EP1408946A4 - Histondeacetylaseinhibitoren - Google Patents

Histondeacetylaseinhibitoren

Info

Publication number
EP1408946A4
EP1408946A4 EP02719311A EP02719311A EP1408946A4 EP 1408946 A4 EP1408946 A4 EP 1408946A4 EP 02719311 A EP02719311 A EP 02719311A EP 02719311 A EP02719311 A EP 02719311A EP 1408946 A4 EP1408946 A4 EP 1408946A4
Authority
EP
European Patent Office
Prior art keywords
histone deacetylase
deacetylase inhibitors
inhibitors
histone
deacetylase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02719311A
Other languages
English (en)
French (fr)
Other versions
EP1408946A2 (de
Inventor
Hsuan-Yin Lan-Hargest
Robert J Kaufman
Norbert L Wiech
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Circagen Pharmaceutical LLC
Original Assignee
Circagen Pharmaceutical LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/812,945 external-priority patent/US7312247B2/en
Priority claimed from US09/812,944 external-priority patent/US6495719B2/en
Priority claimed from US10/025,947 external-priority patent/US8026280B2/en
Application filed by Circagen Pharmaceutical LLC filed Critical Circagen Pharmaceutical LLC
Publication of EP1408946A2 publication Critical patent/EP1408946A2/de
Publication of EP1408946A4 publication Critical patent/EP1408946A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP02719311A 2001-03-27 2002-03-25 Histondeacetylaseinhibitoren Withdrawn EP1408946A4 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US812940 1985-12-23
US81294001A 2001-03-27 2001-03-27
US812945 2001-03-27
US09/812,945 US7312247B2 (en) 2001-03-27 2001-03-27 Histone deacetylase inhibitors
US812944 2001-03-27
US09/812,944 US6495719B2 (en) 2001-03-27 2001-03-27 Histone deacetylase inhibitors
US10/025,947 US8026280B2 (en) 2001-03-27 2001-12-26 Histone deacetylase inhibitors
US25947 2001-12-26
PCT/US2002/008836 WO2002076941A2 (en) 2001-03-27 2002-03-25 Histone deacetylase inhibitors

Publications (2)

Publication Number Publication Date
EP1408946A2 EP1408946A2 (de) 2004-04-21
EP1408946A4 true EP1408946A4 (de) 2004-06-09

Family

ID=27487458

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02719311A Withdrawn EP1408946A4 (de) 2001-03-27 2002-03-25 Histondeacetylaseinhibitoren

Country Status (4)

Country Link
EP (1) EP1408946A4 (de)
AU (1) AU2002250401A1 (de)
CA (1) CA2442366C (de)
WO (1) WO2002076941A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314953B2 (en) 2001-03-27 2008-01-01 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
EP1291015A1 (de) 2001-09-10 2003-03-12 Lunamed AG Darreichungsformen mit verlängerter Wirkstofffreisetzung
JP2005530734A (ja) * 2002-04-15 2005-10-13 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 癌の処置のための併用療法
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
GB0226855D0 (en) 2002-11-18 2002-12-24 Queen Mary & Westfield College Histone deacetylase inhibitors
EP1599449A2 (de) 2003-02-25 2005-11-30 TopoTarget UK Limited Bicyclische heteroaromatische carbaminsäurederivate mit hdac hemmender wirkung
US7169801B2 (en) 2003-03-17 2007-01-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7842835B2 (en) 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
AR050552A1 (es) * 2004-09-02 2006-11-01 Osi Pharm Inc Mercaptoamidas como inhibidores de histona desacetilasa
WO2006029818A2 (en) * 2004-09-16 2006-03-23 Dsm Ip Assets B.V. Cosmetic compositions containing an hydroxamic acid compound optionally in combination with a retinoid
EP1824831A2 (de) 2004-12-16 2007-08-29 Takeda San Diego, Inc. Histondeacetylase-inhibitoren
JP2008540574A (ja) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
JP2009501236A (ja) 2005-07-14 2009-01-15 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
GB0620823D0 (en) 2006-10-19 2006-11-29 Univ London Histone deacetylase inhibitors
JP2019189648A (ja) * 2019-07-08 2019-10-31 国立大学法人東京農工大学 シス桂皮酸類縁体、重力屈性調節剤
CN110523541B (zh) * 2019-09-04 2021-09-28 中南大学 一种烷基硫醚基乙基羟肟酸药剂及其制备方法与应用
CN114805235B (zh) * 2022-05-09 2024-04-23 江苏中旗科技股份有限公司 一种多取代异恶唑烷酮及其中间体的合成制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886278A (en) * 1973-08-22 1975-05-27 Mead Johnson & Co Ammonium carboxylate sebum inhibition process
JPS6054339A (ja) * 1983-09-05 1985-03-28 Kuraray Co Ltd 不飽和カルボン酸エステルの製造方法
EP0405788A2 (de) * 1989-06-29 1991-01-02 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. Di-tert-butyl(hydroxi)phenylthio-substituierte Hydroxamsäurederivate
WO1998001423A1 (en) * 1996-07-09 1998-01-15 Smithkline Beecham S.P.A. 5-indolyl-2,4-pentadienoic acid derivatives useful as inhibitors of bone resorption
WO2000020370A1 (en) * 1998-10-01 2000-04-13 Allergan Sales, Inc. 2, 4-pentadienoic acid derivatives having selective activity for retinoid x (rxr) receptors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110955A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Metabolically stabilized oxyalkylene esters and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886278A (en) * 1973-08-22 1975-05-27 Mead Johnson & Co Ammonium carboxylate sebum inhibition process
JPS6054339A (ja) * 1983-09-05 1985-03-28 Kuraray Co Ltd 不飽和カルボン酸エステルの製造方法
EP0405788A2 (de) * 1989-06-29 1991-01-02 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. Di-tert-butyl(hydroxi)phenylthio-substituierte Hydroxamsäurederivate
WO1998001423A1 (en) * 1996-07-09 1998-01-15 Smithkline Beecham S.P.A. 5-indolyl-2,4-pentadienoic acid derivatives useful as inhibitors of bone resorption
WO2000020370A1 (en) * 1998-10-01 2000-04-13 Allergan Sales, Inc. 2, 4-pentadienoic acid derivatives having selective activity for retinoid x (rxr) receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MANFRED JUNG ET AL: "Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 22, 4 November 1999 (1999-11-04), pages 4669 - 4679, XP002144226, ISSN: 0022-2623 *
PATENT ABSTRACTS OF JAPAN vol. 009, no. 184 (C - 294) 30 July 1985 (1985-07-30) *
RICHON V M ET AL: "A CLASS OF HYBRID POLAR INDUCERS OF TRANSFORMED CELL DIFFERENTIATION INHIBITS HISTONE DEACETYLASES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 6, 17 March 1998 (1998-03-17), pages 3003 - 3007, XP001120542, ISSN: 0027-8424 *
SCHMIDT K ET AL: "INHIBITORS OF HISTONE DEACETYLASE SUPPRESS THE GROWTH OF MCF-7 BREAST CANCER CELLS", ARCHIV DER PHARMAZIE, VCH VERLAGSGESELLSCHAFT MBH, WEINHEIM, DE, vol. 332, no. 10, 1999, pages 353 - 357, XP000985303, ISSN: 0365-6233 *

Also Published As

Publication number Publication date
CA2442366C (en) 2012-09-25
EP1408946A2 (de) 2004-04-21
WO2002076941A3 (en) 2004-02-12
WO2002076941A2 (en) 2002-10-03
CA2442366A1 (en) 2002-10-03
AU2002250401A1 (en) 2002-10-08

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Legal Events

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