EP1468005A4 - METHOD FOR USE OF CONJUGATES OF SACCHARIDES AND ACETAMIDINO OR GUANIDINOVER BINDINGS FOR THE TREATMENT OF BACTERIAL INFECTIONS - Google Patents

METHOD FOR USE OF CONJUGATES OF SACCHARIDES AND ACETAMIDINO OR GUANIDINOVER BINDINGS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Info

Publication number
EP1468005A4
EP1468005A4 EP02796945A EP02796945A EP1468005A4 EP 1468005 A4 EP1468005 A4 EP 1468005A4 EP 02796945 A EP02796945 A EP 02796945A EP 02796945 A EP02796945 A EP 02796945A EP 1468005 A4 EP1468005 A4 EP 1468005A4
Authority
EP
European Patent Office
Prior art keywords
guanidinover
acetamidino
bindings
saccharides
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02796945A
Other languages
German (de)
French (fr)
Other versions
EP1468005A2 (en
Inventor
Aviva Lapidot
Venkat Gopalan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Ohio State University
Original Assignee
Yeda Research and Development Co Ltd
Ohio State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd, Ohio State University filed Critical Yeda Research and Development Co Ltd
Publication of EP1468005A2 publication Critical patent/EP1468005A2/en
Publication of EP1468005A4 publication Critical patent/EP1468005A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EP02796945A 2001-12-26 2002-12-26 METHOD FOR USE OF CONJUGATES OF SACCHARIDES AND ACETAMIDINO OR GUANIDINOVER BINDINGS FOR THE TREATMENT OF BACTERIAL INFECTIONS Withdrawn EP1468005A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34208501P 2001-12-26 2001-12-26
US342085P 2001-12-26
PCT/IL2002/001038 WO2003059246A2 (en) 2001-12-26 2002-12-26 Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections

Publications (2)

Publication Number Publication Date
EP1468005A2 EP1468005A2 (en) 2004-10-20
EP1468005A4 true EP1468005A4 (en) 2006-05-03

Family

ID=23340257

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02796945A Withdrawn EP1468005A4 (en) 2001-12-26 2002-12-26 METHOD FOR USE OF CONJUGATES OF SACCHARIDES AND ACETAMIDINO OR GUANIDINOVER BINDINGS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Country Status (7)

Country Link
US (1) US20050085432A1 (en)
EP (1) EP1468005A4 (en)
JP (1) JP2006502084A (en)
AU (1) AU2002361482A1 (en)
CA (1) CA2471899A1 (en)
IL (1) IL162689A0 (en)
WO (1) WO2003059246A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10209821A1 (en) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of proteins to a modified polysaccharide
ATE409048T1 (en) * 2002-10-08 2008-10-15 Fresenius Kabi De Gmbh PHARMACEUTICALLY ACTIVE OLIGOSACCHARIDE CONJUGATES
US7160992B2 (en) * 2003-04-28 2007-01-09 Yeda Research And Development Co., Ltd. Amino-modified polysaccharides and methods of generating and using same
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
WO2006052930A1 (en) 2004-11-05 2006-05-18 Isis Pharmaceuticals, Inc. Antimicrobial 2-deoxystreptamine compounds
WO2007028012A2 (en) * 2005-09-01 2007-03-08 Isis Pharmaceuticals, Inc. Antibacterial 6'-n-modified 4,5-substituted aminoglycoside analogs
AU2006320374B2 (en) 2005-12-02 2012-08-30 Isis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2011044502A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
CA2777107A1 (en) 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2011044503A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2011044538A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
CN103282370A (en) 2010-11-17 2013-09-04 尔察祯有限公司 Antibacterial amiinoglycoside analogs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0498471A2 (en) * 1986-12-23 1992-08-12 The Liposome Company, Inc. Liposomes comprising a guanidino aminoglycoside
WO1999002145A1 (en) * 1997-07-07 1999-01-21 Cambridge Neuroscience, Inc. Combination drug therapies comprising aminoglycoside antibiotics and n,n'-disubstituted guanidines
WO2001062297A1 (en) * 2000-02-14 2001-08-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across biological membranes and tissues

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NL154600B (en) * 1971-02-10 1977-09-15 Organon Nv METHOD FOR THE DETERMINATION AND DETERMINATION OF SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES.
NL154598B (en) * 1970-11-10 1977-09-15 Organon Nv PROCEDURE FOR DETERMINING AND DETERMINING LOW MOLECULAR COMPOUNDS AND PROTEINS THAT CAN SPECIFICALLY BIND THESE COMPOUNDS AND TEST PACKAGING.
NL154599B (en) * 1970-12-28 1977-09-15 Organon Nv PROCEDURE FOR DETERMINING AND DETERMINING SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES, AND TEST PACKAGING.
US3901654A (en) * 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) * 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) * 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (en) * 1972-05-11 1983-06-01 Akzo Nv METHOD FOR DETERMINING AND DETERMINING BITES AND TEST PACKAGING.
US3850578A (en) * 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) * 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) * 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) * 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) * 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US5011771A (en) * 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) * 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) * 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
DE3873470D1 (en) * 1987-10-14 1992-09-10 Ueno Seiyaku Oyo Kenkyujo Kk TREATING VIRUS DISEASES.
US5272057A (en) * 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) * 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) * 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5593835A (en) * 1995-05-12 1997-01-14 President And Fellows Of Harvard College Methods and kits for RNA binding compounds
US5879219A (en) * 1997-01-17 1999-03-09 Penjuke; Daniel Balloon inflation and illumination device
IL127773A0 (en) * 1998-12-28 1999-10-28 Yeda Res & Dev Saccharide conjugates and pharmaceutical compositions comprising them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0498471A2 (en) * 1986-12-23 1992-08-12 The Liposome Company, Inc. Liposomes comprising a guanidino aminoglycoside
WO1999002145A1 (en) * 1997-07-07 1999-01-21 Cambridge Neuroscience, Inc. Combination drug therapies comprising aminoglycoside antibiotics and n,n'-disubstituted guanidines
WO2001062297A1 (en) * 2000-02-14 2001-08-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across biological membranes and tissues

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAKER, TRACY J. ET AL: "Synthesis and Anti-HIV Activity of Guanidino glycosides", JOURNAL OF ORGANIC CHEMISTRY , 65(26), 9054-9058 CODEN: JOCEAH; ISSN: 0022-3263, 2000, XP002370083 *
CABRERA C ET AL: "Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection.", AIDS RESEARCH AND HUMAN RETROVIRUSES. 1 MAY 2000, vol. 16, no. 7, 1 May 2000 (2000-05-01), pages 627 - 634, XP002370082, ISSN: 0889-2229 *
LITOVCHICK A ET AL: "Aminoglycoside-arginine conjugates that bind TAR RNA: synthesis, characterization, and antiviral activity.", BIOCHEMISTRY. 21 MAR 2000, vol. 39, no. 11, 21 March 2000 (2000-03-21), pages 2838 - 2852, XP002370081, ISSN: 0006-2960 *
LITOVCHICK A ET AL: "Arginine-aminoglycoside conjugates that bind to HIV transactivation responsive element RNA in vitro.", FEBS LETTERS. 19 FEB 1999, vol. 445, no. 1, 19 February 1999 (1999-02-19), pages 73 - 79, XP002370080, ISSN: 0014-5793 *
LUEDTKE N W ET AL: "Guanidinoglycosides: A novel family of RNA ligands [21]", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 06 DEC 2000 UNITED STATES, vol. 122, no. 48, 6 December 2000 (2000-12-06), pages 12035 - 12036, XP002370084, ISSN: 0002-7863 *
STREICHER, W. ET AL: "Synthesis and structure/activity relationships of new guanidino derivatives of aminoglycoside antibiotics", DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH , 9(8-9), 591-8 CODEN: DECRDP; ISSN: 0378-6501, 1983, XP008060843 *

Also Published As

Publication number Publication date
JP2006502084A (en) 2006-01-19
IL162689A0 (en) 2005-11-20
AU2002361482A1 (en) 2003-07-30
EP1468005A2 (en) 2004-10-20
US20050085432A1 (en) 2005-04-21
CA2471899A1 (en) 2003-07-24
WO2003059246A3 (en) 2003-10-16
WO2003059246A2 (en) 2003-07-24

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