EP1578455A4 - Radioisotop-assoziierte polymerehydrogel-mikrokügelchen und verfahren zu ihrer herstellung und verwendung - Google Patents

Radioisotop-assoziierte polymerehydrogel-mikrokügelchen und verfahren zu ihrer herstellung und verwendung

Info

Publication number
EP1578455A4
EP1578455A4 EP03779133A EP03779133A EP1578455A4 EP 1578455 A4 EP1578455 A4 EP 1578455A4 EP 03779133 A EP03779133 A EP 03779133A EP 03779133 A EP03779133 A EP 03779133A EP 1578455 A4 EP1578455 A4 EP 1578455A4
Authority
EP
European Patent Office
Prior art keywords
radioisotopes
making
methods
same
polymer hydrogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03779133A
Other languages
English (en)
French (fr)
Other versions
EP1578455A2 (de
Inventor
James A Krom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosphere Medical Inc
Original Assignee
Biosphere Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosphere Medical Inc filed Critical Biosphere Medical Inc
Publication of EP1578455A2 publication Critical patent/EP1578455A2/de
Publication of EP1578455A4 publication Critical patent/EP1578455A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1213—Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03779133A 2002-11-04 2003-10-17 Radioisotop-assoziierte polymerehydrogel-mikrokügelchen und verfahren zu ihrer herstellung und verwendung Withdrawn EP1578455A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42354702P 2002-11-04 2002-11-04
US423547P 2002-11-04
PCT/US2003/033140 WO2004040972A2 (en) 2002-11-04 2003-10-17 Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same

Publications (2)

Publication Number Publication Date
EP1578455A2 EP1578455A2 (de) 2005-09-28
EP1578455A4 true EP1578455A4 (de) 2008-12-31

Family

ID=32312672

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03779133A Withdrawn EP1578455A4 (de) 2002-11-04 2003-10-17 Radioisotop-assoziierte polymerehydrogel-mikrokügelchen und verfahren zu ihrer herstellung und verwendung

Country Status (4)

Country Link
EP (1) EP1578455A4 (de)
AU (1) AU2003285905A1 (de)
CA (1) CA2507404A1 (de)
WO (1) WO2004040972A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
AU2005290229A1 (en) * 2004-09-24 2006-04-06 Biosphere Medical, Inc. Microspheres capable of binding radioisotopes, optionally comprising metallic microparticles, and methods of use thereof
EP1814519A1 (de) * 2004-11-16 2007-08-08 Université de Liège Wirksubstanz-abgabesystem mit einer hydrogelmatrix und mikroträgern
EP1838354A2 (de) * 2004-12-17 2007-10-03 A.S.B.L. Facultes Universitaires Notre-Dame De La Paix Radioaktive vorrichtung
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US20070141727A1 (en) * 2005-12-15 2007-06-21 Kimberly-Clark Worldwide, Inc. Luminescent metallic cluster particles and uses thereof
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
WO2009046281A2 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Injectable particles
JP6373961B2 (ja) 2013-03-13 2018-08-15 バイオスフィア メディカル，インコーポレイテッド ラジオアイソトープ結合微粒子の組成物及び結合方法
EP2923712A1 (de) 2014-03-28 2015-09-30 Spago Imaging AB Nanostrukturen und Anwendungen davon
KR102405719B1 (ko) * 2016-05-24 2022-06-03 큐에스에이 글로벌 인크. 저밀도 구형 이리듐 소스
CN111012929B (zh) * 2019-11-27 2022-05-17 原子高科股份有限公司 一种携带放射性粒子的栓剂及其制备方法
EP4241793A1 (de) 2022-03-08 2023-09-13 Spago Nanomedical AB Kugelförmige nanostrukturen
EP4241792A1 (de) 2022-03-08 2023-09-13 Spago Nanomedical AB Nanostrukturen und anwendungen davon
CN118806966A (zh) * 2023-04-06 2024-10-22 苏州大学 一种装载活性金属微粒的高分子微球及其制备方法和应用
TW202525349A (zh) * 2023-12-28 2025-07-01 白金科技股份有限公司 微球及其製備方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648100A (en) * 1991-05-29 1997-07-15 Assistance Publique Hopitaux De Paris Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
WO2000023054A1 (en) * 1998-10-16 2000-04-27 Biosphere Medical, S.A. Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same
US6248057B1 (en) * 1998-07-28 2001-06-19 Innerdyne, Inc. Absorbable brachytherapy and chemotherapy delivery devices and methods
WO2002034300A1 (en) * 2000-10-25 2002-05-02 Sirtex Medical Limited Polymer based radionuclide containing particulate material

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648100A (en) * 1991-05-29 1997-07-15 Assistance Publique Hopitaux De Paris Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
US6248057B1 (en) * 1998-07-28 2001-06-19 Innerdyne, Inc. Absorbable brachytherapy and chemotherapy delivery devices and methods
WO2000023054A1 (en) * 1998-10-16 2000-04-27 Biosphere Medical, S.A. Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same
WO2002034300A1 (en) * 2000-10-25 2002-05-02 Sirtex Medical Limited Polymer based radionuclide containing particulate material

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DUCRET R P ET AL: "Therapeutic Embolization: Enhanced Radiolabeled Monitoring", RADIOLOGY, vol. 177, 1990, pages 571 - 575, XP002501359 *
SAKAKIBARA Y ET AL: "Prevascularization with gelatin micro spheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 124, no. 1, 1 July 2002 (2002-07-01), pages 50 - 56, XP002984640, ISSN: 0022-5223 *
VAN ES R J ET AL: "Tumour embolization of the Vx2 rabbit head and neck cancer model with Dextran hydrogel and Holmium-poly(L-lactic acid) microspheres: a radionuclide and histological pilot study", JOURNAL OF CRANIO-MAXILLO-FACIAL SURGERY : OFFICIAL PUBLICATION OF THE EUROPEAN ASSOCIATION FOR CRANIO-MAXILLO-FACIAL SURGERY OCT 2001,, vol. 29, no. 5, 1 October 2001 (2001-10-01), pages 289 - 297, XP002500322 *
XP007906214, Retrieved from the Internet <URL:http://www.springer.com/chemistry/book/978-88-470-1103-8> [retrieved on 20081103] *

Also Published As

Publication number Publication date
WO2004040972A3 (en) 2004-10-14
EP1578455A2 (de) 2005-09-28
CA2507404A1 (en) 2004-05-21
WO2004040972A2 (en) 2004-05-21
AU2003285905A1 (en) 2004-06-07

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