EP1551541B1 - Einweg-misher und homogenisator - Google Patents

Einweg-misher und homogenisator Download PDF

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Publication number
EP1551541B1
EP1551541B1 EP03753192A EP03753192A EP1551541B1 EP 1551541 B1 EP1551541 B1 EP 1551541B1 EP 03753192 A EP03753192 A EP 03753192A EP 03753192 A EP03753192 A EP 03753192A EP 1551541 B1 EP1551541 B1 EP 1551541B1
Authority
EP
European Patent Office
Prior art keywords
laboratory test
cover
test container
cutting
disposable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP03753192A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1551541A1 (de
Inventor
Franz G. Bucher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miltenyi Biotec Swiss AG
Original Assignee
Medic Tools AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medic Tools AG filed Critical Medic Tools AG
Publication of EP1551541A1 publication Critical patent/EP1551541A1/de
Application granted granted Critical
Publication of EP1551541B1 publication Critical patent/EP1551541B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
    • B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
    • B02C18/08—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers
    • B02C18/12—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers with drive arranged below container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
    • B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
    • B02C18/16—Details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
    • B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
    • B02C18/16—Details
    • B02C18/18—Knives; Mountings thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/0056—Other disintegrating devices or methods specially adapted for specific materials not otherwise provided for
    • B02C19/0075—Other disintegrating devices or methods specially adapted for specific materials not otherwise provided for specially adapted for disintegrating medical waste
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
    • B01F27/2721—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces provided with intermeshing elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
    • B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
    • B01F33/83611—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by cutting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/60—Safety arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/082—Handling hazardous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
    • B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
    • B02C18/16—Details
    • B02C18/18—Knives; Mountings thereof
    • B02C2018/188—Stationary counter-knives; Mountings thereof

Definitions

  • the invention relates to a device for mixing and homogenizing materials, in particular infectious or smelling or chemically aggressive materials, in a laboratory test vessel.
  • Magnetic stirrers and mechanical stirrers are well known and commonly used in the laboratory. When shredding infectious tissue fragments in non-hermetically sealed vessels, there is a high risk of infection due to uncontrolled splashes that can escape through the opening of the laboratory test vessel, accidental tipping over of the laboratory test vessel, and the use of reusable mixers. This is the case in particular with test tubes and mixers known therefor.
  • a puncturable membrane allows the homogenate or mixture to be diluted or removed from the laboratory test vessel by means of a pipetting needle or disposable tip without removing the disposable lid or analyzed by a sensor or heated by a heating or cooling bar without having to remove the lid from the laboratory test vessel.
  • the lid is designed as a disposable lid, so that it is disposed of immediately after use and thus contamination in the further work in the laboratory is safely avoided.
  • the Fig. 1 shows a schematic plan view and Fig. 9 a schematic partially sectioned side view of the disposable lid 10.
  • the interior of a cylindrical laboratory test tube 70 with a tapered tip 72 is filled with the materials to be mixed or homogenizing 71. Subsequently, the laboratory test vessel 70 is closed with the disposable screw cap 10 or the disposable snap cap (snap-cap) 10 and then turned upside down.
  • a stirring element 30 with a radial coarse cutter 31, three Heilquetschpase 33 and three Feinquetscherdrillinge of plastic or metal provided at the cutting edges of the Grooves 41, 43, 45 of the retaining sleeve 40 are guided past this stirring element 30 is driven by means of the hollow shaft 50 from outside the laboratory test vessel 70 by an external six-point quick-release pin.
  • the laboratory test vessel 70 with the mixing and homogenizing Materials will be appropriate for inverted vessel position Fig. 9 non-positively placed on the external six-point quick-release pin of an external drive. Due to the transmitted rotational movement, the substances and liquids 71 located in the interior of the laboratory test vessel 70 are mixed, mixed and homogenized in three phases by the coarse cutting knife 31, the three middle squeezer pairs 33 and the three fine squeezer wringers 35 at the grooves 41, 43, 45 of the retaining sleeve 40 and turns upwards.
  • the hydraulic labyrinth lip seal 22, 36 consisting also of three annular intermeshing axial grooves and cams, prevents leakage of the liquid 71.
  • the speed is material-specifically set for optimal homogenization.
  • the number of processing elements 31, 33 and 35 (1, 2, 3, etc.) is arbitrary, with the expert determines their number, among other things, by the height and type of cutting selected.
  • the hydraulic labyrinth lip seal 22, 36 in the lid 10 hermetically seals the material 71 in the interior of the laboratory test vessel 70 both at rest and during the rotational movement of the stirring element 30 against the environment, thereby preventing contamination with the environment and the escape of aerosols before and after mixing or homogenizing.
  • the Fig. 2 shows a schematic partially sectioned side view of the threaded body 20 of the lid.
  • the double thread 21 serves to easily receive the laboratory test vessel 70.
  • the sealing lip 24 provides additional security against leakage of the liquid 71. Twelve lateral grooves 25 prevent the threaded body from rotating during the drive of the hollow shaft 50.
  • the Fig. 3 shows a schematic partially sectioned side view of the hollow body 50 and the Fig. 4 shows a schematic partially sectioned plan view of the hollow body 50.
  • Six axial notches 52 take over from the external six-point quick release bolt frictionally the torque.
  • the hollow body 50 is pressed force-fit into the stirring element 30.
  • the Fig. 5 shows a schematic plan view of the stirring member 30 and the Fig. 6 shows a partially sectioned view of the stirring element 30.
  • the membrane 32 allows the upright laboratory test vessel 70, the implementation of a pipetting needle, a disposable tip, a probe or a heating / cooling component without the disposable lid 10 must be removed from the laboratory test vessel 70. This greatly minimizes potential contamination and aerosols.
  • opening 54 of the hollow body 50 can be the laboratory test tube 70 after completing the piercing of the membrane 32 again hermetically close.
  • the central arrangement of the passage or hollow shaft 53 is advantageous.
  • the stirring element 30, together with the retaining sleeve 40 enables the homogenization in three phases.
  • the radial coarse cutting blade 31 cuts together with the grooves 41 in the retaining sleeve 40 in Fig. 8 the mix into rough fragments.
  • the three radial Mittelquetschercrue 33 crush the mix with the help of the grooves 43 on.
  • the fine squeezer 35 together with the grooves 45 homogenize the mix to the actual homogenate.
  • the Fig. 7 shows a schematic plan view of the retaining sleeve 40 and the Fig. 8 shows a partially sectioned side view of the retaining sleeve 40.
  • the cam pairs 41 and 42 are radially and axially offset so that the retaining sleeve 40 at any time plug in the disposable lid 10 or can be removed from the disposable lid 10.
  • the grooves 41, 43, 45 in the cams 42, 44 and the cams 42, 44 themselves serve to retain the mix 71 in the overhead laboratory test vessel 70 and rotating agitator 30, pinch, cut and crush.
  • sensor lines may be passed through the threaded body 20 having electrical connections on the outward-facing side.
  • a sensor can be easily arranged during mixing in the region 27 of the material 71 to be processed.
  • a light guide can be introduced or a supply line which forms a radiator or a Peltier element in the region 27.
  • heat energy can be introduced into the laboratory test vessel 70 or discharged to the outside.
  • the speed profile of the stirring element 30 in the sample test vessel 70 and the mixing time play a decisive role. Via the coupling element 50, all forms of speed accelerations and decelerations as well as ultrasonic waves can be supplied to the stirring element 30.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Environmental & Geological Engineering (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Liquid Crystal Substances (AREA)
  • Accessories For Mixers (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03753192A 2002-10-15 2003-10-15 Einweg-misher und homogenisator Expired - Lifetime EP1551541B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH17222002 2002-10-15
CH17222002 2002-10-15
PCT/CH2003/000675 WO2004035191A1 (de) 2002-10-15 2003-10-15 Einweg-misher und homogenisator

Publications (2)

Publication Number Publication Date
EP1551541A1 EP1551541A1 (de) 2005-07-13
EP1551541B1 true EP1551541B1 (de) 2008-09-03

Family

ID=32097396

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03753192A Expired - Lifetime EP1551541B1 (de) 2002-10-15 2003-10-15 Einweg-misher und homogenisator

Country Status (8)

Country Link
US (1) US7490976B2 (da)
EP (1) EP1551541B1 (da)
AT (1) ATE406952T1 (da)
AU (1) AU2003271483A1 (da)
DE (1) DE50310447D1 (da)
DK (1) DK1551541T3 (da)
ES (1) ES2314230T3 (da)
WO (1) WO2004035191A1 (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE502005005225D1 (de) 2005-01-21 2008-10-09 Medic Tools Ag Einweg-fraktioniervorrichtung
EP1839027B1 (de) * 2005-01-21 2016-10-19 Medic Tools AG Einwegmischer, -homogenisator, -extrahierer, -fraktionierer oder -aufschlämmer
ATE523255T1 (de) * 2005-02-01 2011-09-15 Medic Tools Ag Vorrichtung zum extrahieren, fragmentieren, mischen und homogenisieren von insbesondere infektiösen, übel riechenden, chemisch aggressiven oder sterilen stoffen
DE102005020460B4 (de) * 2005-04-29 2007-03-29 Ika - Werke Gmbh & Co. Kg Rühr- oder Dispergiervorrichtung
FR2925066B1 (fr) * 2007-12-18 2014-12-19 Bertin Technologies Sa Dispositif de broyage d'un echantillon biologique
EP2255010B1 (en) * 2008-02-20 2018-05-30 Streck Inc. Thermocycler and sample vessel for rapid amplification of dna
US20100270410A1 (en) * 2009-04-27 2010-10-28 SSI Shredding Sytems, Inc. Material Shredder including reverse-facing, pass-by-interlocking, rotor-cutter/bed-knife cutting edges
WO2010132756A2 (en) * 2009-05-14 2010-11-18 Streck, Inc. Sample processing cassette, system, and method
CN101803884B (zh) * 2010-04-12 2012-04-25 王晓东 食品处理机剪切式粉碎刀具结构
KR101288929B1 (ko) * 2010-05-26 2013-07-22 배주한 디스크형 중유 유화장치
FR2960863B1 (fr) * 2010-06-07 2012-07-13 Fillon Technologies Couvercle de fermeture pour recipient equipe d'un joint d'etancheite
WO2012001607A1 (en) * 2010-06-29 2012-01-05 Yadav, Omprakash Disposable homogenizer kit
EP2478962A1 (en) 2011-01-24 2012-07-25 Miltenyi Biotec GmbH Heating device for cylindrical laboratory vessels
WO2012166913A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
ES2574666T3 (es) 2011-06-27 2016-06-21 Miltenyi Biotec Gmbh Dispositivo para fragmentar el tejido
SE536456C2 (sv) * 2011-12-15 2013-11-12 Metso Paper Sweden Ab Blandningsenhet innefattande åtminstone två rotorkroppar föranvändning i en blandningsanordning och en blandningsanordning
DE102012004491B4 (de) * 2012-03-06 2013-10-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Handhabungsvorrichtung zum Handhaben von Röhrchen zum Zell- und/oder Gewebeaufschluss undVerfahren zum Zell- und/oder Gewebeaufschluss
EP2883039A1 (en) 2012-08-10 2015-06-17 Streck Inc. Real-time optical system for polymerase chain reaction
EP3014251A1 (en) 2013-06-28 2016-05-04 Streck Inc. Devices for real-time polymerase chain reaction
CN203436142U (zh) * 2013-07-31 2014-02-19 惠阳亚伦塑胶电器实业有限公司 一种榨汁机
DE102015007435A1 (de) * 2015-06-15 2016-12-15 Pallmann Maschinenfabrik Gmbh & Co. Kg Vorrichtung und Mahlwerkzeug zum Zerkleinern von Aufgabegut
CN107999230A (zh) * 2017-12-28 2018-05-08 郑州游爱网络技术有限公司 一种饲料筛选破碎预搅拌出料装置
CN109364810A (zh) * 2018-10-23 2019-02-22 温碧君 一种化学肥料高效混合搅拌装置
WO2020124263A1 (en) * 2018-12-21 2020-06-25 Nanorial Technologies Ltd. Apparatus, methods, and systems for mixing, dispersing substances
WO2021126068A1 (en) * 2019-12-17 2021-06-24 Kujtim Hyseni Gas generator and cavitator for gas generation
CN111249996A (zh) * 2020-03-13 2020-06-09 山东厚俞实业有限公司 一种干湿分离式加药装置
CN113176123B (zh) * 2021-04-29 2025-08-05 深圳市瑞沃德生命科技股份有限公司 一种实验容器及生物样本制备装置
CN114100484B (zh) * 2021-10-28 2023-01-24 焦作熠星智能电子科技有限公司 一种锂电池电极浆料混合设备及混合方法
CN117380068B (zh) * 2023-12-13 2024-02-20 河北特美特实业集团股份有限公司 一种番茄酱加工用调配罐装置

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CA2363476C (en) * 2001-11-20 2010-06-08 Udo Hendrick Verkerk A device for the addition of a compound or compound mixture to another under various reaction conditions, parallel or otherwise

Also Published As

Publication number Publication date
ATE406952T1 (de) 2008-09-15
EP1551541A1 (de) 2005-07-13
ES2314230T3 (es) 2009-03-16
US7490976B2 (en) 2009-02-17
WO2004035191A1 (de) 2004-04-29
AU2003271483A1 (en) 2004-05-04
DK1551541T3 (da) 2008-12-08
DE50310447D1 (de) 2008-10-16
US20060013064A1 (en) 2006-01-19

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