EP1442297A4 - Methodes de criblage de composes osteogenes - Google Patents

Methodes de criblage de composes osteogenes

Info

Publication number: EP1442297A4
Authority: EP; European Patent Office
Prior art keywords: screening methods; osteogenic compounds; osteogenic; compounds; screening
Prior art date: 2001-10-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP02805698A

Other languages

German (de)

English (en)

Other versions

EP1442297A2 (fr

Inventor

Jonathan Lam

F Patrick Ross

Steven L Teitelbaum

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Barnes Hospital

Original Assignee

Barnes Hospital

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-12

Filing date

2002-10-15

Publication date

2004-12-15

2002-10-15 Application filed by Barnes Hospital filed Critical Barnes Hospital

2004-08-04 Publication of EP1442297A2 publication Critical patent/EP1442297A2/fr

2004-12-15 Publication of EP1442297A4 publication Critical patent/EP1442297A4/fr

Status Withdrawn legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
230000002188 osteogenic effect Effects 0.000 title 1
238000012216 screening Methods 0.000 title 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Public Health (AREA)
Cell Biology (AREA)
Animal Behavior & Ethology (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
General Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Marine Sciences & Fisheries (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Food Science & Technology (AREA)

EP02805698A 2001-10-12 2002-10-15 Methodes de criblage de composes osteogenes Withdrawn EP1442297A4 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US32923101P	2001-10-12	2001-10-12
US32887601P	2001-10-12	2001-10-12
US329231P		2001-10-12
US328876P		2001-10-12
PCT/US2002/033021 WO2003065972A2 (fr)	2001-10-12	2002-10-15	Methodes de criblage de composes osteogenes

Publications (2)

Publication Number	Publication Date
EP1442297A2 EP1442297A2 (fr)	2004-08-04
EP1442297A4 true EP1442297A4 (fr)	2004-12-15

Family

ID=27737317

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP02805698A Withdrawn EP1442297A4 (fr)	2001-10-12	2002-10-15	Methodes de criblage de composes osteogenes

Country Status (4)

Country	Link
EP (1)	EP1442297A4 (fr)
AU (1)	AU2002365426A1 (fr)
CA (1)	CA2463478A1 (fr)
WO (1)	WO2003065972A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070004624A1 (en) *	2004-06-16	2007-01-04	Luc Van Rompaey	Methods for modulating bone tissue formation, orthogenic agents and pharmaceutical compositions
EP1989203A2 (fr)	2006-02-16	2008-11-12	Millennium Pharmaceuticals, Inc.	Alpha carbolines et leurs utilisations
CN102171204B (zh)	2008-10-02	2014-08-20	旭化成制药株式会社	8位取代异喹啉衍生物及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999058674A2 (fr) *	1998-05-14	1999-11-18	Immunex Corporation	Procede pour inhiber l'activite osteoclastique
WO2001036637A1 (fr) *	1999-11-17	2001-05-25	Immunex Corporation	Activateur du recepteur de nf-kappa b
WO2002024896A2 (fr) *	2000-09-22	2002-03-28	Immunex Corporation	Methode de criblage d'agonistes ou d'antagonistes de l'activateur du recepteur de nf-kb

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6242213B1 (en) *	1996-12-23	2001-06-05	Immunex Corporation	Isolated DNA molecules encoding RANK-L
US6271349B1 (en) *	1996-12-23	2001-08-07	Immunex Corporation	Receptor activator of NF-κB

2002
- 2002-10-15 CA CA002463478A patent/CA2463478A1/fr not_active Abandoned
- 2002-10-15 WO PCT/US2002/033021 patent/WO2003065972A2/fr not_active Ceased
- 2002-10-15 EP EP02805698A patent/EP1442297A4/fr not_active Withdrawn
- 2002-10-15 AU AU2002365426A patent/AU2002365426A1/en not_active Abandoned

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999058674A2 (fr) *	1998-05-14	1999-11-18	Immunex Corporation	Procede pour inhiber l'activite osteoclastique
WO2001036637A1 (fr) *	1999-11-17	2001-05-25	Immunex Corporation	Activateur du recepteur de nf-kappa b
WO2002024896A2 (fr) *	2000-09-22	2002-03-28	Immunex Corporation	Methode de criblage d'agonistes ou d'antagonistes de l'activateur du recepteur de nf-kb

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LACEY D L ET AL: "Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 93, no. 2, 17 April 1998 (1998-04-17), pages 165 - 176, XP002117567, ISSN: 0092-8674 *
LAM J ET AL: "RANK ligand stimulates anabolic bone formation", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 16, no. Suppl. 1, September 2001 (2001-09-01), & TWENTY-THIRD ANNUAL MEETING OF THE AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH; PHOENIX, ARIZONA, USA; OCTOBER 12-16, 2001, pages S150, XP009038403, ISSN: 0884-0431 *

Also Published As

Publication number	Publication date
WO2003065972A2 (fr)	2003-08-14
AU2002365426A1 (en)	2003-09-02
CA2463478A1 (fr)	2003-08-14
AU2002365426A8 (en)	2003-09-02
WO2003065972A3 (fr)	2003-10-23
EP1442297A2 (fr)	2004-08-04

Legal Events

Date	Code	Title	Description
2004-06-18	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2004-08-04	17P	Request for examination filed	Effective date: 20040512
2004-08-04	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
2004-08-04	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2004-12-15	A4	Supplementary search report drawn up and despatched	Effective date: 20041028
2004-12-15	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61P 19/00 B Ipc: 7C 12Q 1/00 B Ipc: 7A 61K 38/16 B Ipc: 7C 07K 14/52 B Ipc: 7A 61K 38/00 A
2005-03-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2005-04-20	18W	Application withdrawn	Effective date: 20050228

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FR2832147B1 (fr)	2006-06-02	Procede de resolution de tamsulosine, et composes et compositions associees
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GB0111004D0 (en)	2001-06-27	Screening method
GB0216339D0 (en)	2002-08-21	Detecting analytes
ATE337110T1 (de)	2006-09-15	Siebmaschine
DE59907833D1 (de)	2004-01-08	Siebeinrichtung
EP1377281A4 (fr)	2009-06-17	Composes de taurine
EP1442297A4 (fr)	2004-12-15	Methodes de criblage de composes osteogenes
DE50202621D1 (de)	2005-05-04	Zentrifuge
GB0126386D0 (en)	2002-01-02	Screening methods based on cited family proteins
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DE50115802D1 (de)	2011-04-07	Dafür
GB0100754D0 (en)	2001-02-21	Screening device
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BR0200099B1 (pt)	2010-07-13	triturador de ensaio.
AU2003202103A8 (en)	2003-07-30	Multi-target screening
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