EP1472002A1 - Systeme microfluidique - Google Patents

Systeme microfluidique

Info

Publication number
EP1472002A1
EP1472002A1 EP03708012A EP03708012A EP1472002A1 EP 1472002 A1 EP1472002 A1 EP 1472002A1 EP 03708012 A EP03708012 A EP 03708012A EP 03708012 A EP03708012 A EP 03708012A EP 1472002 A1 EP1472002 A1 EP 1472002A1
Authority
EP
European Patent Office
Prior art keywords
microfluidic
sensors
fluid paths
parallel
microfluidic system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03708012A
Other languages
German (de)
English (en)
Inventor
Fritz Breimesser
Jörg HASSEL
Ingeborg Lades
Arno Steckenborn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Original Assignee
Siemens AG
Siemens Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens AG, Siemens Corp filed Critical Siemens AG
Publication of EP1472002A1 publication Critical patent/EP1472002A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4338—Mixers with a succession of converging-diverging cross-sections, i.e. undulating cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00957—Compositions or concentrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00961—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00963—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00966—Measured properties pH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Definitions

  • the invention relates to a microfluidic system with similar parallel fluid paths.
  • microfluidic systems promise enormous improvements in terms of quality, speed and cost compared to macroscopic systems, since the reaction and residence times in the fluid paths are very short and only very small amounts of substances are used with high precision and reproducibility and processed.
  • reaction and residence times in the fluid paths are very short and only very small amounts of substances are used with high precision and reproducibility and processed.
  • the fluid paths must be connected in parallel (numbering-up).
  • the parallel connection can take place in that several similar microchannels are formed and connected in parallel in microfluidic components, for example a mixer, or in that entire microfluidic components or systems composed of microfluidic components are connected several times in parallel.
  • Suitable methods of microtechnology e.g. etching, LIGA technology or micromechanics
  • etching, LIGA technology or micromechanics can be used to produce the parallel fluid paths with the same high precision, so that the same process conditions, such as pressure, temperature, mass flow, etc., prevail in all fluid paths connected in parallel the same products should be obtained from all parallel fluid paths and should be able to be combined without loss of quality.
  • microfluidic systems tend to operationally change the effective flow resistance both due to local fluctuations in the viscosity of the fluid and due to blockages in the fluid paths, which leads to a further change. operating status and progressive constipation up to a total failure of the system. While in macroscopic systems, for example, the mass flow can be measured easily and almost without interference and a flow control can be given up, this is not possible with reasonable effort for parallelized microfluidic systems for the individual fluid paths.
  • the invention is therefore based on the object of enabling function monitoring of parallelized microfluidic systems.
  • the object is achieved in that, in the microfluidic system of the type specified at the outset, sensors are assigned to the individual fluid paths at the same points in each case to record a physical or chemical quantity that can be influenced by the fluid flow in the fluid paths, and that the sensors are connected to an evaluation device which diagnoses a change in the operating state of the microfluidic system from deviations in the quantities detected by the sensors.
  • the same digits are to be understood as equivalent digits in relation to the size to be recorded; for example, in a channel without a branch, the flow of the fluid is the same everywhere, while the pressure z. B. due to the current-related
  • Pressure drop may be different.
  • the physical parameters can be pressure, temperature and flow, the chemical parameters, for example, the pH value.
  • the fluid paths of the parallelized microfluidic system are of the same design, the same process conditions prevail in all parallel fluid paths at the same locations in the fault-free state of the system, so that the sensors each record the same value of the physical or chemical quantity. If, on the other hand, a size differs in value from the other sizes recorded, so this indicates a malfunction in the associated fluid path. Different measures can then be drawn depending on the system or application. For safety reasons, the entire system or only the fluid path in question can be switched off, and a replacement fluid path that has not been used until then can be switched on instead of the fluid path that was switched off. Another possibility is to initiate a winding process in order to eliminate the disturbance in the fluid path in question. If the process is to be continued without interruption, changes in global sizes such as B.
  • the process conditions are changed.
  • the distribution of the flow in the individual parallel fluid paths can be corrected by actuating micro-control valves in the individual fluid paths or by a local shift in the effective area, that is to say, for example, by a local temperature change; the latter is particularly indicated in strongly exothermic or endothermic reactions, since such reactions tend to accelerate the change to a high degree without correction.
  • the fluid paths which are monitored at the same points with the sensors, can be parallel microchannels in a microfluidic component, for example a microreactor.
  • the monitoring relates to the microfluidic components or systems connected in parallel; that is, the monitored fluid paths are in each case the fluid-carrying structures in the individual microfluidic components connected in parallel, whereby of course the fluid-carrying structures in turn can also have parallel microchannels which, as mentioned above, can be monitored in the same way.
  • the sensors can be pressure sensors, for example, which record the pressures at the same locations in the fluid paths.
  • the inlet pressure or outlet pressure of the fluid at the inlet or outlet of the parallel circuit can serve as the reference pressure, so that in the event of a blockage of the fluid path it can be determined whether the blockage is in the area between the inlet and the location of the pressure measurement or between the location of the Pressure measurement and the output lies.
  • the sensors can be temperature sensors that record the temperatures in the vicinity of the parallel fluid paths at the same locations. If the mass flows through the fluid paths are borrowed, there are temperature differences which indicate a change in the operating state.
  • Another possibility of monitoring is to record the mechanical stresses in the vicinity of the parallel fluid paths. Due to pressure and / or temperature differences in the individual fluid paths, different mechanical stresses can arise at the different locations.
  • sensors of the same type can also be provided at different locations for each fluid path, or different sensors for detecting different physical or chemical variables, in order to be able to localize errors more precisely and to make monitoring more reliable overall.
  • one microfluidic component can advantageously work as a master and the other parallel microfluidic components can work as slaves, with the slaves each having a sensor system that is reduced compared to the master and which connected to the sensors Evaluation device Diagnoses changes in the operating state of the slaves compared to the master.
  • the master is equipped with the complete sensor system to fully control a process or sub-process, the sensor system of the slaves is reduced to a minimum.
  • the settings made by the master as part of process control, e.g. Control commands for control valves, for example, are taken over by the slaves so that the same operating conditions as for the master are set there.
  • the evaluation device connected to the sensors then only monitors whether the operating states of the slaves differ from those of the master. With a parallelized microfluidic system, this can significantly reduce the effort for the sensors.
  • FIG. 1 shows a microfluidic component with parallel microchannels which are monitored by sensors and an evaluation device connected to them
  • FIG. 2 shows a parallelized microfluidic composed of a large number of microfluidic components.
  • FIG. 1 shows a microfluidic component, here a mixer or reactor, in which several parallel microchannels 5 of the same type are formed between two inputs 2 and 3 for two fluids to be mixed and an output 4 for the product produced by mixing, in which the two merged Fluids are mixed in successive mixing stages 6 and react if necessary.
  • Each of the microchannels 5 contains, for example, a pressure sensor 7 halfway in the middle.
  • the pressure sensors 7 and two further pressure sensors 8 and 9 for measuring the inlet and outlet pressures of the microfluidic component 1 are connected to an evaluation device 10. In the trouble-free operating state, the same process conditions prevail in the individual microchannels 5, so that the pressures detected by the sensors 7 are in each case the same.
  • the pressures detected by the sensors 7 each correspond to half of the total pressure drop across the microchannels 5. Is one of the microchannels 5, for example, at the point labeled 29 completely blocked, the associated pressure sensor 7 detects the same pressure as the pressure sensor 8, so that the pressure difference between the assigned sensor 7 and the sensor 8 corresponds to zero and between the sensor 7 and the sensor 9 corresponds to the total pressure drop across the microchannels 5.
  • the evaluation device 10 can therefore diagnose changes in the operating state of the microfluidic component 1 from deviations in the pressures detected by the sensors 7 and localize faults in the individual microchannels 5.
  • microchannels 5 can be compensated for, for example, by additionally heating the microfluidic component 1 at the location of the microchannel 5 in question.
  • the microchannels 5 additional channels 30 of a heat exchanger 31 can be assigned, which can be switched individually via micro valves, not shown here, and thus enable different heating or cooling of the individual microchannels 5.
  • FIG. 2 shows a parallelized microfluidic system, in which a first system with successive micro- fluidic components 11, 12, 13 further similar systems with microfluidic components 14, 15, 16 and 17, 18, 19 are connected in parallel.
  • the microfluidic components 11, 14, 17 are each of the same design; the same applies accordingly to the microfluidic components 12, 15, 18 or 13, 16, 19.
  • the microfluidic components 11, 14, 17 each have a sensor 20, for example a temperature sensor, at the same point, which is connected to a Evaluation device 21 is connected.
  • the other microfluidic components 12, 15, 18 and 13, 16, 19 are also provided with sensors 22 and 23, which are connected to evaluation devices 24 and 25, respectively.
  • the process relationships in the parallel microfluidic components e.g.
  • Deviation of the temperature in question from the temperatures detected at the other microfluidic components 11 and 14 diagnoses a change in the operating state of the microfluidic component 17.
  • the microfluidic components 13, 16, 19 are, for. B. to mixers or reactors, the sensors 23, for example, monitor the pH of the mixed fluids and thus their mixing ratio.
  • the evaluation devices 21, 24 and 25 are part of a device 26 for controlling and regulating the process taking place in the microfluidic system.
  • the system consisting of microfluidic components 11, 12 and 13 is designed as a master, while the systems consisting of microfluidic components 14, 15, 16 and 17, 18, 19 work as slaves.
  • Microfluidic components 11, 12, 13 of the master are equipped with a complete sensor system 27 and report the detected th process states to the device 26.
  • the microfluidic components 14, 15, 16 and 17, 18, 19 of the slaves are only equipped with a reduced sensor system, which is roughly expressed here in that they have no process states to the Report facility 26.
  • the device 26 On the basis of the process states detected by the sensor system 27 of the master, the device 26 generates control commands 28 for the microfluidic components 11, 12, 13 of the master as well as for the microfluidic components 14, 15, 16 and 17, 18, 19 of the slaves , The same operating states as those in the master are thus set in the microfluidic components of the slaves.
  • the evaluation devices 21, 24, 25 then only monitor whether the operating states in the microfluidic components of the slaves differ from those of the master.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un système microfluidique comportant des parcours fluidiques parallèles similaires et vise à permettre une surveillance du fonctionnement dudit système. A cet effet, il est prévu d'associer aux chemins fluidiques (5) individuels, dans chaque cas aux mêmes points, des détecteurs (7) pour enregistrer une grandeur physique pouvant être influencée par le courant fluidique dans les chemins fluidiques (5). Lesdits détecteurs (7) sont connectés à un dispositif d'évaluation (10) qui diagnostique une modification de l'état de fonctionnement du système microfluidique, sur la base d'écarts des grandeurs détectées par les détecteurs (7).
EP03708012A 2002-02-04 2003-01-31 Systeme microfluidique Withdrawn EP1472002A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10204414 2002-02-04
DE10204414A DE10204414A1 (de) 2002-02-04 2002-02-04 Mikrofluidik-System
PCT/DE2003/000278 WO2003066216A1 (fr) 2002-02-04 2003-01-31 Systeme microfluidique

Publications (1)

Publication Number Publication Date
EP1472002A1 true EP1472002A1 (fr) 2004-11-03

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US20050054111A1 (en) 2005-03-10
US7527767B2 (en) 2009-05-05
DE10204414A1 (de) 2003-09-04
DE10390346D2 (de) 2005-01-05
JP4287748B2 (ja) 2009-07-01
WO2003066216A1 (fr) 2003-08-14
AU2003212192A1 (en) 2003-09-02
JP2005517161A (ja) 2005-06-09

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