EP1566215A3 - Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Flüssigkeit - Google Patents

Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Flüssigkeit Download PDF

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Publication number
EP1566215A3
EP1566215A3 EP05002008A EP05002008A EP1566215A3 EP 1566215 A3 EP1566215 A3 EP 1566215A3 EP 05002008 A EP05002008 A EP 05002008A EP 05002008 A EP05002008 A EP 05002008A EP 1566215 A3 EP1566215 A3 EP 1566215A3
Authority
EP
European Patent Office
Prior art keywords
liquid
platform
handling
investigations
cavities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP05002008A
Other languages
English (en)
French (fr)
Other versions
EP1566215A2 (de
Inventor
Gert Dr. Blankenstein
Thomas Willms
Claus Marquordt
Ralf-Peter Dr. Peters
Holger Dr. Bartos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Boehringer Ingelheim Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Microparts GmbH filed Critical Boehringer Ingelheim Microparts GmbH
Priority to EP13152693.1A priority Critical patent/EP2623200A3/de
Publication of EP1566215A2 publication Critical patent/EP1566215A2/de
Publication of EP1566215A3 publication Critical patent/EP1566215A3/de
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5088—Rigid containers without fluid transport within confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0026—Valves using channel deformation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

Für die Untersuchung von Flüssigkeiten in der Biologie, Biochemie, Chemie, Medizin und Pharmazie werden Verfahren angewendet, die mit erheblichem Aufwand für das Handhaben der Flüssigkeiten und für Hilfsmittel verbunden sind, und die eine Mindestmenge an Flüssigkeit benötigen. Die mikrostrukturierte Plattform enthält Hohlräume und Kapillaren, in denen die Flüssigkeit durch Kapillarkraft transportiert wird. Sie umfasst fluidische Schalter, Dosiereinrichtungen für die Flüssigkeit, Abtrennvorrichtungen für die Flüssigkeit aus einer Dispersion und Bereiche zum Zusammenhalten einer begrenzten Flüssigkeitsmenge. Das Kapillarsystem kann verzweigt sein. Die Plattform ist für eine Vielzahl von Untersuchungen mit Flüssigkeitsmengen im Mikroliterbereich geeignet. Es werden nur sehr geringe Mengen von Reagenzien und Hilfsmittel benötigt, die in den Hohlräumen in eingetrockneter oder immobilisierter Form vorgelegt ein können. Auf einer Plattform sind unterschiedliche Untersuchungen, die gleichzeitig nebeneinander oder nacheinander ablaufen können., realisierbar. Die Plattfrom ist in großer Stückzahl wirtschaftlich herstellbar und an viele Forderungen zum Reaktionsablauf und zur Auswertung der Untersuchungsergebnisse anpassbar.
EP05002008A 2004-02-17 2005-02-01 Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Flüssigkeit Ceased EP1566215A3 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP13152693.1A EP2623200A3 (de) 2004-02-17 2005-02-01 Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Fluessigkeit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004007567 2004-02-17
DE102004007567A DE102004007567A1 (de) 2004-02-17 2004-02-17 Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Flüssigkeit

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP13152693.1A Division EP2623200A3 (de) 2004-02-17 2005-02-01 Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Fluessigkeit
EP13152693.1A Previously-Filed-Application EP2623200A3 (de) 2004-02-17 2005-02-01 Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Fluessigkeit

Publications (2)

Publication Number Publication Date
EP1566215A2 EP1566215A2 (de) 2005-08-24
EP1566215A3 true EP1566215A3 (de) 2011-05-25

Family

ID=34706821

Family Applications (2)

Application Number Title Priority Date Filing Date
EP05002008A Ceased EP1566215A3 (de) 2004-02-17 2005-02-01 Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Flüssigkeit
EP13152693.1A Withdrawn EP2623200A3 (de) 2004-02-17 2005-02-01 Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Fluessigkeit

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP13152693.1A Withdrawn EP2623200A3 (de) 2004-02-17 2005-02-01 Mikrostrukturierte Plattform und Verfahren zum Handhaben einer Fluessigkeit

Country Status (4)

Country Link
EP (2) EP1566215A3 (de)
JP (1) JP2005230816A (de)
CN (1) CN1715932B (de)
DE (1) DE102004007567A1 (de)

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EP1946830B1 (de) 2005-11-07 2019-04-03 Konica Minolta Medical & Graphic, Inc. Mikroreaktor
DE102005062723B4 (de) * 2005-12-22 2007-11-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Probenaufarbeitungschip, Reaktionskammer und Verwendung des Probenaufarbeitungschips
SE531948C2 (sv) * 2006-06-20 2009-09-15 Aamic Ab Analysanordning för vätskeprover innefattande filter i direkt kontakt med projektioner
EP2142314A4 (de) * 2007-03-30 2012-04-25 Fujifilm Corp Verfahren zur reinigung von mikrofliesswegen
KR100885074B1 (ko) * 2007-07-26 2009-02-25 주식회사 아이센스 미세유로형 센서 복합 구조물
EP3521833B1 (de) 2007-10-30 2021-05-26 PHC Holdings Corporation Analysevorrichtung
JP5461556B2 (ja) * 2008-08-21 2014-04-02 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 尿残渣分析用多層スライド
US9216413B2 (en) * 2009-07-07 2015-12-22 Boehringer Ingelheim Microparts Gmbh Plasma separation reservoir
JP2011025127A (ja) * 2009-07-23 2011-02-10 Sumitomo Bakelite Co Ltd マイクロデバイス
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KR100961874B1 (ko) * 2010-04-05 2010-06-09 주식회사 나노엔텍 외부동력 없이 유체가 이동하는 유체분석용 칩
US9272277B2 (en) * 2013-02-15 2016-03-01 Honeywell International Inc. Capillary groove for isobaric waste entry
JP6334112B2 (ja) * 2013-08-23 2018-05-30 株式会社日立ハイテクノロジーズ 自動分析装置
CN105848783B (zh) * 2013-09-30 2017-12-01 卡皮坦内尔公司 微流体装置、使用和方法
CN108686593B (zh) * 2017-04-11 2020-08-11 上海交通大学 多尺度微结构反应器
US11185830B2 (en) 2017-09-06 2021-11-30 Waters Technologies Corporation Fluid mixer
WO2019116476A1 (ja) * 2017-12-13 2019-06-20 株式会社ニコン 流体デバイス
CN114207433B (zh) 2019-08-12 2025-01-14 沃特世科技公司 用于色谱系统的混合器
WO2022010666A1 (en) 2020-07-07 2022-01-13 Waters Technologies Corporation Combination mixer arrangement for noise reduction in fluid chromatography
US11898999B2 (en) 2020-07-07 2024-02-13 Waters Technologies Corporation Mixer for liquid chromatography
EP4217729B1 (de) 2020-09-22 2025-08-13 Waters Technologies Corporation Durchlaufmischer
US12399158B2 (en) 2021-05-20 2025-08-26 Waters Technologies Corporation Equal dispersion split-flow mixer
US12551858B2 (en) 2021-06-23 2026-02-17 Waters Technologies Corporation Passive solvent mixer for liquid chromatography
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EP1013341A2 (de) * 1998-12-23 2000-06-28 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Vorrichtung zum Ableiten einer Flüssigkeit aus Kapillaren
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WO2003085395A1 (de) * 2002-04-09 2003-10-16 Humboldt-Universität Zu Berlin Automatischer probensammler
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EP1441131A1 (de) * 2003-01-23 2004-07-28 Steag MicroParts GmbH Mikrofluidischer Schalter zum Anhalten eines Flüssigkeitsstroms während eines Zeitintervalls
EP1459773A1 (de) * 2003-03-21 2004-09-22 Steag MicroParts GmbH Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit,die Partikel enthält
EP1495799A2 (de) * 2003-06-13 2005-01-12 Steag MicroParts GmbH Vorrichtung zum Handhaben von begrenzten Flüssigkeitsmengen

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US6271040B1 (en) * 1992-05-21 2001-08-07 Biosite Diagnostics Incorporated Diagnostic devices method and apparatus for the controlled movement of reagents without membranes
WO1999046045A1 (de) * 1998-03-11 1999-09-16 MICROPARTS GESELLSCHAFT FüR MIKROSTRUKTURTECHNIK MBH Probenträger
US20020036018A1 (en) * 1998-10-13 2002-03-28 Mcneely Michael R. Fluid circuit components based upon passive fluid dynamics
US6447661B1 (en) * 1998-10-14 2002-09-10 Caliper Technologies Corp. External material accession systems and methods
EP1013341A2 (de) * 1998-12-23 2000-06-28 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Vorrichtung zum Ableiten einer Flüssigkeit aus Kapillaren
WO2001087485A2 (en) * 2000-05-15 2001-11-22 Tecan Trading Ag Microfluidics devices and methods for high throughput screening
EP1201304A2 (de) * 2000-10-25 2002-05-02 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Mikrostrukturierte Plattform für die Untersuchung einer Flüssigkeit
US20030185713A1 (en) * 2002-03-29 2003-10-02 Leslie Leonard Capillary flow for a heterogenous assay in a micro-channel environment
WO2003085395A1 (de) * 2002-04-09 2003-10-16 Humboldt-Universität Zu Berlin Automatischer probensammler
WO2004061414A2 (en) * 2002-12-19 2004-07-22 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
EP1441131A1 (de) * 2003-01-23 2004-07-28 Steag MicroParts GmbH Mikrofluidischer Schalter zum Anhalten eines Flüssigkeitsstroms während eines Zeitintervalls
EP1459773A1 (de) * 2003-03-21 2004-09-22 Steag MicroParts GmbH Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit,die Partikel enthält
EP1495799A2 (de) * 2003-06-13 2005-01-12 Steag MicroParts GmbH Vorrichtung zum Handhaben von begrenzten Flüssigkeitsmengen

Also Published As

Publication number Publication date
CN1715932A (zh) 2006-01-04
CN1715932B (zh) 2012-04-18
DE102004007567A1 (de) 2005-09-01
EP1566215A2 (de) 2005-08-24
JP2005230816A (ja) 2005-09-02
EP2623200A3 (de) 2014-04-09
EP2623200A2 (de) 2013-08-07

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