01961855A Withdrawn EP1315510A4 (de) 2000-07-31 2001-07-31 Verfahren und zusammensetzungen zur reparatur und/oder regeneration des beschädigten herzmuskels

Country Status (4)

Country Link
EP (1) EP1315510A4 (de)
AU (1) AU2001283088A1 (de)
CA (1) CA2423592A1 (de)
WO (1) WO2002013760A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412479A4 (de) 2001-07-12 2004-07-28 Geron Corp Aus menschlichen pluripotenten stammzellen produzierte zellen mit kardiomyozytenabstammung
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
AU2003250666A1 (en) 2002-07-29 2004-02-16 Asahi Kasei Kabushiki Kaisha Stem cells for treating pancreatic damage
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
US20110076255A1 (en) 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
US8637005B2 (en) 2005-11-07 2014-01-28 Amorcyte, Inc. Compositions and methods of vascular injury repair
WO2007055905A2 (en) 2005-11-07 2007-05-18 Amorcyte, Inc. Compositions and methods of vascular injury repair
US7998740B2 (en) * 2006-07-18 2011-08-16 Robert Sackstein Cytokine induction of selectin ligands on cells
EP2227238A2 (de) 2007-11-30 2010-09-15 New York Medical College Zusammensetzungen mit vaskulären und myozyten-vorläuferzellen und anwendungsverfahren davon
AU2008333972A1 (en) * 2007-11-30 2009-06-11 New York Medical College Compositions comprising HDAC inhibitors and methods of their use in restoring stem cell function and preventing heart failure
US8512696B2 (en) 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
WO2009073594A1 (en) 2007-11-30 2009-06-11 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
CN101939418A (zh) 2008-01-30 2011-01-05 杰龙公司 用于培养干细胞衍生的心肌细胞的合成表面
BRPI0920976A2 (pt) 2008-12-03 2015-08-18 Amorcyte Inc Composições que melhoram a perfusão da area de infarto e metodos de restauração da lesão vascular.
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
WO2013184527A1 (en) 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP3563859B1 (de) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Von kardiosphären abgeleitete exosomen zur geweberegeneration
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
EP3402543B1 (de) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Aus kardiosphäre stammende zellen und durch solche zellen sekretierte exosomen in der behandlung von herzversagen mit konservierter auswurffraktion
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
EP3612191B1 (de) 2017-04-19 2026-03-11 Cedars-Sinai Medical Center Verfahren und zusammensetzungen zur behandlung von skelettmuskeldystrophie
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (de) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center Verfahren zur therapeutischen verwendung von exosomen und y-rnas
CN118490802B (zh) * 2024-05-31 2025-03-18 中国人民解放军海军特色医学中心 一种用于改善运动心肌损伤的组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018486A1 (en) * 1996-10-25 1998-05-07 Icogen Corporation Use of leptin to stimulate hematopoiesis
WO2000006701A1 (en) * 1998-07-31 2000-02-10 Genzyme Corporation Improvement of cardiac function by mesenchymal stem cell transplantation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018486A1 (en) * 1996-10-25 1998-05-07 Icogen Corporation Use of leptin to stimulate hematopoiesis
WO2000006701A1 (en) * 1998-07-31 2000-02-10 Genzyme Corporation Improvement of cardiac function by mesenchymal stem cell transplantation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TOMITA S ET AL: "AUTOLOGOUS TRANSPLANTATION OF BONE MARROW CELLS IMPROVES DAMAGED HEART FUNCTION", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 110, no. SUPPL 19, 9 November 1999 (1999-11-09), pages II - 247, XP000869909, ISSN: 0009-7322 *
TOMITA S ET AL: "AUTOTRANSPLANTED MESENCHYMAL STEM CELLS IMPROVE FUNCTION AFTER A MYOCARDIAL INFARCTION", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 98, no. 17, SUPPL, 27 October 1998 (1998-10-27), pages I - 200, XP009032355, ISSN: 0009-7322 *

Also Published As

Publication number Publication date
CA2423592A1 (en) 2002-02-21
EP1315510A2 (de) 2003-06-04
AU2001283088A1 (en) 2002-02-25
WO2002013760A3 (en) 2002-04-18
WO2002013760A2 (en) 2002-02-21
WO2002013760A9 (en) 2003-09-04

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS

Owner name: NEW YORK MEDICAL COLLEGE

A4 Supplementary search report drawn up and despatched

Effective date: 20050616

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 9/10 B

Ipc: 7A 61K 35/28 A

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20060301