EP1438567A4 - Verfahren und systeme zur mikrofluidischen verarbeitung - Google Patents

Verfahren und systeme zur mikrofluidischen verarbeitung

Info

Publication number
EP1438567A4
EP1438567A4 EP02715213A EP02715213A EP1438567A4 EP 1438567 A4 EP1438567 A4 EP 1438567A4 EP 02715213 A EP02715213 A EP 02715213A EP 02715213 A EP02715213 A EP 02715213A EP 1438567 A4 EP1438567 A4 EP 1438567A4
Authority
EP
European Patent Office
Prior art keywords
systems
methods
microfluidic processing
microfluidic
processing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02715213A
Other languages
English (en)
French (fr)
Other versions
EP1438567A1 (de
EP1438567B1 (de
Inventor
Gene Parunak
Kalyan Handique
Betty Wu
Karthik Ganesan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HandyLab Inc
Original Assignee
HandyLab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/014,519 external-priority patent/US7192557B2/en
Priority claimed from US10/014,520 external-priority patent/US7270786B2/en
Priority claimed from US10/075,371 external-priority patent/US7323140B2/en
Application filed by HandyLab Inc filed Critical HandyLab Inc
Priority to EP18185265.8A priority Critical patent/EP3427834A1/de
Publication of EP1438567A1 publication Critical patent/EP1438567A1/de
Publication of EP1438567A4 publication Critical patent/EP1438567A4/de
Application granted granted Critical
Publication of EP1438567B1 publication Critical patent/EP1438567B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Read Only Memory (AREA)
EP02715213.1A 2001-07-26 2002-03-27 Verfahren und systeme zur mikrofluidischen verarbeitung Expired - Lifetime EP1438567B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18185265.8A EP3427834A1 (de) 2001-07-26 2002-03-27 Verfahren und systeme zur mikrofluidischen verarbeitung

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US30763801P 2001-07-26 2001-07-26
US307638P 2001-07-26
US10/014,519 US7192557B2 (en) 2001-03-28 2001-12-14 Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US14519 2001-12-14
US10/014,520 US7270786B2 (en) 2001-03-28 2001-12-14 Methods and systems for processing microfluidic samples of particle containing fluids
US14520 2001-12-14
US10/075,371 US7323140B2 (en) 2001-03-28 2002-02-15 Moving microdroplets in a microfluidic device
US75371 2002-02-15
PCT/US2002/009440 WO2003012406A1 (en) 2001-07-26 2002-03-27 Methods and systems for microfluidic processing

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP18185265.8A Division EP3427834A1 (de) 2001-07-26 2002-03-27 Verfahren und systeme zur mikrofluidischen verarbeitung

Publications (3)

Publication Number Publication Date
EP1438567A1 EP1438567A1 (de) 2004-07-21
EP1438567A4 true EP1438567A4 (de) 2010-06-02
EP1438567B1 EP1438567B1 (de) 2018-07-25

Family

ID=27486401

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18185265.8A Withdrawn EP3427834A1 (de) 2001-07-26 2002-03-27 Verfahren und systeme zur mikrofluidischen verarbeitung
EP02715213.1A Expired - Lifetime EP1438567B1 (de) 2001-07-26 2002-03-27 Verfahren und systeme zur mikrofluidischen verarbeitung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP18185265.8A Withdrawn EP3427834A1 (de) 2001-07-26 2002-03-27 Verfahren und systeme zur mikrofluidischen verarbeitung

Country Status (4)

Country Link
EP (2) EP3427834A1 (de)
JP (1) JP4596776B2 (de)
ES (1) ES2683698T3 (de)
WO (1) WO2003012406A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
EP3718635A1 (de) 2003-07-31 2020-10-07 Handylab, Inc. Verarbeitung partikelhaltiger proben
US7156117B2 (en) 2004-03-31 2007-01-02 Lifescan Scotland Limited Method of controlling the movement of fluid through a microfluidic circuit using an array of triggerable passive valves
US7059352B2 (en) 2004-03-31 2006-06-13 Lifescan Scotland Triggerable passive valve for use in controlling the flow of fluid
US7665303B2 (en) 2004-03-31 2010-02-23 Lifescan Scotland, Ltd. Method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit
ES2553097T3 (es) 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
JP6088487B2 (ja) 2011-04-15 2017-03-01 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法
RU2622432C2 (ru) 2011-09-30 2017-06-15 Бектон, Дикинсон Энд Компани Унифицированная полоска для реактивов
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
WO2020112081A1 (en) * 2018-11-26 2020-06-04 Hewlett-Packard Development Company, L.P. Microfluidic devices
CN112023990B (zh) * 2019-06-03 2023-06-23 利多(香港)有限公司 一种微流控检测芯片及制造方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635358A (en) * 1992-05-01 1997-06-03 Trustees Of The University Of Pennsylvania Fluid handling methods for use in mesoscale analytical devices
WO1998022625A1 (en) * 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
US5922591A (en) * 1995-06-29 1999-07-13 Affymetrix, Inc. Integrated nucleic acid diagnostic device

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Publication number Priority date Publication date Assignee Title
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6068751A (en) * 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
JPH10108666A (ja) * 1996-10-04 1998-04-28 Asahi Medical Co Ltd 中空糸型培養器
EP0941766B1 (de) * 1998-03-12 2006-12-20 Miltenyi Biotec GmbH Mikrokolonnen-System für Magnettrennung
JP4074713B2 (ja) * 1998-07-29 2008-04-09 財団法人川村理化学研究所 送液デバイス及びその製造方法
JP2000166535A (ja) * 1998-12-10 2000-06-20 Nippon Laser Denshi Kk 微量分注針体
DE19948473A1 (de) * 1999-10-08 2001-04-12 Nmi Univ Tuebingen Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen
US6272939B1 (en) * 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635358A (en) * 1992-05-01 1997-06-03 Trustees Of The University Of Pennsylvania Fluid handling methods for use in mesoscale analytical devices
US5922591A (en) * 1995-06-29 1999-07-13 Affymetrix, Inc. Integrated nucleic acid diagnostic device
WO1998022625A1 (en) * 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HANDIQUE K ET AL: "ON-CHIP THERMOPNEUMATIC PRESSURE FOR DISCRETE DROP PUMPING", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US LNKD- DOI:10.1021/AC000711F, vol. 73, no. 8, 15 April 2001 (2001-04-15), pages 1831 - 1838, XP001030281, ISSN: 0003-2700 *
See also references of WO03012406A1 *

Also Published As

Publication number Publication date
JP2005514718A (ja) 2005-05-19
EP1438567A1 (de) 2004-07-21
WO2003012406A1 (en) 2003-02-13
EP3427834A1 (de) 2019-01-16
WO2003012406A9 (en) 2003-03-20
ES2683698T3 (es) 2018-09-27
EP1438567B1 (de) 2018-07-25
JP4596776B2 (ja) 2010-12-15

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