EP1578910A4 - Nitrilases - Google Patents

Nitrilases

Info

Publication number
EP1578910A4
EP1578910A4 EP02780877A EP02780877A EP1578910A4 EP 1578910 A4 EP1578910 A4 EP 1578910A4 EP 02780877 A EP02780877 A EP 02780877A EP 02780877 A EP02780877 A EP 02780877A EP 1578910 A4 EP1578910 A4 EP 1578910A4
Authority
EP
European Patent Office
Prior art keywords
nitrilases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02780877A
Other languages
German (de)
French (fr)
Other versions
EP1578910A2 (en
Inventor
Grace Desantis
Jennifer Ann Chaplin
David Paul Weiner
Aileen Milan
Ellen Chi
Jay M Short
Mark Madden
Mark Burk
Dan Robertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Enzymes LLC
Original Assignee
Verenium Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verenium Corp filed Critical Verenium Corp
Priority to EP10190397.9A priority Critical patent/EP2327766B1/en
Priority to EP10189100.0A priority patent/EP2327765B1/en
Priority to EP20100190399 priority patent/EP2327767B1/en
Priority to EP10190401.9A priority patent/EP2319919B1/en
Priority to EP08075753A priority patent/EP2039762A3/en
Publication of EP1578910A2 publication Critical patent/EP1578910A2/en
Publication of EP1578910A4 publication Critical patent/EP1578910A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/002Nitriles (-CN)
    • C12P13/004Cyanohydrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Processing Of Solid Wastes (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Sludge (AREA)
EP02780877A 2001-06-21 2002-05-15 Nitrilases Withdrawn EP1578910A4 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP10190397.9A EP2327766B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP10189100.0A EP2327765B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP20100190399 EP2327767B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP10190401.9A EP2319919B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP08075753A EP2039762A3 (en) 2001-06-21 2002-05-15 Nitralases

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30018901P 2001-06-21 2001-06-21
US300189P 2001-06-21
US30900601P 2001-07-30 2001-07-30
US309006P 2001-07-30
US35133602P 2002-01-22 2002-01-22
US351336P 2002-01-22
PCT/US2002/015983 WO2003000840A2 (en) 2001-06-21 2002-05-15 Nitrilases

Related Child Applications (5)

Application Number Title Priority Date Filing Date
EP10189100.0A Division EP2327765B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP20100190399 Division EP2327767B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP08075753A Division EP2039762A3 (en) 2001-06-21 2002-05-15 Nitralases
EP10190397.9A Division EP2327766B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP10190401.9A Division EP2319919B1 (en) 2001-06-21 2002-05-15 Nitrilases

Publications (2)

Publication Number Publication Date
EP1578910A2 EP1578910A2 (en) 2005-09-28
EP1578910A4 true EP1578910A4 (en) 2008-06-04

Family

ID=27404717

Family Applications (6)

Application Number Title Priority Date Filing Date
EP02780877A Withdrawn EP1578910A4 (en) 2001-06-21 2002-05-15 Nitrilases
EP20100190399 Expired - Lifetime EP2327767B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP10189100.0A Expired - Lifetime EP2327765B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP10190401.9A Expired - Lifetime EP2319919B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP08075753A Withdrawn EP2039762A3 (en) 2001-06-21 2002-05-15 Nitralases
EP10190397.9A Expired - Lifetime EP2327766B1 (en) 2001-06-21 2002-05-15 Nitrilases

Family Applications After (5)

Application Number Title Priority Date Filing Date
EP20100190399 Expired - Lifetime EP2327767B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP10189100.0A Expired - Lifetime EP2327765B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP10190401.9A Expired - Lifetime EP2319919B1 (en) 2001-06-21 2002-05-15 Nitrilases
EP08075753A Withdrawn EP2039762A3 (en) 2001-06-21 2002-05-15 Nitralases
EP10190397.9A Expired - Lifetime EP2327766B1 (en) 2001-06-21 2002-05-15 Nitrilases

Country Status (6)

Country Link
EP (6) EP1578910A4 (en)
JP (2) JP4405258B2 (en)
AU (2) AU2006252258B2 (en)
CA (2) CA2445046C (en)
DK (3) DK2327765T3 (en)
WO (1) WO2003000840A2 (en)

Families Citing this family (74)

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US7521216B2 (en) 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
AU2003251523A1 (en) 2002-06-13 2003-12-31 Diversa Corporation Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
CN100445375C (en) * 2003-02-27 2008-12-24 巴斯福股份公司 Modified nitrilases and their use in methods for producing carboxylic acids
AR044519A1 (en) 2003-05-02 2005-09-14 Novartis Ag DERIVATIVES OF PIRIDIN-TIAZOL AMINA AND PIRIMIDIN-TIAZOL AMINA
US7198926B2 (en) 2003-05-08 2007-04-03 E. I. Du Pont De Nemours And Company Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GT200500281A (en) 2004-10-22 2006-04-24 Novartis Ag ORGANIC COMPOUNDS.
WO2006053131A1 (en) 2004-11-11 2006-05-18 Modular Genetics, Inc. Ladder assembly and system for generating diversity
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
WO2007045477A2 (en) 2005-10-21 2007-04-26 Novartis Ag Human antibodies against il-13 and therapeutic uses
WO2007094885A2 (en) * 2005-12-07 2007-08-23 Southern Methodist University Identification of a nitrilase from b. japonicum by rational genome mining and methods of use
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
PT2322525E (en) 2006-04-21 2013-12-26 Novartis Ag Purine derivatives for use as adenosin a2a receptor agonists
CN100500832C (en) * 2006-04-29 2009-06-17 浙江工业大学 Bacillus subtilis ZJB-063 and its application
WO2008037477A1 (en) 2006-09-29 2008-04-03 Novartis Ag Pyrazolopyrimidines as p13k lipid kinase inhibitors
RS51644B (en) 2007-01-10 2011-10-31 Irm Llc. UNITS AND PREPARATIONS AS CHANNEL INHIBITORS ACTIVATING PROSTHESES
DK2115153T3 (en) * 2007-03-01 2013-09-08 Bp Corp North America Inc Nitrilases, nucleic acids encoding them, and methods of preparing and using them
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CL2008003651A1 (en) 2007-12-10 2009-06-19 Novartis Ag Substituted 3,5-diamino-6-chloropyrazinamide derivative compounds; pharmaceutical composition; pharmaceutical combination; and use in the treatment of an inflammatory or allergic condition, in particular an inflammatory or obstructive disease of the airways.
JP5165393B2 (en) * 2008-01-10 2013-03-21 旭化成ケミカルズ株式会社 Method for producing glycolic acid or ammonium glycolate
AU2009203693B2 (en) 2008-01-11 2012-06-07 Novartis Ag Pyrimidines as kinase inhibitors
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
CA2727196A1 (en) 2008-06-10 2009-12-17 Novartis Ag Organic compounds
PL2391366T3 (en) 2009-01-29 2013-04-30 Novartis Ag Substituted benzimidazoles for the treatment of astrocytomas
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EA201200260A1 (en) 2009-08-12 2012-09-28 Новартис Аг HETEROCYCLIC HYDRAZONES AND THEIR APPLICATION FOR THE TREATMENT OF CANCER AND INFLAMMATION
NZ598220A (en) 2009-08-17 2014-02-28 Intellikine Llc Heterocyclic compounds and uses thereof
CA2771432A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds
US20110098311A1 (en) 2009-10-22 2011-04-28 Vertex Pharmaceuticals Incorported Compositions for treatment of cystic fibrosis and other chronic diseases
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
UY33597A (en) 2010-09-09 2012-04-30 Irm Llc COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE TRK
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
EP2673277A1 (en) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
MA34969B1 (en) 2011-02-25 2014-03-01 Irm Llc COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS
GB201111639D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
GB201111637D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
CA2848809A1 (en) 2011-09-15 2013-03-21 Novartis Ag 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
WO2013038386A1 (en) 2011-09-16 2013-03-21 Novartis Ag Heterocyclic compounds for the treatment of cystic fibrosis
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
ES2882807T3 (en) 2011-09-16 2021-12-02 Novartis Ag N-substituted heterocyclyl carboxamides
JP6130391B2 (en) 2011-11-23 2017-05-17 インテリカイン, エルエルシー Enhanced treatment regimen using MTOR inhibitors
CN102363775B (en) * 2011-11-30 2014-04-02 重庆大学 Method for purifying nitrilase
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
AU2013243097A1 (en) 2012-04-03 2014-10-09 Novartis Ag Combination products with tyrosine kinase inhibitors and their use
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
EP2968340A4 (en) 2013-03-15 2016-08-10 Intellikine Llc Combination of kinase inhibitors and uses thereof
TW201605450A (en) 2013-12-03 2016-02-16 諾華公司 Combination of Mdm2 inhibitor and BRAF inhibitor and their use
US9862711B2 (en) 2014-04-24 2018-01-09 Novartis Ag Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
CA2945212A1 (en) 2014-04-24 2015-10-29 Novartis Ag Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
BR112016024484A2 (en) 2014-04-24 2017-08-15 Novartis Ag aminopyridine derivatives as phosphatidylinositol 3-kinase inhibitors
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
CA2954862A1 (en) 2014-07-31 2016-02-04 Novartis Ag Combination therapy
CN104774825B (en) * 2015-03-23 2017-11-07 浙江工业大学 Nitrilase mutants and its application
WO2017085747A2 (en) * 2015-11-19 2017-05-26 Gsp Crop Science Pvt. Ltd, A novel process for the preparation of trifloxystrobin
CN106854673B (en) * 2016-12-23 2020-05-15 枣庄市杰诺生物酶有限公司 Method for preparing R-o-chloromandelic acid by using nitrilase engineering bacteria
CN109111043B (en) * 2018-09-16 2021-11-09 苏州渭中科技发展有限公司 Treatment method of high-salt high-COD wastewater
BR112021014356A2 (en) * 2019-01-22 2021-10-05 Basf Se ISOLATED NITRILASE, ISOLATED NITRILASE SEQUENCE, 4-CYANOBENZOIC ACID PRODUCTION PROCESSES, RECOMBINANT CONSTRUCTION, RECOMBINANT VECTOR, RECOMBINANT MICRO-ORGANISM, MICRO-ORGANISM, PRODUCTION METHOD OF A NITRILASE, COMPOSITION AND MANUFACTURING METHOD OF AN AQUEOUS SOLUTION
AU2020290094B2 (en) 2019-06-10 2024-01-18 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF, COPD, and bronchiectasis
AU2020338971B2 (en) 2019-08-28 2023-11-23 Novartis Ag Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease
TW202140550A (en) 2020-01-29 2021-11-01 瑞士商諾華公司 Methods of treating an inflammatory or obstructive airway disease using anti-tslp antibody

Citations (1)

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EP0780471A2 (en) * 1995-07-31 1997-06-25 Nitto Chemical Industry Co., Ltd. Novel nitrilase gene

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Also Published As

Publication number Publication date
DK2327766T3 (en) 2016-03-07
EP2327767B1 (en) 2015-04-29
CA2677781C (en) 2013-01-29
JP2007252382A (en) 2007-10-04
AU2010212259A1 (en) 2010-09-02
WO2003000840A3 (en) 2007-11-15
CA2445046A1 (en) 2003-01-03
JP2005509407A (en) 2005-04-14
EP2319919A1 (en) 2011-05-11
EP2039762A2 (en) 2009-03-25
AU2006252258B2 (en) 2010-07-22
EP2039762A3 (en) 2009-07-29
EP2327767A1 (en) 2011-06-01
AU2006252258A1 (en) 2007-01-25
AU2010212259B2 (en) 2012-11-29
EP2327766A1 (en) 2011-06-01
JP4405528B2 (en) 2010-01-27
EP2327765B1 (en) 2015-04-01
DK2327767T3 (en) 2015-07-27
EP2327766B1 (en) 2015-12-02
CA2677781A1 (en) 2003-01-03
CA2445046C (en) 2009-11-24
JP4405258B2 (en) 2010-01-27
EP2327765A1 (en) 2011-06-01
EP1578910A2 (en) 2005-09-28
DK2327765T3 (en) 2015-07-13
EP2319919B1 (en) 2015-08-12
WO2003000840A2 (en) 2003-01-03

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Ipc: C12P 7/00 20060101ALI20071213BHEP

Ipc: C12P 1/00 20060101ALI20071213BHEP

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Ipc: C12N 9/78 20060101ALI20071213BHEP

Ipc: C12N 9/00 20060101AFI20071213BHEP

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