EP1567178A4 - Modulateurs de recepteurs de l'hormone parathyroide et de la proteine liee a l'hormone parathyroide - Google Patents

Modulateurs de recepteurs de l'hormone parathyroide et de la proteine liee a l'hormone parathyroide

Info

Publication number
EP1567178A4
EP1567178A4 EP02793926A EP02793926A EP1567178A4 EP 1567178 A4 EP1567178 A4 EP 1567178A4 EP 02793926 A EP02793926 A EP 02793926A EP 02793926 A EP02793926 A EP 02793926A EP 1567178 A4 EP1567178 A4 EP 1567178A4
Authority
EP
European Patent Office
Prior art keywords
hormone
parathyrois
modulators
receptors
related protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02793926A
Other languages
German (de)
English (en)
Other versions
EP1567178A1 (fr
Inventor
Paul Kostenuik
Colin V Gegg
Mark Anthony Jarosinski
Olaf Boris Kinstler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of EP1567178A1 publication Critical patent/EP1567178A1/fr
Publication of EP1567178A4 publication Critical patent/EP1567178A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP02793926A 2002-11-01 2002-11-01 Modulateurs de recepteurs de l'hormone parathyroide et de la proteine liee a l'hormone parathyroide Withdrawn EP1567178A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/036419 WO2004060386A1 (fr) 2002-11-01 2002-11-01 Modulateurs de recepteurs de l'hormone parathyroide et de la proteine liee a l'hormone parathyroide

Publications (2)

Publication Number Publication Date
EP1567178A1 EP1567178A1 (fr) 2005-08-31
EP1567178A4 true EP1567178A4 (fr) 2009-07-15

Family

ID=32710245

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02793926A Withdrawn EP1567178A4 (fr) 2002-11-01 2002-11-01 Modulateurs de recepteurs de l'hormone parathyroide et de la proteine liee a l'hormone parathyroide

Country Status (4)

Country Link
EP (1) EP1567178A4 (fr)
AU (1) AU2002359391A1 (fr)
CA (1) CA2511966A1 (fr)
WO (1) WO2004060386A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003207512B2 (en) 2002-01-10 2008-06-12 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
EP1893240A2 (fr) * 2005-06-13 2008-03-05 Nastech Pharmaceutical Company Inc. Administration transmucosale de dérivés peptidiques
US8168592B2 (en) 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
AR056806A1 (es) * 2005-11-14 2007-10-24 Amgen Inc Moleculas quimericas de anticuerpo rankl- pth/ pthrp
WO2007124461A2 (fr) 2006-04-20 2007-11-01 Amgen Inc. Composés de glp-1
DK2957278T3 (en) 2006-10-03 2017-07-31 Radius Health Inc STABLE COMPOSITION COMPREHENSIVE PTHRP AND APPLICATIONS THEREOF
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
CA2672907C (fr) 2006-10-13 2013-08-06 Eli Lilly And Company Pht pegyles en tant que modulateurs du recepteur pht et leurs utilisations
JP2013512688A (ja) 2009-12-07 2013-04-18 ミシガン テクノロジカル ユニバーシティ クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法
EP2975138A2 (fr) 2013-03-15 2016-01-20 Fundació Institut de Recerca Biomèdica (IRB Barcelona) Méthode de diagnostic, de pronostic et de traitement des métastases d'un cancer
RS64115B1 (sr) 2014-03-28 2023-04-28 Univ Duke Lečenje kancera dojke upotrebom selektivnih modulatora receptora estrogena
IL310069B2 (en) 2015-04-29 2025-08-01 Radius Pharmaceuticals Inc Rad1901 for use in the treatment of cancer
CN117417263A (zh) 2017-01-05 2024-01-19 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
KR102792490B1 (ko) 2018-07-04 2025-04-04 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
JP7667083B2 (ja) 2019-02-12 2025-04-22 ラジウス ファーマシューティカルズ，インコーポレイテッド 方法および化合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006846A1 (fr) * 1991-10-10 1993-04-15 Pang Peter K T Analogues de l'hormone parathyroidienne et leur utilisation dans le traitement de l'osteoporose
WO1998005683A1 (fr) * 1996-08-02 1998-02-12 National Research Council Of Canada Analogues de la parathormone destines au traitement de l'osteoporose
WO2001081415A2 (fr) * 2000-04-27 2001-11-01 Amgen Inc. Modulateurs de recepteurs pour l'hormone parathyroide et pour la proteine liee a l'hormone parathyroide
WO2002068459A2 (fr) * 2001-02-21 2002-09-06 Clontech Laboratories, Inc. Proteines fluorescentes anti-agregantes et leurs methodes d'utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU1633200A (en) * 1998-11-25 2000-06-13 General Hospital Corporation, The Human parathyroid hormone modifications, preparation and use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006846A1 (fr) * 1991-10-10 1993-04-15 Pang Peter K T Analogues de l'hormone parathyroidienne et leur utilisation dans le traitement de l'osteoporose
WO1998005683A1 (fr) * 1996-08-02 1998-02-12 National Research Council Of Canada Analogues de la parathormone destines au traitement de l'osteoporose
WO2001081415A2 (fr) * 2000-04-27 2001-11-01 Amgen Inc. Modulateurs de recepteurs pour l'hormone parathyroide et pour la proteine liee a l'hormone parathyroide
WO2002068459A2 (fr) * 2001-02-21 2002-09-06 Clontech Laboratories, Inc. Proteines fluorescentes anti-agregantes et leurs methodes d'utilisation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARBIER JEAN-RENE ET AL: "Structure and activities of constrained analogues of human parathyroid hormone and parathyroid hormone-related peptide: Implications for receptor-activating conformations of the hormones", BIOCHEMISTRY, vol. 39, no. 47, 28 November 2000 (2000-11-28), pages 14522 - 14530, XP002530193, ISSN: 0006-2960 *
KINSTLER O ET AL: "Mono-N-terminal poly(ethylene glycol)-protein conjugates", ADVANCED DRUG DELIVERY REVIEWS 20020617 NL, vol. 54, no. 4, 17 June 2002 (2002-06-17), pages 477 - 485, XP002530194, ISSN: 0169-409X *
See also references of WO2004060386A1 *

Also Published As

Publication number Publication date
WO2004060386A1 (fr) 2004-07-22
EP1567178A1 (fr) 2005-08-31
AU2002359391A1 (en) 2004-07-29
CA2511966A1 (fr) 2004-07-22

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KINSTLER, OLAF, BORIS

Inventor name: JAROSINSKI, MARK, ANTHONY

Inventor name: GEGG, COLIN, V.

Inventor name: KOSTENUIK, PAUL

A4 Supplementary search report drawn up and despatched

Effective date: 20090615

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