EP1497314A4 - Compositions et procedes d'utilisation de peptides de ciblage contre les tissus adipeux et placentaires - Google Patents

Compositions et procedes d'utilisation de peptides de ciblage contre les tissus adipeux et placentaires

Info

Publication number
EP1497314A4
EP1497314A4 EP02757531A EP02757531A EP1497314A4 EP 1497314 A4 EP1497314 A4 EP 1497314A4 EP 02757531 A EP02757531 A EP 02757531A EP 02757531 A EP02757531 A EP 02757531A EP 1497314 A4 EP1497314 A4 EP 1497314A4
Authority
EP
European Patent Office
Prior art keywords
placentary
tissues
compositions
methods
targeting peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02757531A
Other languages
German (de)
English (en)
Other versions
EP1497314A2 (fr
Inventor
Renata Pasqualini
Wadih Arap
Mikhail G Kolonin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/027692 external-priority patent/WO2002020769A1/fr
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of EP1497314A2 publication Critical patent/EP1497314A2/fr
Publication of EP1497314A4 publication Critical patent/EP1497314A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/28—Gramicidins A, B, D; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
EP02757531A 2001-09-07 2002-08-30 Compositions et procedes d'utilisation de peptides de ciblage contre les tissus adipeux et placentaires Withdrawn EP1497314A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2001/027692 WO2002020769A1 (fr) 2000-09-08 2001-09-07 Peptides de ciblage humains et murins identifies par expression phagique
WOPCT/US01/27692 2001-09-07
PCT/US2002/027836 WO2003022991A2 (fr) 2001-09-07 2002-08-30 Compositions et procedes d'utilisation de peptides de ciblage contre les tissus adipeux et placentaires

Publications (2)

Publication Number Publication Date
EP1497314A2 EP1497314A2 (fr) 2005-01-19
EP1497314A4 true EP1497314A4 (fr) 2007-10-10

Family

ID=21742817

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02757531A Withdrawn EP1497314A4 (fr) 2001-09-07 2002-08-30 Compositions et procedes d'utilisation de peptides de ciblage contre les tissus adipeux et placentaires

Country Status (4)

Country Link
EP (1) EP1497314A4 (fr)
AU (1) AU2002323543A1 (fr)
CA (1) CA2458047A1 (fr)
WO (1) WO2003022991A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148277A (zh) * 2014-11-03 2017-09-08 清华大学 一种抑制脂肪细胞分化和胰岛素耐受的药物

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US8507445B2 (en) 2001-09-07 2013-08-13 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US7671010B2 (en) 2002-08-30 2010-03-02 The Board Of Regents Of The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US7598341B2 (en) * 2003-10-31 2009-10-06 Burnham Institue For Medical Research Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs
WO2005065418A2 (fr) * 2003-12-31 2005-07-21 Board Of Regents, The University Of Texas System Compositions et procedes d'utilisation de peptides de ciblage pour le diagnostic et la therapie
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
WO2007020405A2 (fr) * 2005-08-12 2007-02-22 Cartela R & D Ab Nouveaux peptides et utilisations associees
HUE038787T2 (hu) 2011-02-11 2018-11-28 Univ Michigan Regents Tripeptid készítmények és alkalmazásuk diabétesz kezelésére
CN114272390B (zh) * 2021-12-29 2022-09-02 中山大学附属第一医院 一种微环境靶向联合细胞靶向肿瘤抑制载体及其制备方法和应用
CN114469891B (zh) * 2021-12-29 2023-01-24 中山大学附属第一医院 一种酶敏感外壳的小分子药物/治疗基因联合递送系统及其制备方法和应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
WO1998039469A1 (fr) * 1997-03-04 1998-09-11 Bio-Technology General Corp. Isolement de ligands peptidiques a specificite tissulaire et utilisation de ces derniers pour cibler des substances pharmaceutiques sur des organes
WO1999004813A1 (fr) * 1997-07-24 1999-02-04 Brigham & Women's Hospital, Inc. Transport trans-epithelial d'agents therapeutiques specifique de recepteur
WO2001013114A1 (fr) * 1999-08-16 2001-02-22 Bio-Rad Pasteur Composes synthetiques portant deux epitopes pour immunodosages
WO2001042276A1 (fr) * 1999-12-13 2001-06-14 Proteom Limited Ligands de peptides complementaires generes a partir de sequences de genomes d'eucaryotes superieurs
WO2001053342A1 (fr) * 2000-01-21 2001-07-26 The Burnham Institute Peptides chimeres de ciblage de la prostate comportant une activite pro-apoptotique
WO2002020769A1 (fr) * 2000-09-08 2002-03-14 Board Of Regents, The University Of Texas System Peptides de ciblage humains et murins identifies par expression phagique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19605175A1 (de) * 1996-02-13 1997-08-14 Sourovoi Andrej Dr Lipidverbindungen und deren Verwendung

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
WO1998039469A1 (fr) * 1997-03-04 1998-09-11 Bio-Technology General Corp. Isolement de ligands peptidiques a specificite tissulaire et utilisation de ces derniers pour cibler des substances pharmaceutiques sur des organes
WO1999004813A1 (fr) * 1997-07-24 1999-02-04 Brigham & Women's Hospital, Inc. Transport trans-epithelial d'agents therapeutiques specifique de recepteur
WO2001013114A1 (fr) * 1999-08-16 2001-02-22 Bio-Rad Pasteur Composes synthetiques portant deux epitopes pour immunodosages
WO2001042276A1 (fr) * 1999-12-13 2001-06-14 Proteom Limited Ligands de peptides complementaires generes a partir de sequences de genomes d'eucaryotes superieurs
WO2001053342A1 (fr) * 2000-01-21 2001-07-26 The Burnham Institute Peptides chimeres de ciblage de la prostate comportant une activite pro-apoptotique
WO2002020769A1 (fr) * 2000-09-08 2002-03-14 Board Of Regents, The University Of Texas System Peptides de ciblage humains et murins identifies par expression phagique

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HUSSAIN MUNIR A ET AL: "Nasal mucosal metabolism and absorption of pentapeptide enkephalin analogs having varying N-terminal amino acids", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 84, no. 1, 1995, pages 62 - 64, XP002447983, ISSN: 0022-3549 *
KOLONIN M G ET AL: "Reversal of obesity by targeted ablation of adipose tissue", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 10, no. 6, June 2004 (2004-06-01), pages 625 - 632, XP002363820, ISSN: 1078-8956 *
KOLONIN MIKHAIL G ET AL: "Teratogenicity induced by targeting a placental immunoglobulin transporter", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, no. 20, 1 October 2002 (2002-10-01), pages 13055 - 13060, XP002433168, ISSN: 0027-8424 *
KOLONIN MIKHAIL GERMAN ET AL: "Targeting physiological and pathological blood vessel formation with in vivo phage display", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 42, March 2001 (2001-03-01), & 92ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; NEW ORLEANS, LA, USA; MARCH 24-28, 2001, pages 822 - 823, XP001536410, ISSN: 0197-016X *
NOMIZU ET AL.: "Cell binding sequences in mouse laminin alpha1 chain", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 1998, pages 32491 - 32499, XP002447984 *
ST HILAIRE P M ET AL: "The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach.", CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY 18 AUG 2000, vol. 1, no. 2, 18 August 2000 (2000-08-18), pages 115 - 122, XP002433167, ISSN: 1439-4227 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148277A (zh) * 2014-11-03 2017-09-08 清华大学 一种抑制脂肪细胞分化和胰岛素耐受的药物

Also Published As

Publication number Publication date
EP1497314A2 (fr) 2005-01-19
WO2003022991A2 (fr) 2003-03-20
AU2002323543A1 (en) 2003-03-24
WO2003022991A3 (fr) 2004-10-28
CA2458047A1 (fr) 2003-03-20

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