EP1325123A4 - INHIBITION OF STENOSIS OR RESTENOSIS USING P-SELECTINE ANTAGONISTS - Google Patents

INHIBITION OF STENOSIS OR RESTENOSIS USING P-SELECTINE ANTAGONISTS

Info

Publication number: EP1325123A4
Authority: EP; European Patent Office
Prior art keywords: selectine; stenosis; restenosis; antagonists; inhibition
Prior art date: 2000-09-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP00963389A

Other languages

German (de)

French (fr)

Other versions

EP1325123A1 (en

Inventor

Anjali Kumar

Robert G Schuab

Jean-Francois Tanguay

Yahye Merhi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Institut de Cardiologie de Montreal

Genetics Institute LLC

Montreal Heart Inst

Original Assignee

Institut de Cardiologie de Montreal

Genetics Institute LLC

Montreal Heart Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-12

Filing date

2000-09-12

Publication date

2004-07-21

2000-09-12 Application filed by Institut de Cardiologie de Montreal, Genetics Institute LLC, Montreal Heart Inst filed Critical Institut de Cardiologie de Montreal

2003-07-09 Publication of EP1325123A1 publication Critical patent/EP1325123A1/en

2004-07-21 Publication of EP1325123A4 publication Critical patent/EP1325123A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Immunology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP00963389A 2000-09-12 2000-09-12 INHIBITION OF STENOSIS OR RESTENOSIS USING P-SELECTINE ANTAGONISTS Withdrawn EP1325123A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2000/025007 WO2002022820A1 (en)	2000-09-12	2000-09-12	Inhibition of stenosis or restenosis by p-selectin antagonists

Publications (2)

Publication Number	Publication Date
EP1325123A1 EP1325123A1 (en)	2003-07-09
EP1325123A4 true EP1325123A4 (en)	2004-07-21

Family

ID=21741767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP00963389A Withdrawn EP1325123A4 (en)	2000-09-12	2000-09-12	INHIBITION OF STENOSIS OR RESTENOSIS USING P-SELECTINE ANTAGONISTS

Country Status (3)

Country	Link
EP (1)	EP1325123A4 (en)
AU (1)	AU2000274809A1 (en)
WO (1)	WO2002022820A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003097658A2 (en)	2002-05-16	2003-11-27	Glycomimetics, Inc.	Compounds and methods for inhibiting selectin-mediated function
EP1763533B1 (en)	2003-11-19	2008-01-09	GlycoMimetics, Inc.	Specific antagonist for both e- and p-selectins
UY28886A1 (en)	2004-05-10	2005-12-30	Boehringer Ingelheim Int	ANTIBODIES CONSISTING IN POLYPEPTIDES AND DERIVATIVES UNDERSTANDING THREE SEQUENCES CONCERNING THE FOLLOWING NUMBERS OF SEQ. ID: 1-3 AND 4-6; 7-9 AND 10-12 AND 13-15 OR 16-18
ES2655833T3 (en) *	2004-05-11	2018-02-21	AbGenomics Coöperatief U.A.	Epitopes that induce the death of T cells
CN101291946B (en)	2005-08-09	2011-06-29	糖模拟物有限公司	Glycomimetic inhibitors of PA-IL lectin, PA-IIL lectin, or both from Pseudomonas
PL2264043T3 (en)	2005-09-02	2018-04-30	Glycomimetics, Inc.	Heterobifunctional pan-selectin inhibitors
WO2009126556A1 (en)	2008-04-08	2009-10-15	Glycomimetics, Inc.	Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8921328B2 (en)	2010-09-14	2014-12-30	Glycomimetics, Inc.	E-selectin antagonists
EP2718325A4 (en)	2011-06-13	2015-03-11	ABGENOMICS COöPERATIEF U A	ANTI-PSGL-1 ANTIBODIES AND USES THEREOF
KR102055958B1 (en)	2011-12-22	2019-12-13	글리코미메틱스, 인크.	E-selectin antagonist compounds, compositions, and methods of use
US9867841B2 (en)	2012-12-07	2018-01-16	Glycomimetics, Inc.	Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
JP6689854B2 (en)	2014-12-03	2020-04-28	グリコミメティクス，インコーポレイテッド	Heterobifunctional inhibitors of E-selectin and CXCR4 chemokine receptors
JP2019502727A (en)	2016-01-22	2019-01-31	グリコミメティクス，インコーポレイテッド	PA-IL and / or PA-IIL lectin glycomimetic inhibitors
WO2017151708A1 (en)	2016-03-02	2017-09-08	Glycomimetics, Inc.	Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en)	2016-08-08	2022-09-06	Glycomimetics, Inc.	Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
AU2017341065B2 (en)	2016-10-07	2023-04-06	Crescent Biopharma, Inc.	Highly potent multimeric E-selectin antagonists
EP3596096A1 (en)	2017-03-15	2020-01-22	GlycoMimetics, Inc.	Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
JP7275131B2 (en)	2017-11-30	2023-05-17	グリコミメティクス，インコーポレイテッド	Methods of mobilizing bone marrow-infiltrating lymphocytes and uses thereof
KR20200104889A (en)	2017-12-29	2020-09-04	글리코미메틱스, 인크.	E-selectin and heterobifunctional inhibitors of galectin-3
KR20200128025A (en)	2018-03-05	2020-11-11	글리코미메틱스, 인크.	Methods of treatment of acute myeloid leukemia and related conditions
US11845771B2 (en)	2018-12-27	2023-12-19	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectin and galectin-3

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995033484A1 (en) *	1994-06-03	1995-12-14	Center For Blood Research, Inc.	Method for treating and preventing atherosclerosis
WO1999043834A2 (en) *	1998-02-27	1999-09-02	Genetics Institute, Inc.	P-selectin ligand protein, including tetrameric fusion proteins
WO2001075107A2 (en) *	2000-03-31	2001-10-11	Genetics Institute, Llc.	Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994010309A1 (en) *	1992-10-23	1994-05-11	Genetics Institute, Inc.	Novel p-selectin ligand protein
WO1995030001A2 (en) *	1994-04-28	1995-11-09	Genetics Institute, Inc.	Novel p-selectin ligand protein
KR100523506B1 (en) *	1995-08-03	2005-10-24		Peptide and O-glycan inhibitors of selectin mediated inflammation
JP2002518354A (en) *	1998-06-16	2002-06-25	ザボードオブリージェンツオブザユニヴァーシティーオブオクラホマ	Glycosulfate peptides, their synthesis and use

2000
- 2000-09-12 EP EP00963389A patent/EP1325123A4/en not_active Withdrawn
- 2000-09-12 AU AU2000274809A patent/AU2000274809A1/en not_active Abandoned
- 2000-09-12 WO PCT/US2000/025007 patent/WO2002022820A1/en not_active Ceased

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995033484A1 (en) *	1994-06-03	1995-12-14	Center For Blood Research, Inc.	Method for treating and preventing atherosclerosis
WO1999043834A2 (en) *	1998-02-27	1999-09-02	Genetics Institute, Inc.	P-selectin ligand protein, including tetrameric fusion proteins
WO2001075107A2 (en) *	2000-03-31	2001-10-11	Genetics Institute, Llc.	Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BIENVENU J G ET AL: "Effect of a recombinant soluble P-selectin glycoprotein ligand-1 on restenosis following arterial injury by repeat angioplasty in pigs", CANADIAN JOURNAL OF CARDIOLOGY, vol. 16, no. Supplement F, September 2000 (2000-09-01), 53rd Annual Meeting of the Canadian Cardiovascular Society;Vancouver, British Columbia, Canada; October 20-November 01, 2000, pages 213F - 214F, XP009031375, ISSN: 0828-282X *
BIENVENU JEAN-GUY ET AL: "Effect of a recombinant soluble P-Selectin Glycoprotein Ligand-1 chimera on restenosis following arterial injury by repeat angioplasty in pigs", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, no. 2 suppl. A, February 2000 (2000-02-01), 29th Annual Scientific Session of the American College of Cardiology.;Anaheim, California, USA; March 12-15, 2000, pages 16A, XP001180900, ISSN: 0735-1097 *
BIENVENU JEAN-GUY ET AL: "Effect of recombinant P-Selectin-Glycoprotein-Ligand-Ig on platelet and neutrophil adhesion following repeat angioplasty in pigs", CIRCULATION, vol. 100, no. 18 SUPPL., 2 November 1999 (1999-11-02), 72nd Scientific Sessions of the American Heart Association;Atlanta, Georgia, USA; November 7-10, 1999, pages I.610, XP009031374, ISSN: 0009-7322 *
CARON A ET AL: "Effect of selectin blockade on porcine and human platelet-neutrophil binding", FASEB JOURNAL, vol. 13, no. 5 PART 2, 15 March 1999 (1999-03-15), Annual Meeting of the Professional Research Scientists on Experimental Biology 99;Washington, D.C., USA; April 17-21, 1999, pages A838, XP009031371, ISSN: 0892-6638 *
KUMAR A ET AL: "RECOMBINANT SOLUBLE FORM OF PSGL-1 ACCELERATES THROMBOLYSIS AND PREVENTS REOCCLUSION IN A PORCINE MODEL", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 99, no. 10, 16 March 1999 (1999-03-16), pages 1363 - 1369, XP001034254, ISSN: 0009-7322 *
KUMAR ET AL.: "Remodeling and neointimal formation in the carotid artery of normal and P-selectin-deficient mice", CIRCULATION, vol. 96, 1997, pages 4333 - 4342 *
MERHI YAHYE ET AL: "Selectin blockade reduces neutrophil interaction with platelets at the site of deep arterial injury by angioplasty in pigs", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 19, no. 2, February 1999 (1999-02-01), pages 372 - 377, XP002282340, ISSN: 1079-5642 *
See also references of WO0222820A1 *
WAKEFIELD T W ET AL: "VENOUS THROMBOSIS PROPHYLAXIS BY INFLAMMATORY INHIBITION WITHOUT ANTICOAGULATION THERAPY", JOURNAL OF VASCULAR SURGERY, C.V. MOSBY CO., ST. LOUIS, MO, US, vol. 31, no. 2, February 2000 (2000-02-01), pages 309 - 324, XP001034251, ISSN: 0741-5214 *

Also Published As

Publication number	Publication date
AU2000274809A1 (en)	2002-03-26
EP1325123A1 (en)	2003-07-09
WO2002022820A1 (en)	2002-03-21

Legal Events

Date	Code	Title	Description
2003-05-23	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2003-07-09	17P	Request for examination filed	Effective date: 20030414
2003-07-09	AK	Designated contracting states	Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2003-07-09	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2004-01-14	RIN1	Information on inventor provided before grant (corrected)	Inventor name: MERHI, YAHYE Inventor name: TANGUAY, JEAN-FRANCOIS Inventor name: SCHUAB, ROBERT, G. Inventor name: KUMAR, ANJALI
2004-07-21	A4	Supplementary search report drawn up and despatched	Effective date: 20040609
2004-11-17	17Q	First examination report despatched	Effective date: 20040930
2007-03-07	17Q	First examination report despatched	Effective date: 20040930
2008-01-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2008-02-06	18D	Application deemed to be withdrawn	Effective date: 20070817

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