EP1423113A4 - Composes de liaison au recepteur nucleaire nr1h4 - Google Patents

Composes de liaison au recepteur nucleaire nr1h4

Info

Publication number: EP1423113A4
Authority: EP; European Patent Office
Prior art keywords: receptor binding; nuclear receptor; binding compounds; nr1h4; nr1h4 nuclear
Prior art date: 2001-08-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP02750474A

Other languages

German (de)

English (en)

Other versions

EP1423113A1 (fr

Inventor

Ulrike Bauer

Zach Cheruvallath

Ulrich Deuschle

Elena Dneprovskaia

Tim Gahman

Kristina Giegrich

Ronnie Hanecak

Normand Hebert

John Kiely

Ingo Kober

Manfred Kogl

Harald Kranz

Claus Kremoser

Matthew Lee

Kerstin Otte

Carlton Sage

Manish Sud

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Phenex Pharmaceuticals AG

Original Assignee

Phenex Pharmaceuticals AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-13

Filing date

2002-08-13

Publication date

2007-04-18

2001-08-13 Priority claimed from EP01119473A external-priority patent/EP1285914B1/fr

2002-08-13 Application filed by Phenex Pharmaceuticals AG filed Critical Phenex Pharmaceuticals AG

2002-08-13 Priority to EP02750474A priority Critical patent/EP1423113A4/fr

2004-06-02 Publication of EP1423113A1 publication Critical patent/EP1423113A1/fr

2007-04-18 Publication of EP1423113A4 publication Critical patent/EP1423113A4/fr

Status Ceased legal-status Critical Current

Links

101150027485 NR1H4 gene Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
- C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP02750474A 2001-08-13 2002-08-13 Composes de liaison au recepteur nucleaire nr1h4 Ceased EP1423113A4 (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP02750474A EP1423113A4 (fr)	2001-08-13	2002-08-13	Composes de liaison au recepteur nucleaire nr1h4

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
EP01119473A EP1285914B1 (fr)	2001-08-13	2001-08-13	Ligands du récepteur nucéaire nr1h4
EP01119473		2001-08-13
US185731		2002-07-01
US10/185,731 US6974830B2 (en)	2001-08-13	2002-07-01	NR1H4 nuclear receptor binding compounds
PCT/US2002/025438 WO2003015777A1 (fr)	2001-08-13	2002-08-13	Composes de liaison au recepteur nucleaire nr1h4
EP02750474A EP1423113A4 (fr)	2001-08-13	2002-08-13	Composes de liaison au recepteur nucleaire nr1h4

Publications (2)

Publication Number	Publication Date
EP1423113A1 EP1423113A1 (fr)	2004-06-02
EP1423113A4 true EP1423113A4 (fr)	2007-04-18

Family

ID=26076685

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP02750474A Ceased EP1423113A4 (fr)	2001-08-13	2002-08-13	Composes de liaison au recepteur nucleaire nr1h4

Country Status (2)

Country	Link
EP (1)	EP1423113A4 (fr)
WO (1)	WO2003015777A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE303399T1 (de)	2001-03-12	2005-09-15	Intercept Pharmaceuticals Inc	Steroide als agonisten für fxr
US6987121B2 (en)	2002-04-25	2006-01-17	Smithkline Beecham Corporation	Compositions and methods for hepatoprotection and treatment of cholestasis
GB0315111D0 (en)	2003-06-27	2003-07-30	Cancer Rec Tech Ltd	Substituted 5-membered ring compounds and their use
JP4638355B2 (ja)	2003-12-26	2011-02-23	協和発酵キリン株式会社	チアゾール誘導体
PL1734970T3 (pl)	2004-03-12	2015-05-29	Intercept Pharmaceuticals Inc	Leczenie zwłóknienia z zastosowaniem ligandów FXR
US10987362B2 (en)	2004-03-12	2021-04-27	Intercept Pharmaceuticals, Inc.	Treatment of fibrosis using FXR ligands
US8026237B2 (en)	2004-07-30	2011-09-27	Exelixis, Inc.	Pyrrole derivatives as pharmaceutical agents
WO2006028970A1 (fr)	2004-09-02	2006-03-16	Cengent Therapeutics, Inc.	Derives d'inhibiteurs de thiazole et de thiadiazole de tyrosine phosphatases
WO2006029719A2 (fr) *	2004-09-14	2006-03-23	Bayer Healthcare Ag	Diagnostics et traitements de maladies associees a la sous-famille 1, du groupe h, membre 4 de recepteur nucleaire (nr1h4)
ITMI20050912A1 (it)	2005-05-19	2006-11-20	Erregierre Spa	Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP5292310B2 (ja)	2007-01-19	2013-09-18	インターセプトファーマシューティカルズ，インコーポレイテッド	Ｔｇｒ５調節剤としての２３−置換胆汁酸およびその使用方法
EA020310B1 (ru)	2008-07-30	2014-10-30	Интерсепт Фармасьютикалз, Инк.	Модуляторы рецептора tgr5 и их применение
ES2663948T3 (es)	2008-11-19	2018-04-17	Intercept Pharmaceuticals, Inc.	Moduladores de TGR5 y método de uso de los mismos
US20110257139A1 (en)	2008-12-19	2011-10-20	Royal College Of Surgeons In Ireland	Treatment of diarrhoea
EP2545964A1 (fr)	2011-07-13	2013-01-16	Phenex Pharmaceuticals AG	Nouveaux composés se liant au fxr (nr1 h4) et modulant son activité
PT3336097T (pt)	2012-06-19	2020-10-29	Intercept Pharmaceuticals Inc	Preparação da forma não cristalina de ácido obeticólico
US9982008B2 (en)	2012-06-19	2018-05-29	Intercept Pharmaceuticals, Inc.	Preparation and uses of obeticholic acid
CA3252823A1 (en)	2016-06-13	2025-02-25	Gilead Sciences, Inc.	Substituted tert-butyl-3-(2-chloro-phenyl)-3-hydroxyazetidine-1-carboxylate compounds
BR112018075734A2 (pt)	2016-06-13	2019-04-02	Gilead Sciences, Inc.	composto, composição farmacêutica, método para tratar um paciente com uma doença ou condição mediada pelo menos em parte por fxr, e, uso de um composto.
CN110461328A (zh)	2017-03-28	2019-11-15	吉利德科学公司	治疗肝疾病的治疗组合
EP4360632B1 (fr)	2019-01-15	2025-10-29	Gilead Sciences, Inc.	Composés modulateurs de fxr (nr1h4)
US11524005B2 (en)	2019-02-19	2022-12-13	Gilead Sciences, Inc.	Solid forms of FXR agonists
US20220227745A1 (en) *	2019-06-14	2022-07-21	Nanjing Ruijie Pharma Tech Co., Ltd.	Compounds For Modulating FXR
AU2020312735A1 (en)	2019-07-18	2021-12-16	Enyo Pharma	Method for decreasing adverse-effects of interferon
US20230060715A1 (en)	2020-01-15	2023-03-02	INSERM (Institut National de la Santé et de la Recherche Médicale)	Use of fxr agonists for treating an infection by hepatitis d virus
US11478533B2 (en)	2020-04-27	2022-10-25	Novo Nordisk A/S	Semaglutide for use in medicine
US20240100125A1 (en)	2021-01-14	2024-03-28	Enyo Pharma	Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection
CN117320722A (zh)	2021-04-28	2023-12-29	埃尼奥制药公司	使用fxr激动剂作为联合治疗强烈增强tlr3激动剂的作用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2022085A (en) *	1978-06-02	1979-12-12	Pfizer	Novel Aminothiazoles
JPH04173782A (ja) *	1990-11-08	1992-06-22	Taisho Pharmaceut Co Ltd	２―スルホンアミド―４，５―ジフェニルチアゾール誘導体
EP0592664A1 (fr) *	1991-03-07	1994-04-20	Hisamitsu Pharmaceutical Co., Inc.	Nouveau derive de diphenylthiazole
JPH07149745A (ja) *	1993-11-30	1995-06-13	Hisamitsu Pharmaceut Co Inc	新規な２−アミノチアゾール誘導体
FR2735777A1 (fr) *	1995-06-21	1996-12-27	Sanofi Sa	Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2796380A1 (fr) *	1999-07-15	2001-01-19	Sanofi Synthelabo	Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2692893B1 (fr) *	1992-06-24	1994-09-02	Sanofi Elf	Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
FR2714059B1 (fr) *	1993-12-21	1996-03-08	Sanofi Elf	Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
AU689972B2 (en) *	1994-11-29	1998-04-09	Hisamitsu Pharmaceutical Co., Inc.	Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof
JP4136024B2 (ja) *	1995-12-29	2008-08-20	富山化学工業株式会社	２−アミノチアゾ−ル誘導体またはその塩

2002
- 2002-08-13 EP EP02750474A patent/EP1423113A4/fr not_active Ceased
- 2002-08-13 WO PCT/US2002/025438 patent/WO2003015777A1/fr not_active Ceased

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2022085A (en) *	1978-06-02	1979-12-12	Pfizer	Novel Aminothiazoles
JPH04173782A (ja) *	1990-11-08	1992-06-22	Taisho Pharmaceut Co Ltd	２―スルホンアミド―４，５―ジフェニルチアゾール誘導体
EP0592664A1 (fr) *	1991-03-07	1994-04-20	Hisamitsu Pharmaceutical Co., Inc.	Nouveau derive de diphenylthiazole
JPH07149745A (ja) *	1993-11-30	1995-06-13	Hisamitsu Pharmaceut Co Inc	新規な２−アミノチアゾール誘導体
FR2735777A1 (fr) *	1995-06-21	1996-12-27	Sanofi Sa	Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2796380A1 (fr) *	1999-07-15	2001-01-19	Sanofi Synthelabo	Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MALONEY P R ET AL: "Identification of a Chemical Tool for the rphan Nuclear Receptor FXR", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 16, 10 August 2000 (2000-08-10), pages 2971 - 2974, XP002992679, ISSN: 0022-2623 *
See also references of WO03015777A1 *

Also Published As

Publication number	Publication date
EP1423113A1 (fr)	2004-06-02
WO2003015777A1 (fr)	2003-02-27

Legal Events

Date	Code	Title	Description
2004-04-16	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2004-06-02	17P	Request for examination filed	Effective date: 20040225
2004-06-02	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
2004-06-02	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2004-06-16	RIN1	Information on inventor provided before grant (corrected)	Inventor name: SUD, MANISH Inventor name: SAGE, CARLTON Inventor name: OTTE, KERSTIN Inventor name: LEE, MATTHEW Inventor name: KREMOSER, CLAUS Inventor name: KRANZ, HARALD Inventor name: KOGL, MANFRED Inventor name: KOBER, INGO Inventor name: KIELY, JOHN Inventor name: HEBERT, NORMAND Inventor name: HANECAK, RONNIE Inventor name: GIEGRICH, KRISTINA Inventor name: GAHMAN, TIM Inventor name: DNEPROVSKAIA, ELENA Inventor name: DEUSCHLE, ULRICH Inventor name: CHERUVALLATH, ZACH Inventor name: BAUER, ULRIKE
2004-06-30	RIN1	Information on inventor provided before grant (corrected)	Inventor name: SUD, MANISH Inventor name: SAGE, CARLTON Inventor name: OTTE, KERSTIN Inventor name: LEE, MATTHEW Inventor name: KREMOSER, CLAUS Inventor name: KRANZ, HARALD Inventor name: KOGL, MANFRED Inventor name: KOBER, INGO Inventor name: KIELY, JOHN Inventor name: HEBERT, NORMAND Inventor name: HANECAK, RONNIE Inventor name: GIEGRICH, KRISTINA Inventor name: GAHMAN, TIM Inventor name: DNEPROVSKAIA, ELENA Inventor name: DEUSCHLE, ULRICH Inventor name: CHERUVALLATH, ZACH Inventor name: BAUER, ULRIKE
2004-12-01	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: PHENEX PHARMACEUTICALS AG
2006-04-05	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: PHENEX PHARMACEUTICALS AG
2007-04-18	A4	Supplementary search report drawn up and despatched	Effective date: 20070315
2007-04-18	RIC1	Information provided on ipc code assigned before grant	Ipc: C07D 277/52 20060101ALI20070309BHEP Ipc: C07D 277/46 20060101ALI20070309BHEP Ipc: C07D 277/44 20060101ALI20070309BHEP Ipc: C07D 277/42 20060101ALI20070309BHEP Ipc: C07D 277/40 20060101ALI20070309BHEP Ipc: A61K 31/426 20060101AFI20030306BHEP
2008-07-02	17Q	First examination report despatched	Effective date: 20080602
2008-11-05	RIN1	Information on inventor provided before grant (corrected)	Inventor name: SUD, MANISH Inventor name: DNEPROVSKAIA, ELENAC Inventor name: DEUSCHLE, ULRICH Inventor name: CHERUVALLATH, ZACH Inventor name: SAGE, CARLTON Inventor name: OTTE, KERSTIN Inventor name: LEE, MATTHEW Inventor name: KREMOSER, CLAUS Inventor name: KRANZ, HARALD Inventor name: KOGL, MANFRED Inventor name: KOBER, INGO Inventor name: KIELY, JOHN Inventor name: HEBERT, NORMANDC Inventor name: HANECAK, RONNIE Inventor name: GIEGRICH, KRISTINA Inventor name: GAHMAN, TIM Inventor name: BAUER, ULRIKE
2011-03-31	REG	Reference to a national code	Ref country code: DE Ref legal event code: R003
2011-07-08	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2011-08-10	18R	Application refused	Effective date: 20110331

Publication	Publication Date	Title
GB0205954D0 (en)	2002-04-24	Binder mechanism
AU7476301A (en)	2002-01-02	Novel compounds
EP1276755A4 (fr)	2004-03-31	Nouveaux composes
AU9261901A (en)	2002-03-26	Novel compounds
EP1255771A4 (fr)	2004-09-29	Nouveaux composes
EP1292617A4 (fr)	2005-04-06	Composes
AU149010S (en)	2002-08-26	Binder
EP1472352A4 (fr)	2005-10-12	Nouveaux composes
EP1343813A4 (fr)	2004-11-17	Nouveaux composes
AU7476401A (en)	2002-01-02	Novel compounds
GB0000474D0 (en)	2000-03-01	Receptor
AU1252102A (en)	2002-05-21	Receptor
EP1299530A4 (fr)	2005-03-09	Nouveaux composes
AU2002234786A1 (en)	2002-09-19	Nuclear hormone receptor ligand binding domain
AU2002319806A1 (en)	2003-03-03	Nr1h4 nuclear receptor binding compounds
AU2002329243A1 (en)	2003-03-03	Nr1h4 nuclear receptor binding compounds
AU2002319805A1 (en)	2003-03-03	Fxr nr1h4 nuclear receptor binding compounds
AU2002319804A1 (en)	2003-03-03	Fxr nr1h4 nuclear receptor binding compounds
AU2002234782A1 (en)	2002-09-19	Nuclear hormone receptor ligand binding domain
AU9462801A (en)	2002-05-06	Chemokine receptor binding heterocyclic compounds
PL359523A1 (en)	2004-08-23	Chemokine receptor binding heterocyclic compounds
GB0126659D0 (en)	2002-01-02	Novel compounds
GB0009907D0 (en)	2000-06-07	Novel compounds
GB0112855D0 (en)	2001-07-18	Novel compounds
CA91927S (en)	2001-03-30	Binder