EP1478655A4 - Procedes et substances de modulation de l'enac-beta - Google Patents

Procedes et substances de modulation de l'enac-beta

Info

Publication number
EP1478655A4
EP1478655A4 EP02799996A EP02799996A EP1478655A4 EP 1478655 A4 EP1478655 A4 EP 1478655A4 EP 02799996 A EP02799996 A EP 02799996A EP 02799996 A EP02799996 A EP 02799996A EP 1478655 A4 EP1478655 A4 EP 1478655A4
Authority
EP
European Patent Office
Prior art keywords
beta
materials
methods
enac
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02799996A
Other languages
German (de)
English (en)
Other versions
EP1478655A2 (fr
Inventor
Samuel J Shuster
Ulf N G Arvidsson
Laura S Stone
Hong-Yan Zhang
Lucy Vulchanova Hart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALGOS THERAPEUTICS Inc
Original Assignee
ALGOS THERAPEUTICS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALGOS THERAPEUTICS Inc filed Critical ALGOS THERAPEUTICS Inc
Publication of EP1478655A2 publication Critical patent/EP1478655A2/fr
Publication of EP1478655A4 publication Critical patent/EP1478655A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP02799996A 2001-12-31 2002-12-31 Procedes et substances de modulation de l'enac-beta Withdrawn EP1478655A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34606901P 2001-12-31 2001-12-31
US346069P 2001-12-31
PCT/US2002/041850 WO2003057847A2 (fr) 2001-12-31 2002-12-31 Procedes et substances de modulation de l'enac-beta

Publications (2)

Publication Number Publication Date
EP1478655A2 EP1478655A2 (fr) 2004-11-24
EP1478655A4 true EP1478655A4 (fr) 2006-05-10

Family

ID=23357796

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02799996A Withdrawn EP1478655A4 (fr) 2001-12-31 2002-12-31 Procedes et substances de modulation de l'enac-beta

Country Status (3)

Country Link
EP (1) EP1478655A4 (fr)
AU (1) AU2002364612A1 (fr)
WO (1) WO2003057847A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4969002B2 (ja) 1999-06-08 2012-07-04 ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン ｒＡＡＶ形質導入を増加するための化合物および方法
AR066984A1 (es) 2007-06-15 2009-09-23 Novartis Ag Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
DK2561077T3 (en) 2010-04-23 2016-08-01 Arrowhead Res Corp Organic compositions for the treatment of beta-ENaC-related diseases
WO2013155406A1 (fr) * 2012-04-12 2013-10-17 The Chinese University Of Hong Kong Contragestion et traitement d'une inflammation par la modulation de l'activité d'un canal sodique dans l'épithélium
WO2017139381A1 (fr) 2016-02-08 2017-08-17 University Of Iowa Research Foundation Procédés pour produire des virus adéno-associés/bocavirus parvovirus chimériques
CA3016985C (fr) 2016-03-07 2023-07-04 University Of Iowa Research Foundation Expression mediee par aav utilisant un promoteur et un activateur synthetiques
WO2017205739A1 (fr) 2016-05-26 2017-11-30 University Of Iowa Research Foundation Configurations cis et trans pour la résolution terminale du bocavirus 1 humain
US11142775B2 (en) 2017-01-13 2021-10-12 University Of Iowa Research Foundation Bocaparvovirus small noncoding RNA and uses thereof
TN2019000308A1 (en) 2017-07-06 2021-05-07 Arrowhead Pharmaceuticals Inc RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2283293A1 (fr) * 1997-03-11 1998-09-17 Yale University Procede de diagnostic et de traitement d'etats pathologiques resultant d'un transport ionique deficient tels que le pseudo-hypoaldosteronisme de type 1 (pha1)
US20030077773A1 (en) * 2000-12-06 2003-04-24 Brandon Rhonda C. Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI 11 June 1993 (1993-06-11), XP002370531, Database accession no. L15695 *
DATABASE NCBI 26 July 2000 (2000-07-26), XP002370524, Database accession no. AJ270360 *
DATABASE NCBI 28 September 1999 (1999-09-28), XP002370529, Database accession no. 1QMS_A *
DATABASE NCBI 3 October 1995 (1995-10-03), XP002370525, Database accession no. 1HAP_D *
DATABASE NCBI 5 June 1997 (1997-06-05), XP002370532, Database accession no. Y13518 *
DATABASE NCBI 6 March 2000 (2000-03-06), XP002370527, Database accession no. AJ132117 *
DATABASE NCBI 7 May 1993 (1993-05-07), XP002370528, Database accession no. S85712 *
DATABASE NCBI 7 May 1993 (1993-05-07), XP002370530, Database accession no. S81274 *
DATABASE NCBI 7 May 1996 (1996-05-07), XP002370526, Database accession no. X87698 *
JAIN LUCKY ET AL: "Antisense oligonucleotides against the alpha-subunit of ENaC decrease lung epithelial cation-channel activity", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 276, no. 6 PART 1, June 1999 (1999-06-01), pages L1046 - L1051, XP002370512, ISSN: 0002-9513 *
JAIN LUCKY ET AL: "Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 280, no. 4 Part 1, April 2001 (2001-04-01), pages L646 - L658, XP002370510, ISSN: 0002-9513 *
MANO I ET AL: "DEG/ENAC CHANNELS A TOUCHY SUPERFAMILY THAT WATCHES ITS SALT", BIOESSAYS, CAMBRIDGE, GB, vol. 21, no. 7, July 1999 (1999-07-01), pages 568 - 578, XP008034073, ISSN: 0265-9247 *
ZUCCHI ILEANA ET AL: "Genetic dissection of dome formation in a mammary cell line: Identification of two genes with opposing action", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, no. 24, 23 November 1999 (1999-11-23), pages 13766 - 13770, XP002370511, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU2002364612A1 (en) 2003-07-24
WO2003057847A3 (fr) 2003-12-11
AU2002364612A8 (en) 2003-07-24
WO2003057847A8 (fr) 2004-01-15
WO2003057847A2 (fr) 2003-07-17
EP1478655A2 (fr) 2004-11-24

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20040729

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO

A4 Supplementary search report drawn up and despatched

Effective date: 20060327

17Q First examination report despatched

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18D Application deemed to be withdrawn

Effective date: 20090701