EP1556007A4 - Composes tetracycline substituee servant au traitement du paludisme - Google Patents

Composes tetracycline substituee servant au traitement du paludisme

Info

Publication number
EP1556007A4
EP1556007A4 EP03781398A EP03781398A EP1556007A4 EP 1556007 A4 EP1556007 A4 EP 1556007A4 EP 03781398 A EP03781398 A EP 03781398A EP 03781398 A EP03781398 A EP 03781398A EP 1556007 A4 EP1556007 A4 EP 1556007A4
Authority
EP
European Patent Office
Prior art keywords
malaria
treatment
tetracycline compounds
substituted tetracycline
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03781398A
Other languages
German (de)
English (en)
Other versions
EP1556007A2 (fr
Inventor
Michael Draper
Mark L Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Priority to EP10171327A priority Critical patent/EP2277504A1/fr
Publication of EP1556007A2 publication Critical patent/EP1556007A2/fr
Publication of EP1556007A4 publication Critical patent/EP1556007A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
EP03781398A 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme Withdrawn EP1556007A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10171327A EP2277504A1 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42125902P 2002-10-24 2002-10-24
US421259P 2002-10-24
PCT/US2003/033927 WO2004038001A2 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme

Publications (2)

Publication Number Publication Date
EP1556007A2 EP1556007A2 (fr) 2005-07-27
EP1556007A4 true EP1556007A4 (fr) 2008-12-17

Family

ID=32176689

Family Applications (2)

Application Number Title Priority Date Filing Date
EP03781398A Withdrawn EP1556007A4 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme
EP10171327A Withdrawn EP2277504A1 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10171327A Withdrawn EP2277504A1 (fr) 2002-10-24 2003-10-24 Composes tetracycline substituee servant au traitement du paludisme

Country Status (6)

Country Link
EP (2) EP1556007A4 (fr)
JP (2) JP2006503898A (fr)
AU (3) AU2003287218C1 (fr)
CA (1) CA2502464A1 (fr)
IL (1) IL209319A0 (fr)
WO (1) WO2004038001A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072506A2 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de 7-pyrollyl tetracycline et procedes d'utilisation associes
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
AU2004259661B2 (en) * 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
SI1753713T1 (sl) 2004-05-21 2017-01-31 President And Fellows Of Harvard College Sinteza tetraciklinov in njihovih analogov
EP2033950A1 (fr) * 2004-10-25 2009-03-11 Paratek Pharmaceuticals, Inc. Composés de tétracycline substitués
FR2891744B1 (fr) * 2005-10-06 2009-10-09 France Etat Armement Application a la chimioprophylaxie du paludisme d'une association de chloroquine et de doxycycline
WO2007117639A2 (fr) 2006-04-07 2007-10-18 The President And Fellows Of Harvard College Synthèse de tétracyclines et d'analogues de celles-ci
EP2487160B1 (fr) 2006-10-11 2016-02-03 President and Fellows of Harvard College Synthèse d'un intermédiaire de l'énone
WO2008079339A2 (fr) * 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Composés de tétracycline substituée
EP2216323A3 (fr) * 2007-04-27 2010-12-29 Paratek Pharmaceuticals, Inc. Procédés de synthèse et de purification de composés d'aminoalkyle de tétracycline
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
KR101746795B1 (ko) 2008-08-08 2017-06-13 테트라페이즈 파마슈티컬스, 인코포레이티드 Ｃ７-플루오로 치환된 테트라시클린 화합물
WO2010126607A2 (fr) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthèse de tétracyclines et intermédiaires de celles-ci
WO2010129057A2 (fr) 2009-05-08 2010-11-11 Tetraphase Pharmaceuticals, Inc. Composés de tétracycline
NO2470500T3 (fr) 2009-08-28 2018-03-03
CN101967108B (zh) * 2010-09-13 2013-06-19 苏春华 一种美他环素的衍生物
KR101732084B1 (ko) 2011-07-26 2017-05-02 케이비피 바이오사이언시즈 씨오., 엘티디. 9-아미노메틸 치환된 테트라사이클린 화합물
CA2883238C (fr) 2012-08-31 2021-11-23 Tetraphase Pharmaceuticals, Inc. Composes de tetracyclines
CA2904387C (fr) 2013-03-15 2021-12-07 Melinta Therapeutics, Inc. Procedes de traitement d'infections chez des patients atteints de surpoids et d'obesite utilisant d'antibiotiques
HUE066360T2 (hu) 2016-10-19 2024-07-28 Tetraphase Pharmaceuticals Inc Eravaciklin kristályformái
AU2019248350B2 (en) * 2018-04-06 2023-07-27 Almirall, Llc Process for making sarecycline hydrochloride
CN117486749A (zh) * 2023-11-23 2024-02-02 传健生物医药(厦门)有限公司 一种奥马环素杂质的制备方法

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999030720A1 (fr) * 1997-12-19 1999-06-24 New York University Inhibition de la cyclooxygenase-2 et du facteur de necrose des tumeurs alpha
WO2000064479A1 (fr) * 1999-04-27 2000-11-02 Antibody Systems, Inc. Compositions contenant des tetracyclines et servant a traiter des infections et d'autres maladies virales hemorragiques
WO2002000208A2 (fr) * 2000-06-29 2002-01-03 Jomaa Pharmaka Gmbh Preparations de derives d'acide 3-n-formylhydroxylaminopropylphosphonique ou de derives d'acide 3-n-acetylhydroxylaminopropylphosphonique combines avec des principes actifs pharmaceutiques speciaux
WO2002004407A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de tetracycline substitues en 7
WO2002004406A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de monocycline 9-substitues
WO2002072532A1 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues en position 7,9
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2002085303A2 (fr) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues destines au traitement de la malaria
WO2003005971A2 (fr) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Composes de tetracycline a activites therapeutiques cibles
WO2003079984A2 (fr) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee

Family Cites Families (27)

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US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (fr) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
YU40295B (en) 1977-04-07 1985-12-31 Pliva Pharm & Chem Works Process for preparing n2-tert.butyl-11a-halo-6-demethyl-6-deoxy-6-methylene tetracycline
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
YU41093B (en) 1978-04-12 1986-12-31 Pliva Pharm & Chem Works Process for preparing 6-deoxy-5hydroxy-tetracycline
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
DK0599397T3 (da) 1992-11-17 1996-09-16 Univ New York State Res Found Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes
US6043231A (en) 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5371076A (en) 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
WO1995022529A1 (fr) 1994-02-17 1995-08-24 Pfizer Inc. Derives de 9-(amino-substitues)-alpha-6-deoxy-5-oxy tetracycline, leur preparation et leur utilisation comme antibiotiques
US5919395A (en) 1997-10-30 1999-07-06 Shell Oil Company Polyol combination
WO1999037306A1 (fr) * 1998-01-23 1999-07-29 Trustees Of Tufts College Composes pharmaceutiquement actifs et procedes d'utilisation correspondants
DE69932846T2 (de) * 1998-11-18 2007-03-15 Collagenex Pharmaceuticals, Inc. Neue 4-dedimethylaminotetracyclinderivate
US6326023B1 (en) * 2000-03-28 2001-12-04 Council Of Scientific & Industrial Research Synergistic anti-malarial formulation
EP1381372A2 (fr) * 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
EP2311451A1 (fr) * 2002-03-08 2011-04-20 Paratek Pharmaceuticals, Inc. Composés de tétracycline à substitution amino-méthyle
US20050143352A1 (en) * 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP5706185B2 (ja) 2011-02-22 2015-04-22 富士レビオ株式会社 測定装置及び測定方法
US9713502B2 (en) 2014-03-09 2017-07-25 Gyrus Acmi, Inc. Narrow band imaging with surgical loupes

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999030720A1 (fr) * 1997-12-19 1999-06-24 New York University Inhibition de la cyclooxygenase-2 et du facteur de necrose des tumeurs alpha
WO2000064479A1 (fr) * 1999-04-27 2000-11-02 Antibody Systems, Inc. Compositions contenant des tetracyclines et servant a traiter des infections et d'autres maladies virales hemorragiques
WO2002000208A2 (fr) * 2000-06-29 2002-01-03 Jomaa Pharmaka Gmbh Preparations de derives d'acide 3-n-formylhydroxylaminopropylphosphonique ou de derives d'acide 3-n-acetylhydroxylaminopropylphosphonique combines avec des principes actifs pharmaceutiques speciaux
WO2002004407A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de tetracycline substitues en 7
WO2002004406A2 (fr) * 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de monocycline 9-substitues
WO2002072532A1 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues en position 7,9
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2002085303A2 (fr) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues destines au traitement de la malaria
WO2003005971A2 (fr) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Composes de tetracycline a activites therapeutiques cibles
WO2003079984A2 (fr) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUNNANG D ET AL: "QUININE-TETRACYCLINE FOR MULTIDRUG RESISTANT FALCIPARUM MALARIA", SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, PROJECT OD SEAMEO, BANGKOK, vol. 27, no. 1, 1 March 1996 (1996-03-01), pages 15 - 18, XP009060760, ISSN: 0125-1562 *
DRAPER M P ET AL: "NOVEL TETRACYCLINE DERIVATIVES AS ANTIMALARIAL DRUGS", PROGRAM AND ABSTRACTS OF THE INTERSCIENCE CONFERENCE ONANTIMICROBIAL AGENTS AND CHEMOTHERAPY, PY, WASHINGTON, DC, vol. 41, 17 December 2001 (2001-12-17), pages 496, XP001208128, ISSN: 0733-6373 *
TOAMA M A: "IN VITRO SYNERGISM BETWEEN TETRACYCLINES AND ANTIMALARIALS", CHEMOTHERAPY, S. KARGER, BASEL, CH, vol. 26, no. 3, 1 January 1980 (1980-01-01), pages 191 - 195, XP009060770, ISSN: 0009-3157 *

Also Published As

Publication number Publication date
AU2003287218C1 (en) 2010-07-15
AU2003287218B2 (en) 2009-12-17
WO2004038001A2 (fr) 2004-05-06
JP2006503898A (ja) 2006-02-02
JP2011037890A (ja) 2011-02-24
AU2003287218A1 (en) 2004-05-13
AU2010200971A1 (en) 2010-04-01
WO2004038001A3 (fr) 2004-11-11
CA2502464A1 (fr) 2004-05-06
IL209319A0 (en) 2011-01-31
EP2277504A1 (fr) 2011-01-26
AU2010200973A1 (en) 2010-04-01
EP1556007A2 (fr) 2005-07-27

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