EP1343539A2 - Substances de taille nanom trique dans des produits d'hygi ne - Google Patents

Substances de taille nanom trique dans des produits d'hygi ne

Info

Publication number
EP1343539A2
EP1343539A2 EP01994777A EP01994777A EP1343539A2 EP 1343539 A2 EP1343539 A2 EP 1343539A2 EP 01994777 A EP01994777 A EP 01994777A EP 01994777 A EP01994777 A EP 01994777A EP 1343539 A2 EP1343539 A2 EP 1343539A2
Authority
EP
European Patent Office
Prior art keywords
acid
acids
propyl
nanoparticles
cooh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01994777A
Other languages
German (de)
English (en)
Inventor
Christian Kropf
Claudia Hundeiker
Melita Heller
Christine Wild
Raymond Mathis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cognis IP Management GmbH
Original Assignee
Henkel AG and Co KGaA
Cognis Deutschland GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel AG and Co KGaA, Cognis Deutschland GmbH and Co KG filed Critical Henkel AG and Co KGaA
Publication of EP1343539A2 publication Critical patent/EP1343539A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/04—Compounds of zinc
    • C09C1/043—Zinc oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84—Accessories, not otherwise provided for, for absorbent pads
    • A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/51—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads
    • A61F13/511—Topsheet, i.e. the permeable cover or layer facing the skin
    • A61F13/51113—Topsheet, i.e. the permeable cover or layer facing the skin comprising an additive, e.g. lotion or odour control
    • A61F2013/51117—Topsheet, i.e. the permeable cover or layer facing the skin comprising an additive, e.g. lotion or odour control the lotion having skin care properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer

Definitions

  • the present invention relates to the field of hygiene products, in particular the field of diapers for babies and adults (incontinence products), panty liners and tampons.
  • the present invention relates to the use of nanoscale particles in such hygiene products.
  • Hygiene products of the type described above are used to absorb urine, faeces, blood and sweat, which the body has excreted. Due to the excretion products, there is an alkaline environment in the wearing situation. This in turn can activate enzymes that attack the skin and thereby cause irritation and / or inflammation of the skin such as diaper rash. Since the excretions also provide a moist to wet environment, the complaints mentioned can occur all the faster, not least because of the rubbing of the hygiene product on the skin. On the other hand, longer wearing times can also lead to odor nuisance, since certain constituents of the excretion products are decomposed.
  • Baby diapers are already known which contain a lotion for skin care on the surface facing the skin (fleece) (Procter & Gamble).
  • topical compositions which contain ZnO with a large surface area (30 to 100 m 2 / g) and with an average particle size of 0.1 to 200 ⁇ m (in diameter). These compositions are particularly recommended for the absorption of body fluids such as sweat, sebum (sebum), urine and water.
  • body fluids such as sweat, sebum (sebum), urine and water.
  • the effect (eg in the treatment of acne or diaper eczema) of the ZnO is attributed to its good antibacterial (antiseptic) effectiveness.
  • the known products have several very important disadvantages: First of all, the fact that classic absorption materials do not influence the pH is disadvantageous. The consequence is the basic environment already mentioned above, through which the skin is irritated. Another disadvantage is that the comparatively large particles or agglomerates on the skin are responsible for a bad feeling. Other disadvantages are also due to the large particle size. This is firstly a large particle requirement and secondly poor stability in the application systems due to sedimentation of the relatively large particles. Finally and thirdly, another disadvantage of the known products is that there is an increased risk of skin irritation due to abrasion due to large particles / agglomerates.
  • EP-A 0 791 681 describes ZnO particles with an average particle size of not more than 100 nm, which are used to coat substrates (such as synthetic, natural and inorganic fibers) are suitable.
  • the substrates with the ZnO particles have an antibacterial effect and suppress odors.
  • the task that the inventors have set themselves to solve in relation to the prior art is to provide hygiene products in the above sense which, in addition to the property of absorbing or absorbing moisture, on the one hand also antibacterial (antiseptic) and anti-inflammatory and / or on the other hand to neutralize the basic environment and smells.
  • a comfortable fit should be achieved. This is to be done by means of appropriate nanoscale inorganic particles which, due to their small size, can be incorporated into the application systems in a sediment-stable manner and are highly effective in use even in low concentrations and do not have a disruptive effect on the skin feel when worn.
  • the inventors of the present invention have tested numerous substances which are compatible with the body for the desired properties and found that various oxides, hydrated oxides, hydroxides, halides, phosphates, sulfides, nitrides, carbides of Al, Si, the alkali and alkaline earth metals as well as sub-group elements including mixed salts of these groups such as hydroxides / halides or halides / phosphates or
  • Hydroxides / halides / phosphates but also numerous layered silicates, which are able to solve the problem posed if they are modified on their surface and are in the form of nanoparticles in the least possible or not agglomerated form.
  • the relevant specialist is of course immediately aware whether a certain substance (also) has the ability to neutralize the basic environment, because to do this it must at least react weakly acidic. Even if the substance itself does not have a neutralizing effect on an alkaline medium, acidic groups on the surface that make up the modification of the substance can nevertheless lower the pH and thus reduce the risk of skin irritation and inflammation.
  • the hygiene product is a diaper for babies or for adults, a pantiliner or a tampon.
  • the chemical or physical modification of the particle surface is carried out with organic compounds, especially with (a) carboxylic acids (mono-, di- and polycarboxylic acids) or their derivatives such as anhydrides, halides and esters (including the lactones); in particular with stearic acid, palmitic acid, lauric acid, capric acid, caprylic acid, caproic acid, oleic acid, sorbic acid, linoleic acid, linolenic acid, ricinoleic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, citric acid, malic acid, lactic acid, tartaric acid; with (b) amino acids, in particular with the naturally occurring amino acids (Gly, Ala, Val, Leu, lle, Phe, Tyr, Trp, Pro, Hy-Pro, Ser, Asp, Glu, Asn, Gin, Arg, Lys, Thr , His, Cys, Met
  • the present invention further relates to a method for producing hygiene products, the substances being applied to the surface of the hygiene product in the form of chemically or physically modified nanoparticles on their surface.
  • Another object of the present invention finally relates to a hygiene product with a substance that is compatible with the body, the surface of the substance being chemically or physically modified.
  • the mean primary particle size of the nanoparticles (diameter) according to the present invention is in the range from 1 to 100 nm, preferably in the range from 10 to 100 nm or 15 to 95 nm and 20 to 80 nm. Particularly preferred values (ranges) for the mean primary particle sizes are 25-70 nm, 30-50 nm, 60-80 nm and 40-85 nm.
  • the specific surface area of the particles is at least 10 m 2 / g, values of at least 30 m 2 / g, 50 m 2 are preferred / g or 80 m 2 / g or at least 125 m 2 / g, values of at least 150 m 2 / g, 180 m 2 / g, 200 m 2 / g or even at least 250 up to 300 m 2 / g being preferred are.
  • the present invention relates to hygiene products or parts thereof (which are in contact with the skin, in particular non-woven materials), which Contain nanoscale particles (nanoparticles) which, on the one hand, due to these particles absorb moisture and odor, on the other hand neutralize the pH, antibacterial (antiseptic) and / or anti-inflammatory.
  • nanoparticles are preferably oxide materials and layered silicates (particularly suitable for absorbing moisture and odors), in particular bentonites, hectorites, montmorillonites, zeolites (for example sodium, potassium, magnesium, calcium aluminosilicates); ZnO (particularly suitable as an antibacterial and / or anti-inflammatory agent, but also suitable for absorbing odors), MgO (particularly suitable for absorbing odors), AIOOH (Böhmite), AI 2 O 3 , ZrO 2 , TiO 2 (all particularly suitable for the absorption of odors and for pH neutralization), and mixtures of these substances.
  • oxide materials and layered silicates particularly suitable for absorbing moisture and odors
  • bentonites hectorites, montmorillonites, zeolites (for example sodium, potassium, magnesium, calcium aluminosilicates)
  • ZnO particularly suitable as an antibacterial and / or anti-inflammatory agent, but also suitable for absorbing odors
  • MgO particularly suitable for
  • the layered silicates mentioned, AIOOH (in particular boehmites of the Disperal Sol of type P from Condea), MgO and ZnO and their mixtures are preferred.
  • Synthetic hectorites (eg Optigel types from Südchemie) and silicates of the empirical formula Na + 0 are particularly preferred, in particular as substances absorbing moisture and odors. [(Si 8 Mg 5. 5 Lio. 3 ) O 2 o (OH) 4 ] 0.7 " (eg Laponite from Laporte).
  • the layered silicates have liquid-absorbing properties and are therefore not only suitable for the top fleece but also can also be used between the top and the fleece underneath.
  • ultra-small particles have properties that differ fundamentally from those of larger particles. Under certain circumstances, they do not scatter light because they are much smaller than the wavelength of the light. So they can give transparent formulations when dispersed to primary particle size. They have a very large specific surface area (10 - 300 m 2 / g) and therefore also a high reactivity.
  • the nanoparticles must be smaller than 100 nm. Particle sizes between 2 and 60 nm are preferred.
  • a further essential criterion for the quality of the nanoparticles according to the invention is a narrow primary particle size distribution so that the particles are as monodisperse as possible. In other words, particle agglomeration should be controlled to avoid excessive agglomeration.
  • the nanoscale particles have to be produced, which then have to be treated further in order to control the particle agglomeration. Therefore, each of those manufacturing processes and then treatment or modification processes which prevent agglomeration are described below. According to the invention, the nanoparticles are therefore used in a form that is chemically or physically modified on their surface for hygiene products.
  • the manufacturing processes for nanoparticles based on inorganic materials can be divided into syntheses using liquid phases (this includes the sol / gel process, the precipitation reaction and the microemulsion) and gas phase processes.
  • hydrolyzable molecular starting compounds for example TiCI 4 , Ti (OEt) 4 , Zr (OPr) 4 , Si (OEt) 4 , where OPr means n-propoxy or isopropoxy
  • water if appropriate under Addition of a catalyst
  • the Hydrolysis products then condense to oxidic nanoparticles. These particles have an extremely large and reactive surface, so that OH groups on the surface of the particles react with one another (condensation) and thus initiate agglomeration.
  • This agglomeration can be prevented by protective colloids or surfactants present during the sol / gel process: the polar groups occupy the particle surface and ensure both steric and electrostatic repulsion of the particles.
  • Another method of preventing aggregates is to modify the surface of the material with carboxylic acids and alkoxysilanes.
  • the reactivity of the particles is used for their (partial) deactivation:
  • the free OH groups are either esterified (carboxylic acids) or silanated.
  • covalent bonds are formed between the particle surfaces and the surface-active substance.
  • the length and functionality of the organic residue essentially determine the dispersibility of the material in different media.
  • Crystalline powders can be obtained by thermal aftertreatment, but normally contain agglomerates.
  • the average particle size, the particle size distribution, the degree of crystallinity, possibly even the crystal structure and the degree of dispersion can be influenced to a certain extent via the reaction kinetics.
  • microemulsions the aqueous phases of w / o emulsions are used as reaction spaces for the display of nanoscale materials.
  • all reactions that are used to display nanoscale materials in aqueous media can also be carried out in microemulsions. This applies particularly to the precipitation reactions and the sol / gel process.
  • the growth of the particles is limited by the size of the reaction space of the nm-sized droplets.
  • a number of review articles provide an overview of ME as reaction media for the representation of nanoscale materials [e.g. Chhabra et al., Surfactants, Surfactants, Deterg. 34: 156-168 (1997); Eastoe et al., Curr. Opin. Colloid interface 1: 800-805 (1996); Schwuger et al., Chem. Rev. 95, 849-864 (1995); Lopez-Quintela et al., J. Colloid Interface Sci. 158, 446-451 (1993)].
  • TEM transmission electron microscopy
  • Dynamic light scattering can also be used to determine the size of colloidal particles. It has since matured into the standard method (Powder and Bulk Engineering, Febr. 1995, 37-45). The advantage of this method is that it is quick and easy to use. On the other hand, it is disadvantageous that the viscosity of the dispersing medium and the refractive index of the particle must be known.
  • the methods of BET isotherm and OH group density can be used as routine methods for further characterization of the material.
  • the specific surface of the material is obtained by recording the BET isotherm.
  • the measured BET surface area should differ only slightly from that calculated for isolated particles. Larger differences therefore give a direct indication of larger and denser agglomerates / aggregates (sintering), although the primary particles can be very small according to X-ray diffraction.
  • the density determination of the hydroxyl groups on the surfaces of the powders gives an important indication of the reactivity and the functionality: A low density means that the material was exposed to very high temperatures during the synthesis and was at least partially "burnt to death". A high hydroxyl group density facilitates the functionalization and stabilization of the particles and is therefore preferred.
  • the powder is reacted with thionyl chloride (exchange OH - »Cl) and then hydrolyzed quantitatively (release of the chloride ions). If the specific surface is known, the titration of the chloride ions gives the value for the hydroxyl group density.
  • nanoscale material can be formulated more easily (without unnecessarily excessive sedimentation of the particles), since the modification reduces the hydrophilic property of the ZnO particles and thus facilitates the formulation with (hydrophobic) creams (provided that they are incorporated into a hydrophobic matrix is necessary).
  • the effectiveness of ZnO is higher due to its increased specific surface area with the same amount of ZnO used (but has nothing to do with the modification).
  • the small primary particle size also leads to an improved sensor system (tactility) on the skin: no granular feeling is felt as with the conventional ZnO particles.
  • the abrasive properties of the particles can be lower with a smaller particle size, and thus the stress (mechanical damage) of the skin is reduced as the particle size decreases.
  • the advantages mentioned are not limited to nanoscale ZnO modified on its surface but apply to all materials relevant according to the invention, provided that they have a chemically or physically modified surface and have a primary particle size in the nm range , in particular if the particle size is below 100 nm, below 90 nm, below 80 nm, below 70 nm, below 60 nm and preferably below 50 nm, but better still below 40 nm, for example 5-15 nm.
  • Preferred materials in this sense are oxide materials and layered silicates, in particular bentonites, hectorites, montmorillonites, zeolites such as sodium, potassium, magnesium or calcium aluminosilicates; MgO; AIOOH (Bohmite); AI 2 O 3 ; ZrO 2 ; TiO 2 and mixtures of these substances.
  • ZnO ZnO
  • antibacterial antiseptic
  • soothing anti-inflammatory
  • odor absorption The properties of ZnO that are relevant according to the invention are, on the one hand, its antibacterial (antiseptic) effect, on the other hand, it has a soothing (anti-inflammatory) effect and additionally the odor absorption.
  • modification means the coating of the particle surface with organic compounds that interact with the surface of the particles via chemical bonds or physical forces.
  • Preferred compounds for modification are in particular (a) carboxylic acids (mono-, di- and polycarboxylic acids) or their derivatives such as anhydrides, halides and esters (including the lactones); in particular stearic acid, palmitic acid, lauric acid, capric acid, caprylic acid, Caproic acid, oleic acid, sorbic acid, linoleic acid, linolenic acid, ricinoleic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, citric acid, malic acid, lactic acid, tartaric acid;
  • Amino acids especially the naturally occurring amino acids (Gly, Ala, Val, Leu, lle, Phe, Tyr, Trp, Pro, Hy-Pro, Ser, Asp, Glu, Asn, Gin, Arg, Lys, Thr, His , Cys, Met);
  • ether carboxylic acids of the general formula R- (O-CH 2 -CH 2 ) n -O-CH 2 -COOH, where n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 and RC 6 -, C 8 -, C 10 -, C 12 -, C 14 -, Ci 6 -, -CC 8 alkyl, alkenyl or alkynyl;
  • modifiers are surfactants such as fatty alcohol (FA) derivatives and alkyl polyglucosides (APGs), polymers such as polyethylene glycols, polypropylene glycols, polyvinyl alcohols, polyvinylpyrrolidone, polyvinyl butyrols or polyaspartic acid, or protective colloids (eg gelatin, starch, dextrin arabic, dextrin, pextran, pextran), pextran and their derivatives or mixtures thereof.
  • FFA fatty alcohol
  • APGs alkyl polyglucosides
  • polymers such as polyethylene glycols, polypropylene glycols, polyvinyl alcohols, polyvinylpyrrolidone, polyvinyl butyrols or polyaspartic acid, or protective colloids (eg gelatin, starch, dextrin arabic, dextrin, pextran, pextran), pextran and their derivatives or mixtures thereof.
  • protective colloids eg gelatin
  • the modification is, as also described in the above-mentioned documents, depending on the solubility of the substance used for the modification in water, alcohol (ethanol, n-propanol, i-propanol, propylene glycol), ether (tetrahydrofuran, diethyl ether) or an aprotic solvent (LM) such as hexane, cyclohexane, heptane, i-octane, toluene.
  • LM aprotic solvent
  • the powder to be modified is dispersed in the LM and, if necessary, freed of water residues by boiling on a water separator.
  • the modification reagent is then added and heated under reflux to a temperature between RT and the boiling point of the LM (at normal pressure). Any water that is formed is separated on the water separator.
  • the powder is then separated from the suspension, for example by filtration or centrifugation, washed and optionally dried (drying cabinet, freeze-drying
  • Another particularly preferred material for the hygiene products according to the invention is one which, owing to acidic surfaces (ie materials with an isoelectric point of less than 7), is particularly suitable for neutralization. These include in particular the boehmite (AIOOH), Al 2 O 3 , ZrO 2 and TiO 2 .
  • AIOOH boehmite
  • Al 2 O 3 Al 2 O 3
  • ZrO 2 ZrO 2
  • TiO 2 TiO 2
  • the use of the nanoscale particles according to the invention is clearly to be preferred for the reasons already mentioned above: (i) the nanoscale material can be formulated more easily (without it leading to unnecessarily strong sedimentation) the particle comes); (ii) it has an improved effectiveness as a result of an increased specific surface area with the same amount of particles used; (iii) the small particle size leads to an improved sensor system (tactility) on the skin: no granular feeling is felt as with the particles of conventional size.
  • the application of the chemically or physically modified nanoparticles on the surface of the hygiene product is carried out according to methods known from the prior art, and can be done, for example, by soaking (foulard), roller application or spraying the hygiene product with a Solution / suspension of the finishing agent containing nanoparticles and subsequent drying.
  • the nanoparticles can be suspended in both anhydrous and aqueous systems.
  • Both the water-free and the aqueous systems can be composed of hydrophobic components on the one hand, but also of hydrophilic components on the other, in order to give the hygiene products a hydrophilic or hydrophobic behavior which is necessary for the different areas of application.
  • the middle part of a top sheet top fleece of a diaper
  • the middle part of a top sheet top fleece of a diaper
  • the outer part of the top sheet is hydrophobic to prevent leakage. An antibacterial and anti-inflammatory treatment is desirable for both areas.
  • the nanoparticle content of such a finish is in the range from 0.1 to 50% by weight, preferably in the range from 0.5 to 30% by weight, particularly preferably in the range from 1 to 10% by weight.
  • Another way of applying the nanoparticles to the hygiene product is to incorporate the nanoparticles into a (skin-caring and hydrophobic) lotion, preferably wax-based, which is applied to the nonwoven material / fabric layer.
  • the waxes can be applied during the manufacture of the fleece or during the manufacture of the ready-to-use hygiene product (e.g. diaper).
  • This embodiment is particularly suitable for ZnO particles as an antibacterial and anti-inflammatory substance.
  • the content of the nanoparticles, in particular of the nanoscale ZnO, in the lotion is lower than in the conditioner, since the amount of lotion applied is higher, and is in the range from 0.1 to 10% by weight, preferably in the range from 0.1 up to 8% by weight,
  • the modified nanoparticles may have acidic groups on the surface that react with the bases contained in the urine with neutralization.
  • the nanoparticles are particularly advantageous due to the fact that they have a large surface area in conjunction with a high density of active (for example acidic) groups on the surface.
  • the amount of nanoparticles used can be correspondingly small.
  • the neutralization of the excretion products in the hygiene product creates a milieu which is unfavorable for the growth of bacteria, so that the risk of irritation and inflammation of the skin is reduced.
  • the nanoparticles absorb the odor-forming substances or those responsible for the smell. The occurrence of unpleasant smells is thus reduced.
  • the nanoparticles swell and therefore absorb moisture and thus ensure a dry hygiene product and a dry skin feel.
  • Example 1 Modification of nanoscale ZnO with stearic acid
  • nano-ZnO 60 g were dispersed in 250 ml of n-octane and adhering water was removed on the water separator (approx. 1 ml). Then 10.7 g of stearic acid (98%) were added and the mixture was refluxed for 5 hours. A further 0.5 ml of water was separated off. The subsequently obtained, chemically or physically modified, nanoscale ZnO powder was separated by centrifugation, washed with n-octane and dried first in air and then for about 8 hours at 50 ° C. in a circulating air dryer.
  • Demineralized water (Aqua demin.) was applied to four skin models. All other skin models were incubated with 80 ⁇ l of a 0.16% Na lauryl sulfate (SDS) solution for one hour (37 ° C, 5% CO 2 , 90% relative humidity). The skin models were then washed with phosphate buffer and then PIT cream 1 (with conventional ZnO) and PIT cream 2 (with stearic acid-coated nano-ZnO) were applied. Quadruple determinations were carried out in each case. As a control, cortisone cream (SDS / Aqua demin.) was applied to four skin models and Aqua demin to four skin models. (Aqua demin. Aqua demin.) Applied.
  • SDS Na lauryl sulfate
  • Inflammation mediators were determined using an ELISA assay (Enzyme Linked Immuno Sorbent Assay).

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Abstract

L'invention concerne l'utilisation de substances tolérées par le corps pour la production de produits d'hygiène, les substances étant présentes sous forme de nanoparticules modifiées chimiquement ou physiquement à leur surface. Les substances tolérées par le corps sont choisies parmi des oxydes, des oxydes hydratés, des hydroxydes, des halogénures, des phosphates, des sulfures, des nitrures et des carbures de Al, Si, des métaux alcalins et alcalino-terreux ainsi que d'éléments de sous-groupes notamment de sels mixtes de ces groupes tels que hydroxydes/halogénures, halogénures/phosphates ou hydroxydes/halogénures/phosphates. La modification chimique ou physique de la surface des particules se fait à l'aide de composés organiques, notamment (a) à l'aide d'acides carboxyliques (acides monocarboxyliques, dicarboxyliques et polycarboxyliques) ou de leurs dérivés, (b) à l'aide d'acides aminés, notamment d'acides aminés présents naturellement, (c) à l'aide d'acides hydroxycarboxyliques et d'acides sacchariques tels que l'acide glucarique, l'acide gluconique, l'acide glucuronique, (d) à l'aide de polyacides glycoliques de formule générale HOOC-CH2-O-(CH2-CH2-O)n-CH2-COOH dans laquelle n vaut 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 ou 12, (e) à l'aide d'acides éther carboxyliques de formule générale R-(O-CH2-CH2)n-O-CH2-COOH dans laquelle n vaut 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 ou 12, R représente alkyle, alcényle ou alcynyle C6, C8, C10, C12, C14, C16, C18, (f) à l'aide d'halogénures d'alkyle ou (g) à l'aide de silanes du type (OR)4-nSiR'n où R représente méthyle, éthyle, propyle, i-propyle, butyle, t-butyle et R' représente un reste organique, notamment aliphatique, ayant des groupes fonctionnels tels que -OH, -COOH, ester, amine ou époxy, R' représentant de préférence alkyle, alcényle ou alcynyle C6, C8, C10, C12, C14, C16, C18, aminopropyle, N-aminoéthyl-3-aminopropyle, chlorure de n- ou i-propyl-N,N,N-diméthyloctadécylammonium, chlorure de n- ou i-propyl-N,N,N-triméthylammonium, anhydride d'acide n- ou i-propylsuccinique.
EP01994777A 2000-12-18 2001-12-12 Substances de taille nanom trique dans des produits d'hygi ne Ceased EP1343539A2 (fr)

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DE10063092A DE10063092A1 (de) 2000-12-18 2000-12-18 Nanoskalige Materialien in Hygiene-Produkten
DE10063092 2000-12-18
PCT/EP2001/014557 WO2002049559A2 (fr) 2000-12-18 2001-12-12 Substances de taille nanométrique dans des produits d'hygiène

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