EP1325123A4 - Stenose- bzw. restenosehemmung durch p-selectin-antagonisten - Google Patents

Stenose- bzw. restenosehemmung durch p-selectin-antagonisten

Info

Publication number
EP1325123A4
EP1325123A4 EP00963389A EP00963389A EP1325123A4 EP 1325123 A4 EP1325123 A4 EP 1325123A4 EP 00963389 A EP00963389 A EP 00963389A EP 00963389 A EP00963389 A EP 00963389A EP 1325123 A4 EP1325123 A4 EP 1325123A4
Authority
EP
European Patent Office
Prior art keywords
selectine
stenosis
restenosis
antagonists
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00963389A
Other languages
English (en)
French (fr)
Other versions
EP1325123A1 (de
Inventor
Anjali Kumar
Robert G Schuab
Jean-Francois Tanguay
Yahye Merhi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut de Cardiologie de Montreal
Genetics Institute LLC
Montreal Heart Inst
Original Assignee
Institut de Cardiologie de Montreal
Genetics Institute LLC
Montreal Heart Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut de Cardiologie de Montreal, Genetics Institute LLC, Montreal Heart Inst filed Critical Institut de Cardiologie de Montreal
Publication of EP1325123A1 publication Critical patent/EP1325123A1/de
Publication of EP1325123A4 publication Critical patent/EP1325123A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP00963389A 2000-09-12 2000-09-12 Stenose- bzw. restenosehemmung durch p-selectin-antagonisten Withdrawn EP1325123A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/025007 WO2002022820A1 (en) 2000-09-12 2000-09-12 Inhibition of stenosis or restenosis by p-selectin antagonists

Publications (2)

Publication Number Publication Date
EP1325123A1 EP1325123A1 (de) 2003-07-09
EP1325123A4 true EP1325123A4 (de) 2004-07-21

Family

ID=21741767

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00963389A Withdrawn EP1325123A4 (de) 2000-09-12 2000-09-12 Stenose- bzw. restenosehemmung durch p-selectin-antagonisten

Country Status (3)

Country Link
EP (1) EP1325123A4 (de)
AU (1) AU2000274809A1 (de)
WO (1) WO2002022820A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097658A2 (en) 2002-05-16 2003-11-27 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
EP1763533B1 (de) 2003-11-19 2008-01-09 GlycoMimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
UY28886A1 (es) 2004-05-10 2005-12-30 Boehringer Ingelheim Int Anticuerpos que consisten en polipéptidos y derivados conprendiendo tres secuencias conteniendo respectivamente los siguientes números de seq. id: 1-3 y 4-6; 7-9 y 10-12 y 13-15 ó 16-18
ES2655833T3 (es) * 2004-05-11 2018-02-21 AbGenomics Coöperatief U.A. Epítopos que inducen la muerte de células T
CN101291946B (zh) 2005-08-09 2011-06-29 糖模拟物有限公司 对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂
PL2264043T3 (pl) 2005-09-02 2018-04-30 Glycomimetics, Inc. Heterobifunkcyjne inhibitory pan-selektyny
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
EP2718325A4 (de) 2011-06-13 2015-03-11 ABGENOMICS COöPERATIEF U A Anti-psgl-1 antikörper und verwendungen davon
KR102055958B1 (ko) 2011-12-22 2019-12-13 글리코미메틱스, 인크. E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
JP6689854B2 (ja) 2014-12-03 2020-04-28 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
JP2019502727A (ja) 2016-01-22 2019-01-31 グリコミメティクス， インコーポレイテッド Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
AU2017341065B2 (en) 2016-10-07 2023-04-06 Crescent Biopharma, Inc. Highly potent multimeric E-selectin antagonists
EP3596096A1 (de) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl-derivate als e-selectin-antagonisten
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
KR20200104889A (ko) 2017-12-29 2020-09-04 글리코미메틱스, 인크. E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제
KR20200128025A (ko) 2018-03-05 2020-11-11 글리코미메틱스, 인크. 급성 골수성 백혈병 및 관련 병태의 치료 방법
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033484A1 (en) * 1994-06-03 1995-12-14 Center For Blood Research, Inc. Method for treating and preventing atherosclerosis
WO1999043834A2 (en) * 1998-02-27 1999-09-02 Genetics Institute, Inc. P-selectin ligand protein, including tetrameric fusion proteins
WO2001075107A2 (en) * 2000-03-31 2001-10-11 Genetics Institute, Llc. Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010309A1 (en) * 1992-10-23 1994-05-11 Genetics Institute, Inc. Novel p-selectin ligand protein
WO1995030001A2 (en) * 1994-04-28 1995-11-09 Genetics Institute, Inc. Novel p-selectin ligand protein
KR100523506B1 (en) * 1995-08-03 2005-10-24 Peptide and O-glycan inhibitors of selectin mediated inflammation
JP2002518354A (ja) * 1998-06-16 2002-06-25 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ 糖硫酸ペプチド、その合成方法および使用方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033484A1 (en) * 1994-06-03 1995-12-14 Center For Blood Research, Inc. Method for treating and preventing atherosclerosis
WO1999043834A2 (en) * 1998-02-27 1999-09-02 Genetics Institute, Inc. P-selectin ligand protein, including tetrameric fusion proteins
WO2001075107A2 (en) * 2000-03-31 2001-10-11 Genetics Institute, Llc. Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BIENVENU J G ET AL: "Effect of a recombinant soluble P-selectin glycoprotein ligand-1 on restenosis following arterial injury by repeat angioplasty in pigs", CANADIAN JOURNAL OF CARDIOLOGY, vol. 16, no. Supplement F, September 2000 (2000-09-01), 53rd Annual Meeting of the Canadian Cardiovascular Society;Vancouver, British Columbia, Canada; October 20-November 01, 2000, pages 213F - 214F, XP009031375, ISSN: 0828-282X *
BIENVENU JEAN-GUY ET AL: "Effect of a recombinant soluble P-Selectin Glycoprotein Ligand-1 chimera on restenosis following arterial injury by repeat angioplasty in pigs", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, no. 2 suppl. A, February 2000 (2000-02-01), 29th Annual Scientific Session of the American College of Cardiology.;Anaheim, California, USA; March 12-15, 2000, pages 16A, XP001180900, ISSN: 0735-1097 *
BIENVENU JEAN-GUY ET AL: "Effect of recombinant P-Selectin-Glycoprotein-Ligand-Ig on platelet and neutrophil adhesion following repeat angioplasty in pigs", CIRCULATION, vol. 100, no. 18 SUPPL., 2 November 1999 (1999-11-02), 72nd Scientific Sessions of the American Heart Association;Atlanta, Georgia, USA; November 7-10, 1999, pages I.610, XP009031374, ISSN: 0009-7322 *
CARON A ET AL: "Effect of selectin blockade on porcine and human platelet-neutrophil binding", FASEB JOURNAL, vol. 13, no. 5 PART 2, 15 March 1999 (1999-03-15), Annual Meeting of the Professional Research Scientists on Experimental Biology 99;Washington, D.C., USA; April 17-21, 1999, pages A838, XP009031371, ISSN: 0892-6638 *
KUMAR A ET AL: "RECOMBINANT SOLUBLE FORM OF PSGL-1 ACCELERATES THROMBOLYSIS AND PREVENTS REOCCLUSION IN A PORCINE MODEL", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 99, no. 10, 16 March 1999 (1999-03-16), pages 1363 - 1369, XP001034254, ISSN: 0009-7322 *
KUMAR ET AL.: "Remodeling and neointimal formation in the carotid artery of normal and P-selectin-deficient mice", CIRCULATION, vol. 96, 1997, pages 4333 - 4342 *
MERHI YAHYE ET AL: "Selectin blockade reduces neutrophil interaction with platelets at the site of deep arterial injury by angioplasty in pigs", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 19, no. 2, February 1999 (1999-02-01), pages 372 - 377, XP002282340, ISSN: 1079-5642 *
See also references of WO0222820A1 *
WAKEFIELD T W ET AL: "VENOUS THROMBOSIS PROPHYLAXIS BY INFLAMMATORY INHIBITION WITHOUT ANTICOAGULATION THERAPY", JOURNAL OF VASCULAR SURGERY, C.V. MOSBY CO., ST. LOUIS, MO, US, vol. 31, no. 2, February 2000 (2000-02-01), pages 309 - 324, XP001034251, ISSN: 0741-5214 *

Also Published As

Publication number Publication date
AU2000274809A1 (en) 2002-03-26
EP1325123A1 (de) 2003-07-09
WO2002022820A1 (en) 2002-03-21

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20030414

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MERHI, YAHYE

Inventor name: TANGUAY, JEAN-FRANCOIS

Inventor name: SCHUAB, ROBERT, G.

Inventor name: KUMAR, ANJALI

A4 Supplementary search report drawn up and despatched

Effective date: 20040609

17Q First examination report despatched

Effective date: 20040930

17Q First examination report despatched

Effective date: 20040930

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20070817