EP1578910A4 - Nitrilasen - Google Patents

Nitrilasen

Info

Publication number
EP1578910A4
EP1578910A4 EP02780877A EP02780877A EP1578910A4 EP 1578910 A4 EP1578910 A4 EP 1578910A4 EP 02780877 A EP02780877 A EP 02780877A EP 02780877 A EP02780877 A EP 02780877A EP 1578910 A4 EP1578910 A4 EP 1578910A4
Authority
EP
European Patent Office
Prior art keywords
nitrilases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02780877A
Other languages
English (en)
French (fr)
Other versions
EP1578910A2 (de
Inventor
Grace Desantis
Jennifer Ann Chaplin
David Paul Weiner
Aileen Milan
Ellen Chi
Jay M Short
Mark Madden
Mark Burk
Dan Robertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Enzymes LLC
Original Assignee
Verenium Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verenium Corp filed Critical Verenium Corp
Priority to EP10190401.9A priority Critical patent/EP2319919B1/de
Priority to EP08075753A priority patent/EP2039762A3/de
Priority to EP10189100.0A priority patent/EP2327765B1/de
Priority to EP20100190399 priority patent/EP2327767B1/de
Priority to EP10190397.9A priority patent/EP2327766B1/de
Publication of EP1578910A2 publication Critical patent/EP1578910A2/de
Publication of EP1578910A4 publication Critical patent/EP1578910A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C12P13/004—Cyanohydrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treatment Of Sludge (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Processing Of Solid Wastes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
EP02780877A 2001-06-21 2002-05-15 Nitrilasen Withdrawn EP1578910A4 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP10190401.9A EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP08075753A EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30018901P 2001-06-21 2001-06-21
US300189P 2001-06-21
US30900601P 2001-07-30 2001-07-30
US309006P 2001-07-30
US35133602P 2002-01-22 2002-01-22
US351336P 2002-01-22
PCT/US2002/015983 WO2003000840A2 (en) 2001-06-21 2002-05-15 Nitrilases

Related Child Applications (5)

Application Number Title Priority Date Filing Date
EP08075753A Division EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A Division EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A Division EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 Division EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190401.9A Division EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen

Publications (2)

Publication Number Publication Date
EP1578910A2 EP1578910A2 (de) 2005-09-28
EP1578910A4 true EP1578910A4 (de) 2008-06-04

Family

ID=27404717

Family Applications (6)

Application Number Title Priority Date Filing Date
EP02780877A Withdrawn EP1578910A4 (de) 2001-06-21 2002-05-15 Nitrilasen
EP10189100.0A Expired - Lifetime EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 Expired - Lifetime EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A Expired - Lifetime EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP08075753A Withdrawn EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190401.9A Expired - Lifetime EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen

Family Applications After (5)

Application Number Title Priority Date Filing Date
EP10189100.0A Expired - Lifetime EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 Expired - Lifetime EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A Expired - Lifetime EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP08075753A Withdrawn EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190401.9A Expired - Lifetime EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen

Country Status (6)

Country Link
EP (6) EP1578910A4 (de)
JP (2) JP4405258B2 (de)
AU (2) AU2006252258B2 (de)
CA (2) CA2677781C (de)
DK (3) DK2327766T3 (de)
WO (1) WO2003000840A2 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
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JP2002537762A (ja) 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
US20040005673A1 (en) 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
US7521216B2 (en) 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US20040002147A1 (en) * 1999-12-29 2004-01-01 Desantis Grace Nitrilases
US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
US7932064B2 (en) 2002-06-13 2011-04-26 Verenium Corporation Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid
ATE435278T1 (de) 2003-02-27 2009-07-15 Basf Se Modifizierte nitrilasen und deren verwendung in verfahren zur herstellung von carbonsäuren
AR044519A1 (es) 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
US7198926B2 (en) 2003-05-08 2007-04-03 E. I. Du Pont De Nemours And Company Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
US7485423B2 (en) 2004-11-11 2009-02-03 Modular Genetics, Inc. Ladder assembly and system for generating diversity
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US7910708B2 (en) 2005-10-21 2011-03-22 Novartis Ag Anti-IL13 human antibodies
WO2007094885A2 (en) * 2005-12-07 2007-08-23 Southern Methodist University Identification of a nitrilase from b. japonicum by rational genome mining and methods of use
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
ATE549337T1 (de) 2006-04-21 2012-03-15 Novartis Ag Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten
CN100500832C (zh) * 2006-04-29 2009-06-17 浙江工业大学 枯草芽孢杆菌zjb-063及其应用
KR20090073121A (ko) 2006-09-29 2009-07-02 노파르티스 아게 Ｐｉ3ｋ 지질 키나제 억제제로서의 피라졸로피리미딘
RS51644B (sr) 2007-01-10 2011-10-31 Irm Llc. Jedinjenja i preparati kao inhibitori kanal aktivirajuće proteaze
WO2008106662A2 (en) * 2007-03-01 2008-09-04 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
KR20100005730A (ko) 2007-05-07 2010-01-15 노파르티스 아게 유기 화합물
EA017919B1 (ru) 2007-12-10 2013-04-30 Новартис Аг Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов
JP5165393B2 (ja) * 2008-01-10 2013-03-21 旭化成ケミカルズ株式会社 グリコール酸又はグリコール酸アンモニウムの製造方法
EP2231642B1 (de) 2008-01-11 2013-10-23 Novartis AG Pyrimidine als kinasehemmer
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
KR20110040818A (ko) 2008-06-10 2011-04-20 노파르티스 아게 상피 나트륨 채널 차단제로서의 피라진 유도체
PL2391366T3 (pl) 2009-01-29 2013-04-30 Novartis Ag Podstawione benzimidazole do leczenia gwiaździaków
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EA201200260A1 (ru) 2009-08-12 2012-09-28 Новартис Аг Гетероциклические гидразоны и их применение для лечения рака и воспаления
MY162604A (en) 2009-08-17 2017-06-30 Intellikine Llc Heterocyclic compounds and uses thereof
MX2012002179A (es) 2009-08-20 2012-03-16 Novartis Ag Compuestos heterociclicos de oxima.
EP2813227A1 (de) 2009-10-22 2014-12-17 Vertex Pharmaceuticals Incorporated Zusammensetzungen für die Behandlung von Mukoviszidose und anderen chronischen Erkrankungen
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
JP2014505088A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー Ｃ−ＭＥＴチロシンキナーゼ阻害剤としての［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン化合物
EP2678016B1 (de) 2011-02-23 2016-08-10 Intellikine, LLC Heterocyclische verbindungen und ihre verwendung
AU2012220572A1 (en) 2011-02-25 2013-08-29 Irm Llc Compounds and compositions as trk inhibitors
GB201111637D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
GB201111639D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
UY34329A (es) 2011-09-15 2013-04-30 Novartis Ag Compuestos de triazolopiridina
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
ES2882807T3 (es) 2011-09-16 2021-12-02 Novartis Ag Heterociclil carboxamidas N-sustituidas
WO2013038386A1 (en) 2011-09-16 2013-03-21 Novartis Ag Heterocyclic compounds for the treatment of cystic fibrosis
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
US20130209543A1 (en) 2011-11-23 2013-08-15 Intellikine Llc Enhanced treatment regimens using mtor inhibitors
CN102363775B (zh) * 2011-11-30 2014-04-02 重庆大学 一种纯化腈水解酶的方法
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
CN110507654A (zh) 2012-04-03 2019-11-29 诺华有限公司 有酪氨酸激酶抑制剂的组合产品和其应用
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
EP2968340A4 (de) 2013-03-15 2016-08-10 Intellikine Llc Kombination von kinaseinhibitoren und verwendungen davon
WO2015084804A1 (en) 2013-12-03 2015-06-11 Novartis Ag Combination of mdm2 inhibitor and braf inhibitor and their use
US10112926B2 (en) 2014-04-24 2018-10-30 Novartis Ag Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
PL3134395T3 (pl) 2014-04-24 2018-07-31 Novartis Ag Pochodne pirazyny jako inhibitory 3-kinazy fosfatydyloinozytolu
EP3134397A1 (de) 2014-04-24 2017-03-01 Novartis AG Aminopyrazinderivate als phosphatidylinositol-3-kinasehemmer
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
KR20170036037A (ko) 2014-07-31 2017-03-31 노파르티스 아게 조합 요법
CN104774825B (zh) * 2015-03-23 2017-11-07 浙江工业大学 腈水解酶突变体及其应用
CN108368033B (zh) * 2015-11-19 2021-05-04 Gsp作物科学有限公司 一种用于制备肟菌酯的方法
CN106854673B (zh) * 2016-12-23 2020-05-15 枣庄市杰诺生物酶有限公司 利用腈水解酶工程菌制备r-邻氯扁桃酸的方法
CN109111043B (zh) * 2018-09-16 2021-11-09 苏州渭中科技发展有限公司 一种高盐高cod废水的处理方法
CN113614242A (zh) * 2019-01-22 2021-11-05 巴斯夫欧洲公司 4-氰基苯甲酸或其盐的生产方法
EP3980121A1 (de) 2019-06-10 2022-04-13 Novartis AG Pyridin- und pyrazinderivate zur behandlung von cf, copd und bronchiektasie
PH12022550468A1 (en) 2019-08-28 2023-03-06 Novartis Ag Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0780471A2 (de) * 1995-07-31 1997-06-25 Nitto Chemical Industry Co., Ltd. Neues Nitrilase-Gen

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Also Published As

Publication number Publication date
AU2006252258B2 (en) 2010-07-22
EP2319919B1 (de) 2015-08-12
DK2327766T3 (en) 2016-03-07
EP2327767B1 (de) 2015-04-29
EP2327765B1 (de) 2015-04-01
JP2007252382A (ja) 2007-10-04
EP2327766B1 (de) 2015-12-02
AU2010212259B2 (en) 2012-11-29
AU2010212259A1 (en) 2010-09-02
JP2005509407A (ja) 2005-04-14
EP2327766A1 (de) 2011-06-01
CA2445046A1 (en) 2003-01-03
JP4405528B2 (ja) 2010-01-27
AU2006252258A1 (en) 2007-01-25
JP4405258B2 (ja) 2010-01-27
EP2319919A1 (de) 2011-05-11
DK2327765T3 (en) 2015-07-13
CA2445046C (en) 2009-11-24
CA2677781A1 (en) 2003-01-03
EP1578910A2 (de) 2005-09-28
WO2003000840A2 (en) 2003-01-03
EP2327765A1 (de) 2011-06-01
EP2327767A1 (de) 2011-06-01
EP2039762A3 (de) 2009-07-29
CA2677781C (en) 2013-01-29
EP2039762A2 (de) 2009-03-25
DK2327767T3 (en) 2015-07-27
WO2003000840A3 (en) 2007-11-15

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