EP1360496A4 - Verfahren und reagenzien zur schnellen und effizienten isolierung zirkulierender krebszellen - Google Patents

Verfahren und reagenzien zur schnellen und effizienten isolierung zirkulierender krebszellen

Info

Publication number
EP1360496A4
EP1360496A4 EP02806645A EP02806645A EP1360496A4 EP 1360496 A4 EP1360496 A4 EP 1360496A4 EP 02806645 A EP02806645 A EP 02806645A EP 02806645 A EP02806645 A EP 02806645A EP 1360496 A4 EP1360496 A4 EP 1360496A4
Authority
EP
European Patent Office
Prior art keywords
reagents
rapid
methods
cancer cells
circulating cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02806645A
Other languages
English (en)
French (fr)
Other versions
EP1360496A1 (de
Inventor
Leon W M M Terstappen
Galla Chandra Rao
Shawn Mark O'hara
Paul A Liberti
Steven Gross
Gerald Doyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunivest Corp
Original Assignee
Immunivest Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunivest Corp filed Critical Immunivest Corp
Publication of EP1360496A1 publication Critical patent/EP1360496A1/de
Publication of EP1360496A4 publication Critical patent/EP1360496A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/561—Immunoelectrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Power Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
EP02806645A 2001-02-16 2002-02-19 Verfahren und reagenzien zur schnellen und effizienten isolierung zirkulierender krebszellen Withdrawn EP1360496A4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US26885901P 2001-02-16 2001-02-16
US268859P 2001-02-16
US26927101P 2001-02-20 2001-02-20
US26927001P 2001-02-20 2001-02-20
US269270P 2001-02-20
US269271P 2001-02-20
PCT/US2002/005233 WO2003065042A1 (en) 2001-02-16 2002-02-19 Methods and reagents for the rapid and efficient isolation of circulating cancer cells

Publications (2)

Publication Number Publication Date
EP1360496A1 EP1360496A1 (de) 2003-11-12
EP1360496A4 true EP1360496A4 (de) 2005-03-09

Family

ID=27670560

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02806645A Withdrawn EP1360496A4 (de) 2001-02-16 2002-02-19 Verfahren und reagenzien zur schnellen und effizienten isolierung zirkulierender krebszellen

Country Status (8)

Country Link
EP (1) EP1360496A4 (de)
JP (1) JP2005516217A (de)
KR (1) KR20030080002A (de)
AU (2) AU2002306561A2 (de)
BR (1) BR0207290A (de)
CA (1) CA2438112A1 (de)
IL (1) IL157256A0 (de)
WO (1) WO2003065042A1 (de)

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US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
WO2004076643A2 (en) 2003-02-27 2004-09-10 Immunivest Corporation CIRCULATING TUMOR CELLS (CTC’s): EARLY ASSESSMENT OF TIME TO PROGRESSION SURVIVAL AND RESPONSE TO THERAPY IN METASTATIC CANCER PATIENTS
WO2005028663A2 (en) * 2003-09-18 2005-03-31 Immunivest Corporation Operator independent programmable sample preparation and analysis system
WO2005085845A1 (es) * 2004-03-03 2005-09-15 Universidad De Salamanca Deteccion multidimensional de fenotipos aberrantes en celulas neoplasicas para monitorizar niveles minimos de enfermedad utilizando citometria de flujo
JP4798801B2 (ja) * 2004-10-06 2011-10-19 ウェルスタット バイオロジクス コーポレイション 循環する癌細胞におけるＨｅｒ−２／ｎｅｕタンパク質のレベルの上昇の検出および処置
US7595380B2 (en) * 2005-04-27 2009-09-29 Tripath Imaging, Inc. Monoclonal antibodies and methods for their use in the detection of cervical disease
CN1772303A (zh) * 2005-10-25 2006-05-17 朱宏 恶性肿瘤磁热疗用纳米磁粉－抗体靶向药物
US7842465B2 (en) * 2006-01-17 2010-11-30 Palo Alto Research Center Incorporated Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection
EP1984735B1 (de) * 2006-02-16 2010-10-06 Ventana Medical Systems, Inc. Reagenzien und verfahren für krebsprognose und pathologische einstufung
JP2009529880A (ja) * 2006-03-13 2009-08-27 ベリデックス・エルエルシー 原発細胞の増殖
JP5078100B2 (ja) * 2006-04-18 2012-11-21 ウェルスタット バイオロジクス コーポレイション 循環癌細胞におけるステロイド受容体の検出および処置
EP2008102A4 (de) * 2006-04-18 2009-07-08 Wellstat Biologics Corp Detektion von proteinen aus zirkulierenden neoplastischen zellen
PT2027470E (pt) * 2006-06-02 2013-01-28 Pfizer Prod Inc Ensaio de células tumorais circulantes
CN101583722A (zh) 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
US8110101B2 (en) 2007-08-30 2012-02-07 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US7828968B2 (en) 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
RU2389024C1 (ru) * 2008-12-02 2010-05-10 Александр Валентинович Шишкин Способ исследования клеток с помощью иммунологического биочипа
WO2010102195A2 (en) * 2009-03-06 2010-09-10 The Johns Hopkins University Annexin a11 and associated genes as biomarkers for cancer
CA2756493C (en) 2009-03-24 2019-07-02 Biocept, Inc. Devices and methods of cell capture and analysis
US20120100538A1 (en) 2009-03-24 2012-04-26 Biocept, Inc. Devices and methods of cell capture and analysis
DE102009047146B4 (de) * 2009-11-25 2012-07-19 Ulrich Pachmann Verfahren zum Vorhersagen des Ansprechens einer Tumorerkrankung auf eine therapeutische Maßnahme
CN102947703A (zh) 2010-06-17 2013-02-27 皇家飞利浦电子股份有限公司 多表位测定
BR112013000433A2 (pt) * 2010-07-07 2016-05-17 Univ Michigan diagnóstico e tratamento de câncer de mama
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
WO2013002309A1 (ja) * 2011-06-29 2013-01-03 三菱化学メディエンス株式会社 非特異反応抑制剤、非特異反応抑制方法及びキット
MX350807B (es) * 2011-11-29 2017-09-20 Genentech Inc Composiciones y metodos para el analisis de cancer de prostata.
WO2013131050A1 (en) * 2012-03-02 2013-09-06 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for differential treatment of cancer
CN102914650B (zh) * 2012-06-14 2014-11-05 北京大成生物工程有限公司 神经元特异性烯醇化酶定量检测试剂盒及其制备方法与应用
CN105209489B (zh) 2013-03-05 2019-06-14 得克萨斯州大学系统董事会 针对间质和上皮-间质转化的循环肿瘤细胞的特异性检测工具
CN104561246B (zh) * 2013-10-18 2018-06-15 深圳先进技术研究院 血液中循环癌细胞的检测信号放大的方法与试剂盒
JP6582486B2 (ja) * 2015-03-27 2019-10-02 コニカミノルタ株式会社 血液中の稀少細胞検出方法
KR101723072B1 (ko) 2016-12-29 2017-04-05 주식회사 지노바이오 셀 분리 시스템
US10758906B2 (en) 2016-02-18 2020-09-01 Genobio, Inc. Cell separation chip and system
KR101723082B1 (ko) 2016-12-29 2017-04-05 주식회사 지노바이오 셀 분리 장치
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
CN110669823B (zh) * 2018-07-03 2022-05-24 中国医学科学院肿瘤医院 一种同时检测多种肝癌常见突变的ctDNA文库构建和测序数据分析方法
JP6935883B2 (ja) * 2018-07-13 2021-09-15 五稜化薬株式会社 蛍光画像診断の前処理方法
US20240295549A1 (en) * 2020-08-07 2024-09-05 Vital Biosciences Inc. Multiplexed analyte detection
CN114958748B (zh) * 2022-04-24 2024-02-13 东北大学 高效捕获和无损释放循环肿瘤细胞的纳米磁性亲和材料
CN118741012B (zh) * 2024-09-02 2024-12-24 浙江芯劢微电子股份有限公司 一种视频信号的滤波方法、电路和计算机可读存储介质

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041613A1 (en) * 1998-02-12 1999-08-19 Immunivest Methods and reagents for the rapid and efficient isolation of circulating cancer cells
WO1999058978A2 (en) * 1998-05-11 1999-11-18 The University Of Nottingham Tumour markers
US5993829A (en) * 1987-04-23 1999-11-30 Bystryn; Jean-Claude Anti-cancer vaccine
WO2000047998A1 (en) * 1999-02-10 2000-08-17 Cell Works Inc. Class characterization of circulating cancer cells isolated from body fluids and methods of use

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EP0651653B1 (de) * 1992-07-22 2004-03-10 The Trustees Of Princeton University P53 impfstoff
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US5993829A (en) * 1987-04-23 1999-11-30 Bystryn; Jean-Claude Anti-cancer vaccine
WO1999041613A1 (en) * 1998-02-12 1999-08-19 Immunivest Methods and reagents for the rapid and efficient isolation of circulating cancer cells
WO1999058978A2 (en) * 1998-05-11 1999-11-18 The University Of Nottingham Tumour markers
WO2000047998A1 (en) * 1999-02-10 2000-08-17 Cell Works Inc. Class characterization of circulating cancer cells isolated from body fluids and methods of use

Non-Patent Citations (2)

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Title
E.RACILA ET AL: "Detection and characterization of carcinoma cells in the blood", PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES USA, vol. 95, 1 April 1998 (1998-04-01) - 1998, pages 4589 - 4594, XP002313397 *
See also references of WO03065042A1 *

Also Published As

Publication number Publication date
WO2003065042A1 (en) 2003-08-07
AU2008249153B2 (en) 2012-05-10
IL157256A0 (en) 2004-02-19
AU2002306561A2 (en) 2003-09-02
BR0207290A (pt) 2005-06-07
JP2005516217A (ja) 2005-06-02
KR20030080002A (ko) 2003-10-10
CA2438112A1 (en) 2003-08-07
AU2008249153A1 (en) 2008-12-11
EP1360496A1 (de) 2003-11-12

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Inventor name: DOYLE, GERALD

Inventor name: GROSS, STEVEN

Inventor name: LIBERTI, PAUL, A.

Inventor name: O'HARA, SHAWN, MARK

Inventor name: RAO, GALLA, CHANDRA

Inventor name: TERSTAPPEN, LEON, W., M., M.

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